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1. 发明申请

US20090047655A1 Method Of Screening Candidate Drug 审中-公开
标题翻译：筛选候选药物的方法
公开(公告)号：US20090047655A1
公开(公告)日：2009-02-19
申请号：US11667855
申请日：2005-11-16
申请人： Chise Mukaidani , Katsutoshi Yoshizato , Yasufumi Nishikura , Toru Horie , Hiroshi Nakazawa , Hiroshi Kanamaru , Chiaki Ueda , Chiemi Hine
发明人： Chise Mukaidani , Katsutoshi Yoshizato , Yasufumi Nishikura , Toru Horie , Hiroshi Nakazawa , Hiroshi Kanamaru , Chiaki Ueda , Chiemi Hine
IPC分类号： C12Q1/00
CPC分类号： G01N33/5088 , G01N33/5067 , G01N2333/80
摘要： It is intended to provide a method of screening a candidate drug mainly metabolized by a drug metabolizing enzyme, CYP2D6, CYP2C9 or CYP2C19 with the use of a chimeric mouse carrying human hepatocytes transplanted thereinto, whereby it is determined whether or not the candidate drug is metabolized in a subject deficient in CYP2D6, CYP2C9 or CYP2C19. It is also intended to provide a method of determining whether or not a candidate drug induces or inhibits the activity of any of drug metabolizing enzymes, CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 with the use of a chimeric mouse carrying human hepatocytes transplanted thereinto.
摘要翻译：本发明提供一种使用携带人肝细胞的嵌合小鼠筛选主要由药物代谢酶CYP2D6，CYP2C9或CYP2C19代谢的候选药物的方法，由此确定候选药物是否被代谢在CYP2D6，CYP2C9或CYP2C19缺乏的受试者中。还旨在提供一种使用携带人肝细胞的嵌合小鼠来确定候选药物是否诱导或抑制任何药物代谢酶CYP1A2，CYP2C9，CYP2C19，CYP2D6和CYP3A4的活性的方法。

2. 发明授权

US5110956A Benzodioxale derivatives 失效
标题翻译： BENZODIOXALE DERIVATIVES
公开(公告)号：US5110956A
公开(公告)日：1992-05-05
申请号：US517444
申请日：1990-04-23
申请人： Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
发明人： Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
IPC分类号： A61K31/335 , C07D317/46 , C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/12 , C07D493/04
CPC分类号： C07D405/12 , C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D413/12 , C07D493/04
摘要： A new benzodioxole derivative has a substituent in the phenyl ring which is a carboxyalkylthioalkyl or the like and is effective to treat a liver disease.
摘要翻译：提供苯并间二氧杂环戊烯衍生物在苯环中具有取代基，羧基烷基硫代烷基等。这样的衍生物有效治疗肝脏疾病。还提供了包含这些衍生物的组合物以及这些衍生物用于制备药物的用途。

3. 发明授权

US07937615B2 Method for improving reliability of multi-core processor computer 有权
标题翻译：提高多核处理器计算机可靠性的方法
公开(公告)号：US07937615B2
公开(公告)日：2011-05-03
申请号：US11729948
申请日：2007-03-30
申请人： Yoshifumi Takamoto , Toru Horie
发明人： Yoshifumi Takamoto , Toru Horie
IPC分类号： G06F11/00
CPC分类号： G06F11/2043 , G06F11/2025
摘要： In a system including a plurality of multi-core processors, a table for managing the processors and cores owned by the processors is provided and a single virtual server is formed by using cores owned by different processors when generating the virtual server. According to the number owned by processors, the number of processors is varied. If a fault preecho in a processor is detected, control is exercised so as not to deliver an execution schedule of a virtualization mechanism to the processor in which the fault preecho has been detected. In a system including a plurality of multi-core processors, arithmetic cores owned by a plurality of different processors are assigned to processing of a process or thread in an operating system. In a system including a plurality of multi-core processors, arithmetic cores owned by a plurality of different processors are assigned to the operating system.
摘要翻译：在包括多个多核处理器的系统中，提供用于管理由处理器拥有的处理器和核的表，并且在生成虚拟服务器时通过使用由不同处理器拥有的核来形成单个虚拟服务器。根据处理器拥有的数量，处理器数量有所不同。如果检测到处理器中的故障前置，则执行控制以便不将虚拟化机制的执行调度传递到已经检测到故障预先检测的处理器。在包括多个多核处理器的系统中，由多个不同处理器拥有的算术核心被分配给操作系统中的处理或线程的处理。在包括多个多核处理器的系统中，由多个不同处理器拥有的算术核心被分配给操作系统。

