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1. 发明授权

US08538537B2 Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropyschiatric and neuropyschological disorders 有权
标题翻译：用于提供靶向神经刺激治疗以解决神经障碍（包括神经精神障碍和神经病理障碍）的系统和方法
公开(公告)号：US08538537B2
公开(公告)日：2013-09-17
申请号：US12330437
申请日：2008-12-08
申请人： Justin Hulvershorn , Brad Fowler , Bradford Evan Gliner , Leif R. Sloan , Brian Kopell , David Alan Soltysik
发明人： Justin Hulvershorn , Brad Fowler , Bradford Evan Gliner , Leif R. Sloan , Brian Kopell , David Alan Soltysik
IPC分类号： A61N1/00
CPC分类号： A61N1/36082
摘要： Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropsychiatric and neuropsychological disorders are disclosed. A method for treating a patient's neurological disorder in accordance with a particular embodiment includes, in a patient identified as having at least one of a neuropsychological disorder and a neuropsychiatric disorder, implanting at least one stimulation electrode within the patient's skull cavity, and outside a cortical surface of the patient's brain. The electrode is implanted at a location in a range of about 15 mm to about 35 mm anterior to a precentral sulcus reference point that is positioned at the precentral sulcus and at the patient's middle frontal gyrus. The method can further include treating the patient's disorder by applying electrical stimulation to the patient via the at least one stimulation electrode.
摘要翻译：公开了用于提供靶向神经刺激治疗以解决神经障碍（包括神经精神和神经心理障碍）的系统和方法。根据特定实施方案的用于治疗患者神经障碍的方法包括在被鉴定为具有神经心理障碍和神经精神障碍中的至少一种的患者中，将至少一个刺激电极植入患者的颅骨腔内，皮质外患者脑部表面。将电极植入在位于中心龈沟处和患者中额叶回的前中央龈下参考点前方约15mm至约35mm范围内的位置处。该方法还可以包括通过经由至少一个刺激电极向患者施加电刺激来治疗患者的病症。

2. 发明申请

US20090149898A1 Systems and Methods for Providing Targeted Neural Stimulation Therapy to Address Neurological Disorders, Including Neuropyschiatric and Neuropyschological Disorders 有权
标题翻译：提供靶向神经刺激治疗解决神经障碍，包括神经精神和神经病理障碍的系统和方法
公开(公告)号：US20090149898A1
公开(公告)日：2009-06-11
申请号：US12330437
申请日：2008-12-08
申请人： Justin Hulvershorn , Brad Fowler , Bradford Evan Gliner , Leif R. Sloan , Brian Kopell , David Alan Soltysik
发明人： Justin Hulvershorn , Brad Fowler , Bradford Evan Gliner , Leif R. Sloan , Brian Kopell , David Alan Soltysik
IPC分类号： A61N1/36
CPC分类号： A61N1/36082
摘要： Systems and methods for providing targeted neural stimulation therapy to address neurological disorders, including neuropsychiatric and neuropsychological disorders are disclosed. A method for treating a patient's neurological disorder in accordance with a particular embodiment includes, in a patient identified as having at least one of a neuropsychological disorder and a neuropsychiatric disorder, implanting at least one stimulation electrode within the patient's skull cavity, and outside a cortical surface of the patient's brain. The electrode is implanted at a location in a range of about 15 mm to about 35 mm anterior to a precentral sulcus reference point that is positioned at the precentral sulcus and at the patient's middle frontal gyrus. The method can further include treating the patient's disorder by applying electrical stimulation to the patient via the at least one stimulation electrode.
摘要翻译：公开了用于提供靶向神经刺激治疗以解决神经障碍（包括神经精神和神经心理障碍）的系统和方法。根据特定实施方案的用于治疗患者神经障碍的方法包括在被鉴定为具有神经心理障碍和神经精神障碍中的至少一种的患者中，将至少一个刺激电极植入患者的颅骨腔内，皮质外患者脑部表面。将电极植入在位于中心龈沟处和患者中额叶回的前中央龈下参考点前方约15mm至约35mm范围内的位置处。该方法还可以包括通过经由至少一个刺激电极向患者施加电刺激来治疗患者的病症。

