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1. 发明授权

US5858193A Electrokinetic pumping 失效
标题翻译：电动泵送
公开(公告)号：US5858193A
公开(公告)日：1999-01-12
申请号：US556423
申请日：1995-11-09
申请人： Peter John Zanzucchi , Charlotte Anna Burton , Sterling Edward McBride , Robert Richard Demers , William Chiang , Richard Morgan Moroney, III
发明人： Peter John Zanzucchi , Charlotte Anna Burton , Sterling Edward McBride , Robert Richard Demers , William Chiang , Richard Morgan Moroney, III
IPC分类号： C04B38/06 , B01F5/06 , B01F13/00 , B01J4/02 , B01J19/00 , B01L3/00 , B81B3/00 , B81C1/00 , C40B40/06 , C40B60/14 , F04B19/00 , F04F99/00 , H02N11/00 , G01N27/26
CPC分类号： B01L3/502738 , B01F13/0077 , B01F15/0264 , B01J19/0046 , B01J19/0093 , B01J4/02 , B01L3/5025 , B01L3/50273 , F04B19/006 , H02N11/006 , B01F5/0601 , B01J2219/00317 , B01J2219/00353 , B01J2219/00358 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00659 , B01J2219/0068 , B01J2219/0072 , B01J2219/00722 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00891 , B01J2219/00952 , B01J2219/00995 , B01L2200/12 , B01L2200/143 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/1827 , B01L2400/0415 , B01L2400/0688 , B01L3/502746 , C40B40/06 , C40B60/14 , H01L2924/0002
摘要： The invention provides electrode-based pumps and methods of operating such pumps. In one embodiment, the invention provides an electrode-based pump situated in a fluid channel comprising a first electrode and a second electrode, wherein the first and second electrodes have a diameter from about 25 microns to about 100 microns and are spaced from about 100 microns to about 2,500 microns apart. In another embodiment, the invention provides an electrode-based pump comprising a first electrode, second electrode and third electrode.
摘要翻译：本发明提供了基于电极的泵和操作这种泵的方法。在一个实施例中，本发明提供一种位于包括第一电极和第二电极的流体通道中的基于电极的泵，其中第一和第二电极具有约25微米至约100微米的直径并且与约100微米的间隔至约2500微米。在另一个实施例中，本发明提供一种包括第一电极，第二电极和第三电极的基于电极的泵。

