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1. 发明申请

US20100179634A1 Methods and Devices for Delivery of Prosthetic Heart Valves and Other Prosthetics 审中-公开
公开(公告)号：US20100179634A1
公开(公告)日：2010-07-15
申请号：US12611025
申请日：2009-11-02
申请人： David C. Forster , Scott Heneveld , Brandon G. Walsh , Brian Beckey
发明人： David C. Forster , Scott Heneveld , Brandon G. Walsh , Brian Beckey
IPC分类号： A61F2/84
CPC分类号： A61F2/2439 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2/2436 , A61F2002/9522 , A61F2220/005 , A61F2220/0058 , A61F2230/0023 , A61F2250/0003
摘要： Prosthetic valves and their component parts are described, as are prosthetic valve delivery devices and methods for their use. The prosthetic valves are particularly adapted for use in percutaneous aortic valve replacement procedures. The delivery devices are particularly adapted for use in minimally invasive surgical procedures. The preferred delivery device includes a catheter having a deployment mechanism attached to its distal end, and a handle mechanism attached to its proximal end. A plurality of tethers are provided to selectively restrain the valve during deployment. A number of mechanisms for active deployment of partially expanded prosthetic valves are also described.

2. 发明申请

US20090254177A1 Method and Apparatuses for Deploying Minimally-Invasive Heart Valves 有权
标题翻译：用于部署微创心脏瓣膜的方法和装置
公开(公告)号：US20090254177A1
公开(公告)日：2009-10-08
申请号：US12488480
申请日：2009-06-19
申请人： Jibin Yang , Matthew Lane Pease , Scott Hyler Heneveld, SR. , Brandon G. Walsh
发明人： Jibin Yang , Matthew Lane Pease , Scott Hyler Heneveld, SR. , Brandon G. Walsh
IPC分类号： A61F2/24
CPC分类号： A61F2/243 , A61F2/2409 , A61F2/2412 , A61F2/2427
摘要： A system for delivering and deploying a self-expandable heart valve to a site of implantation such as the aortic annulus includes a deployment mechanism that engages the valve and regulates the rate of expansion of both the proximal and distal ends thereof. The heart valve may be a rolled-type valve and the deployment mechanism may include a plurality of distal fingers and a plurality of proximal fingers that engage the outer layer of the head valve. Controlled radial movement of the fingers regulates the unwinding of the rolled heart valve. The fingers may be removed prior to inflation of a balloon to fully expand the valve, or the fingers may be repositioned to the inside of the valve for this purpose. The deployment mechanism may include an umbrella structure that forces the rolled valve outward into its fully expanded configuration. Alternatively, a gear shaft that engages one or more gear tracks on the valve may be utilized to regulate expansion of the valve. A stabilization balloon may be used to axially and radially locate the deployment mechanism relative to the site of implantation. Methods of operation of the delivery and deployment mechanism include regulating the rate of self-expansion of the valve and forcing the valve outward into its fully expanded configuration utilizing the same or different means.
摘要翻译：用于将自扩张心脏瓣膜递送和部署到诸如主动脉瓣环的植入部位的系统包括与阀门接合并调节其近端和远端的膨胀速率的展开机构。心脏瓣膜可以是卷状阀，并且展开机构可以包括多个远侧指状物和与头部阀门的外层接合的多个近端指状物。手指的受控径向运动调节卷绕的心脏瓣膜的展开。在气囊膨胀之前可以将手指移除以完全膨胀阀，或者为了这个目的，手指可以重新定位到阀的内部。展开机构可以包括伞形结构，其将卷起的阀向外推入其完全展开的构型。或者，与阀上的一个或多个齿轮啮合的齿轮轴可用于调节阀的膨胀。可以使用稳定气囊来相对于植入位置轴向地和径向地定位展开机构。输送和展开机构的操作方法包括利用相同或不同的装置来调节阀的自膨胀速率并迫使阀向外进入其完全膨胀的构型。

