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1. 发明授权

US09484194B2 Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis 有权
标题翻译：通过频谱控制氢氘交换
公开(公告)号：US09484194B2
公开(公告)日：2016-11-01
申请号：US13885913
申请日：2011-11-16
申请人： Jeffery Mark Brown , Steven Derek Pringle , Keith Richardson
发明人： Jeffery Mark Brown , Steven Derek Pringle , Keith Richardson
IPC分类号： H01J49/00 , H01J49/06 , H01J49/26
CPC分类号： H01J49/0077 , H01J49/00 , H01J49/0031 , H01J49/0036 , H01J49/0054 , H01J49/0072 , H01J49/06 , H01J49/065 , H01J49/26
摘要： A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react.
摘要翻译：公开了一种质谱仪，其包括用于分离离子的液相色谱装置。气相离子中性反应装置设置在下游以进行气相离子 - 中性反应如氢氘交换。控制系统被布置成在第一操作模式和第二操作模式之间来回自动重复地切换反应装置，其中在第一操作模式中，使至少一些母体或前体离子在反应中反应器件，并且其中在第二操作模式中基本上较少或没有使母体或前体离子发生反应。

2. 发明授权

US09136098B2 Ion guide coupled to MALDI ion source 有权
标题翻译：离子导轨耦合到MALDI离子源
公开(公告)号：US09136098B2
公开(公告)日：2015-09-15
申请号：US14130465
申请日：2012-07-06
申请人： Jason Lee Wildgoose , Steven Derek Pringle , Kevil Giles , Jeffery Mark Brown , Paul Murray , Daniel James Kenny
发明人： Jason Lee Wildgoose , Steven Derek Pringle , Kevil Giles , Jeffery Mark Brown , Paul Murray , Daniel James Kenny
IPC分类号： H01J49/40 , H01J49/10 , H01J49/06 , H01J49/00
CPC分类号： H01J49/10 , H01J49/0031 , H01J49/061 , H01J49/065 , H01J49/161
摘要： A pulsed ion source is disclosed wherein the ion source is energized one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other.
摘要翻译：公开了脉冲离子源，其中离子源被激发一次或多次以产生第一组离子和第二组离子。第一和第二组离子同时透过离子导向器同时保持第一和第二组离子彼此隔离。

3. 发明授权

US08952320B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08952320B2
公开(公告)日：2015-02-10
申请号：US11719665
申请日：2005-11-18
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/26 , H01J49/42
CPC分类号： H01J49/4215 , H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device (6). A broadband frequency signal (10) having one or more notches (11a, 11b, 11c) is applied to the rods of the quadrupole rod set (6). The notched broadband frequency signal (10) causes undesired ions to be resonantly ejected from the ion guide (6). The notched broadband frequency signal (10) has frequency components missing which correspond with the resonance frequency of ions which are desired to be onwardly transmitted. The ion guide or mass filter device (6) enables a plurality of desired ions having different mass to charge ratios to be simultaneously transmitted by the ion guide or mass filter device (6) whilst other ions are resonantly ejected from the ion guide or mass filter device (6).
摘要翻译：公开了一种质谱仪，其包括四极杆离子导向器或质量过滤装置（6）。具有一个或多个凹口（11a，11b，11c）的宽频率信号（10）被施加到四极杆组（6）的杆上。有缺口的宽带频率信号（10）使不想要的离子从离子导向器（6）共振地弹出。缺口宽带频率信号（10）具有与期望向前发射的离子的谐振频率相对应的频率分量。离子导向器或质量过滤装置（6）使得具有不同质荷比的多个所需离子能够由离子导向器或质量过滤装置（6）同时传输，而其它离子从离子导向器或质量过滤器装置（6）。

