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1. 发明申请

US20090143571A1 NOVEL GENES AND THEIR USE IN THE MODULATION OF OBESITY, DIABETES AND ENERGY IMBALANCE 审中-公开
标题翻译：新陈代谢及其在肥胖，糖尿病和能量不平衡调节中的应用
公开(公告)号：US20090143571A1
公开(公告)日：2009-06-04
申请号：US12192552
申请日：2008-08-15
申请人： Gregory Collier , Paul Zev Zimmet , Kenneth Russell Walder , Kelly Fiona Windmill , Janine Susan McMillan
发明人： Gregory Collier , Paul Zev Zimmet , Kenneth Russell Walder , Kelly Fiona Windmill , Janine Susan McMillan
IPC分类号： C07H21/04
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates generally to nucleic acid molecules encoding proteins associated with the modulation of obesity, diabetes and/or metabolic energy levels. More particularly, the present invention is directed to nucleic acid molecules and the recombinant and purified proteins encoded thereby and their use in therapeutic and diagnostic protocols for conditions such as obesity, diabetes and energy imbalance. The subject nucleic acid molecules and proteins and their derivatives, homologs, analogs, chemical equivalents and mimetics are proposed as therapeutic and diagnostic agents for obesity, diabetes and energy imbalance.
摘要翻译：本发明一般涉及编码与肥胖，糖尿病和/或代谢能量水平的调节相关的蛋白质的核酸分子。更具体地，本发明涉及由此编码的核酸分子和重组和纯化的蛋白质，以及它们在治疗和诊断方案中用于诸如肥胖症，糖尿病和能量失衡的病症的用途。提出了本研究的核酸分子和蛋白质及其衍生物，同系物，类似物，化学当量和模拟物，作为肥胖，糖尿病和能量失衡的治疗和诊断剂。

2. 发明授权

US06436670B1 Gene and uses therefor 失效
标题翻译：基因和用途
公开(公告)号：US06436670B1
公开(公告)日：2002-08-20
申请号：US09331930
申请日：1999-06-30
申请人： Paul Zev Zimmet , Gregory Collier
发明人： Paul Zev Zimmet , Gregory Collier
IPC分类号： C12N1500
CPC分类号： C07K14/5759 , A61K38/00
摘要： The present invention relates generally to a nucleic acid molecule which encodes a protein associated with the modulation of obesity, diabetes and metabolic energy levels. More particularly, the present invention is directed to a nucleic acid molecule and a recombinant and purified naturally occurring protein encoded thereby and their use in therapeutic and diagnostic protocols for conditions such as obesity, diabetes and energy imbalance. The subject nucleic acid molecule and protein and their derivatives, homologues, analogues and mimetics are proposed as therapeutic and diagnostic agents for obesity, diabetes and energy imbalance.
摘要翻译：本发明一般涉及编码与肥胖，糖尿病和代谢能量水平的调节相关的蛋白质的核酸分子。更具体地说，本发明涉及由此编码的核酸分子和重组和纯化的天然存在的蛋白质及其在治疗和诊断方案中用于肥胖，糖尿病和能量失衡等病症的用途。提出了本研究的核酸分子和蛋白及其衍生物，同系物，类似物和模拟物作为肥胖，糖尿病和能量失衡的治疗和诊断剂。

