专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06665563B2 System and method for enhancing cardiac signal sensing by cardiac pacemakers through genetic treatment 失效
公开(公告)号：US06665563B2
公开(公告)日：2003-12-16
申请号：US09896994
申请日：2001-07-02
申请人： Kenneth B. Stokes , Josée Morissette
发明人： Kenneth B. Stokes , Josée Morissette
IPC分类号： A61N136
CPC分类号： A61N1/3702 , A61B17/3468 , A61K48/00 , A61M37/00 , A61M2025/0057 , A61M2025/0089 , A61N1/0568 , A61N1/0575 , A61N2001/058
摘要： The present invention provides delivery systems for and methods of delivering ion channel protein genetic material to cardiac cells in areas adjacent to where an electrode is to be positioned in a patient's heart to improve or correct the signal to noise ratio of cardiac signals, such as the P-wave. More specifically, there is provided a system and method for delivering sodium ion channel proteins or nucleic acid molecules encoding sodium ion channel proteins to a site in the heart adjacent to an electrode to increase the expression of the same, thereby enhancing the cardiac signal amplitude and enabling improved sensing of cardiac signals by an implanted pacemaker.

2. 发明授权

US07094201B1 System and method for genetically treating cardiac conduction disturbances 失效
标题翻译：用于遗传治疗心脏传导障碍的系统和方法
公开(公告)号：US07094201B1
公开(公告)日：2006-08-22
申请号：US09376317
申请日：1999-08-18
申请人： Kenneth B. Stokes , Josée Morissette
发明人： Kenneth B. Stokes , Josée Morissette
IPC分类号： A61N1/05 , A61N1/36 , A61K48/00 , C12N15/36
CPC分类号： A61K48/0075 , A61K38/1709 , A61K48/00 , A61M5/3291 , A61M2025/0089 , C07K14/705
摘要： The present invention provides delivery systems for and methods of delivering conduction protein genetic material to cardiac cells in localized areas of the heart to improve the conductance therein. More specifically, there is provided a system and method for delivering connexin proteins or nucleic acid molecules encoding connexin proteins to a site in the heart which has been determined by mapping procedures to have a conduction disturbance. For cases where conduction is impaired, selected genetic material is delivered to cells around the disturbance area, in order to enhance overall conductivity patterns; in other cases, genetic material is selected to slow conduction in affected areas, so as to prevent, e.g., brady-tachy syndrome.
摘要翻译：本发明提供了将传导蛋白遗传物质递送到心脏局部区域的心脏细胞的递送系统和方法，以改善其中的电导。更具体地，提供了一种用于将连接蛋白或编码连接蛋白的核酸分子递送至心脏部位的系统和方法，其通过测绘程序确定具有传导障碍。对于传导受损的情况，选择的遗传物质被传递到扰动区周围的细胞，以增强整体的导电性; 在其他情况下，选择遗传物质以缓解受影响区域的传导，以便防止例如缓慢型综合征。

3. 发明授权

US06567705B1 System and method for enhancing cardiac signal sensing by cardiac pacemakers through genetic treatment 有权
标题翻译：通过遗传治疗增强心脏起搏器心脏信号传感的系统和方法
公开(公告)号：US06567705B1
公开(公告)日：2003-05-20
申请号：US09514907
申请日：2000-02-28
申请人： Kenneth B. Stokes , Josée Morissette
发明人： Kenneth B. Stokes , Josée Morissette
IPC分类号： A61N105
CPC分类号： A61N1/3702 , A61B17/3468 , A61K48/00 , A61M37/00 , A61M2025/0057 , A61M2025/0089 , A61N1/0568 , A61N1/0575 , A61N2001/058
摘要： Delivery systems for and methods of delivering ion channel protein genetic material to cardiac cells in areas adjacent to where an electrode is to be positioned in a patient's heart to improve or correct the signal to noise ratio of cardiac signals, such as the P-wave, is described herein. More specifically, there is provided a system and method for delivering sodium ion channel proteins or nucleic acid molecules encoding sodium ion channel proteins to a site in the heart adjacent to an electrode to increase the expression of the same, thereby enhancing the cardiac signal amplitude and enabling improved sensing of cardiac signals by an implanted pacemaker.
摘要翻译：将离子通道蛋白质遗传物质递送到与电极定位在患者心脏中的区域相邻的区域中的递送系统和方法，以改善或校正心脏信号的信噪比，例如P波，在此描述。更具体地，提供了一种用于将钠离子通道蛋白或编码钠离子通道蛋白的核酸分子递送到与电极相邻的心脏中的位点以增加其表达的系统和方法，从而增强心脏信号幅度和能够通过植入式心脏起搏器改善对心脏信号的感测。

