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1. 发明申请

US20120276578A1 Phasor Method to Fluorescence Lifetime Microscopy to Discriminate Metabolic State of Cells in Living Tissue 审中-公开
标题翻译：荧光终生显微镜的相量方法来鉴别生活组织中细胞的代谢状态
公开(公告)号：US20120276578A1
公开(公告)日：2012-11-01
申请号：US13283356
申请日：2011-10-27
申请人： Chiara Stringari , Enrico Gratton , Michelle Digman , Peter Donovan
发明人： Chiara Stringari , Enrico Gratton , Michelle Digman , Peter Donovan
IPC分类号： G01N21/64 , C12M1/34
CPC分类号： G01N21/6486 , G01N21/6408 , G01N21/6458
摘要： “A label-free imaging method to monitor stem cell metabolism discriminates different states of stem cell as they differentiate in a living tissues. We use intrinsic fluorescence biomarkers and the phasor approach to Fluorescence Lifetime Imaging Microscopy (FLIM). We identify and map intrinsic fluorophores such as collagen, retinol, retinoic acid, flavins, nicotinamide adenine dinucleotide (NADH) and porphyrin. We measure the phasor values of germ cells in C. Elegans germ line. Their metabolic fingerprint cluster according to their differentiation state, reflecting changes in FAD concentration and NADH binding during the differentiation pathway. The phasor approach to lifetime imaging provides a label-free, fit-free and sensitive method to identify different metabolic state of cells during differentiation, to sense small changes in the redox state of cells and may identify symmetric and asymmetric divisions and predict cell fate.”
摘要翻译：监测干细胞代谢的无标记成像方法会区分干细胞在活组织中分化的不同状态。我们使用内在荧光生物标志物和荧光寿命成像显微镜（FLIM）的相量方法。我们识别和映射内在的荧光团，如胶原，视黄醇，视黄酸，黄素，烟酰胺腺嘌呤二核苷酸（NADH）和卟啉。我们测量C. Elegans种系中生殖细胞的相量值。他们的代谢指纹簇根据其分化状态，反映分化途径中FAD浓度和NADH结合的变化。终生成像的相量方法提供了无标记，无配对和敏感的方法，以鉴别细胞在分化期间的不同代谢状态，以感测细胞氧化还原状态的小变化，并且可以鉴定对称和不对称分裂并预测细胞命运。

2. 发明授权

US10222335B2 Phasor method to fluorescence lifetime microscopy to discriminate metabolic state of cells in living tissue 有权
公开(公告)号：US10222335B2
公开(公告)日：2019-03-05
申请号：US13283356
申请日：2011-10-27
申请人： Chiara Stringari , Enrico Gratton , Michelle Digman , Peter Donovan
发明人： Chiara Stringari , Enrico Gratton , Michelle Digman , Peter Donovan
IPC分类号： G01N21/64
摘要： A label-free imaging method to monitor stem cell metabolism discriminates different states of stem cell as they differentiate in a living tissues. We use intrinsic fluorescence biomarkers and the phasor approach to Fluorescence Lifetime Imaging Microscopy (FLIM). We identify and map intrinsic fluorophores such as collagen, retinol, retinoic acid, flavins, nicotinamide adenine dinucleotide (NADH) and porphyrin. We measure the phasor values of germ cells in C. Elegans germ line. Their metabolic fingerprint cluster according to their differentiation state, reflecting changes in FAD concentration and NADH binding during the differentiation pathway. The phasor approach to lifetime imaging provides a label-free, fit-free and sensitive method to identify different metabolic state of cells during differentiation, to sense small changes in the redox state of cells and may identify symmetric and asymmetric divisions and predict cell fate.

3. 发明授权

US07525913B2 System and method for providing gaps between data elements at ingress to a network element 有权
标题翻译：在网络元素入口处的数据元素之间提供间隙的系统和方法
公开(公告)号：US07525913B2
公开(公告)日：2009-04-28
申请号：US10195492
申请日：2002-07-16
申请人： Mark Jason Thibodeau , John William Galway , Jason Sterne , Michael Wayne Mitchell , Peter Donovan
发明人： Mark Jason Thibodeau , John William Galway , Jason Sterne , Michael Wayne Mitchell , Peter Donovan
IPC分类号： H04L12/26 , H04L12/56
CPC分类号： H04L12/5601 , H04L47/263 , H04L47/30 , H04L49/506 , H04L2012/5635 , H04L2012/5674 , H04L2012/5679 , H04L2012/5681
摘要： The invention provides a system and method of controlling timing of release of traffic for a communication switch. The traffic originates from at least one source, is directed to a common ingress point of the switch and is directed to a common egress point in the switch. The egress point has a maximum egress transmission rate. The traffic has at least one datastream. Each datastream has a requested transmission rate. The method comprises, for each datastream, establishing a maximum cell release rate such that a sum of each of the maximum cell release rate does not exceed the maximum egress transmission rate and utilizing the maximum cell release rate to govern release of local traffic in the datastream from the ingress point.
摘要翻译：本发明提供了一种用于控制通信交换机的业务释放定时的系统和方法。交通源自至少一个源，被引导到交换机的公共入口点，并被引导到交换机中的公共出口点。出口点具有最大出口传输速率。流量至少有一个数据流。每个数据流都有一个请求的传输速率。该方法包括：对于每个数据流，建立最大小区释放速率，使得每个最大小区释放速率的总和不超过最大出口传输速率，并利用最大小区释放速率来管理数据流中本地业务的释放从入口点。