3. 发明授权

US07306920B2 Gene associated with regulation of energy balance, obesity and diabetes and uses therefor 失效
标题翻译：与能量平衡，肥胖和糖尿病调节相关的基因及其用途
公开(公告)号：US07306920B2
公开(公告)日：2007-12-11
申请号：US10067832
申请日：2002-06-03
申请人： Paul Zev Zimmet , Gregory Collier
发明人： Paul Zev Zimmet , Gregory Collier
IPC分类号： G01N33/53 , C07K14/00
CPC分类号： C07K14/5759 , A61K38/00
摘要： The present invention relates generally to a nucleic acid molecule which encodes a protein associated with the modulation of obesity, diabetes and metabolic energy levels. More particularly, the present invention is directed to a nucleic and a recombinant and purified naturally occurring protein encoded thereby and their uses in therapeutic and diagnostic protocols for conditions such as obesity, diabetes and energy imbalance. The subject nucleic acid molecule and protein and their derivatives, homologues, analogues and mimetics are proposed as therapeutic and diagnostic agents for obesity, diabetes and energy imbalance.
摘要翻译：本发明一般涉及编码与肥胖，糖尿病和代谢能量水平的调节相关的蛋白质的核酸分子。更具体地说，本发明涉及由此编码的核酸和重组和纯化的天然存在的蛋白质及其在治疗和诊断方案中用于诸如肥胖症，糖尿病和能量失衡的病症的用途。提出了本研究的核酸分子和蛋白及其衍生物，同系物，类似物和模拟物作为肥胖，糖尿病和能量失衡的治疗和诊断剂。

4. 发明授权

US6165738A Expression in yeast of antigenically active, recombinant hybrid glutamic acid decarboxylase 失效
标题翻译：在酵母中表达抗原活性，重组杂交谷氨酸脱羧酶
公开(公告)号：US6165738A
公开(公告)日：2000-12-26
申请号：US341824
申请日：1999-09-13
申请人： Ian Reay Mackay , Merrill Joy Rowley , Paul Zev Zimmet , Brian Corner , Ruby Law , Khay-Lin Teoh
发明人： Ian Reay Mackay , Merrill Joy Rowley , Paul Zev Zimmet , Brian Corner , Ruby Law , Khay-Lin Teoh
IPC分类号： G01N33/564 , A61K38/00 , A61K38/46 , A61P3/10 , C07K19/00 , C12N1/19 , C12N1/21 , C12N9/88 , C12N15/09 , C12N15/60 , G01N33/53
CPC分类号： C12N9/88 , A61K38/00 , C07K2319/00
摘要： An antigenically active hybrid glutamic acid decarboxylase (GAD) comprising an amino-terminal moiety derived from the GAD67 isoform linked directly or indirectly with a middle and carboxy-terminal moiety derived from the GAD65 isoform, and production thereof as a recombinant protein by expression in eukaryotic host cells, particularly yeasts.
摘要翻译： PCT No.PCT / AU98 / 00025 Sec。 371日期1999年9月13日 102（e）1999年9月13日PCT PCT 1998年1月21日PCT公布。第WO98 / 31819号公报日期1998年7月23日包含衍生自GAD67同种型的氨基末端部分的抗原性活性杂交谷氨酸脱羧酶（GAD），其直接或间接与源自GAD65同种型的中间和羧基末端部分连接，并且其作为重组体蛋白质通过在真核宿主细胞，特别是酵母中表达。

5. 发明授权

US5770381A Methods for the diagnosis of diabetes and prediabetic conditions 失效
标题翻译：诊断糖尿病和前列腺疾病的方法
公开(公告)号：US5770381A
公开(公告)日：1998-06-23
申请号：US495584
申请日：1995-10-10
申请人： Ian Reay MacKay , Merrill Joy Rowley , Paul Zev Zimmet
发明人： Ian Reay MacKay , Merrill Joy Rowley , Paul Zev Zimmet
IPC分类号： C12N9/88 , G01N33/564 , G01N33/573 , G01N33/53
CPC分类号： C12N9/88 , G01N33/564 , G01N33/573 , G01N2800/042
摘要： A method for detecting autoantibodies to glutamic acid decarboxylase (GAD) in the serum of a patient as diagnostic of a diabetic or prediabetic condition in the patient, comprises contacting a serum sample from the patient with a GAD antigen and detecting binding of autoantibodies to GAD in the sample by the GAD antigen, wherein the GAD antigen comprises a GAD preparation containing an enhanced amount of dimer(s) or oligomer(s) of the 65 kD or 67 kD isoforms, or both, of GAD. A diagnostic kit is also inclosed.
摘要翻译： PCT No.PCT / AU94 / 00056 Sec。 371日期1995年10月10日第 102（e）日期1995年10月10日PCT 1994年2月9日PCT PCT。出版物WO94 / 18568 日期1994年8月18日一种用于检测患者血清中的谷氨酸脱羧酶（GAD）的自身抗体的方法，所述方法包括将来自患者的血清样品与GAD抗原进行接触，并检测结合的GAD抗原对样品中的GAD的自身抗体，其中GAD抗原包含含有增加量的65kD或67kD同种型或两者的GAD的二聚体或寡聚体的GAD制剂。诊断试剂盒也被封闭。