3. 发明授权

US08740975B2 Methods and apparatuses for deploying minimally-invasive heart valves 有权
标题翻译：用于部署微创心脏瓣膜的方法和装置
公开(公告)号：US08740975B2
公开(公告)日：2014-06-03
申请号：US12488480
申请日：2009-06-19
申请人： Jibin Yang , Matthew Lane Pease , Scott Hyler Heneveld, Sr. , Brandon G. Walsh
发明人： Jibin Yang , Matthew Lane Pease , Scott Hyler Heneveld, Sr. , Brandon G. Walsh
IPC分类号： A61F2/24
CPC分类号： A61F2/243 , A61F2/2409 , A61F2/2412 , A61F2/2427
摘要： A method for delivering and deploying a self-expandable heart valve to a site of implantation such as the aortic annulus. The deployment step may include engaging an outer surface of the heart valve with a plurality of distal fingers and a plurality of proximal fingers. Controlled radial movement of the fingers regulates the expansion of the heart valve. The fingers may be removed prior to inflation of a balloon to fully expand the valve, or the fingers may be repositioned to the inside of the valve for this purpose. The deployment step may include an umbrella structure that forces the valve outward into its fully expanded configuration. Alternatively, a gear shaft that engages one or more gear tracks on the valve may be utilized to regulate expansion of the valve. A stabilization balloon may be used to axially and radially locate the deployment mechanism relative to the site of implantation.
摘要翻译：用于将自扩张型心脏瓣膜递送和部署到诸如主动脉环的植入部位的方法。展开步骤可以包括使心脏瓣膜的外表面与多个远端指状物和多个近端指状物接合。手指的受控径向运动调节心脏瓣膜的扩张。在气囊膨胀之前可以将手指移除以完全膨胀阀，或者为了这个目的，手指可以重新定位到阀的内部。展开步骤可以包括将阀门向外推入其完全展开构型的伞形结构。或者，与阀上的一个或多个齿轮啮合的齿轮轴可用于调节阀的膨胀。可以使用稳定气囊来相对于植入位置轴向地和径向地定位展开机构。

4. 发明授权

US08632579B2 Bifurcated stent and delivery system 失效
标题翻译：分叉支架和分娩系统
公开(公告)号：US08632579B2
公开(公告)日：2014-01-21
申请号：US12882726
申请日：2010-09-15
申请人： Gregory G. Brucker , Enrique Malaret , Todd Hall , David Byrd , Gerald Hubbs , Gregory Furnish , Josh Barber , Indaka Gunasekara , Benjamin Morris , Valerie Futral Maron , Sava A. Chernomordik , William C. Mers Kelly , William A. Reuss, Jr. , Simon Furnish , Michael W. Wilson , Hacene Bouadi , John C. Muskivitch , Matthew L. Pease , David A. Rahdert , Travis Rowe , Gregory M. Ruhf , Brandon G. Walsh , Claude A. Vidal , Thomas Banks , Russ J. Redmond
发明人： Gregory G. Brucker , Enrique Malaret , Todd Hall , David Byrd , Gerald Hubbs , Gregory Furnish , Josh Barber , Indaka Gunasekara , Benjamin Morris , Valerie Futral Maron , Sava A. Chernomordik , William C. Mers Kelly , William A. Reuss, Jr. , Simon Furnish , Michael W. Wilson , Hacene Bouadi , John C. Muskivitch , Matthew L. Pease , David A. Rahdert , Travis Rowe , Gregory M. Ruhf , Brandon G. Walsh , Claude A. Vidal , Thomas Banks , Russ J. Redmond
IPC分类号： A61F2/06
CPC分类号： A61F2/856 , A61F2/954 , A61F2/958 , A61F2/966 , A61F2/97 , A61F2002/061 , A61F2002/821 , A61F2002/9583 , A61F2250/006
摘要： Systems for delivering a bifurcated stent to a bifurcation site include catheters and/or bifurcated systems delivered therefrom. A catheter includes a balloon with a bulge region that allows a portion of the stent to be expanded.
摘要翻译：将分叉支架输送到分叉部位的系统包括从其输送的导管和/或分叉系统。导管包括具有允许支架的一部分扩张的凸起区域的气囊。