2. 发明授权

US5980704A Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device 失效
标题翻译：用于抑制组合化学装置流体中交叉污染的方法和系统
公开(公告)号：US5980704A
公开(公告)日：1999-11-09
申请号：US726953
申请日：1996-10-07
申请人： Satyam Choudary Cherukuri , Robert Richard Demers , Zhong Hui Hugh Fan , Aaron W. Levine , Sterling Edward McBride , Peter John Zanzucchi
发明人： Satyam Choudary Cherukuri , Robert Richard Demers , Zhong Hui Hugh Fan , Aaron W. Levine , Sterling Edward McBride , Peter John Zanzucchi
IPC分类号： B01F5/06 , B01J4/02 , B01J19/00 , B01L3/00 , B01L9/00 , C40B40/06 , C40B60/14 , F04B19/00 , H02N11/00 , C25B9/00 , C25B15/08
CPC分类号： B01L3/502738 , B01F15/0264 , B01J19/0046 , B01J19/0093 , B01J4/02 , B01L3/5025 , B01L3/50273 , F04B19/006 , H02N11/006 , B01F13/0059 , B01F5/0601 , B01J2219/00317 , B01J2219/00353 , B01J2219/00358 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00659 , B01J2219/0068 , B01J2219/0072 , B01J2219/00722 , B01J2219/00783 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00853 , B01J2219/00891 , B01L2200/027 , B01L2200/028 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2400/0415 , B01L2400/0487 , B01L9/527 , C40B40/06 , C40B60/14 , Y10S366/03 , Y10T137/87249 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： A system and method for accomplishing a plurality of combinatorial processes in parallel comprising a microelectronic and fluidic array (device array) having micron-sized reservoirs, connecting microchannels and reaction cells etched into a substrate. The device array is supported by a station which serves to interface and perform electro-optic measurements of material in the reaction cells of the device array. The device array incorporates a modular configuration with three distinct layers or plates. The device array comprises a top feedthru plate, a center distribution plate and a bottom cell plate. The three plates are stacked vertically and coupled together to form a liquid-tight seal. Reservoirs, microchannels and reactions cells are controllably etched onto the plates using traditional semiconductor fabrication techniques. The top feedthru plate serves as a cover for the device array and contains apertures selectively positioned above the reservoirs located in the center distribution plate. The center distribution plate comprises a plurality of micron sized reservoirs, microchannels, reservoir feeds, cell feeds and overflow feeds for the distribution of reagent fluids to the reaction cells located in the bottom cell plate. The detachable bottom cell plate serves as a microlaboratory tray of reaction cells. Once the proper reagents or other materials are introduced into the reaction cells, the bottom cell plate is decoupled from the device array and removed for incubation or analysis.
摘要翻译：一种用于并行地实现多个组合过程的系统和方法，包括具有微米级贮存器的微电子和流体阵列（器件阵列），连接微通道和蚀刻到衬底中的反应池。设备阵列由站来支持，该站用于对设备阵列的反应单元中的材料进行接口和电光测量。器件阵列包含具有三个不同层或板的模块化配置。装置阵列包括顶部进料板，中心分配板和底部单元板。三个板垂直堆叠并且联接在一起以形成液密密封。使用传统的半导体制造技术将储存器，微通道和反应池可控地蚀刻到板上。顶部进料板用作装置阵列的盖，并且包含选择性地定位在位于中心分布板中的储存器上方的孔。中心分配板包括多个微米尺寸的储存器，微通道，储存器进料，细胞进料和用于将试剂流体分配到位于底部单元板中的反应池的溢流进料。可拆卸的底部细胞板用作反应池的微实验托盘。一旦将适当的试剂或其他材料引入反应池中，底部细胞板与装置阵列分离并去除以进行孵育或分析。

3. 发明授权

US06331439B1 Device for selective distribution of liquids 有权
标题翻译：用于选择性分配液体的装置
公开(公告)号：US06331439B1
公开(公告)日：2001-12-18
申请号：US09152861
申请日：1998-09-14
申请人： Satyam Choudary Cherukuri , Robert Richard Demers , Zhong Hui Hugh Fan , Aaron W. Levine , Sterling Edward McBride , Peter John Zanzucchi
发明人： Satyam Choudary Cherukuri , Robert Richard Demers , Zhong Hui Hugh Fan , Aaron W. Levine , Sterling Edward McBride , Peter John Zanzucchi
IPC分类号： G01N128
CPC分类号： B01L3/502738 , B01F5/0601 , B01F13/0059 , B01F15/0264 , B01J4/02 , B01J19/0046 , B01J19/0093 , B01J2219/00317 , B01J2219/00353 , B01J2219/00358 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00659 , B01J2219/0068 , B01J2219/0072 , B01J2219/00722 , B01J2219/00783 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00853 , B01J2219/00891 , B01L3/5025 , B01L3/50273 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2400/0415 , B01L2400/0487 , C40B40/06 , C40B60/14 , F04B19/006 , H02N11/006 , Y10S366/03 , Y10T137/87249 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： A method for accomplishing a plurality of combinatorial processes in parallel using a microelectronic and fluidic array (device array) having micron-sized reservoirs, connecting microchannels and reaction cells etched into a substrate. The device array has a top feedthru plate, a center distribution plate and a bottom cell plate. The top feedthru plate serves as a cover for the device array and contains apertures selectively positioned above the reservoirs located in the center distribution plate. The center distribution plate includes a plurality of micron sized reservoirs, microchannels, reservoir feeds, cell feeds and overflow feeds for the distribution of reagent fluids to the reaction cells located in the bottom cell plate. The detachable bottom cell plate serves as a microlaboratory tray of reaction cells. Once the proper reagents or other materials are introduced into the reaction cells, the bottom cell plate is decoupled from the device array and removed for incubation or analysis.
摘要翻译：一种使用具有微米级贮存器的微电子和流体阵列（器件阵列）来并行地完成多个组合处理的方法，连接微通道和蚀刻到衬底中的反应池。器件阵列具有顶部馈通板，中心分配板和底部单元板。顶部进料板用作装置阵列的盖，并且包含选择性地定位在位于中心分布板中的储存器上方的孔。中心分配板包括多个微米尺寸的储存器，微通道，储存器进料，细胞进料和用于将试剂流体分配到位于底部单元板中的反应池的溢流进料。可拆卸的底部细胞板用作反应池的微实验托盘。一旦将适当的试剂或其他材料引入反应池中，底部细胞板与装置阵列分离并去除以进行孵育或分析。

