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1. 发明申请

US20050059108A1 Novel gene and uses therefor 失效
标题翻译：新基因及其用途
公开(公告)号：US20050059108A1
公开(公告)日：2005-03-17
申请号：US10067832
申请日：2002-06-03
申请人： Paul Zimmet , Gregory Collier
发明人： Paul Zimmet , Gregory Collier
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/14 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , C07K14/47 , C07K14/575 , C07K16/18 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C07H21/04 , C12N9/20
CPC分类号： C07K14/5759 , A61K38/00
摘要： The present invention relates generally to a nucleic acid molecule which encodes a protein associated with the modulation of obesity, diabetes and metabolic energy levels. More particularly, the present invention is directed to a nucleic and a recombinant and purified naturally occurring protein encoded thereby and their uses in therapeutic and diagnostic protocols for conditions such as obesity, diabetes and energy imbalance. The subject nucleic acid molecule and protein and their derivatives, homologues, analogues and mimetics are proposed as therapeutic and diagnostic agents for obesity, diabetes and energy imbalance.
摘要翻译：本发明一般涉及编码与肥胖，糖尿病和代谢能量水平的调节相关的蛋白质的核酸分子。更具体地说，本发明涉及由此编码的核酸和重组和纯化的天然存在的蛋白质及其在治疗和诊断方案中用于诸如肥胖症，糖尿病和能量失衡的病症的用途。提出了本研究的核酸分子和蛋白及其衍生物，同系物，类似物和模拟物作为肥胖，糖尿病和能量失衡的治疗和诊断剂。

2. 发明申请

US20070032642A1 Novel genes and their use in the modulation of obesity, diabetes and energy imbalance 审中-公开
标题翻译：新型基因及其在调节肥胖，糖尿病和能量失衡中的应用
公开(公告)号：US20070032642A1
公开(公告)日：2007-02-08
申请号：US11544140
申请日：2006-10-06
申请人： Gregory Collier , Paul Zimmet , Kenneth Walder , Kelly Windmill , Janine McMillan
发明人： Gregory Collier , Paul Zimmet , Kenneth Walder , Kelly Windmill , Janine McMillan
IPC分类号： C07H21/04
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates generally to nucleic acid molecules encoding proteins associated with the modulation of obesity, diabetes and/or metabolic energy levels. More particularly, the present invention is directed to nucleic acid molecules and the recombinant and purified proteins encoded thereby and their use in therapeutic and diagnostic protocols for conditions such as obesity, diabetes and energy imbalance. The subject nucleic acid molecules and proteins and their derivatives, homologs, analogs, chemical equivalents and mimetics are proposed as therapeutic and diagnostic agents for obesity, diabetes and energy imbalance.
摘要翻译：本发明一般涉及编码与肥胖，糖尿病和/或代谢能量水平的调节相关的蛋白质的核酸分子。更具体地，本发明涉及由此编码的核酸分子和重组和纯化的蛋白质，以及它们在治疗和诊断方案中用于诸如肥胖症，糖尿病和能量失衡的病症的用途。提出了本研究的核酸分子和蛋白质及其衍生物，同系物，类似物，化学当量和模拟物，作为肥胖，糖尿病和能量失衡的治疗和诊断剂。

