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1. 发明授权

US08673339B2 Demand-release bioactive composition for implantable medical devices 有权
标题翻译：可植入医疗器械的需求释放生物活性成分
公开(公告)号：US08673339B2
公开(公告)日：2014-03-18
申请号：US10386967
申请日：2003-03-11
申请人： Kenneth B. Stokes , Michael J. Ebert , Christopher M. Hobot
发明人： Kenneth B. Stokes , Michael J. Ebert , Christopher M. Hobot
IPC分类号： A61F2/00 , A61K9/00
CPC分类号： A61L31/16 , A61L27/54 , A61L2300/222 , A61L2300/41 , A61L2300/602 , A61L2300/606 , A61N1/056 , A61N1/0575
摘要： A biostable polymeric substrate of an implantable medical device unit includes a demand-release bioactive composition including one or more bioactive agents covalently bound to surface-modifying end groups of the substrate. Certain cellular activities, in proximity to the polymeric substrate, release substances reacting with the end groups such that the end groups release the one or more bioactive agents, which modify the certain cellular activities.
摘要翻译：植入式医疗装置单元的生物稳定的聚合物基质包括需求释放生物活性组合物，其包含与基底的表面改性端基共价结合的一种或多种生物活性剂。在聚合物底物附近的某些细胞活性释放与端基反应的物质，使得端基释放一种或多种改变某些细胞活性的生物活性剂。

2. 发明授权

US07094201B1 System and method for genetically treating cardiac conduction disturbances 失效
标题翻译：用于遗传治疗心脏传导障碍的系统和方法
公开(公告)号：US07094201B1
公开(公告)日：2006-08-22
申请号：US09376317
申请日：1999-08-18
申请人： Kenneth B. Stokes , Josée Morissette
发明人： Kenneth B. Stokes , Josée Morissette
IPC分类号： A61N1/05 , A61N1/36 , A61K48/00 , C12N15/36
CPC分类号： A61K48/0075 , A61K38/1709 , A61K48/00 , A61M5/3291 , A61M2025/0089 , C07K14/705
摘要： The present invention provides delivery systems for and methods of delivering conduction protein genetic material to cardiac cells in localized areas of the heart to improve the conductance therein. More specifically, there is provided a system and method for delivering connexin proteins or nucleic acid molecules encoding connexin proteins to a site in the heart which has been determined by mapping procedures to have a conduction disturbance. For cases where conduction is impaired, selected genetic material is delivered to cells around the disturbance area, in order to enhance overall conductivity patterns; in other cases, genetic material is selected to slow conduction in affected areas, so as to prevent, e.g., brady-tachy syndrome.
摘要翻译：本发明提供了将传导蛋白遗传物质递送到心脏局部区域的心脏细胞的递送系统和方法，以改善其中的电导。更具体地，提供了一种用于将连接蛋白或编码连接蛋白的核酸分子递送至心脏部位的系统和方法，其通过测绘程序确定具有传导障碍。对于传导受损的情况，选择的遗传物质被传递到扰动区周围的细胞，以增强整体的导电性; 在其他情况下，选择遗传物质以缓解受影响区域的传导，以便防止例如缓慢型综合征。

3. 发明授权

US06567705B1 System and method for enhancing cardiac signal sensing by cardiac pacemakers through genetic treatment 有权
标题翻译：通过遗传治疗增强心脏起搏器心脏信号传感的系统和方法
公开(公告)号：US06567705B1
公开(公告)日：2003-05-20
申请号：US09514907
申请日：2000-02-28
申请人： Kenneth B. Stokes , Josée Morissette
发明人： Kenneth B. Stokes , Josée Morissette
IPC分类号： A61N105
CPC分类号： A61N1/3702 , A61B17/3468 , A61K48/00 , A61M37/00 , A61M2025/0057 , A61M2025/0089 , A61N1/0568 , A61N1/0575 , A61N2001/058
摘要： Delivery systems for and methods of delivering ion channel protein genetic material to cardiac cells in areas adjacent to where an electrode is to be positioned in a patient's heart to improve or correct the signal to noise ratio of cardiac signals, such as the P-wave, is described herein. More specifically, there is provided a system and method for delivering sodium ion channel proteins or nucleic acid molecules encoding sodium ion channel proteins to a site in the heart adjacent to an electrode to increase the expression of the same, thereby enhancing the cardiac signal amplitude and enabling improved sensing of cardiac signals by an implanted pacemaker.
摘要翻译：将离子通道蛋白质遗传物质递送到与电极定位在患者心脏中的区域相邻的区域中的递送系统和方法，以改善或校正心脏信号的信噪比，例如P波，在此描述。更具体地，提供了一种用于将钠离子通道蛋白或编码钠离子通道蛋白的核酸分子递送到与电极相邻的心脏中的位点以增加其表达的系统和方法，从而增强心脏信号幅度和能够通过植入式心脏起搏器改善对心脏信号的感测。

