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1. 发明申请

US20070207450A1 System and method for process automation 审中-公开
标题翻译：过程自动化的系统和方法
公开(公告)号：US20070207450A1
公开(公告)日：2007-09-06
申请号：US11584042
申请日：2006-10-20
申请人： Seth Rodgers , Ian MacGregor , Todd Basque , Scott Miller , Zhimin Lu , Andrey Zarur , Mohamed Shaheen
发明人： Seth Rodgers , Ian MacGregor , Todd Basque , Scott Miller , Zhimin Lu , Andrey Zarur , Mohamed Shaheen
IPC分类号： C12Q3/00 , C12M1/36
CPC分类号： G01N35/0099 , B01J19/0046 , B01J2219/0031 , B01J2219/00315 , B01J2219/00317 , B01J2219/00364 , B01J2219/00376 , B01J2219/00387 , B01J2219/00389 , B01J2219/00479 , B01J2219/00495 , B01J2219/00542 , B01J2219/00545 , B01J2219/00549 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00704 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/0803 , B01L2300/0806 , C40B40/10 , C40B70/00 , G01N2035/00158 , G01N2035/00366
摘要： Disclosed are systems and methods for manipulating chemical, biological, and/or biochemical samples, optionally supported on substrates and/or within chambers, for example biological samples contained on chips, within biological chambers, etc. In certain embodiments, an apparatus configured to be able to position a chamber or other substrate in one or more modules surrounding the apparatus is disclosed. The apparatus may be configured to be able to move the chamber or substrate in any set of directions, such as radially, vertically, and/or rotationally, with respect to the apparatus. The apparatus may be manually operated and/or automatically controlled. Examples of modules include, but are not limited to, stacking or holding modules, barcode readers, filling modules, sampling modules, incubation modules, sensor modules (e.g., for determining cell density, cell viability, pH, oxygen concentration, nutrient concentration, fluorescence measurements, etc.), assay modules (e.g., for ELISA or other biological assays), data analysis and management modules, control modules, etc. Sensors, control systems, and the like may also be positioned to facilitate operation of the device. Certain embodiments of the invention may be used, for example, to promote or optimize chemical synthesis or cell or biological growth, for instance, for the production of compounds such as drugs or other therapeutics.
摘要翻译：公开了用于操纵化学，生物学和/或生物化学样品的系统和方法，任选地在衬底和/或腔室内支撑，例如包含在芯片上，生物室内的生物样品等。在某些实施方案中，公开了能够将腔室或其他衬底定位在围绕设备的一个或多个模块中。该装置可以被配置为能够相对于该装置以任何一组方向（例如径向，垂直和/或旋转地）移动腔室或衬底。该装置可以手动操作和/或自动控制。模块的示例包括但不限于堆叠或保持模块，条形码读取器，填充模块，采样模块，孵化模块，传感器模块（例如，用于确定细胞密度，细胞活力，pH，氧浓度，营养浓度，荧光测量等），测定模块（例如，用于ELISA或其他生物测定），数据分析和管理模块，控制模块等。传感器，控制系统等也可以被定位以便于设备的操作。本发明的某些实施方案可用于例如促进或优化化学合成或细胞或生物生长，例如用于生产化合物如药物或其它治疗剂。

