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1. 发明授权

US09612239B2 Substance determining apparatus 有权
公开(公告)号：US09612239B2
公开(公告)日：2017-04-04
申请号：US14001566
申请日：2012-02-27
申请人： Joannes Baptist Adrianus Dionisius Van Zon , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout , Wilhelmina Maria Hardeman , Derk Jan Wilfred Klunder
发明人： Joannes Baptist Adrianus Dionisius Van Zon , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout , Wilhelmina Maria Hardeman , Derk Jan Wilfred Klunder
IPC分类号： G01N21/17 , G01N33/543 , G01N21/552 , G01N21/64 , G01N21/77 , G01N27/74
CPC分类号： G01N33/54326 , G01N21/552 , G01N21/648 , G01N21/7703 , G01N27/745
摘要： The invention relates to a substance determining apparatus (19) for determining a substance within a fluid. A location event determination unit (34) determines location events indicating that a particle, which may have attached the substance, is located in a sensing region and a property of the location events from the sensing signal generated by sensing the sensing region. A location events selection unit (70) selects a part of the location events having a property in a predefined property range, and a substance determination unit (40) determines the substance within the fluid (3) based on the selected part of the location events. This allows tuning the determination of the substance within the fluid to a desired property range, which can relate to a desired kind of bound particles, thereby reducing the influence of unwanted effects on the determination of the substance and, thus, improving the determination accuracy.

2. 发明授权

US09075052B2 Biosensor system for single particle detection 有权
标题翻译：用于单粒子检测的生物传感器系统
公开(公告)号：US09075052B2
公开(公告)日：2015-07-07
申请号：US13498482
申请日：2010-09-23
申请人： Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Josephus Arnoldus Henricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko
发明人： Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Josephus Arnoldus Henricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko
IPC分类号： G01N21/00 , G01N33/543 , G01N21/47 , G01N21/552 , G01N21/64 , G01R33/12 , G01N21/51 , G01N21/49 , G01N27/72 , G01N15/10 , G01N15/00
CPC分类号： G01N33/54373 , G01N15/10 , G01N15/1031 , G01N21/47 , G01N21/49 , G01N21/51 , G01N21/552 , G01N21/6458 , G01N27/72 , G01N33/54313 , G01N2015/0065 , G01N2201/12 , G01R33/1269
摘要： A biosensor system for the detection of particles includes a biosensor cartridge having a sensor surface. A biosensor magnet assembly is disposed on one side of the cartridge for generating a magnetic field effective at the cartridge and the sensor surface. The biosensor magnet assembly includes at least two magnetic sub-units separated by a gap. A first optical detection system detects the particles arranged at the same side of the cartridge as the magnet assembly. The magnet assembly and the first optical sensor are disposed such that the optical detection is accomplished through the gap of the magnet assembly.
摘要翻译：用于检测颗粒的生物传感器系统包括具有传感器表面的生物传感器盒。生物传感器磁体组件设置在盒的一侧，用于在盒和传感器表面产生有效的磁场。生物传感器磁体组件包括由间隙分开的至少两个磁性子单元。第一光学检测系统检测与磁体组件布置在盒的同一侧的颗粒。磁体组件和第一光学传感器被布置成使得通过磁体组件的间隙实现光学检测。

3. 发明授权

US09772272B2 Substance determining apparatus 有权
公开(公告)号：US09772272B2
公开(公告)日：2017-09-26
申请号：US13498615
申请日：2010-09-24
申请人： Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Josephus Arnoldus Hendricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko , Kim Van Ommering
发明人： Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Josephus Arnoldus Hendricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko , Kim Van Ommering
IPC分类号： G01N15/06 , G01N15/14 , G01N21/47 , G01N21/552 , G01N21/64 , G01N27/74 , G01N33/543 , G01N15/02 , G01N35/00
CPC分类号： G01N15/0612 , G01N15/1434 , G01N21/47 , G01N21/552 , G01N21/648 , G01N27/745 , G01N33/54333 , G01N35/0098 , G01N2015/025 , G01N2201/0627
摘要： A substance determining apparatus determines a substance within a fluid where particles, which have attached the substance, are bound to a binding surface. A sensing unit is configured to generate a sensing signal being indicative of at least one of i) a distance between the particles bound on the binding surface and the binding surface, and ii) an in-plane position of the particles bound on the binding surface. A binding discrimination unit is configured to discriminate between different kinds of binding of the particles bound on the binding surface depending on the generated sensing signal. The binding discrimination unit may be a unit for determining the part of the sensing signal being caused by specifically bound particles and for determining the substance based on this determined part of the sensing signal.