4. 发明授权

US06366819B1 Biostable small French lead 有权
标题翻译： Biostable小法国铅
公开(公告)号：US06366819B1
公开(公告)日：2002-04-02
申请号：US09677914
申请日：2000-10-03
申请人： Kenneth B. Stokes
发明人： Kenneth B. Stokes
IPC分类号： A61N105
CPC分类号： A61N1/056 , A61N1/0565
摘要： A medical lead having a diameter of no greater than 3 French and employing an insulation material that is substantially stiffer than would normally be employed in the context of a permanently implantable cardiac pacing lead is disclosed. A material having a Young's modulus of at least 25,000 pounds per square inch such as Pellethane 2363-75D, or an even stiffer polymer, is used to provide a lead body that does not exhibit a whip-like effect in response to such movement as would occur during a heart beat. In order to prevent the increased stiffness of the lead body from increasing the possibility that the distal lead tip will perforate the heart tissue, the lead is provided with a distal surface that is not reduced in size. This surface reduces the pressure exerted by the distal lead tip upon body tissue to no greater than 3.6 pounds per square inch. The distal tip may carry an electrode of the same or substantially smaller surface area, allowing the lead to retain desirable electrical characteristics for sensing of cardiac depolarizations and delivery of cardiac pacing pulses.
摘要翻译：公开了一种直径不大于3法国的医用引线，并且采用比通常在永久植入式心脏起搏引线的上下文中更加坚硬的绝缘材料。使用具有至少25,000磅/平方英寸的杨氏模量的材料，例如Pellethane 2363-75D或甚至更硬的聚合物，以提供引线体，其不响应于这样的运动而呈现鞭状效应发生在心跳期间。为了防止引线体的增加的刚度增加远侧引线端头穿孔心脏组织的可能性，引线设置有未减小的远端表面。该表面将远端引线尖端施加在身体组织上的压力降低至不大于3.6磅/平方英寸。远侧末端可以携带相同或基本上较小的表面积的电极，允许引线保持用于感测心脏去极化和心脏起搏脉冲输送的期望的电特性。

5. 发明授权

US5443492A Medical electrical lead and introducer system for implantable pulse generator 失效
标题翻译：用于植入式脉冲发生器的医用电气引线和引导系统
公开(公告)号：US5443492A
公开(公告)日：1995-08-22
申请号：US189565
申请日：1994-02-02
申请人： Kenneth B. Stokes , Keith J. Proctor , Rick D. McVenes
发明人： Kenneth B. Stokes , Keith J. Proctor , Rick D. McVenes
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/0568 , A61N1/0573 , A61N2001/0578
摘要： An implantable lead for establishing electrical contact between a medical device and body tissue, in which an active fixation mechanism secures the lead in place while allowing a distal electrode on the lead to mechanically "float" with respect to the body tissue. In one embodiment, the active fixation mechanism comprises a curved hook disposed on the lead at a point spaced proximally back from the distal end of the lead. The curved hook defines a helix around at least a portion of the lead's circumference. A hollow introducer needle is slidably disposed on the lead. The hollow needle provided with a longitudinal slit in a distal section of is length, such that the distal section of the needle can be advanced over the distal end of the lead, past the fixation hook, which is received in the longitudinal slit. With the needle slid over the distal end of the lead, the needle is stabbed tangentially into an implant site, bringing the fixation hook proximal to the surface of the body tissue. Then, the needle is twisted (bringing about a twisting of the lead), causing the curved fixation hook to pierce and engage the body tissue, securing the lead in place. Then the needle is withdrawn from the body tissue and removed from the lead. In an alternative embodiment, the lead can be placed by an endocardial approach using a flexible cannula with a longitudinally slotted tip.
摘要翻译：一种用于在医疗装置和身体组织之间建立电接触的可植入引线，其中主动固定机构将引线固定在适当位置，同时允许引线上的远端电极相对于身体组织机械地“浮动”。在一个实施例中，主动固定机构包括设置在引线上的远离引导件远端的近距离间隔的点的弯曲钩。弯曲的钩子围绕引线的周边的至少一部分限定螺旋。中空导引针可滑动地设置在引线上。中空针在远端部分设置有长度方向的狭缝，使得针的远端部分能够超过引线的远端延伸穿过容纳在纵向狭缝中的固定钩。当针滑过导线的远端时，针被切向地刺入植入部位，使固定钩靠近身体组织的表面。然后，针头扭转（导致引线扭转），导致弯曲的固定钩刺穿并接合身体组织，将导线固定到位。然后将针从身体组织中取出并从铅中取出。在替代实施例中，引线可以通过使用具有纵向开口尖端的柔性套管的心内膜方式放置。

