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1. 发明授权

US08209032B2 Implantable medical device conductor insulation and process for forming 有权
标题翻译：可植入医疗器械导体绝缘和成型工艺
公开(公告)号：US08209032B2
公开(公告)日：2012-06-26
申请号：US12683561
申请日：2010-01-07
申请人： Michael J Ebert , John L Sommer , Richard D Ries , Jordan D Honeck , Pedro A Meregotte , Kenneth R Brennen
发明人： Michael J Ebert , John L Sommer , Richard D Ries , Jordan D Honeck , Pedro A Meregotte , Kenneth R Brennen
IPC分类号： A61N1/00
CPC分类号： H01B3/306 , A61L31/10 , A61N1/056 , C08L79/08
摘要： An elongate medical electrical lead conductor includes a layer of hydrolytically stable polyimide formed thereover.
摘要翻译：细长的医用电引线导体包括一层形成在其上的水解稳定的聚酰亚胺。

2. 发明授权

US5662119A Steerable stylet and manipulative handle assembly 失效
标题翻译：可导向的探针和操纵手柄总成
公开(公告)号：US5662119A
公开(公告)日：1997-09-02
申请号：US426355
申请日：1995-04-21
申请人： Kenneth R. Brennen , Peter J. Pohndorf
发明人： Kenneth R. Brennen , Peter J. Pohndorf
IPC分类号： A61M25/01 , A61M25/092 , A61B5/00
CPC分类号： A61M25/0138 , A61M25/0136 , A61M25/0147 , A61M2025/0163
摘要： A steerable stylet and manipulative handle assembly especially adapted for guiding the introduction of an endocardial pacing or cardioversion/defibrillation lead or a catheter to a desired location in a patient's cardiovascular system. The steerable stylet or catheter designed to be introduced into the lumen of a lead comprises an outer, elongated tubular member of a length sufficient to extend through the length of the lead or catheter from its proximal opening to the distal end thereof, a traction element or pull wire extending generally through the length of the tubular member and within its lumen except for a predetermined distance in the distal portion thereof, and a manipulative handle coupled to the proximal ends of the tubular member and wire which may be employed with one hand to both rotate the tubular member and impart a continuously variable curve in the distal portion thereof. The distal portion of the tubular member is especially configured to be either attached to or cooperate with the distal end of the pull wire so that proximally-directed traction applied by the handle to the wire causes the distal portion of the tubular member to bend. The distal portion of the tubular member is provided with openings to allow the wire to exit and re-enter the lumen of the tubular member in the distal portion so that traction applied to the wire bows the tubular member into a curve of desired radius.
摘要翻译：特别适用于引导将心内膜起搏或心脏复律/除颤引导或导管引入患者心血管系统中所需位置的可操纵的探针和操纵手柄组件。设计成被引导到导管的内腔中的可引导的管心针或导管包括外部细长的管状构件，其长度足以延伸穿过引导件或导管的长度从其近端开口到其远端，牵引元件或拉线通常延伸通过管状构件的长度并且在其管腔中延伸，除了其远端部分中的预定距离之外，以及联接到管状构件和线的近端的操纵手柄，其可以用一只手同时使用旋转管状构件并在其远端部分赋予连续可变的曲线。管状构件的远端部分被特别地构造成可以与拉线的远端连接或配合，使得由手柄施加到导线的向近侧引导的牵引导致管状构件的远端部分弯曲。管状构件的远端部分设置有开口，以允许线离开并重新进入远端部分中的管状构件的内腔，使得施加到电线的牵引将弓形管弯曲成所需半径的曲线。