2. 发明申请

US20050037485A1 System and method for process automation 审中-公开
标题翻译：过程自动化的系统和方法
公开(公告)号：US20050037485A1
公开(公告)日：2005-02-17
申请号：US10863585
申请日：2004-06-07
申请人： Seth Rodgers , Ian MacGregor , Todd Basque , Scott Miller , Zhimin Lu , Andrey Zarur , Mohamed Shaheen
发明人： Seth Rodgers , Ian MacGregor , Todd Basque , Scott Miller , Zhimin Lu , Andrey Zarur , Mohamed Shaheen
IPC分类号： B01J19/00 , B01L3/00 , B25J7/00 , C40B40/10 , C40B70/00 , G01N35/00 , G01N35/02 , G01N35/04 , C12M1/34 , C12Q1/70
CPC分类号： G01N35/0099 , B01J19/0046 , B01J2219/0031 , B01J2219/00315 , B01J2219/00317 , B01J2219/00364 , B01J2219/00376 , B01J2219/00387 , B01J2219/00389 , B01J2219/00479 , B01J2219/00495 , B01J2219/00542 , B01J2219/00545 , B01J2219/00549 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00704 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/0803 , B01L2300/0806 , C40B40/10 , C40B70/00 , G01N2035/00158 , G01N2035/00366
摘要： Disclosed are systems and methods for manipulating chemical, biological, and/or biochemical samples, optionally supported on substrates and/or within chambers, for example biological samples contained on chips, within biological chambers, etc. In certain embodiments, an apparatus configured to be able to position a chamber or other substrate in one or more modules surrounding the apparatus is disclosed. The apparatus may be configured to be able to move the chamber or substrate in any set of directions, such as radially, vertically, and/or rotationally, with respect to the apparatus. The apparatus may be manually operated and/or automatically controlled. Examples of modules include, but are not limited to, stacking or holding modules, barcode readers, filling modules, sampling modules, incubation modules, sensor modules (e.g., for determining cell density, cell viability, pH, oxygen concentration, nutrient concentration, fluorescence measurements, etc.), assay modules (e.g., for ELISA or other biological assays), data analysis and management modules, control modules, etc. Sensors, control systems, and the like may also be positioned to facilitate operation of the device. Certain embodiments of the invention may be used, for example, to promote or optimize chemical synthesis or cell or biological growth, for instance, for the production of compounds such as drugs or other therapeutics.
摘要翻译：公开了用于操纵化学，生物学和/或生物化学样品的系统和方法，任选地在衬底和/或腔室内支撑，例如包含在芯片上，生物室内的生物样品等。在某些实施方案中，公开了能够将腔室或其他衬底定位在围绕设备的一个或多个模块中。该装置可以被配置为能够相对于该装置以任何一组方向（例如径向，垂直和/或旋转地）移动腔室或衬底。该装置可以手动操作和/或自动控制。模块的示例包括但不限于堆叠或保持模块，条形码读取器，填充模块，采样模块，孵化模块，传感器模块（例如，用于确定细胞密度，细胞活力，pH，氧浓度，营养浓度，荧光测量等），测定模块（例如，用于ELISA或其他生物测定），数据分析和管理模块，控制模块等。传感器，控制系统等也可以被定位以便于设备的操作。本发明的某些实施方案可用于例如促进或优化化学合成或细胞或生物生长，例如用于生产化合物如药物或其它治疗剂。

3. 发明申请

US20050106714A1 Rotatable reactor systems and methods 审中-公开
标题翻译：可旋转反应器系统和方法
公开(公告)号：US20050106714A1
公开(公告)日：2005-05-19
申请号：US10927789
申请日：2004-08-27
申请人： Andrey Zarur , Todd Basque , Derek Stevens , Nicholas Flannery , Seth Rodgers , A. Russo , Scott Miller , Ian MacGregor
发明人： Andrey Zarur , Todd Basque , Derek Stevens , Nicholas Flannery , Seth Rodgers , A. Russo , Scott Miller , Ian MacGregor
IPC分类号： B01L3/00 , C12M1/34 , C12M1/36 , C12Q1/02 , G01N21/47 , G01N21/63 , G01N21/64 , G01N21/77 , G01N33/50 , G01N33/543 , G01N33/84 , C12M3/00
CPC分类号： G01N33/84 , B01J2219/00317 , B01J2219/00704 , B01J2219/00743 , B01L3/5025 , B01L3/5027 , B01L3/502723 , B01L2200/0668 , B01L2200/12 , B01L2300/0654 , B01L2300/0861 , B01L2300/163 , B01L2300/1838 , B01L2400/046 , B01L2400/0487 , C12M23/16 , C12Q1/02 , G01N21/47 , G01N21/64 , G01N21/648 , G01N21/7703 , G01N33/5005 , G01N33/54373 , G01N2021/635
摘要： The present invention generally relates to chips, particularly microfluidic chips, that are rotatable and/or have a generally circular or rotationally symmetric geometry. The chips may be substantially planar in certain instances. In some cases, the chips of the invention can have more than one reaction site, which can, for example, contain cells. The reaction site can be very small, in some cases with a volume of less than about 1 ml. Reactions, transport, and/or other manipulations within the chip can be facilitated by rotating the chip, for example, at tens, hundreds or thousands of revolutions per minute (RPM). In some cases, data may also be written to and/or read from the chip. The chips of the invention can be used, for example, to move fluid from one portion of a chip to another, to concentrate and/or separate a mixture (e.g., a cell suspension), to lyse or fractionate a cell, or the like.
摘要翻译：本发明通常涉及可旋转和/或具有大致圆形或旋转对称几何形状的芯片，特别是微流体芯片。在某些情况下，芯片可能基本上是平面的。在一些情况下，本发明的芯片可以具有多于一个反应位点，其可以例如含有细胞。反应位点可以非常小，在一些情况下体积小于约1ml。芯片内的反应，运输和/或其他操作可以通过例如以数十，数百或数千转/分钟（RPM）旋转芯片来实现。在某些情况下，数据也可能被写入和/或从芯片读取。本发明的芯片可以用于例如将流体从芯片的一部分移动到另一部分，以浓缩和/或分离混合物（例如，细胞悬液），以将细胞裂解或分馏等。