4. 发明授权

US07731653B2 System and method for genetically treating cardiac conduction disturbances 失效
标题翻译：用于遗传治疗心脏传导障碍的系统和方法
公开(公告)号：US07731653B2
公开(公告)日：2010-06-08
申请号：US11421301
申请日：2006-05-31
申请人： Kenneth B. Stokes , Josée Morissette
发明人： Kenneth B. Stokes , Josée Morissette
IPC分类号： A61N1/05 , A61N1/36 , A61K48/00 , C12N15/36
CPC分类号： A61K48/0075 , A61K38/1709 , A61K48/00 , A61M5/3291 , A61M2025/0089 , C07K14/705
摘要： The present invention provides delivery systems for and methods of delivering conduction protein genetic material to cardiac cells in localized areas of the heart to improve the conductance therein. More specifically, there is provided a system and method for delivering connexin proteins or nucleic acid molecules encoding connexin proteins to a site in the heart which has been determined by mapping procedures to have a conduction disturbance. For cases where conduction is impaired, selected genetic material is delivered to cells around the disturbance area, in order to enhance overall conductivity patterns; in other cases, genetic material is selected to slow conduction in affected areas, so as to prevent, e.g., brady-tachy syndrome.
摘要翻译：本发明提供了将传导蛋白遗传物质递送到心脏局部区域的心脏细胞的递送系统和方法，以改善其中的电导。更具体地，提供了一种用于将连接蛋白或编码连接蛋白的核酸分子递送至心脏部位的系统和方法，其通过测绘程序确定具有传导障碍。对于传导受损的情况，选择的遗传物质被传递到扰动区周围的细胞，以增强整体的导电性; 在其他情况下，选择遗传物质以缓解受影响区域的传导，以便防止例如缓慢型综合征。

5. 发明授权

US07337011B2 System and method for enhancing cardiac signal sensing by cardiac pacemakers through genetic treatment 有权
标题翻译：通过遗传治疗增强心脏起搏器心脏信号传感的系统和方法
公开(公告)号：US07337011B2
公开(公告)日：2008-02-26
申请号：US10852840
申请日：2004-05-26
申请人： Kenneth B. Stokes , Josée Morissette
发明人： Kenneth B. Stokes , Josée Morissette
IPC分类号： A61N1/05
CPC分类号： A61N1/3702 , A61B17/3468 , A61K48/00 , A61M37/00 , A61M2025/0057 , A61M2025/0089 , A61N1/0568 , A61N1/0575 , A61N2001/058
摘要： The present invention provides delivery systems for and methods of delivering ion channel protein genetic material to cardiac cells in areas adjacent to where an electrode is to be positioned in a patient's heart to improve or correct the signal to noise ratio of cardiac signals, such as the P-wave. More specifically, there is provided a system and method for delivering sodium ion channel proteins or nucleic acid molecules encoding sodium ion channel proteins to a site in the heart adjacent to an electrode to increase the expression of the same, thereby enhancing the cardiac signal amplitude and enabling improved sensing of cardiac signals by an implanted pacemaker.
摘要翻译：本发明提供了用于将离子通道蛋白质遗传物质递送到心脏细胞的递送系统和方法，所述心脏细胞在邻近于患者心脏中的电极位置的区域中以改善或校正心脏信号的信噪比，例如 P波。更具体地，提供了一种用于将钠离子通道蛋白或编码钠离子通道蛋白的核酸分子递送到与电极相邻的心脏中的位点以增加其表达的系统和方法，从而增强心脏信号幅度和能够通过植入式心脏起搏器改善对心脏信号的感测。