3. 发明申请

US20050148525A1 Obesity related genes expressed at least in the hypothalamus, liver or pancreas 审中-公开
标题翻译：肥胖相关基因至少在下丘脑，肝脏或胰腺中表达
公开(公告)号：US20050148525A1
公开(公告)日：2005-07-07
申请号：US10488350
申请日：2002-08-28
申请人： Greg Collier , Ken Walder , Andrea De Silva , Lakshmi Kantham , Paul Zimmet
发明人： Greg Collier , Ken Walder , Andrea De Silva , Lakshmi Kantham , Paul Zimmet
IPC分类号： G01N33/53 , A61K38/17 , A61K45/00 , A61K48/00 , A61P1/14 , A61P3/04 , A61P3/10 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/705 , C12N15/09 , C12N15/12 , G01N33/566
CPC分类号： C07K14/47
摘要： The present invention relates generally to nucleic acid molecules expressed at least in the hypothalamus, liver or pancreas identified using differential display techniques under differing physiological conditions. The nucleic acid molecules are associated with or act as markers for conditions of a healthy state, obesity, anorexia, weight maintenance, diabetes and/or metabolic energy levels. More particularly, the present invention is directed to a nucleic acid molecule and/or its expression product for use in therapeutic and diagnostic protocols for conditions such as obesity, anorexia, weight maintenance, diabetes and energy imbalance. The subject nucleic acid molecule and expression product and their derivatives, homologs, analogs and mimetics are proposed to be useful, therefore, as therapeutic and diagnostic agents for obesity, anorexia, weight maintenance, diabetes and energy imbalance or as targets for the design and/or identification of modulators of their activity and/or function.
摘要翻译：本发明一般涉及在不同生理条件下使用差异显示技术鉴定的至少在下丘脑，肝脏或胰腺中表达的核酸分子。核酸分子与健康状态，肥胖，厌食，体重维持，糖尿病和/或代谢能量水平的条件相关联或用作标志物。更具体地说，本发明涉及一种用于治疗和诊断方案的核酸分子和/或其表达产物，用于诸如肥胖症，厌食症，体重维持，糖尿病和能量失衡的病症。提出了本发明的核酸分子和表达产物及其衍生物，同系物，类似物和模拟物是有用的，因此，作为肥胖，厌食，体重维持，糖尿病和能量失衡的治疗和诊断剂，或作为设计和/ 或其活动和/或功能的调节剂的鉴定。

4. 发明申请

US20050132448A1 Assay for beta cell toxic macrolides 审中-公开
标题翻译：测定β细胞毒性大环内酯类
公开(公告)号：US20050132448A1
公开(公告)日：2005-06-16
申请号：US10479127
申请日：2002-05-22
申请人： Mark Myers , Ian Mackay , Paul Zimmet
发明人： Mark Myers , Ian Mackay , Paul Zimmet
IPC分类号： A61K49/00 , A61P3/00 , C12Q1/68 , C12Q1/6895 , G01N33/569 , A01H1/00 , C12N15/82 , C12Q1/00 , A61K31/33
CPC分类号： C12Q1/6895 , A61K49/0004 , G01N33/56911 , G01N2333/36
摘要： The present invention relates to a method of assessing the propensity of a plant, if consumed, to contribute to the onset and/or progression of diabetes in a mammal and, more particularly, to a method of assessing the propensity of a tuberous vegetable, if consumed, to contribute to the onset and/or progression of diabetes in a mammal. The method of the present invention is useful, inter alia, for identifying mammals at risk of developing diabetes based on dietary intake. The present invention is further directed to methods of assessing the risk status of an individual for development of diabetes. The present invention still further provides methods for the prophylactic and/or therapeutic treatment of diabetes.
摘要翻译：本发明涉及评估植物在消费时对哺乳动物糖尿病发病和/或进展有促进作用的方法，更具体地说，涉及一种评估块茎植物倾向的方法，如果消耗，以促进哺乳动物的糖尿病的发作和/或进展。本发明的方法尤其用于鉴定基于饮食摄入发生糖尿病风险的哺乳动物。本发明还涉及评估个体发展糖尿病风险状态的方法。本发明还提供了用于预防和/或治疗糖尿病的方法。