6. 发明授权

US5300107A Universal tined myocardial pacing lead 失效
标题翻译：通用定心心肌起搏导联
公开(公告)号：US5300107A
公开(公告)日：1994-04-05
申请号：US964737
申请日：1992-10-22
申请人： Kenneth B. Stokes , Keith J. Proctor , Tommy D. Bennett , Rick D. McVenes
发明人： Kenneth B. Stokes , Keith J. Proctor , Tommy D. Bennett , Rick D. McVenes
IPC分类号： A61N1/05 , A61N1/362
CPC分类号： A61N1/057
摘要： A myocardial pacing lead includes two sets of at least two tines placed to oppose each other. The lead is pressed against the epicardium and is rotated until a rough porous tip abrades the epicardium and allows the tip and the first row of tines to penetrate the myocardium. Excessive penetration and lead migration is prevented by the second row of tines which is mounted backward and just proximal from the first row of tines. The first row of tines anchor on the inside surface of the epicardium which prevents dislodgment. Dacron pads on the second row of tines assures chronic fixation by adhering to the outer surface of the patient's epicardium.
摘要翻译：心肌起搏引线包括两组至少两根相对放置的齿。将引线压向心外膜并旋转直到粗糙的多孔尖端磨损心外膜，并允许尖端和第一排刺入心肌。通过第二排尖齿被安装在第一排尖端的后方并刚好靠近的第二排齿可以防止过度的穿透和牵伸移动。第一排尖齿锚定在心外膜的内表面上，防止脱落。第二排尖齿上的涤纶垫片通过粘附在患者的心外膜的外表面上来确保慢性固定。

7. 发明授权

US4643201A Single-pass A-V lead 失效
标题翻译：单通A-V引线
公开(公告)号：US4643201A
公开(公告)日：1987-02-17
申请号：US230940
申请日：1981-02-02
申请人： Kenneth B. Stokes
发明人： Kenneth B. Stokes
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/056
摘要： A single-pass body implantable lead for transvenous insertion through a single vein to simultaneously sense and/or stimulate the tissue of both the right atrium and right ventricle. The lead employs a single bifurcated connector at the proximal end. Insulated conductors for the ventricle and atrium are branched from a single outer sheath. The ventricular and atrial branches are established in fixed relation to one another. The ventricular branch is of sufficient length that it has excess length for the largest heart. The electrode of the ventricular branch is held within the right ventricular apex by tines. The atrial branch has a "J" shape imparted to the conductor coil. The atrial electrode is maintained in position within the right atrial appendage by tines. The ventricular branch is sufficiently flexible such that any excess length is merely coiled in some convenient position. The distal portion of the ventricular branch is made slightly more stiff than the proximal portion causing the excess length to loop within the atrium. Stylets are used to guide insertion.
摘要翻译：单通体植入式导线，用于通过单个静脉经静脉插入，以同时感测和/或刺激右心房和右心室的组织。引线在近端使用单个分叉连接器。用于心室和心房的绝缘导体从单个外护套分支。心室和心房分支建立在彼此固定的关系上。心室分支具有足够的长度，它对于最大的心脏具有多余的长度。心室分支的电极通过尖齿保持在右心室顶点内。心房分支具有赋予导体线圈的“J”形状。心房电极通过尖齿保持在右心耳内的位置。心室分支具有足够的弹性，使得任何多余的长度仅在一些方便的位置被卷起。使心室分支的远侧部分比近端部分稍微更硬，导致过度长度在心房内循环。样式用于指导插入。

8. 发明授权

US4271847A Temporary adjustable bipolar lead 失效
标题翻译：临时可调双极引线
公开(公告)号：US4271847A
公开(公告)日：1981-06-09
申请号：US53001
申请日：1979-06-28
申请人： Kenneth B. Stokes
发明人： Kenneth B. Stokes
IPC分类号： A61B18/14 , A61N1/02 , A61N1/05 , A61N1/362 , A61N1/375 , A61N1/04
CPC分类号： A61N1/056
摘要： Temporary adjustable bipolar lead including an inner lead and an outer coaxial lead. A self-sealing lead introducer head at a junction of the inner lead and outer lead provides for takeoff of the end of the outer coaxial lead. The inner lead is in slidable engagement with the outer lead through a hole in a diaphragm of the lead introducer head.
摘要翻译：临时可调双极引线，包括内引线和外同轴引线。在内部引线和外部引线的接合处的自密封引线导引头提供外部同轴引线端部的起飞。内引线通过引导引导头的隔膜中的孔与外引线滑动接合。

