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1. 发明授权

US5646302A Heterotrifunctional compounds for photoaffinity labelling 失效
标题翻译：用于光亲和标记的异双官能化合物
公开(公告)号：US5646302A
公开(公告)日：1997-07-08
申请号：US085719
申请日：1993-06-30
申请人： Richard Barner , Walter Huber , Josef Hubscher , Jurg Hurst , Daniel Schlatter
发明人： Richard Barner , Walter Huber , Josef Hubscher , Jurg Hurst , Daniel Schlatter
IPC分类号： C07C247/16 , C07C247/18 , C07D207/40 , C07D207/416 , C07D213/18 , C07K1/113 , C07K14/00 , C07K16/00 , C07K19/00 , G01N33/532 , C07D207/452
CPC分类号： C07D207/416 , C07C247/18 , G01N33/532
摘要： The invention is concerned with novel heterotrifunctional compounds which contain a chemically reactive group R, a photochemically reactive group Ar--N.sup.3 and a reductively cleavable S--S(X.sub.2)-group. The chemically reactive group and the photochemically reactive group are separated by a spacer group which contains a disulfide group. The water-solubilizing groups are carboxylic acids and sulfonic acids or derivatives thereof which are attached either to the aromatic ring or to the spacer group between the aromatic ring and the cleavable SS group. The compounds facilitate a novel photoaffinity method for the labelling of biomolecules, whereby the labelled biomolecule preserves its water solubility and the labelling molecule preferably projects free into the solution after anchorage to the surface of the biomolecule.
摘要翻译：本发明涉及含有化学反应性基团R，光化学反应性基团Ar-N 3和还原性可切割的S-S（X 2） - 基团的新型异三官能化合物。化学反应性基团和光化学反应性基团被含有二硫基的间隔基隔开。水溶性基团是羧酸和磺酸或其衍生物，其连接到芳香环或芳族环和可切割SS基团之间的间隔基。该化合物促进用于标记生物分子的新型光亲和方法，由此标记的生物分子保持其水溶性，并且标记分子优选在锚定到生物分子的表面之后自由地投入溶液中。

2. 发明授权

US4268453A Process for the manufacture of cholestene derivatives and novel intermediates in their manufacture 失效
标题翻译：胆石衍生物和新型中间体制造方法
公开(公告)号：US4268453A
公开(公告)日：1981-05-19
申请号：US146880
申请日：1980-05-05
申请人： Richard Barner , Josef Hubscher
发明人： Richard Barner , Josef Hubscher
IPC分类号： C07J9/00 , C07J53/00 , C07J1/00
CPC分类号： C07J53/00 , C07J9/00
摘要： The present disclosure is directed to 6-lower alkoxy-25,26-(lower alkyl or lower alkylene)methylene dioxy-3,5-cyclocholest-22-ene derivatives which are useful in the manufacture of 25,26-dihydroxycholecalciferol.
摘要翻译：本公开内容涉及可用于制备25,26-二羟基胆钙化甾醇的6-低级烷氧基-25,26-（低级烷基或低级亚烷基）亚甲基二氧-3,5-环己二醇-22-烯衍生物。