4. 发明授权

US08822914B2 Method of screening a sample for the presence of one or more known compounds of interest and a mass spectrometer performing this method 有权
标题翻译：筛选样品中存在一种或多种已知的目标化合物的方法和进行该方法的质谱仪
公开(公告)号：US08822914B2
公开(公告)日：2014-09-02
申请号：US13394089
申请日：2010-09-06
申请人： Jeffrey Alan Goshawk , Steven Derek Pringle , Steve Smith
发明人： Jeffrey Alan Goshawk , Steven Derek Pringle , Steve Smith
IPC分类号： B01D59/44
CPC分类号： H01J49/40 , H01J49/0027 , H01J49/004
摘要： A method of screening a sample for the presence of one or more known compounds of interest is disclosed. A fragmentation device is repeatedly switched between a fragmentation mode of operation and a non-fragmentation mode of operation. A determination is made whether a candidate parent ion of interest is present in a non-fragmentation data set and whether one or more corresponding fragment ions of interest are present in a fragmentation data set. A further determination is made to check if the candidate parent ion of interest and the one or more corresponding fragment ions of interest have substantially similar elution or retention times and/or ion mobility drift times.
摘要翻译：公开了筛选样品中存在一种或多种已知化合物的方法。分段设备在分段操作模式和非分段操作模式之间重复切换。确定感兴趣的候选母体离子是否存在于非碎裂数据集中，以及感兴趣的一个或多个相应的碎片离子是否存在于碎裂数据集中。进一步确定检查感兴趣的候选亲本离子和感兴趣的一个或多个相应碎片离子是否具有基本相似的洗脱或保留时间和/或离子迁移率漂移时间。

5. 发明申请

US20140191123A1 Ion Guide Coupled to MALDI Ion Source 有权
标题翻译：离子导向器与MALDI离子源耦合
公开(公告)号：US20140191123A1
公开(公告)日：2014-07-10
申请号：US14130465
申请日：2012-07-06
申请人： Jason Lee Wildgoose , Steven Derek Pringle , Kevil Giles , Jeffery Mark Brown , Paul Murray , Daniel James Kenny
发明人： Jason Lee Wildgoose , Steven Derek Pringle , Kevil Giles , Jeffery Mark Brown , Paul Murray , Daniel James Kenny
IPC分类号： H01J49/10 , H01J49/00
CPC分类号： H01J49/10 , H01J49/0031 , H01J49/061 , H01J49/065 , H01J49/161
摘要： A pulsed ion source is disclosed wherein the ion source is energised one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other.
摘要翻译：公开了脉冲离子源，其中离子源被激发一次或多次以产生第一组离子和第二组离子。第一和第二组离子同时透过离子导向器同时保持第一和第二组离子彼此隔离。

6. 发明申请

US20130122599A1 Fragmentation Reagents For Mass Spectrometry 审中-公开
标题翻译：用于质谱的碎裂试剂
公开(公告)号：US20130122599A1
公开(公告)日：2013-05-16
申请号：US13522513
申请日：2011-01-31
申请人： Jeffery Mark Brown , Iain Campuzano , Darryl W. Brousmiche , Craig Dorschel , Jonathan Paul Williams , Steven Derek Pringle , Keith Richardson
发明人： Jeffery Mark Brown , Iain Campuzano , Darryl W. Brousmiche , Craig Dorschel , Jonathan Paul Williams , Steven Derek Pringle , Keith Richardson
IPC分类号： G01N33/68 , C07C205/06 , C07C47/55 , C07C255/51 , C07C47/54 , C07C205/44
摘要： A mass spectrometry electron transfer dissociation reagent comprising an unsaturated compound having a Frank Condon factor between 0.1 and 1.0 and an electron affinity having a positive value between 0.1 to 150 kJ/mol.
摘要翻译：一种质谱电子转移离解试剂，其包含Frank Condon因子在0.1至1.0之间的不饱和化合物和具有0.1至150kJ / mol的正值的电子亲和力。

7. 发明授权

US08294088B2 Gas electron multiplier detector 有权
标题翻译：气体电子倍增检测器
公开(公告)号：US08294088B2
公开(公告)日：2012-10-23
申请号：US12745265
申请日：2008-12-01
申请人： Steven Derek Pringle
发明人： Steven Derek Pringle
IPC分类号： H01J49/02
CPC分类号： H01J49/025 , H01J47/02
摘要： A mass spectrometer is disclosed comprising a Gas Electron Multiplier ion detector. The ion detector comprises three gas electron multiplier stages GEM1, GEM2, GEM3 wherein a counter electrode (12) is arranged adjacent the first electron multiplier stage GEM1.
摘要翻译：公开了一种质谱仪，其包括气体电子倍增器离子检测器。离子检测器包括三个气体电子倍增器级GEM1，GEM2，GEM3，其中相对电极（12）被布置为与第一电子倍增器级GEM1相邻。