4. 发明申请

US20050026273A1 Reactor with memory component 审中-公开
标题翻译：具有内存组件的电抗器
公开(公告)号：US20050026273A1
公开(公告)日：2005-02-03
申请号：US10863636
申请日：2004-06-07
申请人： Andrey Zarur , Ian MacGregor , Todd Basque , Seth Rodgers , A. Russo , Sean Leblanc
发明人： Andrey Zarur , Ian MacGregor , Todd Basque , Seth Rodgers , A. Russo , Sean Leblanc
IPC分类号： B01J19/00 , B01L3/00 , C40B40/10 , C40B70/00 , G01N35/00 , C12M1/36
CPC分类号： B01L3/5027 , B01J19/0046 , B01J2219/0031 , B01J2219/00315 , B01J2219/00317 , B01J2219/00364 , B01J2219/00376 , B01J2219/00387 , B01J2219/00389 , B01J2219/00479 , B01J2219/00495 , B01J2219/00542 , B01J2219/00545 , B01J2219/00549 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00704 , B01J2219/00725 , B01J2219/00743 , B01L3/545 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/0806 , B01L2300/0816 , B01L2400/046 , C40B40/10 , C40B70/00 , G01N35/0099
摘要： The present invention provides techniques for conveniently and reliably storing and/or retrieving data associated with a chemical, biological, or biochemical chip, reactor, or reaction system. The data can pertain to the reactor; to chemical, biological, or biochemical species introduced into, taken from, or otherwise associated with the reactor; to conditions to which the reactor and/or some or all of its contents has been, is being, or will be exposed to, or the like. Various aspects of the present invention relate to memory and data storage components suitable for use in chips or other reaction systems. These components may include silicon integrated circuits, magnetic media, optical media, radio-frequency tags, smart cards, bar-codes and other kinds of data storage devices. The chip may contain a reaction site having a volume of less than about 2 ml. In some embodiments, the chip may be constructed in such a way as to be able to support a living cell. The chip may be used for imaging or analysis, or the chip may be used to facilitate a chemical or biological reaction, which may be light-sensitive or light-activated in certain cases. Other facilitated reactions may include the production and/or consumption of a chemical or biological species. In some embodiments, the chip may include more than one component or component type, and/or more than one reaction site.
摘要翻译：本发明提供了用于方便和可靠地存储和/或检索与化学，生物或生物化学芯片，反应器或反应系统相关的数据的技术。数据可以与反应堆有关; 化学，生物或生物化学物质引入，取自或以其他方式与反应器相关; 反应器和/或其一部分或全部内容物已经或将要暴露于或类似物的条件。本发明的各个方面涉及适用于芯片或其他反应系统的存储器和数据存储组件。这些组件可以包括硅集成电路，磁介质，光介质，射频标签，智能卡，条形码和其他种类的数据存储设备。芯片可以含有体积小于约2ml的反应位点。在一些实施例中，芯片可以以能够支撑活细胞的方式构造。该芯片可以用于成像或分析，或者芯片可以用于促进在某些情况下可能是光敏感或光激活的化学或生物反应。其他促进反应可能包括化学或生物物种的生产和/或消费。在一些实施方案中，芯片可以包括多于一种组分或组分类型和/或多于一个的反应位点。