3. 发明授权

US5439006A Steerable stylet and manipulative handle assembly 失效
标题翻译：可导向的探针和操纵手柄总成
公开(公告)号：US5439006A
公开(公告)日：1995-08-08
申请号：US13126
申请日：1993-02-03
申请人： Kenneth R. Brennen , Peter J. Pohndorf
发明人： Kenneth R. Brennen , Peter J. Pohndorf
IPC分类号： A61M25/01 , A61M25/092 , A61B5/00
CPC分类号： A61M25/0138 , A61M25/0136 , A61M25/0147 , A61M2025/0163
摘要： A steerable stylet and manipulative handle assembly especially adapted for guiding the introduction of an endocardial pacing or cardioversion/defibrillation lead or a catheter to a desired location in a patient's cardiovascular system. The steerable stylet or catheter designed to be introduced into the lumen of a lead comprises an outer, elongated tubular member of a length sufficient to extend through the length of the lead or catheter from its proximal opening to the distal end thereof, a traction element or pull wire extending generally through the length of the tubular member and within its lumen except for a predetermined distance in the distal portion thereof, and a manipulative handle coupled to the proximal ends of the tubular member and wire which may be employed with one hand to both rotate the tubular member and impart a continuously variable curve in the distal portion thereof. The distal portion of the tubular member is especially configured to be either attached to or cooperate with the distal end of the pull wire so that proximally-directed traction applied by the handle to the wire causes the distal portion of the tubular member to bend. The distal portion of the tubular member is provided with openings to allow the wire to exit and re-enter the lumen of the tubular member in the distal portion so that traction applied to the wire bows the tubular member into a curve of desired radius.
摘要翻译：特别适用于引导将心内膜起搏或心脏复律/除颤引导或导管引入患者心血管系统中所需位置的可操纵的探针和操纵手柄组件。设计成被引导到导管的内腔中的可引导的管心针或导管包括外部细长管状构件，其长度足以延伸穿过导线或导管的长度从其近端开口到其远端，牵引元件或拉线通常延伸通过管状构件的长度并且在其管腔中延伸，除了其远端部分中的预定距离之外，以及联接到管状构件和线的近端的操纵手柄，其可以用一只手同时使用旋转管状构件并在其远端部分赋予连续可变的曲线。管状构件的远端部分被特别地构造成可以与拉线的远端连接或配合，使得由手柄施加到导线的向近侧引导的牵引导致管状构件的远端部分弯曲。管状构件的远端部分设置有开口，以允许线离开并重新进入远端部分中的管状构件的内腔，使得施加到电线的牵引将弓形管弯曲成所需半径的曲线。

4. 发明授权

US5336254A Defibrillation lead employing electrodes fabricated from woven carbon fibers 失效
标题翻译：除颤线使用由编织碳纤维制成的电极
公开(公告)号：US5336254A
公开(公告)日：1994-08-09
申请号：US950533
申请日：1992-09-23
申请人： Kenneth R. Brennen , Terrell M. Williams , Robert A. Gabler
发明人： Kenneth R. Brennen , Terrell M. Williams , Robert A. Gabler
IPC分类号： A61N1/05
CPC分类号： A61N1/0587
摘要： An implantable cardioversion or defibrillation lead provided with a large surface, carbon fiber electrode. The lead takes the form of an elongated tubular braid of carbon fiber, provided with a central core of insulating plastic. Over the majority of the braid's length, it is covered by an outer sheath of insulating plastic as well, serving as a lead conductor. At its distal end, the braid is not covered, and the exposed portion of the braid serves as the electrode.
摘要翻译：一种植入式心脏复律或除颤线，提供有大面积的碳纤维电极。引线采用细长的碳纤维编织物的形式，其具有绝缘塑料的中心芯。在编织长度的大部分上，它也被绝缘塑料的外护套覆盖，用作导线。在其远端处，编织物不被覆盖，并且编织物的暴露部分用作电极。