4. 发明授权

US09339813B2 Substance determining apparatus 有权
标题翻译：物质确定装置
公开(公告)号：US09339813B2
公开(公告)日：2016-05-17
申请号：US13516060
申请日：2010-12-10
申请人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon , Johannes Joseph Hubertina Barbara Schleipen , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout
发明人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon , Johannes Joseph Hubertina Barbara Schleipen , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout
IPC分类号： G01N21/17 , B01L3/00 , G01N21/552 , G01N21/84 , G01N33/543
CPC分类号： B01L3/5027 , B01L2200/0605 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , G01N21/552 , G01N21/8483 , G01N33/54373
摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles attach the substance and bind to a binding surface (30), wherein a sensing signal is generated depending on the bound particles. Binding events indicating a binding of a particle on the binding surface (30) are determined from the generated sensing signal, and the substance within the fluid is determined based on the determined binding events. During a procedure of determining a substance within a fluid, particles may bind to the binding surface and may leave the binding surface. Therefore, during this procedure a number of binding events can be determined being much larger than the number of bound particles. The determination of the substance within the fluid can therefore be based on a very large amount of data, thereby increasing the accuracy of determining the substance within the fluid.
摘要翻译：本发明涉及一种用于确定流体内物质的物质确定装置。颗粒附着物质并结合到结合表面（30），其中根据结合的颗粒产生感测信号。根据产生的感测信号确定指示结合表面（30）上的颗粒结合的结合事件，并且基于所确定的结合事件确定流体内的物质。在确定流体内的物质的过程中，颗粒可能结合到结合表面并且可能离开结合表面。因此，在此过程中，可以确定许多结合事件比结合粒子的数量大得多。因此，流体内的物质的测定可以基于非常大量的数据，从而提高确定流体内物质的准确性。

5. 发明申请

US20120329039A1 SUBSTANCE DETERMINING APPARATUS 有权
标题翻译：物质确定装置
公开(公告)号：US20120329039A1
公开(公告)日：2012-12-27
申请号：US13516060
申请日：2010-12-10
申请人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon , Johannes Joseph Hubertina Barbara Schleipen , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout
发明人： Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon , Johannes Joseph Hubertina Barbara Schleipen , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout
IPC分类号： G01N33/566 , C12M1/34 , C12Q1/70 , G01N30/00 , G01N33/53
CPC分类号： B01L3/5027 , B01L2200/0605 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , G01N21/552 , G01N21/8483 , G01N33/54373
摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles attach the substance and bind to a binding surface (30), wherein a sensing signal is generated depending on the bound particles. Binding events indicating a binding of a particle on the binding surface (30) are determined from the generated sensing signal, and the substance within the fluid is determined based on the determined binding events. During a procedure of determining a substance within a fluid, particles may bind to the binding surface and may leave the binding surface. Therefore, during this procedure a number of binding events can be determined being much larger than the number of bound particles. The determination of the substance within the fluid can therefore be based on a very large amount of data, thereby increasing the accuracy of determining the substance within the fluid.
摘要翻译：本发明涉及一种用于确定流体内物质的物质确定装置。颗粒附着物质并结合到结合表面（30），其中根据结合的颗粒产生感测信号。根据产生的感测信号确定指示结合表面（30）上的颗粒结合的结合事件，并且基于所确定的结合事件确定流体内的物质。在确定流体内的物质的过程中，颗粒可能结合到结合表面并且可能离开结合表面。因此，在此过程中，可以确定许多结合事件比结合粒子的数量大得多。因此，流体内的物质的测定可以基于非常大量的数据，从而提高确定流体内物质的准确性。