5. 发明申请

US20050019904A1 Apparatus and method for manipulating substrates 失效
标题翻译：用于操纵基板的装置和方法
公开(公告)号：US20050019904A1
公开(公告)日：2005-01-27
申请号：US10863584
申请日：2004-06-07
申请人： Andrey Zarur , Seth Rodgers , Todd Basque , Ian MacGregor , Timothy Johnson
发明人： Andrey Zarur , Seth Rodgers , Todd Basque , Ian MacGregor , Timothy Johnson
IPC分类号： B01F9/00 , B01F11/00 , B01L7/00 , B01L9/00 , C12M1/00 , C12N15/82 , C12N15/87
CPC分类号： C12M23/08 , B01F9/0001 , B01F9/002 , B01F11/00 , B01L7/00 , B01L9/52 , B01L2300/0819 , B01L2300/0822 , B01L2300/0829 , B01L2400/0409 , C12M23/10 , C12M23/48 , C12M27/10 , C12M41/14 , Y10S435/809
摘要： This disclosure generally relates to systems and methods for manipulating chambers and other substrates for chemical, biological, or biochemical samples, such as cell culture and other chambers, within units such as incubators. In certain embodiments, the invention provides a technique for maintaining a plurality of substrates or chambers in a housing within which a predetermined environment is maintained, different from the environment external to the housing, and moving substrates or chambers in and out of the housing, in some cases without creating a large opening in the housing (e.g., by opening a door significantly larger than the substrates). A technique is provided, in certain embodiments, in which a plurality of substrates are mounted in fixed, secured relation to each other within a housing providing a predetermined, controlled environment, and are moved within the housing so that they can be evenly exposed to any differences in environment within the housing. In certain embodiments, the invention provides a technique for agitating a fluid within one or more chambers or substrates within a housing that can provide environmental control, in certain embodiments without physically stirring the fluid, such as with a stir bar or other stirring element in direct contact with the fluid. In still another embodiment, the invention provides a method for rotating a substrate or chamber about a substantially vertical and/or horizontal axis. In some cases, any of the above-described systems can be rotated at a speed sufficient to cause separation of a substance within the chamber or substrate.
摘要翻译：本公开总体上涉及用于在诸如培养箱的单元内操作用于化学，生物或生化样品（例如细胞培养物和其它室）的室和其它底物的系统和方法。在某些实施例中，本发明提供了一种用于将多个基板或腔室保持在壳体内的技术，在壳体内保持预定环境，不同于壳体外部的环境，以及将基板或腔室移入和移出壳体，一些情况下，在外壳中不会形成大的开口（例如，通过打开比基板大得多的门）。在某些实施例中提供了一种技术，其中多个基板在壳体内以固定的，固定的关系安装在提供预定的受控环境的壳体内，并且在壳体内移动，使得它们可以均匀地暴露于任何房屋环境差异。在某些实施例中，本发明提供了一种用于在一个或多个腔室内的流体搅拌的技术，其可以在某些实施例中提供环境控制，而不用物理地搅拌流体，例如直接用搅拌棒或其它搅拌元件与流体接触。在另一个实施例中，本发明提供了一种用于围绕基本垂直和/或水平轴线旋转衬底或室的方法。在一些情况下，任何上述系统可以以足以使物质在室或衬底内分离的速度旋转。

