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1. 发明授权

US6022713A Process for producing nucleoside 5'-triphosphates and application of the same 失效
标题翻译：制备核苷5'-三磷酸的方法及其应用
公开(公告)号：US6022713A
公开(公告)日：2000-02-08
申请号：US101683
申请日：1998-07-15
申请人： Toshitada Noguchi , Toshikazu Shiba
发明人： Toshitada Noguchi , Toshikazu Shiba
IPC分类号： C12N9/12 , C12N9/90 , C12P19/30 , C12P19/00 , C12P19/18 , C12P19/26
CPC分类号： C12N9/1229 , C12N9/1241 , C12N9/90 , C12P19/30 , C12Y207/04001 , C12Y207/07009 , C12Y501/03002 , Y02P20/582
摘要： The present invention relates to a process for producing nucleoside 5'-triphosphates (NTP) from nucleoside 5'-diphosphates (NDP) other than adenosine 5'-diphosphate (ADP), characterized by using a polyphosphate kinase as an enzyme and polyphosphate as the phosphate donor; and application of this process to various glycosylation reactions.This process makes it possible to conveniently and economically synthesize NTP from NDP enzymatically. Also, it becomes possible thereby to economically recycle and synthesize sugar nucleotides and synthesize, for example, oligosaccharides associating therewith without resort to expensive phosphoenol pyruvate, ATP, etc. in the reactions for reproducing or converting NDP into NTP in the systems for enzymatically synthesizing oligosaccharides by combining, for example, with the synthesis of sugar nucleotides.
摘要翻译： PCT No.PCT / JP97 / 04159 Sec。 371日期：1998年7月15日 102（e）日期1998年7月15日PCT 1997年11月14日PCT PCT。第WO98 / 22614号公报日期1998年5月28日本发明涉及一种由5'-二磷酸腺苷（ADP）以外的核苷5'-二磷酸（NDP）生产核苷5'-三磷酸（NTP）的方法，其特征在于使用多磷酸激酶作为酶和多磷酸盐作为磷酸盐供体; 并将该方法应用于各种糖基化反应。该方法使得可以方便和经济地从NDP酶合成NTP。另外，可以经济地循环和合成糖核苷酸，并合成例如在与低聚糖合成的系统中用于再生或将NDP再生或转化成NTP的反应中，与昂贵的磷酸烯醇丙酮酸，ATP等缔合而成的寡糖通过例如与糖核苷酸的合成组合。

2. 发明申请

US20060088918A1 Novel polyphosphate:amp phosphotransferase 有权
标题翻译：新型多磷酸盐：amp磷酸转移酶
公开(公告)号：US20060088918A1
公开(公告)日：2006-04-27
申请号：US10514726
申请日：2003-05-28
申请人： Toshikazu Shiba , Toshitada Noguchi
发明人： Toshikazu Shiba , Toshitada Noguchi
IPC分类号： C12P19/30 , C12N9/12
CPC分类号： C12N9/1229 , C12N9/12 , C12P19/30 , C12P19/32 , C12P19/40
摘要： This invention relates to a novel polyphosphate: AMP phosphotransferase (PAP), a gene coding this PAP, and their use. The PAP has the following properties: (A) action: catalyzing of the following two reactions: NMP+PolyP(n)→NDP+PolyP(n-1) dNMP+POlyP(n)→dNDP+PolyP(n-1) (wherein NMP represents nucleoside monophosphate, NDP represents nucleoside diphosphate, dNMP represents deoxynucleoside monophosphate, dNDP represents deoxynucleoside diphosphate, n represents degree of polymerization of the polyphosphate which is an integer of up to 100); (B) substrate specificity: specific to AMP, GMP, IMP, dAMP, and dGMP, also acting with CMP, UMP, dCMP, and TMP; (C) molecular weight: about 55 to 56 Kd (kilodalton); and (D) specific activity: at least 70 units per 1 mg of enzyme protein,
摘要翻译：本发明涉及新型多磷酸盐：AMP磷酸转移酶（PAP），编码该PAP的基因及其用途。 PAP具有以下性质：（A）作用：催化以下两个反应：<？in-line-formula description =“In-line Formulas”end =“lead”？> NMP + PolyP（n） - > NDP + PolyP（n-1） <？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-Line Formulas”end =“lead”？> dNMP + POlyP（n） - > dNDP + PolyP（n-1）（其中NMP表示核苷单磷酸，NDP表示核苷二磷酸，dNMP表示脱氧核苷单磷酸，dNDP表示脱氧核苷二磷酸，n表示多磷酸酯的聚合度，整数高达100）; （B）底物特异性：特异于AMP，GMP，IMP，dAMP和dGMP，也与CMP，UMP，dCMP和TMP起作用; （C）分子量：约55至56Kd（千道尔顿）; 和（D）比活性：每1mg酶蛋白至少70个单位，