6. 发明申请

US20120202194A1 SUBSTANCE DETERMINING APPARATUS 有权
标题翻译：物质确定装置
公开(公告)号：US20120202194A1
公开(公告)日：2012-08-09
申请号：US13498615
申请日：2010-09-24
申请人： Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Josephus Arnoldus Hendricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko , Kim Van Ommering
发明人： Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Josephus Arnoldus Hendricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko , Kim Van Ommering
IPC分类号： G01N21/63 , C12M1/34 , C12Q1/02 , C12Q1/70 , G01N33/53 , G01N21/64
CPC分类号： G01N15/0612 , G01N15/1434 , G01N21/47 , G01N21/552 , G01N21/648 , G01N27/745 , G01N33/54333 , G01N35/0098 , G01N2015/025 , G01N2201/0627
摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles, which have attached the substance, are bound to a binding surface (30). A sensing unit (33) is adapted to generate a sensing signal being indicative of at least one of i) a distance between the particles bound on the binding surface (30) and the binding surface (30) and ii) an in-plane position of the particles bound on the binding surface. A binding discrimination unit (34) is adapted to discriminate between different kinds of binding of the particles bound on the binding surface (30) depending on the generated sensing signal. The binding discrimination unit (34) is preferentially a unit for determining the part of the sensing signal being caused by specifically bound particles and to determine the substance based on this determined part of the sensing signal.
摘要翻译：本发明涉及一种用于确定流体内物质的物质确定装置。具有附着物质的颗粒结合至结合表面（30）。感测单元（33）适于产生感测信号，该感测信号指示i）结合在装订表面（30）和装订表面（30）上的颗粒之间的距离和ii）平面内位置的结合表面上的颗粒。绑定识别单元（34）适于根据产生的感测信号来区分绑定在绑定表面（30）上的粒子的不同种类的绑定。装订识别单元（34）优选地是用于确定由特定结合的粒子引起的感测信号的部分的单元，并且基于该确定的感测信号的部分来确定物质。

7. 发明申请

US20120250005A1 BIOSENSOR SYSTEM FOR SINGLE PARTICLE DETECTION 有权
标题翻译：用于单颗粒检测的生物传感器系统
公开(公告)号：US20120250005A1
公开(公告)日：2012-10-04
申请号：US13498482
申请日：2010-09-23
申请人： Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Josephus Arnoldus Henricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko
发明人： Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Josephus Arnoldus Henricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko
IPC分类号： G01N21/49 , G01R33/12
CPC分类号： G01N33/54373 , G01N15/10 , G01N15/1031 , G01N21/47 , G01N21/49 , G01N21/51 , G01N21/552 , G01N21/6458 , G01N27/72 , G01N33/54313 , G01N2015/0065 , G01N2201/12 , G01R33/1269
摘要： The present invention is related to a biosensor system for the detection of particles comprising: a biosensor cartridge comprising a sensor surface, a biosensor magnet assembly on one side of the cartridge for generating a magnetic field effective at the cartridge and the sensor surface, the first biosensor magnet assembly comprising at least two magnetic sub-units separated by a gap, a first optical detection system for detecting the particles arranged at the same side of the cartridge as the magnet assembly, whereas the magnet assembly is designed in a way that the optical detection is accomplished through the gap of the magnet assembly.
摘要翻译：本发明涉及一种用于检测颗粒的生物传感器系统，包括：生物传感器盒，包括传感器表面，在盒的一侧上的生物传感器磁体组件，用于产生在盒和感测器表面有效的磁场;第一生物传感器磁体组件，其包括由间隙分隔开的至少两个磁性子单元;第一光学检测系统，用于检测与磁体组件位于盒的同一侧的颗粒，而磁体组件设计成使得光学通过磁体组件的间隙实现检测。

8. 发明授权

US10466163B2 Concurrently evaluating assays with optical inhomogeneities 有权
公开(公告)号：US10466163B2
公开(公告)日：2019-11-05
申请号：US14113964
申请日：2012-04-23
申请人： Toon Hendrik Evers , Derk Jan Wilfred Klunder , Jeroen Hans Nieuwenhuis , Joannes Baptist Adrianus Dionisius Van Zon
发明人： Toon Hendrik Evers , Derk Jan Wilfred Klunder , Jeroen Hans Nieuwenhuis , Joannes Baptist Adrianus Dionisius Van Zon
IPC分类号： G01N33/53 , G01N21/00 , G01N21/552 , G01N21/88 , G01N21/94 , G06T7/00 , G01N33/52 , G01N21/15
摘要： During an assay, optical measurements are made at a sensing surface (112), and at least one “homogeneity-image” of the sensing surface (112) is generated. From this image, an “homogeneity-indicator” is determined for at least one region of interest, and the optical measurements are then evaluated in dependence on said indicator. The homogeneity-indicator may for example be a binary value which indicates if an inhomogeneity was detected or not. If an inhomogeneity was detected, all optical measurements may be rejected, only measurements for the involved region of interest may be rejected, or measurements for a selected sub-area of the involved region of interest (ROI) may be rejected.