6. 发明申请

US20090215669A1 COMPOSITIONS AND METHODS FOR TREATMENT OF DIABETES 审中-公开
标题翻译：用于治疗糖尿病的组合物和方法
公开(公告)号：US20090215669A1
公开(公告)日：2009-08-27
申请号：US12094693
申请日：2006-11-22
申请人： Mark A. Myers , Robyn Gray , Sarah Paule , Paul Zev Zimmet
发明人： Mark A. Myers , Robyn Gray , Sarah Paule , Paul Zev Zimmet
IPC分类号： A61K38/28 , C07K14/62
CPC分类号： A61K38/07 , A61K38/28 , A61K2300/00
摘要： The present invention relates to a composition comprising a peptide of the formula: (Xaa)n1-Xaa1-His-Thr-Asp-(Xaa)n2 wherein Xaa is any amino acid; Xaa1 is a hydrophobic amino acid; n1 is 0-10; and n2 is 0-10; and derivatives thereof; and insulin. Complexes of insulin and the peptides, methods of dispersing multimeric insulin complexes and methods of regulating in vivo blood glucose levels, particularly in the treatment of diabetes are also described.
摘要翻译：本发明涉及包含下式的肽的组合物：（Xaa）n1-Xaa1-His-Thr-Asp-（Xaa）n2其中Xaa是任何氨基酸; Xaa1是疏水性氨基酸; n1为0-10; n2为0-10; 及其衍生物; 和胰岛素。还描述了胰岛素和肽的复合物，分散多聚胰岛素复合物的方法和调节体内血糖水平的方法，特别是治疗糖尿病。

7. 发明授权

US07173012B2 Hypoglycaemic peptides and methods of use thereof 失效
标题翻译：低血糖肽及其使用方法
公开(公告)号：US07173012B2
公开(公告)日：2007-02-06
申请号：US10481662
申请日：2002-06-27
申请人： Paul Zev Zimmet , Frank Man-Woon Ng
发明人： Paul Zev Zimmet , Frank Man-Woon Ng
IPC分类号： A61K38/07 , A61K38/08 , C07K5/103 , C07K7/04
CPC分类号： C07K5/1008 , A61K38/00 , C07K5/0202 , C07K5/101 , C07K5/1021
摘要： A peptide of the formula (Xaa)n1-Xaa1-His-Thr-Asp-(Xaa)n2, wherein Xaa is any amino acid; Xaa1 is a hydrophobic amino acid, preferably Gly or Val; n1 is 0–10; and n2 is 0–10; and use thereof in regulating in vivo blood glucose levels in a human or other mammal, particularly in the treatment of Type 2 diabetes in a human. Preferably, the peptide is a tetrapeptide selected from Gly-His-Thr-Asp and Val-His-Thr-Asp. These hypoglycaemic peptides are isolated from human urine and they also have been chemically synthesized.
摘要翻译：式（Xaa）n1 -Xaa 1 -His-Thr-Asp-（Xaa）N 2 N的肽，其中Xaa是任何氨基酸; Xaa 1是疏水性氨基酸，优选Gly或Val; n1为0-10; n2为0-10; 及其用于调节人或其他哺乳动物体内血糖水平，特别是用于治疗人类中的2型糖尿病。优选地，肽是选自Gly-His-Thr-Asp和Val-His-Thr-Asp的四肽。这些低血糖肽是从人尿中分离出来的，也是化学合成的。

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