6. 发明授权

US06801805B2 System and method for enhancing cardiac signal sensing by cardiac pacemakers through genetic treatment 失效
公开(公告)号：US06801805B2
公开(公告)日：2004-10-05
申请号：US09896995
申请日：2001-07-02
申请人： Kenneth B. Stokes , Josée Morissette
发明人： Kenneth B. Stokes , Josée Morissette
IPC分类号： A61N1365
CPC分类号： A61N1/3702 , A61B17/3468 , A61K48/00 , A61M37/00 , A61M2025/0057 , A61M2025/0089 , A61N1/0568 , A61N1/0575 , A61N2001/058
摘要： The present invention provides delivery systems for and methods of delivering ion channel protein genetic material to cardiac cells in areas adjacent to where an electrode is to be positioned in a patient's heart to improve or correct the signal to noise ratio of cardiac signals, such as the P-wave. More specifically, there is provided a system and method for delivering sodium ion channel proteins or nucleic acid molecules encoding sodium ion channel proteins to a site in the heart adjacent to an electrode to increase the expression of the same, thereby enhancing the cardiac signal amplitude and enabling improved sensing of cardiac signals by an implanted pacemaker.

7. 发明授权

US5522875A Medical electrical lead system having a torque transfer stylet 失效
标题翻译：具有扭矩传递通丝针的医用电气引线系统
公开(公告)号：US5522875A
公开(公告)日：1996-06-04
申请号：US282421
申请日：1994-07-28
申请人： James T. Gates , Kenneth B. Stokes
发明人： James T. Gates , Kenneth B. Stokes
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0573 , A61N2001/0578
摘要： A medical electrical lead system having a torque transfer stylet. In a preferred embodiment, the torque transfer stylet comprises an elongated, stylet wire having proximal, intermediate and distal sections. The proximal and distal section of the stylet wire have a first diameter. The intermediate section spans between the proximal and distal sections. The stylet wire in this region, however, has a second diameter, the second diameter smaller than the first diameter of the proximal and distal sections. In addition, the intermediate section further has a length of torque coil wrapped thereabout. The torque coil preferably is wound in a coiled diameter which is the same as the first diameter of the proximal and distal sections of the stylet wire. Through such a configuration the stylet has an overall nearly uniformed diameter through its length.
摘要翻译：一种具有扭矩传递探针的医用电引线系统。在优选实施例中，扭矩传递探针包括具有近端，中间和远端部分的细长的探针线。探针线的近端和远端部分具有第一直径。中间部分跨越近端部分和远端部分。然而，该区域中的探针线具有第二直径，第二直径小于近端部分和远端部分的第一直径。此外，中间部分还具有缠绕在其上的扭矩线圈的长度。扭矩线圈优选缠绕成与通孔针线的近端部分和远端部分的第一直径相同的线圈直径。通过这种配置，探针具有通过其长度的整体近似均匀的直径。

8. 发明授权

US5396902A Steerable stylet and manipulative handle assembly 失效
标题翻译：可导向的探针和操纵手柄总成
公开(公告)号：US5396902A
公开(公告)日：1995-03-14
申请号：US69310
申请日：1993-05-28
申请人： Kenneth R. Brennen , Peter J. Pohndorf , Kenneth B. Stokes
发明人： Kenneth R. Brennen , Peter J. Pohndorf , Kenneth B. Stokes
IPC分类号： A61M25/01 , A61B5/00
CPC分类号： A61M25/0138 , A61M25/0136 , A61M25/0147
摘要： A steerable stylet and manipulative handle assembly for guiding a lead or a catheter to a desired location in a patient. The steerable stylet comprises an outer, elongated tubular member of a length sufficient to extend through the length of the lead or catheter from its proximal opening to the distal end thereof, a traction element or pull wire extending generally through the length of the tubular member and within its lumen except for a span in the distal portion thereof, and a manipulative handle coupled to the proximal ends of the tubular member and wire. Traction applied with one hand to the pull wire via the handle causes the distal portion of the tubular member to bend. Distal portion of the tubular member is provided with openings to allow the wire to exit and re-enter the lumen and facilitate bending of the tubular member. Distal portion of the tubular member which bends is preferably deformed, such as cut out or flattened or indented, to avoid kinking. A retainer surrounds the area proximate the openings and protects the exposed pull wire.
摘要翻译：用于将引线或导管引导到患者期望位置的可操纵的探针和操纵手柄组件。可操纵的探针包括一长度足以从其近端开口延伸到其远端的长度足够的长度的细长管状构件，大体通过管状构件的长度延伸的牵引元件或拉丝，在其管腔内，除了其远端部分中的跨度，以及联接到管状构件和线的近端的操纵手柄。通过手柄将牵引力一只手牵引到拉线，导致管状构件的远端部分弯曲。管状构件的远端部分设置有开口，以允许电线离开并重新进入内腔并有利于管状构件的弯曲。弯曲的管状构件的远端部分优选地变形，例如切割或变平或缩进，以避免扭结。保持器围绕开口附近的区域并且保护暴露的拉线。