3. 发明申请

US20080108111A1 NOVEL POLYPHOSPHATE: AMP PHOSPHOTRANSFERASE 审中-公开
标题翻译：新型聚磷酸酯：AMP磷酸酯酶
公开(公告)号：US20080108111A1
公开(公告)日：2008-05-08
申请号：US11875268
申请日：2007-10-19
申请人： Toshikazu SHIBA , Toshitada Noguchi
发明人： Toshikazu SHIBA , Toshitada Noguchi
IPC分类号： C12P19/30
CPC分类号： C12N9/1229 , C12N9/12 , C12P19/30 , C12P19/32 , C12P19/40
摘要： This invention relates to a novel polyphosphate: AMP phosphotransferase (PAP), a gene coding this PAP, and their use. The PAP has the following properties: (A) action: catalyzing of the following two reactions: NMP+PolyP(n)→NDP+PolyP(n-1) dNMP+PolyP(n)→dNDP+PolyP(n-1) (wherein NMP represents nucleoside monophosphate, NDP represents nucleoside diphosphate, dNMP represents deoxynucleoside monophosphate, dNDP represents deoxynucleoside diphosphate, n represents degree of polymerization of the polyphosphate which is an integer of up to 100); (B) substrate specificity: specific to AMP, GMP, IMP, dAMP, and dGMP, also acting with CMP, UMP, dCMP, and TMP; (C) molecular weight: about 55 to 56 Kd (kilodalton); and (D) specific activity: at least 70 units per 1 mg of enzyme protein,
摘要翻译：本发明涉及新型多磷酸盐：AMP磷酸转移酶（PAP），编码该PAP的基因及其用途。 PAP具有以下性质：（A）作用：催化以下两个反应：<？in-line-formula description =“In-line Formulas”end =“lead”？> NMP + PolyP（n） - > NDP + PolyP（n-1） <？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-line Formulas”end =“lead”？> dNMP + PolyP（n） - > dNDP + PolyP（n-1）

4. 发明授权

US07329522B2 Polyphosphate:AMP phosphotransferase 有权
标题翻译：多磷酸盐：AMP磷酸转移酶
公开(公告)号：US07329522B2
公开(公告)日：2008-02-12
申请号：US10514726
申请日：2003-05-28
申请人： Toshikazu Shiba , Toshitada Noguchi
发明人： Toshikazu Shiba , Toshitada Noguchi
IPC分类号： C12N9/12 , C12N1/20 , C12P19/30 , C12P21/06 , C07H21/04
CPC分类号： C12N9/1229 , C12N9/12 , C12P19/30 , C12P19/32 , C12P19/40
摘要： This invention relates to a novel polyphosphate: AMP phosphotransferase (PAP), a gene coding this PAP, and their use. The PAP has the following properties:(A) action: catalyzing of the following two reactions: NMP+PolyP(n)→NDP+PolyP(n-1) dNMP+POlyP(n)→dNDP+PolyP(n-1) (wherein NMP represents nucleoside monophosphate, NDP represents nucleoside diphosphate, dNMP represents deoxynucleoside monophosphate, dNDP represents deoxynucleoside diphosphate, n represents degree of polymerization of the polyphosphate which is an integer of up to 100); (B) substrate specificity: specific to AMP, GMP, IMP, dAMP, and dGMP, also acting with CMP, UMP, dCMP, and TMP;(C) molecular weight: about 55 to 56 Kd (kilodalton); and(D) specific activity: at least 70 units per 1 mg of enzyme protein.
摘要翻译：本发明涉及新型多磷酸盐：AMP磷酸转移酶（PAP），编码该PAP的基因及其用途。 PAP具有以下性质：（A）作用：催化以下两个反应：<？in-line-formula description =“In-line Formulas”end =“lead”？> NMP + PolyP（n） - > NDP + PolyP（n-1） <？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In-Line Formulas”end =“lead”？> dNMP + POlyP（n） - > dNDP + PolyP（n-1）（其中NMP表示核苷单磷酸，NDP表示核苷二磷酸，dNMP表示脱氧核苷单磷酸，dNDP表示脱氧核苷二磷酸，n表示多磷酸酯的聚合度，整数高达100）; （B）底物特异性：特异于AMP，GMP，IMP，dAMP和dGMP，也与CMP，UMP，dCMP和TMP起作用; （C）分子量：约55至56Kd（千道尔顿）; 和（D）比活性：每1mg酶蛋白至少70个单位。