9. 发明申请

US20120252033A1 SUBSTANCE DETERMINING APPARATUS 审中-公开
标题翻译：物质确定装置
公开(公告)号：US20120252033A1
公开(公告)日：2012-10-04
申请号：US13515853
申请日：2010-12-10
申请人： Joannes Baptist Adrianus Dionisius Van Zon , Toon Hendrik Evers , Maatje Koets
发明人： Joannes Baptist Adrianus Dionisius Van Zon , Toon Hendrik Evers , Maatje Koets
IPC分类号： G01N33/53 , G01N33/566 , G01N30/00
CPC分类号： G01N21/552 , G01N33/54373
摘要： The invention relates to a substance determining apparatus and method for determining a substance within a fluid. Particles attach to the substance and bind to a binding surface (30), wherein a particle release curve being indicative of a release of bound particles from the binding surface (30) is determined, and a part of the particle release curve caused by particles bound to the binding surface via a predefined kind of binding is determined based on the temporal behaviour of the particle release curve. The substance within the fluid is determined based on the part of the particle release curve. The substance can therefore be determined based on particles which are bound to the binding surface via a certain kind of binding, i.e. other kinds of binding substantially do not affect the determination of the substance, thereby improving the accuracy of determining the substance.
摘要翻译：本发明涉及一种用于确定流体内的物质的物质确定装置和方法。颗粒附着于物质并结合至结合表面（30），其中确定指示结合颗粒从结合表面（30）释放的颗粒释放曲线，并且由颗粒结合引起的部分颗粒释放曲线基于粒子释放曲线的时间行为来确定经由预定类型的结合的结合表面。基于颗粒释放曲线的部分确定流体内的物质。因此，物质可以基于通过某种结合结合到结合表面的颗粒来确定，即其它种类的结合基本上不影响物质的测定，从而提高了确定物质的准确性。

10. 发明申请

US20130088221A1 DETECTION OF MAGNETIC PARTICLES AND THEIR CLUSTERING 审中-公开
标题翻译：检测磁性颗粒及其聚集
公开(公告)号：US20130088221A1
公开(公告)日：2013-04-11
申请号：US13705000
申请日：2010-11-30
申请人： Joannes Baptist Adrianus Dionisius Van Zon , Mkhail Mikhaylovich Ovsyanko , Toon Hendrik Evers , Mara Johanna Jacoba Sijbers
发明人： Joannes Baptist Adrianus Dionisius Van Zon , Mkhail Mikhaylovich Ovsyanko , Toon Hendrik Evers , Mara Johanna Jacoba Sijbers
IPC分类号： G01N27/72
CPC分类号： G01N27/72 , B01L3/502761 , B82Y25/00 , G01N15/06 , G01N15/0656 , G01N2015/0693 , G01R33/1276 , H01F1/0036
摘要： The invention relates to a method and associated apparatuses (100) for the detection of magnetic particles (MP) in a sample chamber (111). The method comprises the determination of a “particle-parameter” that is related to the amount of magnetic particles (MP) in a first detection region (P, C), the determination of a “cluster-parameter” that is related to the degree of clustering of magnetic particles (MP) in a second detection region (P, C), and the evaluation of the particle-parameter based on the cluster-parameter. Various apparatuses are disclosed that can be applied in said method. In one apparatus (100), a magnetic field (B) is generated in the sample chamber (111) in such a way that it has different inclinations in a first and second field region (P, C) and/or that it is oblique to the binding surface (112) in at least one field region. Magnetic particles (MP) are then detected in said first and second field region and/or in said at least one field region before and after a permanent switch-off of the inclined magnetic field. The resulting detection signals are related to each other to determine a cluster-parameter. In other embodiments, a cluster-parameter may be determined from light transmission measurements during the application of a magnetic field that is switched on and off.
摘要翻译：本发明涉及一种用于检测样品室（111）中的磁性颗粒（MP）的方法和相关装置（100）。该方法包括确定与第一检测区域（P，C）中的磁性粒子（MP）的量相关的粒子参数，确定与磁性聚类程度相关的聚类参数颗粒（MP）在第二检测区域（P，C）中，以及基于聚类参数的粒子参数的评估。公开了可以应用于所述方法的各种装置。在一个装置（100）中，在样品室（111）中产生磁场（B），使得其在第一和第二场区域（P，C）中具有不同的倾斜度和/或倾斜到达至少一个场区域中的结合表面（112）。然后在永久关闭倾斜磁场之前和之后，在所述第一和第二场区和/或所述至少一个场区中检测磁性颗粒（MP）。所得到的检测信号彼此相关，以确定簇参数。在其他实施例中，可以在施加接通和关断的磁场期间的光透射测量来确定簇参数。

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