5. 发明申请

US20120179243A1 METHODS AND APPARATUSES FOR DEPLOYING MINIMALLY-INVASIVE HEART VALVES 有权
标题翻译：用于配置微小入场心脏瓣膜的方法和装置
公开(公告)号：US20120179243A1
公开(公告)日：2012-07-12
申请号：US13350730
申请日：2012-01-13
申请人： Jibin Yang , Scott Hyler Heneveld, SR. , Matthew Lane Pease , Brandon G. Walsh
发明人： Jibin Yang , Scott Hyler Heneveld, SR. , Matthew Lane Pease , Brandon G. Walsh
IPC分类号： A61F2/24
CPC分类号： A61F2/243 , A61F2/2409 , A61F2/2412 , A61F2/2427
摘要： A method for replacing native valve function of a diseased aortic valve in a patient is provided. The method comprises: (a) guiding a catheter system having a balloon through the vasculature of the patient; (b) guiding an artificial heart valve assembly through the vasculature of the patient; (c) while the catheter system is in the patient's vasculature, positioning the artificial heart valve assembly about the balloon of the catheter system; (d) delivering the artificial heart valve assembly to the region of the diseased aortic valve; (e) while the patient's heart is beating, expanding the artificial heart valve assembly in the region of the diseased aortic valve; and (f) withdrawing the catheter system from the patient's vasculature.
摘要翻译：提供了一种用于替换患者中患病主动脉瓣的天然瓣膜功能的方法。该方法包括：（a）通过患者的脉管系统引导具有气囊的导管系统; （b）引导人造心脏瓣膜组件通过患者的脉管系统; （c）当导管系统处于患者脉管系统中时，将人造心脏瓣膜组件围绕导管系统的球囊定位; （d）将人造心脏瓣膜组件递送到患病主动脉瓣的区域; （e）当患者的心脏跳动时，在患病主动脉瓣的区域内扩张人造心脏瓣膜组件; 和（f）将导管系统从患者的脉管系统中取出。

6. 发明授权

US07947072B2 Two-part expandable heart valve 有权
标题翻译：两部分可扩张心脏瓣膜
公开(公告)号：US07947072B2
公开(公告)日：2011-05-24
申请号：US11749722
申请日：2007-05-16
申请人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
发明人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/2436 , A61F2/848 , A61F2/91 , A61F2/92 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2250/006 , Y10S623/90
摘要： Expandable heart valves for minimally invasive valve replacement surgeries are disclosed. The valves are rolled into a first, contracted configuration for minimally invasive delivery and then unrolled or unfurled at the implantation site. One- and two-piece stents may be used in conjunction with a plurality of flexible leaflet-forming membranes. The one-piece stents may include an annulus anchoring section, a sinus section with the membranes attached over sinus apertures, and a rigid outflow section. The two-piece stent may include a primary stent to provide a tubular base at the annulus, and a secondary stent having the membranes that couples within the primary stent. Lockout tabs to secure the stents in their expanded shapes are provided. Also, alignment structure may be provided to ensure concentric unfurling. Anchoring barbs at the stent edges or in the stent body secure the valve within the annulus. Methods of implantation are also provided.
摘要翻译：公开了用于微创瓣膜置换手术的可扩张心脏瓣膜。这些阀门被卷入第一个收缩构造，用于微创输送，然后在植入部位展开或展开。单件和两件式支架可与多个柔性成叶膜结合使用。一体式支架可以包括环形锚固部分，具有附着在窦口上的膜的窦部分和刚性流出部分。两件式支架可以包括在环形空间处提供管状基部的主支架，以及具有在主支架内连接的膜的辅助支架。提供锁定标签以将支架固定在其扩展形状中。此外，可以提供对准结构以确保同心展开。在支架边缘或支架主体中锚定倒钩固定瓣膜内的瓣膜。还提供了植入方法。