5. 发明授权

US5873842A Steerable stylet and manipulative handle assembly 失效
公开(公告)号：US5873842A
公开(公告)日：1999-02-23
申请号：US882810
申请日：1997-06-26
申请人： Kenneth R. Brennen , Peter J. Pohndorf
发明人： Kenneth R. Brennen , Peter J. Pohndorf
IPC分类号： A61M25/01 , A61M25/092 , A61B5/00
CPC分类号： A61M25/0138 , A61M25/0136 , A61M25/0147 , A61M2025/0163
摘要： A steerable stylet and manipulative handle assembly especially adapted for guiding the introduction of an endocardial pacing or cardioversion/defibrillation lead or a catheter to a desired location in a patient's cardiovascular system. The steerable stylet or catheter designed to be introduced into the lumen of a lead comprises an outer, elongated tubular member of a length sufficient to extend through the length of the lead or catheter from its proximal opening to the distal end thereof, a traction element or pull wire extending generally through the length of the tubular member and within its lumen except for a predetermined distance in the distal portion thereof, and a manipulative handle coupled to the proximal ends of the tubular member and wire which may be employed with one hand to both rotate the tubular member and impart a continuously variable curve in the distal portion thereof. The distal portion of the tubular member is especially configured to be either attached to or cooperate with the distal end of the pull wire so that proximally-directed traction applied by the handle to the wire causes the distal portion of the tubular member to bend. The distal portion of the tubular member is provided with openings to allow the wire to exit and re-enter the lumen of the tubular member in the distal portion so that traction applied to the wire bows the tubular member into a curve of desired radius. In use, the distal portion of the wire residing outside the lumen of the tubular member is constrained within the lumen of the lead or catheter. Traction applied by the manipulative handle to the wire is sufficient to cause the distal portion of the pacing lead to assume various angles of curvature from straight to approximately one hundred eighty degrees. The distal portion of the tubular member which bows in response to the applied traction is preferably cut out or flattened to avoid kinking. The manipulative handle may be employed with one hand to impart the desired degree of curvature while rotating the lead or catheter to direct its distal end through the venus system and into the desired site within a chamber of the heart or the coronary sinus. The ability to dynamically change the degree of curvature during advancement avoids the necessity of removing and recurving the stylet during the introduction of the lead or catheter.

6. 发明授权

US5395310A Iontophoresis electrode 失效
标题翻译：离子电渗电极
公开(公告)号：US5395310A
公开(公告)日：1995-03-07
申请号：US631753
申请日：1990-12-21
申请人： Darrel F. Untereker , Joseph B. Phipps , Patrick T. Cahalan , Kenneth R. Brennen
发明人： Darrel F. Untereker , Joseph B. Phipps , Patrick T. Cahalan , Kenneth R. Brennen
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0444 , A61N1/0448
摘要： An improved iontophoresis electrode employing a current distributing member and a drug reservoir containing an ionic drug. The drug reservoir is applied to the skin of a patient, and includes a charge selective ion permeable membrane adapted to contact the skin, through which the ionic drug is delivered.
摘要翻译：使用电流分布构件的改进的离子电渗电极和含有离子药物的药物储存器。药物储存器被施加到患者的皮肤，并且包括适于接触皮肤的电荷选择性离子渗透膜，离子药物通过该皮肤递送。

7. 发明授权

US5076285A Screw-in lead 失效
标题翻译：螺丝导线
公开(公告)号：US5076285A
公开(公告)日：1991-12-31
申请号：US502605
申请日：1990-03-30
申请人： Douglas M. Hess , Kenneth R. Brennen , Wayne R. Bass
发明人： Douglas M. Hess , Kenneth R. Brennen , Wayne R. Bass
IPC分类号： A61N1/05
CPC分类号： A61N1/0573
摘要： A cardiac pacing lead for endocardial use, having a pacing electrode which takes the form of a tapered, conical helix extending from the distal end of the lead. The helix is used to attach the distal end of the lead to heart tissues. The tapered shape of the helix facilitates passage of the lead through the venous system and through the tricuspid valve. Rotation of the fixation helix is accomplished by means of rotation of a coiled conductor extending the length of the lead, in conjunction with rotation of a stylet, passing down the conductor. The stylet is fixedly mounted with respect to the coiled conductor at both the proximal and distal ends of the lead.
摘要翻译：用于心内膜使用的心脏起搏引线，具有起搏电极，其采取从引线的远端延伸的锥形锥形螺旋形式。螺旋用于将引线的远端附接到心脏组织。螺旋形的锥形促进引线通过静脉系统并通过三尖瓣。固定螺旋的旋转通过延伸引线的长度的线圈导体的旋转以及通过导体的探针的旋转来实现。在引线的近端和远端处，探针相对于线圈导体固定安装。

8. 发明申请

US20100114282A1 IMPLANTABLE MEDICAL DEVICE CONDUCTOR INSULATION AND PROCESS FOR FORMING 有权
标题翻译：可植入医疗器械导体绝缘及其成型工艺
公开(公告)号：US20100114282A1
公开(公告)日：2010-05-06
申请号：US12683561
申请日：2010-01-07
申请人： Michael J. Ebert , John L. Sommer , Richard D. Ries , Jordan D. Honeck , Pedro A. Meregotte , Kenneth R. Brennen
发明人： Michael J. Ebert , John L. Sommer , Richard D. Ries , Jordan D. Honeck , Pedro A. Meregotte , Kenneth R. Brennen
IPC分类号： A61N1/05
CPC分类号： H01B3/306 , A61L31/10 , A61N1/056 , C08L79/08
摘要： An elongate medical electrical lead conductor includes a layer of hydrolytically stable polyimide formed thereover.
摘要翻译：细长的医用电引线导体包括一层形成在其上的水解稳定的聚酰亚胺。

