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1. 发明申请

US20090036773A1 METHODS AND APPARATUS FOR ENGAGEMENT AND COUPLING OF AN INTRACAVITORY IMAGING AND HIGH INTENSITY FOCUSED ULTRASOUND PROBE 有权
标题翻译：入侵和联合成像和高强度聚焦超声探头的方法和装置
公开(公告)号：US20090036773A1
公开(公告)日：2009-02-05
申请号：US11831048
申请日：2007-07-31
申请人： Michael P. H. Lau , Gregory Paul Darlington , Michael J. Connolly , Zihong Guo
发明人： Michael P. H. Lau , Gregory Paul Darlington , Michael J. Connolly , Zihong Guo
IPC分类号： A61B8/12 , A61N7/00
CPC分类号： A61B8/12 , A61B8/4209 , A61B8/4272 , A61B8/4281 , A61B8/445 , A61B17/2202 , A61B17/2256 , A61B17/4241 , A61B2017/2253 , A61B2017/4216 , A61B2018/00029 , A61B2090/3782 , A61B2090/3784 , A61N7/022
摘要： A combined imaging/HIFU probe includes an imaging scan head, a HIFU transducer, and an outlet port that delivers a flow of fluid across the HIFU transducer. At least a portion of the body cavity is filled with fluid in which the probe is immersed. The fluid provides a coupling for transmission of ultrasound energy between the probe and the patient. A flow of fluid may also be used to flush obstructions from an area of tissue near the HIFU transducer. Further described herein is a cuff to help retain fluid in the body cavity, a regulator to regulate fluid flow with respect to the body cavity according to a desired fluid pressure, and a cover for the HIFU transducer that has at least one perforation defined therethrough to allow fluid to flow through the cover. Further disclosed herein are methods of deploying a combined imaging/HIFU probe in a body cavity.
摘要翻译：组合的成像/ HIFU探头包括成像扫描头，HIFU换能器和输出流体穿过HIFU换能器的出口。体腔的至少一部分填充有探针浸入其中的流体。流体提供用于在探针和患者之间传输超声能量的耦合。流体流也可用于冲洗HIFU换能器附近的组织区域的障碍物。本文进一步描述的是用于帮助保持体腔中的流体的袖带，根据期望的流体压力调节流体相对于体腔的流体的调节器，以及用于HIFU换能器的覆盖物，其具有至少一个穿过其定义的穿孔允许流体流过盖子。本文进一步公开的是将组合成像/ HIFU探针部署在体腔中的方法。

2. 发明授权

US08052604B2 Methods and apparatus for engagement and coupling of an intracavitory imaging and high intensity focused ultrasound probe 有权
标题翻译：腔内成像和高强度聚焦超声探头的接合和耦合的方法和装置
公开(公告)号：US08052604B2
公开(公告)日：2011-11-08
申请号：US11831048
申请日：2007-07-31
申请人： Michael P. H. Lau , Gregory Paul Darlington , Michael J. Connolly , Zihong Guo
发明人： Michael P. H. Lau , Gregory Paul Darlington , Michael J. Connolly , Zihong Guo
IPC分类号： A61B8/00 , A61B8/14
CPC分类号： A61B8/12 , A61B8/4209 , A61B8/4272 , A61B8/4281 , A61B8/445 , A61B17/2202 , A61B17/2256 , A61B17/4241 , A61B2017/2253 , A61B2017/4216 , A61B2018/00029 , A61B2090/3782 , A61B2090/3784 , A61N7/022
摘要： A combined imaging/HIFU probe includes an imaging scan head, a HIFU transducer, and an outlet port that delivers a flow of fluid across the HIFU transducer. At least a portion of the body cavity is filled with fluid in which the probe is immersed. The fluid provides a coupling for transmission of ultrasound energy between the probe and the patient. A flow of fluid may also be used to flush obstructions from an area of tissue near the HIFU transducer. Further described herein is a cuff to help retain fluid in the body cavity, a regulator to regulate fluid flow with respect to the body cavity according to a desired fluid pressure, and a cover for the HIFU transducer that has at least one perforation defined therethrough to allow fluid to flow through the cover. Further disclosed herein are methods of deploying a combined imaging/HIFU probe in a body cavity.
摘要翻译：组合的成像/ HIFU探头包括成像扫描头，HIFU换能器和输出流体穿过HIFU换能器的出口。体腔的至少一部分填充有探针浸入其中的流体。流体提供用于在探针和患者之间传输超声能量的耦合。流体流也可用于冲洗HIFU换能器附近的组织区域的障碍物。本文进一步描述的是用于帮助保持体腔中的流体的袖带，根据期望的流体压力调节流体相对于体腔的流体的调节器，以及用于HIFU换能器的覆盖物，其具有至少一个穿过其定义的穿孔允许流体流过盖子。本文进一步公开的是将组合成像/ HIFU探针部署在体腔中的方法。