4. 发明授权

US07254112B2 System and method for reassembling packets in a network element 有权
标题翻译：用于在网络元件中重新组装数据包的系统和方法
公开(公告)号：US07254112B2
公开(公告)日：2007-08-07
申请号：US10294630
申请日：2002-11-15
申请人： Jerome Cornet , John C. Fischer , Jason Sterne , Peter Donovan
发明人： Jerome Cornet , John C. Fischer , Jason Sterne , Peter Donovan
IPC分类号： H04L12/28 , H04L12/66 , H04J1/16 , H04J3/22 , H04J3/24
CPC分类号： H04L12/5601 , H04L45/30 , H04L49/258 , H04L49/3081 , H04L49/9094 , H04L2012/5653 , H04L2012/5665
摘要： A method and apparatus for sending packets from traffic flows to queues in a network element is provided. Each traffic flow has a packet size parameter indicating a sizing constraint for its packets. The method includes the step of grouping the traffic flows into groups utilizing the packet size parameter of each traffic flow. The method further includes the step of sending packets only from traffic flows of one group to at least one designated queue. Traffic flows of the one group are identified utilizing the packet size parameter of each traffic flow.
摘要翻译：提供了一种从网络元件将流量从数据包发送到队列的方法和装置。每个流量具有指示其分组的大小约束的分组大小参数。该方法包括利用每个业务流的分组大小参数将业务流分组成组的步骤。该方法还包括仅从一个组的业务流发送分组到至少一个指定队列的步骤。使用每个业务流的分组大小参数来识别一组的业务流。

5. 发明申请

US20060242400A1 Server blade network boot method that minimizes required network bandwidth 有权
标题翻译：服务器刀片式网络引导方法，可最大限度地减少所需的网络带宽
公开(公告)号：US20060242400A1
公开(公告)日：2006-10-26
申请号：US11112132
申请日：2005-04-22
申请人： Jeffrey Anderson , Simon Chu , Richard Dayan , Peter Donovan
发明人： Jeffrey Anderson , Simon Chu , Richard Dayan , Peter Donovan
IPC分类号： G06F9/00
CPC分类号： G06F9/4405
摘要： A method and system for remotely booting a plurality of server blades in a BLADECENTER® and for updating each blade without the need for an administrator to access each blade via a separate user identification number and corresponding password. A temporary virtual local area network is created to provide an out-of-band communication channel between a management module and the plurality of server blades. The management module receives and saves the original boot sequence for each server blade and alters each boot sequence such that each server blade begins with a network boot. After receiving an initial transmission over the network containing server blade boot instructions and storing the boot instructions in a temporary boot server, subsequent server blade boot requests from the network are intercepted and the stored boot instructions are re-routed from the temporary boot server to each of the remaining blades in the blade server thus removing the need for repeated boot packet transmission over the network.
摘要翻译：一种用于在BLADECENTER中远程启动多个服务器刀片并且用于更新每个刀片而不需要管理员通过单独的用户标识号和对应密码访问每个刀片的方法和系统。创建临时虚拟局域网以在管理模块和多个服务器刀片之间提供带外通信信道。管理模块接收并保存每个服务器刀片的原始引导顺序，并更改每个引导顺序，以使每个服务器刀片以网络引导开始。在收到包含服务器刀片引导指令的网络上的初始传输并将引导指令存储在临时引导服务器中之后，将拦截来自网络的后续服务器刀片引导请求，并将存储的引导指令从临时引导服务器重新路由到每个的刀片服务器中的剩余刀片，从而消除了对通过网络重复引导分组传输的需要。

6. 发明申请

US20090166976A1 INFLATABLE SEAL, SET OF FLANGE PARTS AND CONTAINER COMPRISING SUCH SEAL, AND METHOD OF MANUFACTURING SUCH SEAL 审中-公开
标题翻译：可充气密封件，法兰部件组和包括这种密封件的容器，以及制造这种密封件的方法
公开(公告)号：US20090166976A1
公开(公告)日：2009-07-02
申请号：US12298636
申请日：2006-04-28
申请人： Lars Rubner-Petersen , John Peter Donovan
发明人： Lars Rubner-Petersen , John Peter Donovan
IPC分类号： F16J15/48 , F16J15/50 , B29C45/00
CPC分类号： F16J15/46 , B01J19/0073
摘要： An inflatable seal for sealing an annular space between two flange parts is formed by a hollow ring composed of elastic material. The hollow ring has a tubular cross-section with a peripheral wall and is provided with a connection for an inflation medium. The peripheral wall comprises, in at least one area of the tubular cross-section, a blocking element having a substantially larger cross-sectional dimension than the remaining part of the peripheral wall. Furthermore, a set of flange parts and a container comprising such a seal, and a method of manufacturing such a seal are disclosed.
摘要翻译：用于密封两个凸缘部分之间的环形空间的可充气密封件由弹性材料构成的中空环形成。该空心环具有带有周壁的管状横截面并且具有用于充气介质的连接。周壁在管状横截面的至少一个区域中包括具有比周壁的其余部分大得多的横截面尺寸的阻挡元件。此外，公开了一组凸缘部件和包括这种密封件的容器以及制造这种密封件的方法。