6. 发明授权

US09134202B2 Robotic end effector for frozen aliquotter and methods of taking a frozen aliquot from biological samples 有权
标题翻译：用于冷冻等分试样的机器人末端效应器和从生物样品中取出冷冻等分试样的方法
公开(公告)号：US09134202B2
公开(公告)日：2015-09-15
申请号：US13359301
申请日：2012-01-26
申请人： Michel Bruehwiler , Saeed Sokhanvar , Cole Constantineau , Melissa Rosen , Todd Basque
发明人： Michel Bruehwiler , Saeed Sokhanvar , Cole Constantineau , Melissa Rosen , Todd Basque
IPC分类号： G01N1/08 , G01F17/00 , G01N1/42 , G01N35/00 , G01N35/10
CPC分类号： G01N1/08 , B25J15/0019 , G01F17/00 , G01N1/42 , G01N35/0099 , G01N35/10 , G01N2035/1025 , Y10S901/41
摘要： A robotic end effector for collecting frozen aliquots from an array of frozen samples in a plurality of containers has a coring bit for taking frozen sample cores from the frozen samples and a frozen sample core extraction system adapted to extract frozen sample cores from the frozen samples. A fill level detection system is adapted to detect the positions of the surfaces of the frozen samples. A processor is adapted to receive signals from the fill level detection system and use the signals and information concerning operation of the frozen sample core extraction system to determine at least one of the following: (a) the amount of material contained in a frozen sample core obtained by the coring bit; and (b) the number of frozen sample cores needed from a particular frozen sample to obtain a predetermined amount of material from that frozen sample.
摘要翻译：用于从多个容器中的冷冻样品阵列收集冷冻等分试样的机器人末端执行器具有用于从冷冻样品中取出冷冻样品核心的取芯钻头和适于从冷冻样品中提取冷冻样品核心的冷冻样品芯提取系统。填充水平检测系统适于检测冷冻样品的表面的位置。处理器适于接收来自填充水平检测系统的信号，并且使用关于冷冻样品芯提取系统的操作的信号和信息来确定以下中的至少一个：（a）冷冻样品核心中所含的材料的量由取芯钻头获得; 和（b）特定冷冻样品所需的冷冻样品核心的数量，以从该冷冻样品获得预定量的材料。

7. 发明申请

US20130192391A1 Robotic End Effector for Frozen Aliquotter and Methods of Taking a Frozen Aliquot from Biological Samples 有权
标题翻译：用于冷冻等分试样的机器人终端效应器和从生物样品中取出冷冻等分试样的方法
公开(公告)号：US20130192391A1
公开(公告)日：2013-08-01
申请号：US13359301
申请日：2012-01-26
申请人： Michel Bruehwiler , Saeed Sokhanvar , Cole Constantineau , Melissa Rosen , Todd Basque
发明人： Michel Bruehwiler , Saeed Sokhanvar , Cole Constantineau , Melissa Rosen , Todd Basque
IPC分类号： G01N1/08 , B25J15/00
CPC分类号： G01N1/08 , B25J15/0019 , G01F17/00 , G01N1/42 , G01N35/0099 , G01N35/10 , G01N2035/1025 , Y10S901/41
摘要： A robotic end effector for collecting frozen aliquots from an array of frozen samples in a plurality of containers has a coring bit for taking frozen sample cores from the frozen samples and a frozen sample core extraction system adapted to extract frozen sample cores from the frozen samples. A fill level detection system is adapted to detect the positions of the surfaces of the frozen samples. A processor is adapted to receive signals from the fill level detection system and use the signals and information concerning operation of the frozen sample core extraction system to determine at least one of the following: (a) the amount of material contained in a frozen sample core obtained by the coring bit; and (b) the number of frozen sample cores needed from a particular frozen sample to obtain a predetermined amount of material from that frozen sample.
摘要翻译：用于从多个容器中的冷冻样品阵列收集冷冻等分试样的机器人末端执行器具有用于从冷冻样品中取出冷冻样品核心的取芯钻头和适于从冷冻样品中提取冷冻样品核心的冷冻样品芯提取系统。填充水平检测系统适于检测冷冻样品的表面的位置。处理器适于接收来自填充水平检测系统的信号，并且使用关于冷冻样品芯提取系统的操作的信号和信息来确定以下中的至少一个：（a）冷冻样品核心中所含的材料的量由取芯钻头获得; 和（b）特定冷冻样品所需的冷冻样品核心的数量，以从该冷冻样品获得预定量的材料。

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