5. 发明申请

US20080039364A1 Modulating serum amyloid a interaction with tanis and agents useful for same 审中-公开
标题翻译：调节血清淀粉样蛋白与tanis的相互作用和对其有用的药剂
公开(公告)号：US20080039364A1
公开(公告)日：2008-02-14
申请号：US11707300
申请日：2007-02-16
申请人： Greg Collier , Ken Walder , Paul Zimmet , Lyndal Bayles , Yuan Gao
发明人： Greg Collier , Ken Walder , Paul Zimmet , Lyndal Bayles , Yuan Gao
IPC分类号： A61K48/00 , G01N33/53
CPC分类号： A61K38/1709 , G01N33/502 , G01N33/5023 , G01N33/92
摘要： The present invention relates generally to a method of modulating the functional activity of a serum amyloid A or derivative, homologue, analogue, equivalent or mimetic thereof and, more particularly, to a method of modulating the functional activity of a serum amyloid A by modulating intracellular levels of Tanis or derivative, homologue, analogue, chemical equivalent or mimetic thereof. The method of the present invention is particularly useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate serum amyloid A activity. The present invention is further directed to methods for identifying and/or designing agents capable of modulating Tanis mediated regulation of a serum amyloid A functional activity.
摘要翻译：本发明一般涉及一种调节血清淀粉样蛋白A或其衍生物，同系物，类似物，等同物或模拟物的功能活性的方法，更具体地涉及通过调节细胞内调节血清淀粉样蛋白A的功能活性的方法 Tanis或其衍生物，同系物，类似物，化学等价物或模拟物的水平。本发明的方法尤其可用于治疗和/或预防以异常，不想要的或其他不适当的血清淀粉样蛋白A活性为特征的病症。本发明还涉及用于鉴定和/或设计能够调节Tanis介导的血清淀粉样蛋白A功能活性调节的试剂的方法。

6. 发明申请

US20060194233A1 Ligand of the protein "beacon" 审中-公开
标题翻译：蛋白质配体“灯塔”
公开(公告)号：US20060194233A1
公开(公告)日：2006-08-31
申请号：US11354263
申请日：2006-02-13
申请人： Greg Collier , Ken Walder , Paul Zimmet
发明人： Greg Collier , Ken Walder , Paul Zimmet
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/12
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/5759
摘要： The present invention relates generally to a ligand for a protein associated with modulating obesity, diabetes and metabolic energy levels in animals and humans and to genetic sequences encoding the ligand. More particularly, the present invention is directed to a ligand of the protein “beacon” and its homologues. The identification of the ligand molecule permits the development of a range of therapeutic and diagnostic protocols for obesity, diabetes and energy imbalance.
摘要翻译：本发明一般涉及与调节动物和人类的肥胖，糖尿病和代谢能量水平以及编码配体的遗传序列相关的蛋白质配体。更具体地，本发明涉及蛋白质“信标”及其同源物的配体。配体分子的鉴定允许开发一系列用于肥胖，糖尿病和能量失衡的治疗和诊断方案。

7. 发明申请

US20060155111A9 Novel genes and their use in the modulation of obesity, diabetes and energy imbalance 审中-公开
公开(公告)号：US20060155111A9
公开(公告)日：2006-07-13
申请号：US10039050
申请日：2001-12-31
申请人： Gregory Collier , Paul Zimmet , Kenneth Walder , Kelly Windmill , Janine McMillan
发明人： Gregory Collier , Paul Zimmet , Kenneth Walder , Kelly Windmill , Janine McMillan
IPC分类号： C07K14/435 , C07H21/04 , C12P21/02 , C12N5/06
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates generally to nucleic acid molecules encoding proteins associated with the modulation of obesity, diabetes and/or metabolic energy levels. More particularly, the present invention is directed to nucleic acid molecules and the recombinant and purified proteins encoded thereby and their use in therapeutic and diagnostic protocols for conditions such as obesity, diabetes and energy imbalance. The subject nucleic acid molecules and proteins and their derivatives, homologs, analogs, chemical equivalents and mimetics are proposed as therapeutic and diagnostic agents for obesity, diabetes and energy imbalance.