3. 发明授权

US08277379B2 Methods and apparatus for the treatment of menometrorrhagia, endometrial pathology, and cervical neoplasia using high intensity focused ultrasound energy 有权
标题翻译：使用高强度聚焦超声能量治疗子宫肌瘤，子宫内膜病理和子宫颈瘤的方法和装置
公开(公告)号：US08277379B2
公开(公告)日：2012-10-02
申请号：US11735279
申请日：2007-04-13
申请人： Michael P. H. Lau , Nelson Teng , Shahram Vaezy , Alexander Lebedev , Michael William Lau , Michael J. Connolly
发明人： Michael P. H. Lau , Nelson Teng , Shahram Vaezy , Alexander Lebedev , Michael William Lau , Michael J. Connolly
IPC分类号： A61B8/00
CPC分类号： A61N7/022 , A61B1/303 , A61B8/12 , A61B2017/22008 , A61B2017/4216 , A61B2090/378
摘要： A probe having a high intensity focused ultrasound (HIFU) transducer is positioned in a female patient. The HIFU transducer is deployed within the vagina of the patient outside of the cervix and uterine cavity and is configured to direct HIFU energy to a treatment site within the uterus of the patient. An imaging component positioned relative to the patient images a portion of the patient's uterus that includes the treatment site to help guide the delivery of the HIFU energy to the treatment site. A liquid medium may be infused into the uterine cavity of the patient where it is maintained during imaging and delivery of the HIFU therapy. The HIFU transducer produces a thermal heating of tissue at a focus within the treatment site to initiate necrosis of the tissue. The location of the focus is controlled in accordance with an image obtained by the imaging component.
摘要翻译：具有高强度聚焦超声（HIFU）换能器的探针定位在女性患者体内。 HIFU传感器部署在患者子宫颈和子宫腔外的阴道内，并配置为将HIFU能量引导到患者子宫内的治疗部位。相对于患者定位的成像组件对包括治疗部位的患者子宫的一部分进行成像，以帮助指导将HIFU能量递送到治疗部位。液体培养基可以输注到患者的子宫腔中，在HIFU治疗的成像和传送过程中维持它。 HIFU换能器在处理部位的焦点处产生组织的热加热，以引起组织的坏死。根据由成像部件获得的图像来控制焦点的位置。

4. 发明授权

US09050449B2 System for treating a volume of tissue with high intensity focused ultrasound 有权
标题翻译：用高强度聚焦超声治疗体积的组织的系统
公开(公告)号：US09050449B2
公开(公告)日：2015-06-09
申请号：US12753813
申请日：2010-04-02
申请人： Gregory P. Darlington , Michael J. Connolly , Justin A. Reed , Jessica E. Parsons , Roland Horth , John Murkowski , Charles D. Emery
发明人： Gregory P. Darlington , Michael J. Connolly , Justin A. Reed , Jessica E. Parsons , Roland Horth , John Murkowski , Charles D. Emery
IPC分类号： A61H1/00 , A61H1/02 , A61H5/00 , A61N7/02 , A61B17/00 , A61B19/00 , A61N7/00
CPC分类号： A61N7/02 , A61B2017/00172 , A61B2090/378 , A61N2007/0065 , A61N2007/0082 , A61N2007/0091 , A61N2007/0095
摘要： A method for treating a desired volume of tissue using HIFU or other energy modality to ablate a pattern of elemental treatment volumes each having a volume that is greater than that of the focal zone of the HIFU transducer but smaller than the overall volume of the desired treatment volume. In one embodiment, the pattern of elemental treatment volumes are arranged to form a shell which partially or wholly encapsulates the desired volume of tissue, which then necroses in situ due to effects other than direct HIFU damage (including some combination of ischemia, thermal conduction, inflammation, apoptosis, etc.). The necrosed tissue remains in the body and is subsequently resorbed and/or healed via normal body mechanisms.
摘要翻译：一种使用HIFU或其他能量模式来治疗期望体积的组织的方法，以消融每个具有大于HIFU换能器的焦点区域的体积的体积的元素处理体积的图案，但小于所需治疗的总体积卷。在一个实施方案中，元件处理体积的图案被布置成形成部分地或完全地包封所需体积的组织的壳，其由于除了直接HIFU损伤之外的作用（包括局部缺血，热传导，炎症，凋亡等）。坏死的组织保留在体内，随后通过正常的身体机制吸收和/或愈合。