9. 发明授权

US06253110B1 Method for tissue stimulation and fabrication of low polarization implantable stimulation electrode 有权
标题翻译：低极化植入式刺激电极的组织刺激和制造方法
公开(公告)号：US06253110B1
公开(公告)日：2001-06-26
申请号：US09300020
申请日：1999-04-27
申请人： Scott J. Brabec , Kenneth R. Brennen , William J. Schindeldecker , Stanten C. Spear , Roger E. Rugland , Bruce C. Johnson
发明人： Scott J. Brabec , Kenneth R. Brennen , William J. Schindeldecker , Stanten C. Spear , Roger E. Rugland , Bruce C. Johnson
IPC分类号： A61N105
CPC分类号： A61N1/056 , A61N1/0568
摘要： A method of fabricating a stimulation electrode for use on an implantable lead, the lead and electrode so fabricated and a method of their use. The electrode is made by coating a conductive electrode member with a coating of a high surface area coating having micron or sub-micron surface features and after coating, plasma cleaning the electrode member. The electrode is coupled to an insulated conductor of an implantable lead and is employed to stimulate body tissue. The high surface area coating may be platinum black, ruthenium oxide, another metal oxide, a metal nitride or the like. Steroid may be applied to the electrode member after coating.
摘要翻译：一种制造用于可植入引线，如此制造的引线和电极的刺激电极的方法及其使用方法。电极通过用具有微米或亚微米表面特征的高表面积涂层的涂层涂覆导电电极构件并在涂覆之后进行等离子体清洁来制造。电极耦合到可植入引线的绝缘导体并用于刺激身体组织。高表面积涂层可以是铂黑，氧化钌，另一种金属氧化物，金属氮化物等。类固醇可以在涂覆之后施加到电极部件上。

10. 发明授权

US5396902A Steerable stylet and manipulative handle assembly 失效
标题翻译：可导向的探针和操纵手柄总成
公开(公告)号：US5396902A
公开(公告)日：1995-03-14
申请号：US69310
申请日：1993-05-28
申请人： Kenneth R. Brennen , Peter J. Pohndorf , Kenneth B. Stokes
发明人： Kenneth R. Brennen , Peter J. Pohndorf , Kenneth B. Stokes
IPC分类号： A61M25/01 , A61B5/00
CPC分类号： A61M25/0138 , A61M25/0136 , A61M25/0147
摘要： A steerable stylet and manipulative handle assembly for guiding a lead or a catheter to a desired location in a patient. The steerable stylet comprises an outer, elongated tubular member of a length sufficient to extend through the length of the lead or catheter from its proximal opening to the distal end thereof, a traction element or pull wire extending generally through the length of the tubular member and within its lumen except for a span in the distal portion thereof, and a manipulative handle coupled to the proximal ends of the tubular member and wire. Traction applied with one hand to the pull wire via the handle causes the distal portion of the tubular member to bend. Distal portion of the tubular member is provided with openings to allow the wire to exit and re-enter the lumen and facilitate bending of the tubular member. Distal portion of the tubular member which bends is preferably deformed, such as cut out or flattened or indented, to avoid kinking. A retainer surrounds the area proximate the openings and protects the exposed pull wire.
摘要翻译：用于将引线或导管引导到患者期望位置的可操纵的探针和操纵手柄组件。可操纵的探针包括一长度足以从其近端开口延伸到其远端的长度足够的长度的细长管状构件，大体通过管状构件的长度延伸的牵引元件或拉丝，在其管腔内，除了其远端部分中的跨度，以及联接到管状构件和线的近端的操纵手柄。通过手柄将牵引力一只手牵引到拉线，导致管状构件的远端部分弯曲。管状构件的远端部分设置有开口，以允许电线离开并重新进入内腔并有利于管状构件的弯曲。弯曲的管状构件的远端部分优选地变形，例如切割或变平或缩进，以避免扭结。保持器围绕开口附近的区域并且保护暴露的拉线。

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