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1. 发明申请

US20090199620A1 CHROMATOGRAPH MASS ANALYSIS DATA PROCESSING APPARATUS 审中-公开
标题翻译：色谱分析数据处理设备
公开(公告)号：US20090199620A1
公开(公告)日：2009-08-13
申请号：US12303471
申请日：2006-06-08
申请人： Shuichi Kawana , Katsuyuki Taneda , Manabu Shimomura
发明人： Shuichi Kawana , Katsuyuki Taneda , Manabu Shimomura
IPC分类号： G01N30/02 , H01J49/00
CPC分类号： G01N30/8603 , G01N30/72 , G01N30/8617 , H01J49/0036
摘要： In the case where a given mass range is repeatedly scanned to sequentially create mass spectra and create a mass chromatogram or the like, when a number of data, which are arranged on the mass axis and constitute a mass profile of the given mass range, are collected for a predetermined number of the alignment (S1 and S2), a two-dimensional filtering process is performed by correcting the target data, for each data aligned in the mass axis direction, using the data contiguous before and after in the mass axis direction and the data contiguous before and after in the time axis direction (S3). For the mass profile constituted of the data thus processed, a peak detection is performed (S4) and the peak's mass number is determined to create a mass spectrum (S5). Consequently, the mass numbers' fluctuation in the mass spectrum is moderated, the mass resolution is increased, and the accuracy of the mass chromatogram is also increased.
摘要翻译：在重复扫描给定质量范围以依次产生质谱并产生质谱图的情况下，当排列在质量轴上并构成给定质量范围的质量分布的多个数据为对于预定数量的对准（S1和S2）收集，通过使用在质量轴方向上前后相邻的数据，对于在质量轴方向上对齐的每个数据来校正目标数据，执行二维滤波处理和在时间轴方向上前后相邻的数据（S3）。对于由这样处理的数据构成的质量分布，进行峰值检测（S4），确定峰值质量以产生质谱（S5）。因此，质谱数量波动变小，质量分辨率提高，质谱图精度也提高。

2. 发明申请

US20040204864A1 Signal to noise ratio in chromatography 审中-公开
标题翻译：色谱中的信噪比
公开(公告)号：US20040204864A1
公开(公告)日：2004-10-14
申请号：US10410373
申请日：2003-04-09
发明人： Robert W. Allington
IPC分类号： G01N030/02
CPC分类号： G01N30/8603 , G01N30/78 , G01N2030/626 , G01N2030/324
摘要： Signals obtained in High Performance Liquid Chromatography (HPLC) are notoriously noisy. The signal can be improved by increasing the path length of the light passing through the sample, but increased path length also invites greater refraction and reflection of that light. A novel approach is to utilize a number of photocell sensors lined up along a capillary through which the solution passes. Through careful measurement and calculation, a signal for a single fluid particle can be produced by all the photocell sensors. By incorporating an appropriate delay between each signal, to take into account the finite speed of the fluid, the resulting plurality of noisy signals can be summed or statistically correlated. The signal, containing the important information about the fluid, will increase with the number of photocells used, while the noise increases by the square root of the number of photocells used. The signal to noise ratio, then, increases as the square of the number of photocells used. In this way, the effective path length is increased without including any moving parts.
摘要翻译：在高效液相色谱（HPLC）中获得的信号是臭名昭着的噪音。可以通过增加通过样品的光的路径长度来改善信号，但是增加的路径长度也引起该光的更大的折射和反射。一种新颖的方法是利用沿溶液通过的毛细管排列的多个光电池传感器。通过仔细的测量和计算，可以通过所有的光电池传感器产生单个流体颗粒的信号。通过在每个信号之间引入适当的延迟，考虑到流体的有限速度，所得到的多个噪声信号可以相加或统计相关。含有关于流体的重要信息的信号将随着使用的光电池的数量而增加，而噪声则以所使用的光电池数量的平方根增加。然后，信噪比随着使用的光电管的数量的平方而增加。以这种方式，增加有效路径长度而不包括任何移动部件。