4. 发明授权

US06474563B2 Spraying device for dispensing home care formulations with electrostatic liquid droplets 失效
标题翻译：用于分配具有静电液滴的家庭护理配方的喷涂装置
公开(公告)号：US06474563B2
公开(公告)日：2002-11-05
申请号：US09794441
申请日：2001-02-27
申请人： Timothy Allen Pletcher , Peter John Zanzucchi , Robert Richard Demers , Howard Christopher Rivenburg
发明人： Timothy Allen Pletcher , Peter John Zanzucchi , Robert Richard Demers , Howard Christopher Rivenburg
IPC分类号： B05B5025
CPC分类号： B05B5/1691 , B05B5/047
摘要： A spraying device for dispensing electrostatic liquid droplets includes a container holding a liquid at one end, and having a nozzle assembly with an aperture at another end. The nozzle assembly includes a longitudinal hollow tube terminating in a metallic structure. The metallic structure includes a metallic base plate having at least one aperture formed therein for fluid communication with the hollow tube. The longitudinal hollow tube includes an end inserted in the liquid. A charge accumulator disposed in the liquid accumulates electrostatic charges. A wire conductor between the base plate and the charge accumulator transfers the electrostatic charges from the liquid to the nozzle assembly.
摘要翻译：用于分配静电液滴的喷射装置包括在一端保持液体的容器，并且具有在另一端具有孔的喷嘴组件。喷嘴组件包括终止于金属结构的纵向中空管。金属结构包括金属底板，其具有形成在其中的至少一个孔，用于与中空管流体连通。纵向中空管包括插入液体中的端部。设置在液体中的电荷蓄积剂蓄积静电电荷。基板和充电蓄能器之间的导线将静电电荷从液体转移到喷嘴组件。

5. 发明授权

US5677688A Optomechanical information entry device 失效
标题翻译：机电信息输入装置
公开(公告)号：US5677688A
公开(公告)日：1997-10-14
申请号：US882432
申请日：1992-05-13
申请人： Kerry Dennis O'Mara , Robert Richard Demers , William John Bachman , Paul Joseph Smalser, Sr.
发明人： Kerry Dennis O'Mara , Robert Richard Demers , William John Bachman , Paul Joseph Smalser, Sr.
IPC分类号： H03K17/969 , H03K17/94
CPC分类号： H03K17/969
摘要： A full N-key rollover capability information entry device includes first and second sets of intersecting light guides oriented at an angle to one another which may comprise a mesh of waveguides that together form a self-supporting planar sheet of a substantially transparent material at the wavelength of light introduced into one end of at least one of the first and second sets of light guides. This permits each intersection to comprise a common portion of both a light guide of the first set and a light guide of the second set that intersect at that intersection. Detection of changes in the intensity of the light in at least one of the sets of light guides in response to key actuation that blocks a portion of the light at a certain intersection is indicative of that actuated key.
摘要翻译：完整的N键翻转能力信息输入装置包括彼此成角度定向的第一组和第二组交叉的光导体，其可以包括波导网，它们一起形成波长为基本上透明材料的自支撑平板的光引入第一组和第二组光导中的至少一个。这允许每个交叉点包括第一组的光导和在该交叉点相交的第二组的光导的公共部分。响应于阻挡某一交叉路口处的光的一部分的按键致动来检测至少一组光导中的光的强度的变化，表示该致动键。