3. 发明授权

US08090446B2 Methods and systems for establishing neural stimulation parameters and providing neural stimulation 有权
标题翻译：建立神经刺激参数并提供神经刺激的方法和系统
公开(公告)号：US08090446B2
公开(公告)日：2012-01-03
申请号：US12099415
申请日：2008-04-08
申请人： Brad Fowler , Justin Hulvershorn , Bradford E. Gliner , Leif R. Sloan
发明人： Brad Fowler , Justin Hulvershorn , Bradford E. Gliner , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61N1/36025
摘要： Methods for providing electrical stimulation therapy to a cortex of a patient via a plurality of electrodes proximate to the cortex and a pulse generator implanted in the patient. One embodiment of a method in accordance with the invention comprises determining whether the current applied via the plurality of electrodes results in a sufficient current density in the cortex. The current density, for example, may need to be high enough to induce a response in the patient for determining the activation threshold of the specific stimulation site, or the current density may need to be high enough to perform a specific therapy. If the current density is not sufficient, the method continues by selecting a subset of the plurality of electrodes, and applying electrical current to the cortex via the subset of the electrodes. For example, if the current density is not sufficient when the current is applied to the full plurality of electrodes at approximately the maximum output of the pulse generator, then the current level from the pulse generator can be applied to only a subset of the electrodes to effectively increase the current density in the cortex at the active electrodes.
摘要翻译：用于通过靠近皮层的多个电极和植入患者中的脉冲发生器向患者的皮层提供电刺激治疗的方法。根据本发明的方法的一个实施例包括确定经由多个电极施加的电流是否导致皮层中的足够的电流密度。例如，电流密度可能需要足够高以在患者中诱导用于确定特定刺激部位的激活阈值的响应，或者电流密度可能需要足够高以执行特定治疗。如果电流密度不足，则该方法通过选择多个电极的子集，并且经由电极的子集将电流施加到皮质来继续。例如，如果电流密度在脉冲发生器的大致最大输出处施加到整个多个电极上时电流密度不足，则来自脉冲发生器的电流电平可以仅施加到电极的子集有效增加有源电极皮质中的电流密度。

4. 发明申请

US20090099622A1 Methods and Systems for Establishing Neural Stimulation Parameters and Providing Neural Stimulation 有权
标题翻译：建立神经刺激参数并提供神经刺激的方法与系统
公开(公告)号：US20090099622A1
公开(公告)日：2009-04-16
申请号：US12099415
申请日：2008-04-08
申请人： Brad Fowler , Justin Hulvershorn , Bradford E. Gliner , Leif R. Sloan
发明人： Brad Fowler , Justin Hulvershorn , Bradford E. Gliner , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61N1/36025
摘要： Methods for providing electrical stimulation therapy to a cortex of a patient via a plurality of electrodes proximate to the cortex and a pulse generator implanted in the patient. One embodiment of a method in accordance with the invention comprises determining whether the current applied via the plurality of electrodes results in a sufficient current density in the cortex. The current density, for example, may need to be high enough to induce a response in the patient for determining the activation threshold of the specific stimulation site, or the current density may need to be high enough to perform a specific therapy. If the current density is not sufficient, the method continues by selecting a subset of the plurality of electrodes, and applying electrical current to the cortex via the subset of the electrodes. For example, if the current density is not sufficient when the current is applied to the full plurality of electrodes at approximately the maximum output of the pulse generator, then the current level from the pulse generator can be applied to only a subset of the electrodes to effectively increase the current density in the cortex at the active electrodes.
摘要翻译：用于通过靠近皮层的多个电极和植入患者中的脉冲发生器向患者的皮层提供电刺激治疗的方法。根据本发明的方法的一个实施例包括确定经由多个电极施加的电流是否导致皮层中的足够的电流密度。例如，电流密度可能需要足够高以在患者中诱导用于确定特定刺激部位的激活阈值的响应，或者电流密度可能需要足够高以执行特定治疗。如果电流密度不足，则该方法通过选择多个电极的子集，并且经由电极的子集将电流施加到皮质来继续。例如，如果电流密度在脉冲发生器的大致最大输出处施加到整个多个电极上时电流密度不足，则来自脉冲发生器的电流电平可以仅施加到电极的子集有效增加有源电极皮质中的电流密度。