5. 发明授权

US08450441B2 Synthetic N-linked sialo-glycan-containing polymer and method for producing the same 失效
标题翻译：合成的N-连接唾液酸聚糖聚合物及其制备方法
公开(公告)号：US08450441B2
公开(公告)日：2013-05-28
申请号：US12666482
申请日：2008-06-24
申请人： Taiichi Usui , Takeomi Murata , Takashi Suzuki , Ilpal Jwa , Yusuke Ohba , Tomoki Hamamoto , Toshitada Noguchi
发明人： Taiichi Usui , Takeomi Murata , Takashi Suzuki , Ilpal Jwa , Yusuke Ohba , Tomoki Hamamoto , Toshitada Noguchi
IPC分类号： C08F251/00 , C07H15/06 , C12Q1/70
CPC分类号： C08G69/48 , A61K31/7012 , A61K47/645 , C08G69/04 , C08G69/10 , C08G69/40
摘要： A polymer containing an N-linked sialo-glycan wherein a sialo-glycan is condensed to a γ-polyglutamic acid using a chemical compound having an amino group on one end and a carboxyl group on another end and represented by the structural formula (I). Formula (I) (In the formula, Z means a hydroxy group or a residue represented by the formula (II), and n represents an integer of 10 or more, with the proviso that any one or more of the Z's is represented by the formula in (II).) Formula (II) (In the formula, X means a hydroxy group or an acetylamino group, Y1 and Y2 mean a hydroxyl group or an N-acetylneuraminic acid residue, L means a hydrocarbon, an m represents 0 or an integer of 1 or 2, with the proviso that Y1 and Y2 are not the same.)
摘要翻译：一种含有N-连接的唾液酸聚糖的聚合物，其中使用一端具有氨基的化合物和另一端的羧基并由结构式（I）表示的唾液酸聚糖与γ-聚谷氨酸缩合，。式（I）（式中，Z表示羟基或式（II）表示的残基，n表示10以上的整数，条件是Z中的任一个以上可以由式（II）中，式（II）（式中，X表示羟基或乙酰氨基，Y1和Y2表示羟基或N-乙酰神经氨酸残基，L表示烃，m表示0 或1或2的整数，条件是Y1和Y2不相同。）