5. 发明申请

US20100210976A1 METHOD AND APPARATUS FOR TREATING TISSUES WITH HIFU 有权
标题翻译：用HIFU治疗组织的方法和装置
公开(公告)号：US20100210976A1
公开(公告)日：2010-08-19
申请号：US12573840
申请日：2009-10-05
申请人： Gregory P. Darlington , Michael J. Connolly , Justin A. Reed , Jessica E. Parsons , Roland Horth , John Murkowski
发明人： Gregory P. Darlington , Michael J. Connolly , Justin A. Reed , Jessica E. Parsons , Roland Horth , John Murkowski
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61B2090/378 , A61N2007/0082
摘要： A method for treating a desired volume of tissue using HIFU or other energy modality to ablate a pattern of elemental treatment volumes each having a volume that is greater than that of the focal zone of the HIFU transducer but smaller than the overall volume of the desired treatment volume. In one embodiment, the pattern of elemental treatment volumes are arranged to form a shell which partially or wholly encapsulates the desired volume of tissue, which then necroses in situ due to effects other than direct HIFU damage (including some combination of ischemia, thermal conduction, inflammation, apoptosis, etc.). The necrosed tissue remains in the body and is subsequently resorbed and/or healed via normal body mechanisms.
摘要翻译：一种使用HIFU或其他能量模式来治疗期望体积的组织的方法，以消融每个具有大于HIFU换能器的焦点区域的体积的体积的元素处理体积的图案，但小于所需治疗的总体积卷。在一个实施方案中，元件处理体积的图案被布置成形成部分地或完全地包封所需体积的组织的壳，其由于除了直接HIFU损伤之外的作用（包括局部缺血，热传导，炎症，凋亡等）。坏死的组织保留在体内，随后通过正常的身体机制吸收和/或愈合。

6. 发明申请

US20090118729A1 HEMOSTATIC SPARK EROSION TISSUE TUNNEL GENERATOR WITH INTEGRAL TREATMENT PROVIDING VARIABLE VOLUMETRIC NECROTIZATION OF TISSUE 失效
标题翻译：具有综合治疗的HEMOSTATIC SPARK EROSION TISSUE TUNNEL发生器提供组织的可变体积分解
公开(公告)号：US20090118729A1
公开(公告)日：2009-05-07
申请号：US11936748
申请日：2007-11-07
申请人： David C. Auth , Alexander Lebedev , Michael J. Connolly
发明人： David C. Auth , Alexander Lebedev , Michael J. Connolly
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B8/12 , A61B18/1815 , A61B2018/00791 , A61B2018/1213 , A61B2018/1472 , A61B2018/1475 , A61B2090/3784 , A61B2218/002 , A61B2218/007
摘要： A catheter for insertion into and treatment of tissue in a patient comprises a radio frequency (RF) electrode having an elongated body that conducts electrical RF energy to a conductive tip. An insulating sleeve surrounding the elongated body prevents leakage of RF energy from the elongated body when the catheter is being inserted into the tissue of the patient. In a first mode of operation, the conductive tip is exposed outside the insulating sleeve and the RF electrode delivers first RF energy capable of producing sparks that erode the tissue of the patient and create a tunnel through which the catheter can advance into the tissue of the patient. In a second mode of operation, the insulating sleeve is retracted to expose a portion of the RF electrode. Second RF energy is delivered to the volume of tissue around the catheter to necrotize the tissue by heating without producing sparks.
摘要翻译：用于插入和治疗患者组织的导管包括射频（RF）电极，其具有将电RF能量传导到导电尖端的细长主体。围绕细长主体的绝缘套管防止当导管插入到患者组织中时，来自细长体的RF能量的泄漏。在第一操作模式中，导电尖端暴露在绝缘套管外部，并且RF电极提供能够产生火花的第一RF能量，该火花侵蚀患者的组织并产生通道，导管可穿过该通道进入组织中患者。在第二操作模式中，绝缘套管缩回以暴露RF电极的一部分。将第二RF能量传递到导管周围的组织体积，以通过加热而不产生火花来坏死组织。