5. 发明申请

US20080139870A1 Systems and methods for treating patient hypertonicity 审中-公开
标题翻译：用于治疗患者高渗性的系统和方法
公开(公告)号：US20080139870A1
公开(公告)日：2008-06-12
申请号：US11638326
申请日：2006-12-12
申请人： Bradford E. Gliner , Brad Fowler , Justin Hulvershorn , Leif R. Sloan
发明人： Bradford E. Gliner , Brad Fowler , Justin Hulvershorn , Leif R. Sloan
IPC分类号： A61N2/02
CPC分类号： A61N1/36082 , A61N1/0531 , A61N2/006
摘要： Systems and methods for treating patient hypertonicity are disclosed. A method in accordance with one embodiment includes identifying a cortical target neural population associated with hypertonicity in a patient, and reducing or eliminating patient hypertonicity by applying electromagnetic signals to the target neural population. In further particular embodiments, the electromagnetic signals are first electromagnetic signals, and the method can further include reducing or eliminating an additional patient dysfunction by applying second electromagnetic signals.
摘要翻译：公开了用于治疗患者高渗性的系统和方法。根据一个实施例的方法包括识别与患者中的高渗性相关的皮质靶神经群体，以及通过向目标神经群体施加电磁信号来减少或消除患者的高渗性。在另外的特定实施例中，电磁信号是第一电磁信号，并且该方法还可以包括通过施加第二电磁信号来减少或消除另外的患者功能障碍。

6. 发明授权

US08262714B2 Techniques for selecting signal delivery sites and other parameters for treating depression and other neurological disorders, and associated systems and methods 有权
标题翻译：用于选择信号传递部位的技术和用于治疗抑郁症和其他神经障碍的其它参数，以及相关的系统和方法
公开(公告)号：US08262714B2
公开(公告)日：2012-09-11
申请号：US12395257
申请日：2009-02-27
申请人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
发明人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
IPC分类号： A61N5/055 , A61N1/36
CPC分类号： A61B5/055 , A61B5/4064 , A61B6/501 , A61N1/0531 , A61N1/36082 , A61N2/004
摘要： The present disclosure is directed generally to techniques for selecting signal delivery sites and other signal delivery parameters for treating depression and other neurological disorders, and associated systems and methods. A method in accordance with a particular embodiment includes obtaining first imaging information corresponding to a first region of a patient's brain, the first imaging information being based at least in part on functional characteristics of the first region. The method further includes obtaining second imaging information corresponding to a second region of the patient's brain, the second region being a subset of the first region, the second imaging information being based at least in part on functional or structural characteristics of the second region. A target neural population is then selected based at least in part on the second imaging information. The method still further includes applying an electromagnetic signal to the target neural population to improve a patient function.
摘要翻译：本公开一般涉及用于选择用于治疗抑郁症和其他神经障碍以及相关系统和方法的信号传递部位和其他信号传递参数的技术。根据特定实施例的方法包括获得对应于患者大脑的第一区域的第一成像信息，第一成像信息至少部分地基于第一区域的功能特征。该方法还包括获得对应于患者大脑第二区域的第二成像信息，第二区域是第一区域的子集，第二成像信息至少部分地基于第二区域的功能或结构特征。然后至少部分地基于第二成像信息来选择目标神经群体。该方法还包括将电磁信号应用于目标神经群体以改善患者功能。

7. 发明申请

US20130066391A1 TECHNIQUES FOR SELECTING SIGNAL DELIVERY SITES AND OTHER PARAMETERS FOR TREATING DEPRESSION AND OTHER NEUROLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：用于选择信号传递站点和其他参数用于治疗衰竭和其他神经疾病的技术及相关系统和方法
公开(公告)号：US20130066391A1
公开(公告)日：2013-03-14
申请号：US13606906
申请日：2012-09-07
申请人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
发明人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
IPC分类号： A61N1/36
CPC分类号： A61B5/055 , A61B5/4064 , A61B6/501 , A61N1/0531 , A61N1/36082 , A61N2/004
摘要： The present disclosure is directed generally to techniques for selecting signal delivery sites and other signal delivery parameters for treating depression and other neurological disorders. A method in accordance with a particular embodiment includes obtaining first imaging information corresponding to a first region of a patient's brain, the first imaging information being based at least in part on functional characteristics of the first region. The method includes obtaining second imaging information corresponding to a second region of the patient's brain, the second region being a subset of the first region, the second imaging information being based at least in part on functional or structural characteristics of the second region. A target neural population is selected based in part on the second imaging information. The method still further includes applying an electromagnetic signal to the target neural population to improve a patient function.
摘要翻译：本公开一般涉及用于选择用于治疗抑郁症和其他神经障碍的信号递送部位和其它信号传递参数的技术。根据特定实施例的方法包括获得对应于患者大脑的第一区域的第一成像信息，第一成像信息至少部分地基于第一区域的功能特征。该方法包括获得对应于患者大脑第二区域的第二成像信息，第二区域是第一区域的子集，第二成像信息至少部分地基于第二区域的功能或结构特征。部分基于第二成像信息选择目标神经群体。该方法还包括将电磁信号应用于目标神经群体以改善患者功能。