7. 发明授权

US07420983B2 Dynamic assignment of re-assembly queues 有权
标题翻译：重新组装队列的动态分配
公开(公告)号：US07420983B2
公开(公告)日：2008-09-02
申请号：US10386702
申请日：2003-03-13
申请人： Peter Donovan
发明人： Peter Donovan
IPC分类号： H04L12/54 , H04L12/56
CPC分类号： H04L45/505 , H04L12/5601 , H04L45/50 , H04L49/90 , H04L49/9094 , H04L2012/5618 , H04L2012/5652 , H04L2012/5667
摘要： Methods and apparatus for the dynamic assignment of re-assembly queues to multiple connections in a communications system are described. In a preferred embodiment of the invention an ATM to MPLS mediation application is implemented. In the mediation process ATM cells are assigned to re-assembly queues where they are converted to MPLS packets for transmission over a MPLS tunnel. Typically there are many more connections than re-assembly queues which necessitates a dynamic assignment of the re-assembly queues to ensure efficient operation of the system. Re-assembly queues are serviced based on either a cell count or a timing factor.
摘要翻译：描述了将通信系统中的重新组装队列动态分配给多个连接的方法和装置。在本发明的优选实施例中，实现了ATM到MPLS中介应用。在中介过程中，ATM信元被分配给重新组装队列，在那里它们被转换成MPLS数据包，以便通过MPLS隧道进行传输。通常，存在比重新组装队列更多的连接，这需要重新组装队列的动态分配以确保系统的有效操作。基于单元计数或时序因子对重新组装队列进行服务。

8. 发明授权

US06298656B1 Compressed air steam generator for cooling combustion turbine transition section 有权
标题翻译：用于冷却燃气轮机过渡段的压缩空气蒸汽发生器
公开(公告)号：US06298656B1
公开(公告)日：2001-10-09
申请号：US09677043
申请日：2000-09-29
申请人： Jon Peter Donovan , Michael Todd McManus
发明人： Jon Peter Donovan , Michael Todd McManus
IPC分类号： F02C618
CPC分类号： F02C7/18 , F01D25/12 , F02C6/18 , F05D2260/2322
摘要： A cooling system for a combustion turbine transition section. The combustion turbine includes a compressor assembly with a compressed air bleed line, a combustor assembly, a transition section with integral cooling channels, a turbine assembly with integral cooling channels. The compressor assembly is coupled to the combustor assembly, the combustor assembly is further coupled to the transition section, the transition section is further coupled to the turbine assembly. The compressor assembly, combustor assembly, transition section, and turbine assembly form a flow path. The cooling device includes a compressed air steam generator, a feed water source coupled to, and providing water to, the compressed air steam generator, a steam pipe coupled to the transition section cooling channels and the compressed air steam generator. The compressed air bleed line passes through the compressed air steam generator. In operation, the compressor compresses the ambient air thereby raising the ambient air temperature. The majority of the compressed air flows into the combustor assembly where it is mixed with a fuel and ignited. A portion of the hot compressed air is directed to the compressed air steam generator and converts water in the compressed air steam generator into steam. The steam passes through the steam pipe into the transition section cooling channels, thereby cooling the transition section.
摘要翻译：一种用于燃气轮机过渡部分的冷却系统。燃气轮机包括具有压缩空气排放管线的压缩机组件，燃烧器组件，具有整体冷却通道的过渡部分，具有整体冷却通道的涡轮组件。压缩机组件联接到燃烧器组件，燃烧器组件进一步联接到过渡部分，过渡部分进一步联接到涡轮组件。压缩机组件，燃烧器组件，过渡部分和涡轮组件形成流动路径。冷却装置包括压缩空气蒸汽发生器，与压缩空气蒸汽发生器耦合并向其提供水的给水源，耦合到过渡段冷却通道的蒸汽管和压缩空气蒸汽发生器。压缩空气排出管线通过压缩空气蒸汽发生器。在运行中，压缩机压缩环境空气，从而提高环境空气温度。大部分压缩空气流入燃烧器组件，在那里与燃料混合并点燃。一部分热压缩空气被引导到压缩空气蒸汽发生器并将压缩空气蒸汽发生器中的水转化为蒸汽。蒸汽通过蒸汽管进入过渡段冷却通道，从而冷却过渡段。

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