4. 发明授权

US07660918B2 Method for switching node and an information processing system 失效
标题翻译：交换节点和信息处理系统的方法
公开(公告)号：US07660918B2
公开(公告)日：2010-02-09
申请号：US12369994
申请日：2009-02-12
申请人： Yusuke Ohashi , Toru Horie , Akio Tatsumi
发明人： Yusuke Ohashi , Toru Horie , Akio Tatsumi
IPC分类号： G06F3/00
CPC分类号： G06F3/0637 , G06F3/0626 , G06F3/0635 , G06F3/0674
摘要： In an information processing system including host computers and disk devices, each of an execution-node host and a standby-node host includes an I/O request unit and an access-right change command unit. The I/O request unit issues an I/O request. The access-right change command unit transmits an access-right change command. The access-right change command results from causing I/O-enable/disable information and the host identification information to correspond to each other. The disk device includes an access control table, an access control unit, and an access-right change unit. The access control table stores information of the access-right change commands from the hosts. The access control unit judges the execution enablement/disablement for the I/O requests from the host identification information and the access control table. The access-right change unit, in accordance with the access-right change commands from the hosts, changes in batch the I/O-enable/disable information on each host basis within the access control table.
摘要翻译：在包括主计算机和磁盘设备的信息处理系统中，执行节点主机和备用节点主机中的每一个包括I / O请求单元和访问权限改变命令单元。 I / O请求单元发出I / O请求。访问权限改变命令单元发送访问权限改变命令。访问权限改变命令是由于导致I / O使能/禁止信息和主机标识信息彼此对应而产生的。磁盘装置包括访问控制表，访问控制单元和访问权限改变单元。访问控制表存储来自主机的访问权限改变命令的信息。访问控制单元从主机识别信息和访问控制表判断对I / O请求的执行启用/禁止。访问权限改变单元根据来自主机的访问权限改变命令，在访问控制表内基于每个主机批量地改变I / O启用/禁用信息。

5. 发明申请

US20080148015A1 Method for improving reliability of multi-core processor computer 有权
标题翻译：提高多核处理器计算机可靠性的方法
公开(公告)号：US20080148015A1
公开(公告)日：2008-06-19
申请号：US11729948
申请日：2007-03-30
申请人： Yoshifumi Takamoto , Toru Horie
发明人： Yoshifumi Takamoto , Toru Horie
IPC分类号： G06F15/00
CPC分类号： G06F11/2043 , G06F11/2025
摘要： In a system including a plurality of multi-core processors, a table for managing the processors and cores owned by the processors is provided and a single virtual server is formed by using cores owned by different processors when generating the virtual server. According to the number owned by processors, the number of processors is varied. If a fault preecho in a processor is detected, control is exercised so as not to deliver an execution schedule of a virtualization mechanism to the processor in which the fault preecho has been detected. In a system including a plurality of multi-core processors, arithmetic cores owned by a plurality of different processors are assigned to processing of a process or thread in an operating system. In a system including a plurality of multi-core processors, arithmetic cores owned by a plurality of different processors are assigned to the operating system.
摘要翻译：在包括多个多核处理器的系统中，提供用于管理由处理器拥有的处理器和核的表，并且在生成虚拟服务器时通过使用由不同处理器拥有的核来形成单个虚拟服务器。根据处理器拥有的数量，处理器数量有所不同。如果检测到处理器中的故障前置，则执行控制以便不将虚拟化机制的执行调度传递到已经检测到故障预先检测的处理器。在包括多个多核处理器的系统中，由多个不同处理器拥有的算术核心被分配给操作系统中的处理或线程的处理。在包括多个多核处理器的系统中，由多个不同处理器拥有的算术核心被分配给操作系统。