3. 发明授权

US6014213A High dynamic range apparatus for separation and detection of polynucleotide fragments 失效
标题翻译：用于分离和检测多核苷酸片段的高动态范围装置
公开(公告)号：US6014213A
公开(公告)日：2000-01-11
申请号：US819910
申请日：1997-03-18
申请人： Paul Waterhouse , Alexandre M. Izmailov , Henryk Zaleski , John A. Renfrew , James W. Cassidy
发明人： Paul Waterhouse , Alexandre M. Izmailov , Henryk Zaleski , John A. Renfrew , James W. Cassidy
IPC分类号： G01N27/447 , G01N30/86 , G01N21/00
CPC分类号： G01N30/8603 , G01N27/44721
摘要： A high dynamic range apparatus for separation and detection of polynucleotide fragments has a housing adapted to receive an electrophoresis gel holder containing an electrophoresis gel loaded with fluorophore-labeled samples; one or more laser diodes for providing radiation of a frequency suitable for excitation of the fluorophore which irradiates a an array of excitation/detection sites on the electrophoresis gel; an array of detectors aligned with the excitation/detection sites for collecting fluorescent emissions; and one or more components for increasing the dynamic range of the instrument by at least an order of magnitude. These components, which can be used individually or in combination include detectors that are connected to a signal processing system that modulates the period of signal integration employed so that large signals are totaled at short time intervals and smaller signals are totaled at longer time intervals; the use of a beam splitter to produces a high intensity beam of emitted light and a low intensity beam of emitted light from each excitation/detection site; and a device for modulating the intensity of the excitation beam can be used to improve the dynamic range of the instrument.
摘要翻译：用于分离和检测多核苷酸片段的高动态范围装置具有适于接收含有装载有荧光团标记的样品的电泳凝胶的电泳凝胶保持器的壳体; 用于提供适于激发荧光团的频率的辐射的一个或多个激光二极管，其照射电泳凝胶上的激发/检测位点阵列; 与用于收集荧光发射的激发/检测部位对准的检测器阵列; 以及用于将仪器的动态范围增加至少一个数量级的一个或多个组件。可以单独或组合使用的这些组件包括连接到信号处理系统的检测器，该信号处理系统调制所采用的信号积分的周期，以便以较短的时间间隔合计大信号，并以更长的时间间隔合计较小的信号; 使用分束器产生高强度发射光束和来自每个激发/检测部位的低强度发射光束; 并且可以使用用于调制激发光束的强度的装置来改善仪器的动态范围。

4. 发明授权

US3614409A Timing device, particularly for chromatographs 失效
标题翻译：时序设备，特别适用于色谱
公开(公告)号：US3614409A
公开(公告)日：1971-10-19
申请号：US3614409D
申请日：1969-02-20
申请人： BRITISH PETROLEUM CO
发明人： WATKIN BRIAN LESLIE HIGHFORD
IPC分类号： G01N30/86 , G06G7/18
CPC分类号： G01N30/8624 , G01N30/8603
摘要： A waveform-analyzing system, particularly for use with chromatographs, wherein the waveform is integrated between selected characteristic points thereof, and selected peaks of the waveform are used as recycling zero time markers which act to restart a timing device programmed to stop before each successive one of said selected peaks instead of operating relative to a continuously running time scale defined by a single point at the beginning of the waveform.

5. 发明授权

US3500028A Automatic chromatography system 失效
标题翻译：自动色谱系统
公开(公告)号：US3500028A
公开(公告)日：1970-03-10
申请号：US3500028D
申请日：1965-03-10
申请人： FOSTER GRANT CO INC
发明人： KILLIAN CHARLES R
IPC分类号： G01N3/08 , B65H67/04 , G01N30/86 , G06G7/75 , G06G7/18 , G06F15/20 , G06G7/48
CPC分类号： G01N30/8651 , B65H67/0434 , B65H2701/31 , G01N30/8603 , G01N30/8606 , G06G7/75

6. 发明授权

US3286179A Plural range electro-mechanical integrating apparatus having variable transmission ratio gear assembly to provide for constant rate recording 失效
标题翻译：具有可变传动比齿轮组件的多范围机电一体化装置，以提供恒定速率记录
公开(公告)号：US3286179A
公开(公告)日：1966-11-15
申请号：US23449162
申请日：1962-10-31
申请人： SHELL OIL CO
发明人： ALBERTUS SCHURINGA
IPC分类号： G01N30/86 , G06G7/188
CPC分类号： G01N30/86 , G01N30/8603 , G06G7/188

7. 发明授权

US3026502A Peak signal summation system 失效
标题翻译：峰值信号求和系统
公开(公告)号：US3026502A
公开(公告)日：1962-03-20
申请号：US7403560
申请日：1960-12-06
申请人： UNION CARBIDE CORP
发明人： ROGERS LOUIS J , WEISS MARVIN D
IPC分类号： G01N30/86 , G05D3/14
CPC分类号： G01N30/8603 , G01N30/8606 , G05D3/14