9. 发明授权

US4269198A Body implantable lead 失效
标题翻译：身体可植入铅
公开(公告)号：US4269198A
公开(公告)日：1981-05-26
申请号：US106854
申请日：1979-12-26
申请人： Kenneth B. Stokes
发明人： Kenneth B. Stokes
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/057
摘要： A body implantable lead of the type having a lead body, at least one electrode carried by the lead body and tissue engaging tines extending at an acute angle from the lead body at a location adjacent the electrode. The present invention correlates the tensile stiffness of the lead body with the stiffness of the tines to optimize the tine holding force. The tines provide an adequate holding force to minimize unintentional lead dislodgements without requiring in an excessive force for intentional dislodgement of the lead for repositioning. Tine length and the angle at which they extend from the lead body are also discussed as affecting the probability of tine engagement with cardiac structure as well as having an effect on the holding force. In a preferred embodiment, the lead body has a spring constant (as defined herein) of 2.0 lb-in./10 in. or less and a tine stiffness (also defined herein) of less than 5.times.10.sup.-3 lb-in..sup.2. The tines are from two to six millimeters long and extend from the lead body at an angle from 30.degree. to 80.degree.. More preferably, the tine stiffness is 3.times.10.sup.-3 lb-in..sup.2 or less with the tines being from four to six millimeters long and forming an angle with the lead body from 45.degree. to 60.degree.. In the preferred embodiments, the exposed surface of the lead body and the tines are formed of a body compatible urethane. In the most preferred embodiment, the tine stiffness is approximately 2.5.times.10.sup.-3 lb-in..sup.2.
摘要翻译：具有引线主体的主体可植入引线，由引线主体承载的至少一个电极和在与电极相邻的位置处从引线主体以锐角延伸的组织接合齿。本发明将引线体的拉伸刚度与齿的刚度相关联，以优化齿保持力。齿提供足够的持力以最大限度地减少无意的引线移动，而不需要过度的力量有意导致重新定位的引线。针脚长度和它们从引线体延伸的角度也被讨论为影响与心脏结构接合的可能性以及对保持力的影响。在优选实施例中，引线本体具有2.0磅/英寸10英寸或更小的弹簧常数（如本文所定义）以及小于5×10 -3磅/英寸2的齿刚度（此处也定义）。齿长为2〜6毫米，从铅体延伸30度至80度。更优选的是，齿的刚度为3×10 -3 lb-in.2或更小，齿的长度为4至6毫米，与铅体形成45度至60度的角度。在优选实施例中，引线体的暴露表面和尖齿由主体相容的聚氨酯形成。在最优选的实施例中，齿的刚度约为2.5×10 -3 lb-in.2。

10. 发明授权

US07731653B2 System and method for genetically treating cardiac conduction disturbances 失效
标题翻译：用于遗传治疗心脏传导障碍的系统和方法
公开(公告)号：US07731653B2
公开(公告)日：2010-06-08
申请号：US11421301
申请日：2006-05-31
申请人： Kenneth B. Stokes , Josée Morissette
发明人： Kenneth B. Stokes , Josée Morissette
IPC分类号： A61N1/05 , A61N1/36 , A61K48/00 , C12N15/36
CPC分类号： A61K48/0075 , A61K38/1709 , A61K48/00 , A61M5/3291 , A61M2025/0089 , C07K14/705
摘要： The present invention provides delivery systems for and methods of delivering conduction protein genetic material to cardiac cells in localized areas of the heart to improve the conductance therein. More specifically, there is provided a system and method for delivering connexin proteins or nucleic acid molecules encoding connexin proteins to a site in the heart which has been determined by mapping procedures to have a conduction disturbance. For cases where conduction is impaired, selected genetic material is delivered to cells around the disturbance area, in order to enhance overall conductivity patterns; in other cases, genetic material is selected to slow conduction in affected areas, so as to prevent, e.g., brady-tachy syndrome.
摘要翻译：本发明提供了将传导蛋白遗传物质递送到心脏局部区域的心脏细胞的递送系统和方法，以改善其中的电导。更具体地，提供了一种用于将连接蛋白或编码连接蛋白的核酸分子递送至心脏部位的系统和方法，其通过测绘程序确定具有传导障碍。对于传导受损的情况，选择的遗传物质被传递到扰动区周围的细胞，以增强整体的导电性; 在其他情况下，选择遗传物质以缓解受影响区域的传导，以便防止例如缓慢型综合征。

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