9. 发明授权

US5002067A Medical electrical lead employing improved penetrating electrode 失效
标题翻译：医用电线采用改进的穿透电极
公开(公告)号：US5002067A
公开(公告)日：1991-03-26
申请号：US398349
申请日：1989-08-23
申请人： Wendy A. Berthelsen , Kenneth B. Stokes
发明人： Wendy A. Berthelsen , Kenneth B. Stokes
IPC分类号： A61N1/05 , A61N1/30
CPC分类号： A61N1/0575 , A61N1/0568 , A61N1/306
摘要： A cardiac pacing lead or other stimulation lead carrying a drug compounded into a matrix, located within the distal portion of the lead. The drug is delivered to the tissue adjacent the distal end of the lead. In connection with the polymer matrix, the lead is provided with a penetrating electrode, which takes the form of a sharpened helix. The electrode is provided with a groove, running the length of the electrode and exposed to the matrix. In use, the drug elutes out of the matrix, through the groove in the electrode, and into the tissue to be stimulated. The drug may be an antiinflammatory agent, such as a glucocorticosteroid, to minimize the effects of implantation of the electrode into the tissue to be stimulated.
摘要翻译：心脏起搏引线或其他刺激引线，其携带药物复合到基质中，位于引线的远端部分内。药物被递送到邻近导线远端的组织。与聚合物基质相关，引线设有穿透电极，其采用锐化的螺旋形式。电极设有沟槽，延伸电极的长度并暴露于基体。在使用中，药物从基质中流出，通过电极中的凹槽，并进入待刺激的组织。药物可以是抗炎剂，例如糖皮质激素，以最小化将电极植入待刺激的组织中的作用。

10. 发明授权

US4972848A Medical electrical lead with polymeric monolithic controlled release device and method of manufacture 失效
标题翻译：具有聚合物单片控制释放装置的医用电线和制造方法
公开(公告)号：US4972848A
公开(公告)日：1990-11-27
申请号：US398220
申请日：1989-08-23
申请人： Edward D. Di Domenico , Christopher M. Hobot , Kenneth B. Stokes , Arthur J. Coury , Phong D. Doan , Richard D. Sandstrom
发明人： Edward D. Di Domenico , Christopher M. Hobot , Kenneth B. Stokes , Arthur J. Coury , Phong D. Doan , Richard D. Sandstrom
IPC分类号： A61K9/00 , A61K9/20 , A61K9/70 , A61K47/34 , A61M37/00 , A61N1/05
CPC分类号： A61K9/0024 , A61K9/2031 , A61K9/7007 , A61N1/0568 , A61N1/0573
摘要： A cardiac pacing lead or other stimulation lead carrying a steroid compounded within a polymer matrix. The steroid is dispersed in thermoplastic or thermoset polyurethane or polyurea forming monomers or prepolymers. The mixture is then chain extended by addition of the appropriate difunctional or multifunctional isocyanate, hydroxyl or amine curing agent to form a solid polymer. The resulting formulation is molded or cast into a desired shape, and incorporated in the distal end of a medical electrical lead, adjacent to or within the electrode. In a preferred embodiment, the medical lead employs an extendable helix which is screwed into body tissue, and the polymer containing the drug takes the form of a generally dimensionally stable annular member mounted to the lead, encircling the helix.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式