8. 发明授权

US08153960B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08153960B2
公开(公告)日：2012-04-10
申请号：US11916438
申请日：2006-06-05
申请人： Kevin Giles , Martin Green , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Green , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/26
CPC分类号： H01J49/427 , H01J49/4235
摘要： An ion guide or ion trap (1) is disclosed having an entrance electrode (2) and an exit electrode (3). The potential of the exit electrode (3) is periodically dropped for a relatively short period of time allowing some ions to escape from the ion guide or ion trap (1) via an aperture in the exit electrode (3). The period of time that the potential of the exit electrode (3) is dropped for is progressively increased and ions emerge from the ion guide or ion trap (1) in a mass to charge ratio dependent manner. The ion guide or ion trap (1) may be operated as a mass separator or low resolution mass analyser.
摘要翻译：公开了一种具有入口电极（2）和出口电极（3）的离子导向器或离子阱（1）。出口电极（3）的电位周期性地下降相当短的时间段，允许一些离子通过出射电极（3）中的孔从离子导向器或离子阱（1）逸出。退出电极（3）的电位下降的时间段逐渐增加，并且离子导向器或离子阱（1）以质荷比依赖的方式出现离子。离子导向器或离子阱（1）可以作为质量分离器或低分辨率质量分析器来操作。

9. 发明授权

US08076637B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08076637B2
公开(公告)日：2011-12-13
申请号：US12524378
申请日：2008-01-25
申请人： Steven Derek Pringle , Jason Lee Wildgoose
发明人： Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device. Broadband frequency-signals (13, 14, 15) having a plurality of frequency notches (16a; 16b; 16c) are applied sequentially to the rods of the quadrupole rod set. The notched broadband frequency signals (16a, 16b, 16c) cause undesired ions to be resonantly or parametrically ejected from the ion guide. The resulting ion signals are deconvoluted to provide a mass spectrum.
摘要翻译：公开了一种质谱仪，其包括四极棒离子导向器或质量过滤器装置。具有多个频率切口（16a; 16b; 16c）的宽带频率信号（13,14,15）被依次施加到四极杆组的杆上。缺口宽带频率信号（16a，16b，16c）使离子引导不需要的离子共振或参数地喷出。所得到的离子信号被去卷积以提供质谱。

10. 发明申请

US20090194688A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20090194688A1
公开(公告)日：2009-08-06
申请号：US11719665
申请日：2005-11-18
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/4215 , H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device (6). A broadband frequency signal (10) having one or more notches (11a, 11b, 11c) is applied to the rods of the quadrupole rod set (6). The notched broadband frequency signal (10) causes undesired ions to be resonantly ejected from the ion guide (6). The notched broadband frequency signal (10) has frequency components missing which correspond with the resonance frequency of ions which are desired to be onwardly transmitted. The ion guide or mass filter device (6) enables a plurality of desired ions having different mass to charge ratios to be simultaneously transmitted by the ion guide or mass filter device (6) whilst other ions are resonantly ejected from the ion guide or mass filter device (6).
摘要翻译：公开了一种质谱仪，其包括四极杆离子导向器或质量过滤装置（6）。具有一个或多个凹口（11a，11b，11c）的宽频率信号（10）被施加到四极杆组（6）的杆上。有缺口的宽带频率信号（10）使不想要的离子从离子导向器（6）共振地弹出。缺口宽带频率信号（10）具有与期望向前发射的离子的谐振频率相对应的频率分量。离子导向器或质量过滤装置（6）使得具有不同质荷比的多个所需离子能够由离子导向器或质量过滤装置（6）同时传输，而其它离子从离子导向器或质量过滤器装置（6）。

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