8. 发明申请

US20050232918A1 Differentially expressed genes associated with obesity and type 2 diabetes 审中-公开
标题翻译：与肥胖和2型糖尿病相关的差异表达基因
公开(公告)号：US20050232918A1
公开(公告)日：2005-10-20
申请号：US10826448
申请日：2004-04-16
申请人： Greg Collier , Paul Zimmet , Ken Walder , Janine McMillan , Andrea Sanigorski , Kelly Windmill
发明人： Greg Collier , Paul Zimmet , Ken Walder , Janine McMillan , Andrea Sanigorski , Kelly Windmill
IPC分类号： A61K39/00 , A61K39/395 , C07H21/04 , C07K14/47 , C07K14/705 , C07K16/28 , C12N15/09 , C12Q1/68
CPC分类号： C07K14/4702 , A61K39/00
摘要： The present invention relates generally to a nucleic acid molecule which is expressed in at least the stomach, hypothalamus or liver identified using differential display techniques under differing physiological conditions. It is proposed that the nucleic acid molecules encode expression products associated with the modulation of obesity, anorexia, weight maintenance, diabetes and/or metabolic energy levels. More particularly, the present invention is directed to nucleic acid molecules and expression products produced by recombinant means from the nucleic acid molecule or isolated from natural sources and their use in therapeutic and diagnostic protocols for conditions such as obesity, anorexia, weight maintenance, diabetes and/or energy imbalance. The subject nucleic acid molecule and expression products and their derivatives, homologs, analogs and mimetics are proposed to be useful, therefore, as therapeutic and diagnostic agents for obesity, anorexia, weight maintenance, diabetes and/or energy imbalance or as targets for the design and/or identification of modulators of their activity and/or function.
摘要翻译：本发明一般涉及至少在不同生理条件下使用差异显示技术鉴定的胃，下丘脑或肝中表达的核酸分子。提出核酸分子编码与肥胖调节，厌食，体重维持，糖尿病和/或代谢能量水平相关的表达产物。更具体地说，本发明涉及由核酸分子或从天然来源分离的重组方法产生的核酸分子和表达产物及其在诸如肥胖，厌食，体重维持，糖尿病等病症的治疗和诊断方案中的用途， /或能量不平衡。提出了本发明的核酸分子和表达产物及其衍生物，同系物，类似物和模拟物是有用的，因此，作为肥胖，厌食，体重维持，糖尿病和/或能量不平衡的治疗和诊断剂，或作为设计目标和/或其活动和/或功能的调节剂的鉴定。

9. 发明申请

US20050032706A1 Hypoglycaemic peptides and methods of use thereof 失效
标题翻译：低血糖肽及其使用方法
公开(公告)号：US20050032706A1
公开(公告)日：2005-02-10
申请号：US10481662
申请日：2002-06-27
申请人： Paul Zimmet , Frank Ng
发明人： Paul Zimmet , Frank Ng
IPC分类号： A61K38/00 , A61K38/07 , A61K38/08 , A61P5/50 , C07K5/02 , C07K5/103 , C07K5/113 , C07K7/04 , A61K38/10 , C07K7/06 , C07K7/08
CPC分类号： C07K5/1008 , A61K38/00 , C07K5/0202 , C07K5/101 , C07K5/1021
摘要： A peptide of the formula (Xaa)n1-Xaa1-His-Thr-Asp(Xaa)n2, wherein Xaa is any amino acid; Xaa1 is a hydrophobic amino acid, preferably Gly or Val; n1 is 0-10; and n2 is 0-10; and use thereof in regulating in vivo blood glucose levels in a human or other mammal, particularly in the treatment of Type 2 diabetes in a human. Preferably, the peptide is a tetrapeptide selected from Gly-His-Thr-Asp and Val-His-Thr-Asp. These hypoglycaemic peptides are isolated from human urine and they also have been chemically synthesized.
摘要翻译：式（Xaa）n1-Xaa1-His-Thr-Asp（Xaa）n2的肽，其中Xaa是任何氨基酸; Xaa1是疏水性氨基酸，优选为Gly或Val; n1为0-10; n2为0-10; 以及其用于调节人或其他哺乳动物体内血糖水平，特别是用于治疗人类中的2型糖尿病。优选地，肽是选自Gly-His-Thr-Asp和Val-His-Thr-Asp的四肽。这些低血糖肽是从人尿中分离出来的，也是化学合成的。

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