8. 发明申请

US20100036453A1 TECHNIQUES FOR SELECTING SIGNAL DELIVERY SITES AND OTHER PARAMETERS FOR TREATING DEPRESSION AND OTHER NEUROLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS AND METHODS 有权
标题翻译：用于选择信号传递站点的技术和用于治疗衰竭和其他神经疾病的其他参数以及相关系统和方法
公开(公告)号：US20100036453A1
公开(公告)日：2010-02-11
申请号：US12395257
申请日：2009-02-27
申请人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
发明人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
IPC分类号： A61N1/36 , A61B5/055
CPC分类号： A61B5/055 , A61B5/4064 , A61B6/501 , A61N1/0531 , A61N1/36082 , A61N2/004
摘要： The present disclosure is directed generally to techniques for selecting signal delivery sites and other signal delivery parameters for treating depression and other neurological disorders, and associated systems and methods. A method in accordance with a particular embodiment includes obtaining first imaging information corresponding to a first region of a patient's brain, the first imaging information being based at least in part on functional characteristics of the first region. The method further includes obtaining second imaging information corresponding to a second region of the patient's brain, the second region being a subset of the first region, the second imaging information being based at least in part on functional or structural characteristics of the second region. A target neural population is then selected based at least in part on the second imaging information. The method still further includes applying an electromagnetic signal to the target neural population to improve a patient function.
摘要翻译：本公开一般涉及用于选择用于治疗抑郁症和其他神经障碍以及相关系统和方法的信号传递部位和其他信号传递参数的技术。根据特定实施例的方法包括获得对应于患者大脑的第一区域的第一成像信息，第一成像信息至少部分地基于第一区域的功能特征。该方法还包括获得对应于患者大脑的第二区域的第二成像信息，第二区域是第一区域的子集，第二成像信息至少部分地基于第二区域的功能或结构特征。然后至少部分地基于第二成像信息来选择目标神经群体。该方法还包括将电磁信号应用于目标神经群体以改善患者功能。

9. 发明授权

US10463838B2 Vascular access methods and devices 有权
公开(公告)号：US10463838B2
公开(公告)日：2019-11-05
申请号：US12806798
申请日：2010-08-19
申请人： Justin Hulvershorn , Karl Schmidt , Douglas Swartz
发明人： Justin Hulvershorn , Karl Schmidt , Douglas Swartz
IPC分类号： A61M25/06 , A61B5/0215 , A61B5/00 , A61M5/42 , A61B90/00 , A61B8/08 , A61M5/168 , A61M5/46 , A61B17/34 , A61B8/00
摘要： Methods and devices for detecting positioning of a probe in a tissue of a patient. A method can include providing a detection device; advancing a device coupled probe through the tissue of the patient and toward the patient's target tissue; detecting a change in pressure about the distal portion of the coupled probe during advancing, where the detected pressure change indicates probe positioning in a vein or artery of the patient; outputting the detected pressure change or indication of probe positioning to a visual display.

10. 发明授权

US08814807B2 Spinal canal access and probe positioning, devices and methods 有权
标题翻译：脊柱通道和探针定位，装置和方法
公开(公告)号：US08814807B2
公开(公告)日：2014-08-26
申请号：US12806747
申请日：2010-08-19
申请人： Justin Hulvershorn , Karl Schmidt , Douglas Swartz
发明人： Justin Hulvershorn , Karl Schmidt , Douglas Swartz
IPC分类号： A61B5/103 , A61B5/00 , A61B5/03 , A61M25/06 , A61B17/34 , A61B19/00
CPC分类号： A61B17/3401 , A61B5/032 , A61B5/036 , A61B5/065 , A61B5/4821 , A61B2090/034 , A61B2090/065 , A61M25/06 , A61M25/0693
摘要： Methods and devices for detecting positioning of a probe in a tissue of a patient. A method can include providing a detection device; advancing a device coupled probe through the tissue of the patient and toward the patient's spinal canal; detecting a change in pressure about the distal portion of the coupled probe during advancing, where the detected pressure change indicates probe positioning in the patient's spinal canal; outputting the detected pressure change or indication of probe positioning to a visual display.
摘要翻译：用于检测探针在患者组织中的定位的方法和装置。一种方法可以包括提供检测装置; 将装置耦合的探针推进穿过患者的组织并朝向患者的椎管; 检测在推进期间围绕耦合探头的远端部分的压力变化，其中检测到的压力变化指示患者脊柱中的探针定位; 将检测到的压力变化或探针定位的指示输出到视觉显示器。

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