7. 发明授权

US08845559B2 Method and apparatus for treating tissues with HIFU 有权
标题翻译：用HIFU治疗组织的方法和装置
公开(公告)号：US08845559B2
公开(公告)日：2014-09-30
申请号：US12573840
申请日：2009-10-05
申请人： Gregory P. Darlington , Michael J. Connolly , Justin A. Reed , Jessica E. Parsons , Roland Horth , John Murkowski
发明人： Gregory P. Darlington , Michael J. Connolly , Justin A. Reed , Jessica E. Parsons , Roland Horth , John Murkowski
IPC分类号： A61H1/00 , A61H1/02 , A61H5/00 , A61N7/02 , A61N7/00 , A61B19/00
CPC分类号： A61N7/02 , A61B2090/378 , A61N2007/0082
摘要： A method for treating a desired volume of tissue using HIFU or other energy modality to ablate a pattern of elemental treatment volumes each having a volume that is greater than that of the focal zone of the HIFU transducer but smaller than the overall volume of the desired treatment volume. In one embodiment, the pattern of elemental treatment volumes are arranged to form a shell which partially or wholly encapsulates the desired volume of tissue, which then necroses in situ due to effects other than direct HIFU damage (including some combination of ischemia, thermal conduction, inflammation, apoptosis, etc.). The necrosed tissue remains in the body and is subsequently resorbed and/or healed via normal body mechanisms.
摘要翻译：一种使用HIFU或其他能量模式来治疗期望体积的组织的方法，以消融每个具有大于HIFU换能器的焦点区域的体积的体积的元素处理体积的图案，但小于所需治疗的总体积卷。在一个实施方案中，元件处理体积的图案被布置成形成部分地或完全地包封所需体积的组织的壳，其由于除了直接HIFU损伤之外的作用（包括局部缺血，热传导，炎症，凋亡等）。坏死的组织保留在体内，随后通过正常的身体机制吸收和/或愈合。

8. 发明授权

US08187270B2 Hemostatic spark erosion tissue tunnel generator with integral treatment providing variable volumetric necrotization of tissue 失效
标题翻译：止血火花侵蚀组织隧道发生器，具有整体治疗，提供组织的可变体积坏死
公开(公告)号：US08187270B2
公开(公告)日：2012-05-29
申请号：US11936748
申请日：2007-11-07
申请人： David C. Auth , Alexander Lebedev , Michael J. Connolly
发明人： David C. Auth , Alexander Lebedev , Michael J. Connolly
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B8/12 , A61B18/1815 , A61B2018/00791 , A61B2018/1213 , A61B2018/1472 , A61B2018/1475 , A61B2090/3784 , A61B2218/002 , A61B2218/007
摘要： A catheter for insertion into and treatment of tissue in a patient comprises a radio frequency (RF) electrode having an elongated body that conducts electrical RF energy to a conductive tip. An insulating sleeve surrounding the elongated body prevents leakage of RF energy from the elongated body when the catheter is being inserted into the tissue of the patient. In a first mode of operation, the conductive tip is exposed outside the insulating sleeve and the RF electrode delivers first RF energy capable of producing sparks that erode the tissue of the patient and create a tunnel through which the catheter can advance into the tissue of the patient. In a second mode of operation, the insulating sleeve is retracted to expose a portion of the RF electrode. Second RF energy is delivered to the volume of tissue around the catheter to necrotize the tissue by heating without producing sparks.
摘要翻译：用于插入和治疗患者组织的导管包括射频（RF）电极，其具有将电RF能量传导到导电尖端的细长主体。围绕细长主体的绝缘套管防止当导管插入到患者组织中时，来自细长体的RF能量的泄漏。在第一操作模式中，导电尖端暴露在绝缘套管外部，并且RF电极提供能够产生火花的第一RF能量，该火花侵蚀患者的组织并产生通道，导管可穿过该通道进入组织中患者。在第二操作模式中，绝缘套管缩回以暴露RF电极的一部分。将第二RF能量传递到导管周围的组织体积，以通过加热而不产生火花来坏死组织。