3. 发明授权

US5986066A Biosensory layers 失效
标题翻译：生物传感层
公开(公告)号：US5986066A
公开(公告)日：1999-11-16
申请号：US878105
申请日：1997-06-18
申请人： Richard Barner , Walter Huber , Josef Hubscher , Jurg Hurst , Daniel Schlatter
发明人： Richard Barner , Walter Huber , Josef Hubscher , Jurg Hurst , Daniel Schlatter
IPC分类号： G01N33/53 , G01N33/543 , C07K16/00 , G01N33/547
CPC分类号： G01N33/5438 , G01N33/54353 , Y10S436/823 , Y10S436/828 , Y10S977/714 , Y10S977/795 , Y10S977/92
摘要： A biologically recognizing layer on a solid phase consisting of biologically recognizing molecules comprising regions which recognize a substance to be analyzed and regions which do not recognize a substance to be analyzed.The biologically recognizing molecules are aligned on a suitably modified surface by means of molecular regions which do not recognize the substance to be analyzed. The biologically recognizing molecules are cross-linked with the aligning surface and are consequently covalently altered. The molecular regions recognizing the substance to be analyzed are not altered by the covalent bonding and retain their bonding activity.The layer is produced in a novel two-stage method. In the first step, the biologically recognizing molecules, the aligning molecules and carrier molecules are adsorbed. In the second step, the molecules are covalently anchored by cross-linking. Cross-linking is brought about by photolytic activation of a water soluble reagent bonded to the carrier molecules.
摘要翻译：由包含识别待分析物质的区域和不能识别被分析物质的区域的生物识别分子组成的固相上的生物识别层。生物识别分子通过不识别待分析物质的分子区域在适当修饰的表面上排列。生物识别分子与对准表面交联并因此共价改变。识别待分析物质的分子区域不会因共价键而改变，并保持其结合活性。该层以新颖的两阶段方法生产。在第一步中，生物识别分子，对准分子和载体分子被吸附。在第二步中，分子通过交联共价锚定。交联是通过与载体分子结合的水溶性试剂的光解活化引起的。

4. 发明授权

US5153344A Vitamin E intermediates and a process for their manufacture and conversion into vitamin E 失效
标题翻译：维生素E中间体及其制造和转化成维生素E的方法
公开(公告)号：US5153344A
公开(公告)日：1992-10-06
申请号：US594215
申请日：1990-10-09
申请人： Richard Barner , Josef Hubscher
发明人： Richard Barner , Josef Hubscher
IPC分类号： C07C43/13 , C07C27/00 , C07C29/36 , C07C31/20 , C07C31/42 , C07C39/235 , C07C39/44 , C07C41/00 , C07C43/23 , C07C43/315 , C07C67/00 , C07C309/63 , C07D303/04 , C07D311/72
CPC分类号： C07D311/72 , C07C309/73 , C07D303/04
摘要： Novel methyl carbinol derivatives of Vitamin E and a method for their manufacture.
摘要翻译：维生素E的新型甲基甲醇衍生物及其制备方法。

5. 发明授权

US4958035A Process for synthesizing chromanes 失效
标题翻译：合成色满的方法
公开(公告)号：US4958035A
公开(公告)日：1990-09-18
申请号：US373000
申请日：1989-06-29
申请人： Richard Barner , Josef Hubscher
发明人： Richard Barner , Josef Hubscher
IPC分类号： C07D311/70 , B01J31/02 , C07D311/72
CPC分类号： C07D311/72
摘要： The present invention is directed to a novel process for producing chromane derivatives, which are suitable as intermediates for the manufacture of d-.alpha.-tocopherol (natural vitamin E), and with a process for producing d-.alpha.-tocopherol itself.

6. 发明授权

US4851585A Vitamin E intermediates 失效
标题翻译：维生素E中间体
公开(公告)号：US4851585A
公开(公告)日：1989-07-25
申请号：US119879
申请日：1987-11-12
申请人： Richard Barner , Josef Hubscher
发明人： Richard Barner , Josef Hubscher
IPC分类号： C07C43/13 , C07C27/00 , C07C29/36 , C07C31/20 , C07C31/42 , C07C39/235 , C07C39/44 , C07C41/00 , C07C43/23 , C07C43/315 , C07C67/00 , C07C309/63 , C07D303/04 , C07D311/72
CPC分类号： C07C31/20 , C07C29/32 , C07C43/23 , C07D303/04 , C07D311/72 , C07B2200/07
摘要： Novel methyl carbinol derivatives of Vitamin E and a method for their manufacture.
摘要翻译：维生素E的新型甲基甲醇衍生物及其制备方法。