6. 发明申请

US20060005198A1 Method for automatically imparting reserve resource to logical partition and logical partitioned computer system 失效
标题翻译：自动赋予逻辑分区和逻辑分区计算机系统的预留资源的方法
公开(公告)号：US20060005198A1
公开(公告)日：2006-01-05
申请号：US11221814
申请日：2005-09-09
申请人： Michihiro Uchishiba , Toru Horie
发明人： Michihiro Uchishiba , Toru Horie
IPC分类号： G06F9/46
CPC分类号： G06F9/5077
摘要： A logical partitioned computer system. A hypervisor includes a resource management table for managing resources assigned to the hypervisor and an assigning/collecting unit for assigning and collecting resources to logical partitions. Each logical partiion has a guest resource monitoring unit for monitoring the amount of the resource being used out of the amount of the resource assigned to the logical partiion and an adding/separating unit for requesting addition and separation of a resource to the assigning/collecting unit based on results of monitoring. In response to the request, assigning/collecting unit searches resource management table, assigns a resource to logical partition when a reserve resource exists in case of an assignment request, and collects a resource as a reserve resource in the resource management table in case of a collection request.
摘要翻译：逻辑分区计算机系统。管理程序包括用于管理分配给管理程序的资源的资源管理表和用于向逻辑分区分配和收集资源的分配/收集单元。每个逻辑单元具有一个来宾资源监视单元，用于监视分配给该逻辑单元的资源量的正在使用的资源量;以及添加/分离单元，用于请求向分配/收集单元添加和分离资源基于监测结果。响应于该请求，分配/收集单元搜索资源管理表，当在分配请求的情况下存在预留资源时，将资源分配给逻辑分区，并且在资源管理表中将资源作为备用资源收集在资源管理表中收集请求。

7. 发明授权

US5475024A Benzodioxole derivatives 失效
标题翻译：苯并二恶醇衍生物
公开(公告)号：US5475024A
公开(公告)日：1995-12-12
申请号：US166019
申请日：1993-10-14
申请人： Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
发明人： Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
IPC分类号： C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/12 , C07D493/04 , A61K31/36
CPC分类号： C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/10 , C07D493/04
摘要： A new benzodioxole derivative has a substituent in the phenyl ring which is a carboxyalkylthioalkyl or the like and is effective to treat a liver disease.
摘要翻译：新的苯并间二氧杂环戊烯衍生物在苯环中具有取代基，其是羧烷基硫代烷基等，并且有效治疗肝脏疾病。

8. 发明授权

US5262565A Naphthalene derivatives 失效
标题翻译：萘衍生物
公开(公告)号：US5262565A
公开(公告)日：1993-11-16
申请号：US790541
申请日：1991-11-12
申请人： Hiroyuki Yoshimura , Shinya Abe , Tetsuya Kawahara , Takashi Inoue , Hiroshi Shirota , Kenichi Chiba , Kenichi Kusube , Toru Horie , Takeshi Suzuki , Isao Yamatsu , Naoyuki Shimomura , Kazuo Okano , Richard S. J. Clark , Takashi Mori , Shuhei Miyazawa , Ryoichi Hashida , Kenzo Muramoto , Koukichi Harada
发明人： Hiroyuki Yoshimura , Shinya Abe , Tetsuya Kawahara , Takashi Inoue , Hiroshi Shirota , Kenichi Chiba , Kenichi Kusube , Toru Horie , Takeshi Suzuki , Isao Yamatsu , Naoyuki Shimomura , Kazuo Okano , Richard S. J. Clark , Takashi Mori , Shuhei Miyazawa , Ryoichi Hashida , Kenzo Muramoto , Koukichi Harada
IPC分类号： A61K31/165 , A61K31/19 , A61K31/192 , A61K31/197 , A61K31/215 , A61K31/22 , A61K31/222 , A61K31/275 , A61P19/02 , A61P25/04 , A61P29/00 , A61P43/00 , C07C39/40 , C07C43/20 , C07C43/23 , C07C43/253 , C07C45/00 , C07C47/575 , C07C59/52 , C07C59/64 , C07C59/72 , C07C59/84 , C07C59/90 , C07C69/157 , C07C69/734 , C07C69/738 , C07C235/34 , C07C251/48 , C07C255/41 , C07C62/06 , C07C69/76
CPC分类号： C07C255/41 , C07C251/48 , C07C39/40 , C07C43/202 , C07C43/23 , C07C43/253 , C07C45/00 , C07C47/575 , C07C59/52 , C07C59/64 , C07C59/72 , C07C59/90 , C07C69/734 , C07C69/738 , C07C2101/08
摘要： Compounds of the formula: ##STR1## where R.sup.1 is a hydrogen atom or a lower alkyl group;R.sub.2 is a lower alkoxy group;R.sub.3 is a hydroxyl or lower alkoxy group;Z is represented by the formula: ##STR2## where R.sub.2 and R.sub.3 may be the same or different from each other and each stands for a hydrogen atom or a lower alkyl;Y is represented by the formula: --(CH.sub.2).sub.n -- where n is 0 or an integer of 1 to 2 or a group represented by the formula: ##STR3## where R.sup.2 and R.sup.3 may be the same or different from each other and each stands for a lower alkyl group; andR.sup.4 represents a group of the formula: ##STR4## where p is 0 or an integer of 1 to 3 and R.sup.12 is hydrogen, a halogen atom, a lower alkyl or a lower alkoxy group a hydrogen atom, R.sup.2 is a methoxy group, R.sup.3 is a hydroxy group and R.sup.4 is a benzyl group having anti-inflammatory activity.