9. 发明申请

US20100241005A1 OFFICE-BASED SYSTEM FOR TREATING UTERINE FIBROIDS OR OTHER TISSUES WITH HIFU 有权
标题翻译：用于治疗子宫纤维蛋白或其他与HIFU的组织的基于办公室的系统
公开(公告)号：US20100241005A1
公开(公告)日：2010-09-23
申请号：US12753813
申请日：2010-04-02
申请人： Gregory P. Darlington , Michael J. Connolly , Justin A. Reed , Jessica E. Parsons , Roland Horth , John Murkowski , Charles D. Emery
发明人： Gregory P. Darlington , Michael J. Connolly , Justin A. Reed , Jessica E. Parsons , Roland Horth , John Murkowski , Charles D. Emery
IPC分类号： A61B8/14 , A61N7/00
CPC分类号： A61N7/02 , A61B2017/00172 , A61B2090/378 , A61N2007/0065 , A61N2007/0082 , A61N2007/0091 , A61N2007/0095
摘要： A method for treating a desired volume of tissue using HIFU or other energy modality to ablate a pattern of elemental treatment volumes each having a volume that is greater than that of the focal zone of the HIFU transducer but smaller than the overall volume of the desired treatment volume. In one embodiment, the pattern of elemental treatment volumes are arranged to form a shell which partially or wholly encapsulates the desired volume of tissue, which then necroses in situ due to effects other than direct HIFU damage (including some combination of ischemia, thermal conduction, inflammation, apoptosis, etc.). The necrosed tissue remains in the body and is subsequently resorbed and/or healed via normal body mechanisms.
摘要翻译：一种使用HIFU或其他能量模式来治疗期望体积的组织的方法，以消融每个具有大于HIFU换能器的焦点区域的体积的体积的元素处理体积的图案，但小于所需治疗的总体积卷。在一个实施方案中，元件处理体积的图案被布置成形成部分地或完全地包封所需体积的组织的壳，其由于除了直接HIFU损伤之外的作用（包括局部缺血，热传导，炎症，凋亡等）。坏死的组织保留在体内，随后通过正常的身体机制吸收和/或愈合。

10. 发明授权

US07284728B2 Pipe hanger assembly 失效
标题翻译：管衣架总成
公开(公告)号：US07284728B2
公开(公告)日：2007-10-23
申请号：US11023484
申请日：2004-12-29
申请人： Michael J. Connolly
发明人： Michael J. Connolly
IPC分类号： E21F17/02 , F16L3/00
CPC分类号： F16L3/11 , F16B2200/406 , F16L3/133 , F16L3/18 , Y10T403/1683 , Y10T403/581
摘要： The pipe hanger assembly is a pipe hanger and a holding assembly for retaining the pipe hanger against a pipe support. The pipe hanger has an inverted, generally U-shaped yoke having a slot defined in the bight of the yoke, a U-shaped saddle for supporting the pipe, and a bolt connecting the yoke and the saddle to each other. The holding assembly is at least a bracket having a pair of flanges defining a guide channel, the bracket being attached to a stud, threaded rod, or other pipe support suspended from a ceiling. The pipe hanger is assembled to the pipe, the bracket is attached to the rod, and the yoke is slid onto the rod between the bracket and a keeper, the yoke being aligned with the guide channel. The keeper is tightened to secure the pipe hanger to the pipe support. A pair of embossments protrude from an inner surface of the saddle.
摘要翻译：管衣架组件是管衣架和用于将管衣架保持在管支架上的保持组件。管挂架具有倒置的大致U形的轭，其具有限定在轭的弯曲部中的槽，用于支撑管的U形鞍座和将轭和鞍座彼此连接的螺栓。保持组件至少是具有限定引导通道的一对凸缘的支架，该支架附接到从天花板悬挂的螺柱，螺杆或其它管道支撑件。管衣架组装在管子上，支架与杆连接，轭架滑动到支架与保持器之间的杆上，轭架与引导通道对齐。管子被拧紧以将管衣架固定在管道支架上。一对压花从鞍座的内表面突出。

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