7. 发明申请

US20100256750A1 Prosthetic Heart Valves, Scaffolding Structures, and Systems and Methods for Implantation of Same 审中-公开
公开(公告)号：US20100256750A1
公开(公告)日：2010-10-07
申请号：US12755655
申请日：2010-04-07
申请人： David C. Forster , Scott Heneveld , Brandon G. Walsh
发明人： David C. Forster , Scott Heneveld , Brandon G. Walsh
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2220/0008 , A61F2220/0016 , A61F2220/0033 , A61F2220/005 , A61F2220/0091 , A61F2230/0013 , A61F2230/005 , A61F2230/0091 , A61F2250/001 , A61F2250/006 , A61F2250/0063
摘要： Prosthetic valves and their component parts are described, as are prosthetic valve delivery devices and methods for their use. The prosthetic valves are particularly adapted for use in percutaneous aortic valve replacement procedures. The delivery devices are particularly adapted for use in minimally invasive surgical procedures.

8. 发明授权

US07758634B2 Bifurcated stent and delivery system 失效
标题翻译：分叉支架和分娩系统
公开(公告)号：US07758634B2
公开(公告)日：2010-07-20
申请号：US11726144
申请日：2007-03-21
申请人： Gregory G. Brucker , Enrique Malaret , Todd Hall , David Byrd , Gerald Hubbs , Gregory Furnish , Josh Barber , Indaka Gunasekara , Benjamin Morris , Valerie Futral , Sava A. Chernomordik , William C. Mers Kelly , William A. Reuss , Simon Furnish , Michael A. Wilson , Hacene Bouadi , John C. Muskivitch , Matthew L. Pease , David A. Rahdert , Travis Rowe , Gregory M. Ruhf , Brandon G. Walsh , Thomas Banks , Russ Redmond , Claude Vidal
发明人： Gregory G. Brucker , Enrique Malaret , Todd Hall , David Byrd , Gerald Hubbs , Gregory Furnish , Josh Barber , Indaka Gunasekara , Benjamin Morris , Valerie Futral , Sava A. Chernomordik , William C. Mers Kelly , William A. Reuss , Simon Furnish , Michael A. Wilson , Hacene Bouadi , John C. Muskivitch , Matthew L. Pease , David A. Rahdert , Travis Rowe , Gregory M. Ruhf , Brandon G. Walsh , Thomas Banks , Russ Redmond , Claude Vidal
IPC分类号： A61F2/06
CPC分类号： A61F2/856 , A61F2/954 , A61F2/958 , A61F2/966 , A61F2/97 , A61F2002/061 , A61F2002/821 , A61F2002/9583 , A61F2250/006
摘要： A bifurcated stent includes a first stent section and a second stent section. The first stent section is balloon expandable, has an unexpanded configuration, an expanded configuration, and a tubular wall defining a secondary opening. The secondary stent section is self-expanding and an end of the secondary stent section is engaged to a portion of the tubular wall of the primary stent section defining the secondary opening. The secondary stent section has an unexpanded configuration with a first length and an expanded configuration with a second length where the first length is less than the second length. The secondary stent section is expanded to the expanded configuration after the primary stent section is expanded to the expanded configuration. The secondary stent section forms a portion of the tubular wall of the primary stent section in the unexpanded configuration.
摘要翻译：分支支架包括第一支架部分和第二支架部分。第一支架部分是球囊可膨胀的，具有未膨胀的构造，膨胀的构型和限定次级开口的管状壁。辅助支架部分是自膨胀的，并且次级支架部分的端部接合到限定第二开口的主支架部分的管状壁的一部分。次级支架部分具有第一长度和第二长度的膨胀构造的未膨胀构型，其中第一长度小于第二长度。在将主支架部分扩展到扩张构型之后，将二次支架部分扩大到扩张构型。辅助支架部分以未展开的构型形成主支架部分的管状壁的一部分。