6. 发明授权

US6047854A Bead dispersement devices 失效
标题翻译：珠分散装置
公开(公告)号：US6047854A
公开(公告)日：2000-04-11
申请号：US805413
申请日：1997-02-26
申请人： Robert Richard Demers , Satyam Choudary Cherukuri
发明人： Robert Richard Demers , Satyam Choudary Cherukuri
IPC分类号： B01J4/02 , B01J19/00 , B65G59/06 , C40B60/14 , B65G59/00
CPC分类号： B01J4/02 , B01J19/0046 , B65G59/067 , B01J2219/00315 , B01J2219/00468 , B01J2219/005 , C40B60/14
摘要： The invention provides, among other things, bead dispenser for holding a charged bead and selectively dispensing the bead, the dispenser comprising: (a) a feeder channel having a lower outlet; (b) a bead selection escapement with a depression having an outer lip and located below the first lower outlet such that a bead exiting the lower outlet comes to rest in the depression; (c) a dispenser channel descending from the level of the lip, wherein the lip impedes a bead situated on the bead selection escapement from entering the dispenser channel; and a first dispensing electrode for creating an electromagnetic potential to pull or push the bead over the rim and into the dispenser channel.
摘要翻译：本发明尤其提供了用于保持带电珠粒并选择性地分配珠粒的珠粒分配器，该分配器包括：（a）具有下部出口的进料通道; （b）具有凹部的珠选择擒纵装置，所述凹陷具有外唇缘并且位于所述第一下出口下方，使得离开所述下出口的珠子在所述凹陷中静止; （c）从所述唇缘的水平面下降的分配器通道，其中所述唇缘阻止位于所述珠选择擒纵机构上的胎圈进入所述分配器通道; 以及第一分配电极，用于产生电磁势，以将凸缘拉动或推动在凸缘上并进入分配器通道。

7. 发明授权

US5840256A Plate for reaction system 失效
标题翻译：反应体系板
公开(公告)号：US5840256A
公开(公告)日：1998-11-24
申请号：US630018
申请日：1996-04-09
申请人： Robert Richard Demers , Satyam Choudary Cherukuri , Aaron Wiliam Levine , Kerry Dennis O'Mara
发明人： Robert Richard Demers , Satyam Choudary Cherukuri , Aaron Wiliam Levine , Kerry Dennis O'Mara
IPC分类号： B01J19/00 , B01L3/00 , C40B60/14 , B01L11/00
CPC分类号： B01L3/5025 , B01J19/0046 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , C40B60/14 , Y10S436/809
摘要： The invention provides a plate having a plurality uniformly sized reaction cells formed in its upper surface, wherein the density of the reaction cells is at least about 10 cells per cm.sup.2. Preferably, the area of each of the openings of the reaction cells is no more than about 55% of the area defined by the multiplication product of (1) the pitch between reaction cells in separate rows and (2) the pitch between reaction cells in separate columns.
摘要翻译：本发明提供一种具有在其上表面形成的多个均匀尺寸的反应池的板，其中反应池的密度至少约为10个/ cm 2。优选地，反应池的每个开口的面积不超过由（1）的乘积定义的面积的大约55％，单独的行中的反应单元之间的间距和（2）反应单元之间的间距单独列。

8. 发明授权

US3997807A Mechanically adjustable electron gun apparatus 失效
标题翻译：机械可调电子枪装置
公开(公告)号：US3997807A
公开(公告)日：1976-12-14
申请号：US613534
申请日：1975-09-15
申请人： George Herbert Needham Riddle , Robert Richard Demers
发明人： George Herbert Needham Riddle , Robert Richard Demers
IPC分类号： G01Q10/00 , G01Q30/16 , H01J3/02 , H01J29/46
CPC分类号： H01J3/028
摘要： An electron gun apparatus comprises a cathode subassembly which is movably mounted relative to a fixedly mounted and registered grid/anode subassembly to permit mechanical adjustment of the cathode with respect to the grid/anode subassembly. An evacuated chamber, including resilient bellows interconnecting the movably mounted cathode assembly to the fixedly mounted grid/anode subassembly for permitting the mechanical adjustment, houses the cathode and the grid/anode subassemblies. Means are provided for electrical energization of the cathode, the grid, and the anode. According to a further feature of the invention, the cathode comprises a line filament, and the grid and the anode are slotted for providing an elongated line image.
摘要翻译：电子枪装置包括阴极子组件，其相对于固定安装和注册的栅格/阳极子组件可移动地安装，以允许阴极相对于栅极/阳极子组件的机械调节。真空室包括将可移动安装的阴极组件与固定安装的栅格/阳极子组件相互连接的弹性波纹管，用于允许机械调节，容纳阴极和栅极/阳极子组件。提供了用于阴极，栅极和阳极的电通电的装置。根据本发明的另一个特征，阴极包括线灯丝，栅格和阳极被开槽以提供细长的线图像。