7. 发明授权

US4904823A Hydroquinone derivatives and a process for their preparation 失效
标题翻译：氢醌衍生物及其制备方法
公开(公告)号：US4904823A
公开(公告)日：1990-02-27
申请号：US299588
申请日：1989-01-23
申请人： Richard Barner , Josef Hubscher
发明人： Richard Barner , Josef Hubscher
IPC分类号： C07C43/23 , C07C51/347 , C07C59/64 , C07C59/90 , C07D311/66 , C07F7/28
CPC分类号： C07F7/28 , C07C43/23 , C07C51/347 , C07C59/64 , C07C59/90 , C07D311/66 , Y02P20/55
摘要： There is described a process for the manufacture of hydroquinone derivatives of the formulae ##STR1## which are valuable intermediates in the synthesis of natural vitamin E.

8. 发明授权

US4709055A (Alkoxy-methyl)-phenyl-methyl-epoxybutanes 失效
标题翻译：（烷氧基甲基） - 苯基 - 甲基 - 环氧丁烷
公开(公告)号：US4709055A
公开(公告)日：1987-11-24
申请号：US818451
申请日：1986-01-13
申请人： Richard Barner , Josef Hubscher
发明人： Richard Barner , Josef Hubscher
IPC分类号： C07C41/00 , C07C41/02 , C07C41/26 , C07C41/30 , C07C43/23 , C07D303/12 , C07D303/18 , C07D303/22 , C07D303/24 , C07D311/72 , C07D309/12
CPC分类号： C07D303/22 , C07C309/00 , C07C41/26 , C07C41/30 , C07D311/72 , C07B2200/07 , Y02P20/55
摘要： There is described a novel process for producing hydroquinone derivatives of the formula ##STR1## wherein R is an ether protecting group, and their conversion into d-.alpha.-tocopherol, starting from compounds of the formula ##STR2## wherein R is an ether protecting group and R.sup.1 is hydrogen or an ether protecting group.
摘要翻译：描述了一种制备式II的氢醌衍生物的新方法，其中R是醚保护基团，并且它们转化成d-α-生育酚，从其中R是醚的式保护基，R1是氢或醚保护基。

9. 发明授权

US5034546A Novel vitamin E intermediates and a process for their manufacture and conversion into vitamin E 失效
标题翻译：新型维生素E中间体及其生产和转化为维生素E的方法
公开(公告)号：US5034546A
公开(公告)日：1991-07-23
申请号：US594913
申请日：1990-10-09
申请人： Richard Barner , Josef Hubscher
发明人： Richard Barner , Josef Hubscher
IPC分类号： C07C43/23 , C07D303/04 , C07D311/72
CPC分类号： C07D303/04 , C07C43/23 , C07D311/72
摘要： Novel methyl carbinol derivatives of Vitamin E and a method for their manufacture.
摘要翻译：维生素E的新型甲基甲醇衍生物及其制备方法。

10. 发明授权

US4996375A Vitamin E intermediates and a process for their manufacture and conversion into Vitamin E 失效
标题翻译：维生素E中间体及其生产和转化为维生素E的方法
公开(公告)号：US4996375A
公开(公告)日：1991-02-26
申请号：US341889
申请日：1989-04-24
申请人： Richard Barner , Josef Hubscher
发明人： Richard Barner , Josef Hubscher
IPC分类号： C07C43/13 , C07C27/00 , C07C29/36 , C07C31/20 , C07C31/42 , C07C39/235 , C07C39/44 , C07C41/00 , C07C43/23 , C07C43/315 , C07C67/00 , C07C309/63 , C07D303/04 , C07D311/72 , C07C43/303 , C07F7/08
CPC分类号： C07C31/20 , C07C29/32 , C07C43/23 , C07D303/04 , C07D311/72 , C07B2200/07
摘要： Novel methyl carbinol derivatives of Vitamin E and a method for their manufacture.
摘要翻译：维生素E的新型甲基甲醇衍生物及其制备方法。

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