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    • 2. 发明授权
    • Gene and uses therefor
    • 基因和用途
    • US06436670B1
    • 2002-08-20
    • US09331930
    • 1999-06-30
    • Paul Zev ZimmetGregory Collier
    • Paul Zev ZimmetGregory Collier
    • C12N1500
    • C07K14/5759A61K38/00
    • The present invention relates generally to a nucleic acid molecule which encodes a protein associated with the modulation of obesity, diabetes and metabolic energy levels. More particularly, the present invention is directed to a nucleic acid molecule and a recombinant and purified naturally occurring protein encoded thereby and their use in therapeutic and diagnostic protocols for conditions such as obesity, diabetes and energy imbalance. The subject nucleic acid molecule and protein and their derivatives, homologues, analogues and mimetics are proposed as therapeutic and diagnostic agents for obesity, diabetes and energy imbalance.
    • 本发明一般涉及编码与肥胖,糖尿病和代谢能量水平的调节相关的蛋白质的核酸分子。 更具体地说,本发明涉及由此编码的核酸分子和重组和纯化的天然存在的蛋白质及其在治疗和诊断方案中用于肥胖,糖尿病和能量失衡等病症的用途。 提出了本研究的核酸分子和蛋白及其衍生物,同系物,类似物和模拟物作为肥胖,糖尿病和能量失衡的治疗和诊断剂。
    • 7. 发明申请
    • Methods and Compositions for Modulating Satiety
    • 调节饱腹感的方法和组合
    • US20070281986A1
    • 2007-12-06
    • US10588576
    • 2005-02-01
    • Gregory CollierKenneth Walder
    • Gregory CollierKenneth Walder
    • A61K31/4178
    • G01N33/6872A61K31/4178A61K33/24A61K45/06G01N2500/02G01N2800/044
    • The present invention relates generally to a method for modulating the sensation of satiety perception and to agents useful for same. More particularly, the present invention identifies molecules which interact with ion channels thereby modulating the perception of satiety. The present invention contemplates, therefore, a method for modulating gastric distension by the administration of agents which control the activation or inhibition of mechanoreceptors. The present invention further provides compositions comprising these agents and methods of treatment using same. In a particular embodiment, the present invention permits modulation of the sensation of gastric distension by the administration of agents which control the activation of mechanoreceptors associated with mechanical stretch.
    • 本发明一般涉及一种调节饱腹感觉感觉的方法以及对其有用的药剂。 更具体地,本发明鉴定与离子通道相互作用的分子,从而调节饱腹感。 因此,本发明考虑了通过施用控制机械感受器的活化或抑制的试剂调节胃膨胀的方法。 本发明还提供了包含这些试剂的组合物和使用它们的治疗方法。 在一个具体实施方案中,本发明允许通过施用控制与机械拉伸相关的机械感受器的活化的试剂调节胃胀气的感觉。