8. 发明公开

US20240085387A1 MULTI-STAGE TANDEM MASS SPECTROMETRY FOR PROTONATED GLYCAN ISOMER ASSIGNMENT 审中-公开
公开(公告)号：US20240085387A1
公开(公告)日：2024-03-14
申请号：US18329495
申请日：2023-06-05
申请人： University of Washington
发明人： Abhigya Mookherjee , Miklos Guttman
IPC分类号： G01N30/86 , H01J49/00 , H01J49/42
CPC分类号： G01N30/8631 , G01N30/8603 , G01N30/8679 , H01J49/0072 , H01J49/424 , G01N2030/027 , G01N2030/862
摘要： The present disclosure provides a method of analyzing the structure of a glycan sample, the method including: receiving data indicative of one or more spectra of mass-to-charge ratio (m/z) versus relative abundance of the glycan sample from a mass spectrometer (MS) instrument; generating a ratio according to the following Equation:

a

a
+
b

wherein a is a magnitude of one or more first peaks in the one or more spectra and b is the magnitude of one or more second peaks in the one or more spectra; determining that the ratio is within a range of a predetermined ratio; based on determining that the ratio is within the range of the predetermined ratio, determining that a predetermined structural characteristic is present in the glycan sample; and outputting an indication of the predetermined structural characteristic in the glycan sample.

9. 发明申请

US20060284067A1 Methods for improved data dependent acquisition 有权
标题翻译：改进数据相关获取的方法
公开(公告)号：US20060284067A1
公开(公告)日：2006-12-21
申请号：US11144178
申请日：2005-06-02
申请人： Michael Senko , Eric Hemenway , Tina Hemenway
发明人： Michael Senko , Eric Hemenway , Tina Hemenway
IPC分类号： B01D59/44
CPC分类号： H01J49/0036 , G01N30/72 , G01N30/8603 , G01N30/8693
摘要： A method of analyzing data from a mass spectrometer for a data dependent acquisition is described. In an embodiment of this method, mass spectral scans are taken of a sample eluted from a liquid chromatography column. An extracted ion chromatogram (XIC) is then created for each m/z data point of the mass spectral scans and the XIC for each m/z data point are correlated to a model function, such as a monotonically increasing function, or the first half of a gaussian function, to obtain a XIC correlation value. A weighting function is then applied to the XIC correlation value to obtain a current weighted intensity. The current weighted intensity for each m/z point is used to reconstruct a weighted mass spectrum, which is then used to make a real-time decision for the data dependent acquisition. In an embodiment, the data dependent acquisition is the performance of tandem mass spectrometry. Embodiments of the invention also describe a sample processing apparatus for the data dependent acquisition and a computer readable medium that provides instructions to the sample processing apparatus to perform the method described above.
摘要翻译：描述了从质谱仪分析数据依赖获取的数据的方法。在该方法的一个实施方案中，从液相色谱柱洗脱的样品进行质谱扫描。然后为质谱扫描的每个m / z数据点创建提取的离子色谱图（XIC），并且对于每个m / z数据点，XIC与模型函数（例如单调递增函数）或上半部分的高斯函数，以获得XIC相关值。然后将加权函数应用于XIC相关值以获得当前加权强度。每个m / z点的当前加权强度用于重建加权质谱，然后将其用于对依赖于数据的获取进行实时决策。在一个实施例中，依赖于数据的获取是串联质谱法的性能。本发明的实施例还描述了用于数据相关获取的样本处理装置和向样本处理装置提供指令以执行上述方法的计算机可读介质。

10. 发明授权

US06694265B2 Method and apparatus for determining the boundaries of a detector response profile and for controlling processes 有权
标题翻译：用于确定检测器响应曲线的边界并用于控制过程的方法和装置
公开(公告)号：US06694265B2
公开(公告)日：2004-02-17
申请号：US09949199
申请日：2001-09-07
申请人： Marc V. Gorenstein
发明人： Marc V. Gorenstein
IPC分类号： G06F1900
CPC分类号： G01N30/8624 , G01N30/82 , G01N30/8603 , G01N30/861 , G01N30/8627 , G01N30/8631 , G01N30/8634 , G01N30/8641
摘要： An improved method and apparatus for identifying peaks and for determining the boundaries of those peaks, and boundaries of multiple peaks and shoulders within chromatograms. The method and apparatus effects real time identification and determination of the boundaries of these peaks for the purpose of fraction collection. The method and apparatus determines the boundary of a peak within a detector response profile that comprises data points plotted graphically on an X and Y-axis wherein the X-axis represents a first variable and the Y-axis represents a second variable, each variable having a value. The plot at each of the data points has a slope. Data points having a slope which deviates from a consistent value define a peak, and data points having a slope with a consistent value define a baseline.
摘要翻译：一种改进的方法和装置，用于鉴定峰和确定这些峰的边界，以及色谱图内多个峰和肩的边界。该方法和装置实现了这些峰的边界的实时鉴定和确定，用于分馏收集。所述方法和装置确定检测器响应曲线内的峰值的边界，其包括在X和Y轴上以图形方式绘制的数据点，其中X轴表示第一变量，Y轴表示第二变量，每个变量具有一个值。每个数据点的曲线都有一个斜率。具有偏离一致值的斜率的数据点定义峰值，具有一致值的斜率的数据点定义基线。

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