6. 发明申请

US20090018327A1 SUGAR CHAIN CONTAINING 4-POSITION HALOGENATED GALACTOSE AND APPLICATION THEREOF 失效
标题翻译：含有4-位羟基糖的糖链及其应用
公开(公告)号：US20090018327A1
公开(公告)日：2009-01-15
申请号：US11815329
申请日：2006-02-14
申请人： Shin-Ichiro Nishimura , Noriko Nagahori , Tomoki Hamamoto , Kiyoshi Okuyama , Toshitada Noguchi
发明人： Shin-Ichiro Nishimura , Noriko Nagahori , Tomoki Hamamoto , Kiyoshi Okuyama , Toshitada Noguchi
IPC分类号： C07H5/02 , C12P19/30
CPC分类号： C12P19/32 , C07H15/08
摘要： The present invention is directed to, for example, an oligosaccharide having at an end thereof a 4-position halogenated galactose residue represented by formula (I): (wherein X represents a halogen atom, and R represents a monosaccharide, an oligosaccharide, or a carrier), a transferase inhibitor containing the oligosaccharide, and a method for inhibiting sugar chain elongation reaction in the presence of glycosyltransferase, the method including employing the inhibitor.The invention also provides a method for producing a 4-position halogenated galactose sugar nucleotide represented by formula (II): (wherein each of R1 to R3 represents a hydroxyl group, an acetyl group, a halogen atom, or a hydrogen atom; X represents a halogen atom; and M represents a hydrogen ion or a metal ion), wherein the method employs bacterium-derived galactokinase and bacterium-derived hexose-1-phosphate uridylyltransferase.The invention is also directed to a sugar chain containing 4-position halogenated galactose envisaged to be employed as drugs and other materials, and to applications of the compound.
摘要翻译：本发明涉及例如末端具有由式（I）表示的4-位卤代半乳糖残基的寡糖：（其中，X表示卤素原子，R表示单糖，寡糖，或载体），含有寡糖的转移酶抑制剂，以及在糖基转移酶存在下抑制糖链延长反应的方法，该方法包括使用该抑制剂。本发明还提供了由式（II）表示的4-位卤代半乳糖糖核苷酸的制备方法：（式中，R 1〜R 3各自表示羟基，乙酰基，卤素原子或氢原子; X表示卤素原子; M表示氢离子或金属离子），其中该方法采用细菌来源的半乳糖激酶和细菌来源的己糖-1-磷酸尿苷酰转移酶。本发明还涉及设想用作药物和其它材料的4-位卤代半乳糖的糖链以及该化合物的应用。

7. 发明授权

US06890739B1 Use of uridine diphosphate glucose 4-epimerase 有权
标题翻译：使用尿苷二磷酸葡萄糖4-差向异构酶
公开(公告)号：US06890739B1
公开(公告)日：2005-05-10
申请号：US10130785
申请日：2000-11-22
申请人： Tomoki Hamamoto , Toshitada Noguchi
发明人： Tomoki Hamamoto , Toshitada Noguchi
IPC分类号： C12N9/90 , C12P19/30 , C12P19/38
CPC分类号： C12P19/305 , C12N9/90
摘要： The present invention relates to a new use of uridine diphosphate glucose 4-epimerase (also called uridine diphosphate galactose 4-epimerase), and a method of converting uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) to uridine diphosphate N-acetylgalactosamine (UDP-GalNAc) by using the said enzyme. The process for producing UDP-GalNAc by using the uridine diphosphate glucose 4-epimerase and the UDP-GalNAc supply system according to the present invention are practical and efficient, and greatly beneficial to the industries.
摘要翻译：本发明涉及尿苷二磷酸葡萄糖4-差向异构酶（也称为尿苷二磷酸半乳糖4-差向异构酶）的新用途，以及将尿苷二磷酸N-乙酰葡糖胺（UDP-GlcNAc）转化为尿苷二磷酸N-乙酰半乳糖胺（UDP- GalNAc）。通过使用本发明的尿苷二磷酸葡萄糖4-差向异构酶和UDP-GalNAc供给系统生产UDP-GalNAc的方法是实用和有效的，对工业有很大的益处。

8. 发明授权

US06287819B1 Process for producing uridine diphosphate-n-acetylglucosamine 失效
标题翻译：生产尿苷二磷酸正乙酰葡糖胺的方法
公开(公告)号：US06287819B1
公开(公告)日：2001-09-11
申请号：US09297306
申请日：1999-04-29
申请人： Kenji Takenouchi , Kazuya Ishige , Yuichiro Midorikawa , Kiyoshi Okuyama , Tomoki Hamamoto , Toshitada Noguchi
发明人： Kenji Takenouchi , Kazuya Ishige , Yuichiro Midorikawa , Kiyoshi Okuyama , Tomoki Hamamoto , Toshitada Noguchi
IPC分类号： C12P1930
CPC分类号： C12N9/1205 , C12P19/305
摘要： A process for producing uridine diphosphate-N-acetylglucosamine (UDPAG) from uridylic acid (UMP) and N-acetylglucosamine by use of microorganism cells, characterized by adding N-acetylglucosamine kinase thereto. According to the present invention, UDPAG can be efficiently produced even when N-acetylglucosamine is used as a substrate.
摘要翻译：通过使用微生物细胞从尿苷酸（UMP）和N-乙酰葡糖胺生产尿苷二磷酸-N-乙酰氨基葡萄糖（UDPAG）的方法，其特征在于向其中加入N-乙酰葡糖胺激酶。根据本发明，即使使用N-乙酰氨基葡糖作为底物，也能够有效地制造UDPAG。