9. 发明申请

US20090132035A1 Prosthetic Heart Valves, Support Structures and Systems and Methods for Implanting the Same 审中-公开
标题翻译：假体心脏瓣膜，支撑结构及其植入系统及方法
公开(公告)号：US20090132035A1
公开(公告)日：2009-05-21
申请号：US12209719
申请日：2008-09-12
申请人： Alex T. Roth , David C. Forster , Brandon G. Walsh , Brian Beckey , Scott Heneveld , Richard S. Ginn
发明人： Alex T. Roth , David C. Forster , Brandon G. Walsh , Brian Beckey , Scott Heneveld , Richard S. Ginn
IPC分类号： A61F2/24 , A61B19/00
CPC分类号： A61F2/2418 , A61F2/2415 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0091 , A61F2230/005
摘要： Prosthetic valves and their component parts are described, as are prosthetic valve delivery devices and methods for their use. The prosthetic valves are particularly adapted for use in percutaneous aortic valve replacement procedures. The delivery devices may be adapted for use in minimally invasive or endovascular surgical procedures.
摘要翻译：描述了假体瓣膜及其组成部分，以及假体瓣膜输送装置及其使用方法。人造瓣膜特别适用于经皮主动脉瓣置换手术。输送装置可适用于微创或血管外手术。

10. 发明授权

US07374571B2 Rolled minimally-invasive heart valves and methods of manufacture 有权
标题翻译：滚动的微创心脏瓣膜和制造方法
公开(公告)号：US07374571B2
公开(公告)日：2008-05-20
申请号：US10286009
申请日：2002-11-01
申请人： Matthew L. Pease , Brandon G. Walsh , Jibin Yang
发明人： Matthew L. Pease , Brandon G. Walsh , Jibin Yang
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/848 , A61F2/92 , A61F2220/0016 , A61F2220/0075
摘要： Expandable heart valves for minimally invasive valve replacement surgeries are disclosed. The valves are rolled into a first, contracted configuration for minimally invasive delivery using a catheter, and then unrolled or unfurled at the implantation site. One- and two-piece stents may be used in conjunction with a plurality of flexible leaflet-forming membranes. The stents may include an annulus section, a sinus section with the membranes attached over sinus apertures, and an outflow section. Lockout tabs and making slots secure the stents in their expanded shapes. Alignment structure ensures concentric unfurling of the stent. Anchoring elements at the stent edges or in the stent body secure the valve within the annulus. A method of manufacture includes shape setting the sheet-like stent to ensure an outward bias during deployment. The stent may also include dear tracks for engagement with a gear mechanism for deployment. The stent is desirably made of a superelastic material such as Nitinol and may have areas removed or thinned to reduce the bending stresses when rolled into its small spiral for catheter delivery.
摘要翻译：公开了用于微创瓣膜置换手术的可扩张心脏瓣膜。使用导管将瓣膜卷成第一收缩构造用于微创递送，然后在植入部位展开或展开。单件和两件式支架可与多个柔性成叶膜结合使用。支架可以包括环形部分，具有附接在窦孔上的膜的窦部分和流出部分。锁定标签和插槽将支架固定在其扩展形状中。对准结构确保支架的同心展开。在支架边缘处或支架主体中的锚定元件将瓣膜固定在环形空间内。一种制造方法包括使片状支架的形状设定，以确保在展开期间向外偏置。支架还可以包括用于与用于展开的齿轮机构接合的亲爱的轨道。支架理想地由诸如镍钛诺的超弹性材料制成，并且可以具有去除或变薄的区域，以便在卷入其用于导管递送的小螺旋时减小弯曲应力。

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