9. 发明申请

US20070278750A1 Fuel Injection Valve 审中-公开
标题翻译：燃油喷射阀
公开(公告)号：US20070278750A1
公开(公告)日：2007-12-06
申请号：US10586058
申请日：2005-01-14
申请人： Shinji Okuhara , Toru Horie , Kiyoshi Matsuzaki , Kenichi Neki , Kazuo Koshizuka
发明人： Shinji Okuhara , Toru Horie , Kiyoshi Matsuzaki , Kenichi Neki , Kazuo Koshizuka
IPC分类号： F02F11/00
CPC分类号： F02M61/166 , F02M47/027 , F02M61/18 , F02M2200/90 , F02M2200/9038 , F02M2547/003 , F02M2547/006
摘要： In a fuel injection valve (1) having a nozzle body (31) with a nozzle hole (35) at its tip that is opened and closed by a nozzle needle (32) housed in the nozzle body (31), the area of contact between the nozzle needle (32) and a seat (31A) on the nozzle body (31) is provided with a coating layer (Y) to reduce the frictional resistance with the nozzle body (31). When the nozzle needle (32) seats on the seat (31A), between the time from when the tip of the nozzle needle (32) contacts the seat (31A) to when it is pressed against the seat (31A), the nozzle needle (32) slides on the surface of the nozzle body (31) with low frictional resistance. As a result, wear on the seat (31A) when the nozzle needle (32) is seated to open the valve can be kept down.
摘要翻译：在具有喷嘴孔（31）的燃料喷射阀（1）的喷嘴孔（35）的顶端处，其被容纳在喷嘴体（31）内的喷嘴针（32）开闭，在喷嘴体（31）上的喷嘴针（32）和座（31A）之间设置有涂层（Y），以减少与喷嘴体（31）的摩擦阻力。当喷嘴针（32）位于座椅（31a）上时，在从喷嘴针（32）的尖端与座（31A）接触到压靠在座椅（21A）之间的时间之间，喷嘴针（32）以低摩擦阻力在喷嘴体（31）的表面上滑动。结果，当喷嘴针（32）就座以打开阀时，座椅（31A）上的磨损可以保持下降。

10. 发明申请

US20050091419A1 Method for switching node and an information processing system 审中-公开
标题翻译：交换节点和信息处理系统的方法
公开(公告)号：US20050091419A1
公开(公告)日：2005-04-28
申请号：US10806338
申请日：2004-03-23
申请人： Yusuke Ohashi , Toru Horie , Akio Tatsumi
发明人： Yusuke Ohashi , Toru Horie , Akio Tatsumi
IPC分类号： G06F12/14 , G06F3/00 , G06F3/06 , G06F11/20
CPC分类号： G06F3/0637 , G06F3/0626 , G06F3/0635 , G06F3/0674
摘要： In an information processing system including host computers and disk devices, each of an execution-node host and a standby-node host includes an I/O request unit and an access-right change command unit. The I/O request unit issues an I/O request. The access-right change command unit transmits an access-right change command. The access-right change command results from causing I/O-enable/disable information and the host identification information to correspond to each other. The disk device includes an access control table, an access control unit, and an access-right change unit. The access control table stores information of the access-right change commands from the hosts. The access control unit judges the execution enablement/disablement for the I/O requests from the host identification information and the access control table. The access-right change unit, in accordance with the access-right change commands from the hosts, changes in batch the I/O-enable/disable information on each host basis within the access control table.
摘要翻译：在包括主计算机和磁盘设备的信息处理系统中，执行节点主机和备用节点主机中的每一个包括I / O请求单元和访问权限改变命令单元。 I / O请求单元发出I / O请求。访问权限改变命令单元发送访问权限改变命令。访问权限改变命令是由于导致I / O使能/禁止信息和主机标识信息彼此对应而产生的。磁盘装置包括访问控制表，访问控制单元和访问权限改变单元。访问控制表存储来自主机的访问权限改变命令的信息。访问控制单元从主机识别信息和访问控制表判断对I / O请求的执行启用/禁止。访问权限改变单元根据来自主机的访问权限改变命令，在访问控制表内基于每个主机批量地改变I / O启用/禁用信息。

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