9. 发明授权

US6117396A Device for delivering defined volumes 失效
标题翻译：用于传递定义的卷的设备
公开(公告)号：US6117396A
公开(公告)日：2000-09-12
申请号：US25380
申请日：1998-02-18
申请人： Robert Richard Demers
发明人： Robert Richard Demers
IPC分类号： G01N31/20 , B01J4/02 , B01J19/00 , B01L3/00 , B01L3/02 , B01L99/00 , C40B60/14 , G01N1/00 , G01N35/10 , G01N37/00 , G01N1/14
CPC分类号： B01L3/502715 , B01J19/0046 , B01J19/0093 , B01L3/0293 , B01J2219/00317 , B01J2219/00351 , B01J2219/00389 , B01J2219/00585 , B01J2219/00659 , B01J2219/00783 , B01J2219/00889 , B01J2219/00891 , B01L2200/025 , B01L2200/0605 , B01L2300/0864 , B01L2300/0874 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , B01L3/0268 , B01L3/5025 , C40B60/14 , G01N1/14 , Y10T436/2575
摘要： Provided is a liquid dispensing device for delivering defined volumes comprising (a) a reagent fill channel, (b) one or more metering capillaries connected to the reagent fill channel and having an exit, and (c) one or more sources of gas connected to the reagent fill channel, wherein after filing the one or more metering capillaries the reagent fill channel can be drained of liquid while liquid is retained in the one or more metering capillaries, and the source of gas can be operated to eject the liquid in the metering capillaries.
摘要翻译：提供了一种用于输送限定体积的液体分配装置，包括（a）试剂填充通道，（b）连接到试剂填充通道并具有出口的一个或多个计量毛细管，和（c）一个或多个气体源连接到所述试剂填充通道，其中在填充所述一个或多个计量毛细管之后，所述试剂填充通道可以排出液体，同时液体保留在所述一个或多个计量毛细管中，并且所述气体源可以被操作以将所述液体喷射到所述计量毛细血管

10. 发明授权

US5879632A Apportioning system 失效
标题翻译：分配制度
公开(公告)号：US5879632A
公开(公告)日：1999-03-09
申请号：US630047
申请日：1996-04-09
申请人： Robert Richard Demers
发明人： Robert Richard Demers
IPC分类号： G01N1/00 , B01J4/02 , B01J19/00 , B01L3/00 , B01L3/02 , C25B15/08 , C40B60/14 , F17D1/14 , G01N35/10
CPC分类号： B01L3/0241 , B01J19/0046 , B01J19/0093 , B01L3/0268 , B01J2219/00317 , B01J2219/00353 , B01J2219/00783 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00952 , B01L2200/0689 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/1827 , B01L2400/0415 , B01L2400/0688 , B01L3/5027 , C40B60/14 , Y10T137/7761 , Y10T137/8158 , Y10T137/87249
摘要： The invention provides an apportioning system comprising a first apportioning chamber having a first outlet and fillable with liquid to a first defined level such that if liquid is added to fill the first apportioning chamber above the first defined level, then the extra fluid drains through the first outlet, an inlet channel that distributes liquid to the first apportioning chamber, and a first electrode-based pump for moving liquid in the first apportioning chamber out the first outlet.
摘要翻译：本发明提供了一种分配系统，其包括具有第一出口并且可用液体填充到第一限定水平的第一分配室，使得如果添加液体以将第一分配室填充到高于第一限定水平面上，则额外的流体排出第一出口，将液体分配到第一分配室的入口通道和用于将第一分配室中的液体移出第一出口的第一电极式泵。

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