9. 发明授权

US6040158A Process for preparing sugar nucleotide 失效
标题翻译：制备糖核苷酸的方法
公开(公告)号：US6040158A
公开(公告)日：2000-03-21
申请号：US68198
申请日：1998-05-05
申请人： Kenji Takenouchi , Tomoki Hamamoto , Toshitada Noguchi
发明人： Kenji Takenouchi , Tomoki Hamamoto , Toshitada Noguchi
IPC分类号： C12P19/30 , C12P19/00 , C12P19/26 , C12P19/32 , C12P19/40
CPC分类号： C12P19/30 , C12P19/305
摘要： A process for preparing a sugar nucleotide from a nucleotide by using a yeast cell, characterized in that both a nucleoside diphosphate-sugar pyrophosphorylase and a sugar 1-phosphate are present in the reaction system. According to this process, various sugar nucleotides, which have been prepared only in low productivity by the conventional yeast cell process, can be efficiently prepared.
摘要翻译： PCT No.PCT / JP97 / 03021 Sec。 371日期：1998年5月5日 102（e）日期1998年5月5日PCT 1997年8月29日PCT公布。公开号WO98 / 11248 日期：1998年3月19日一种通过使用酵母细胞从核苷酸制备糖核苷酸的方法，其特征在于在反应体系中存在核苷二磷酸 - 糖焦磷酸化酶和糖1-磷酸二糖。根据该方法，可以有效地制备通过常规酵母细胞过程仅以低生产率制备的各种糖核苷酸。

10. 发明授权

US08148112B2 Sugar chain containing 4-position halogenated galactose and application thereof 失效
标题翻译：含有4-位卤代半乳糖的糖链及其应用
公开(公告)号：US08148112B2
公开(公告)日：2012-04-03
申请号：US11815329
申请日：2006-02-14
申请人： Shin-Ichiro Nishimura , Noriko Nagahori , Tomoki Hamamoto , Kiyoshi Okuyama , Toshitada Noguchi
发明人： Shin-Ichiro Nishimura , Noriko Nagahori , Tomoki Hamamoto , Kiyoshi Okuyama , Toshitada Noguchi
IPC分类号： C12P19/50 , C12P19/52 , C12P19/26 , C07H15/00 , C07H5/04 , C07H5/06 , C08B37/00
CPC分类号： C12P19/32 , C07H15/08
摘要： The present invention is directed to, for example, an oligosaccharide having at an end thereof a 4-position halogenated galactose residue represented by formula (I): (wherein X represents a halogen atom, and R represents a monosaccharide, an oligosaccharide, or a carrier), a transferase inhibitor containing the oligosaccharide, and a method for inhibiting sugar chain elongation reaction in the presence of glycosyltransferase, the method including employing the inhibitor. The invention also provides a method for producing a 4-position halogenated galactose sugar nucleotide represented by formula (II): (wherein each of R1 to R3 represents a hydroxyl group, an acetyl group, a halogen atom, or a hydrogen atom; X represents a halogen atom; and M represents a hydrogen ion or a metal ion), wherein the method employs bacterium-derived galactokinase and bacterium-derived hexose-1-phosphate uridylyltransferase. The invention is also directed to a sugar chain containing 4-position halogenated galactose envisaged to be employed as drugs and other materials, and to applications of the compound.
摘要翻译：本发明涉及例如末端具有由式（I）表示的4位卤代半乳糖残基的寡糖：（其中X表示卤素原子，R表示单糖，寡糖或载体），含有寡糖的转移酶抑制剂，以及在糖基转移酶存在下抑制糖链延长反应的方法，该方法包括使用该抑制剂。本发明还提供了由式（II）表示的4-位卤代半乳糖糖核苷酸的制备方法：（式中，R 1〜R 3各自表示羟基，乙酰基，卤素原子或氢原子; X表示卤素原子; M表示氢离子或金属离子），其中该方法采用细菌来源的半乳糖激酶和细菌来源的己糖-1-磷酸尿苷酰转移酶。本发明还涉及设想用作药物和其它材料的4-位卤代半乳糖的糖链以及该化合物的应用。

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