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1. 发明授权

US09241788B2 Method for treating an aortic valve 有权
标题翻译：治疗主动脉瓣的方法
公开(公告)号：US09241788B2
公开(公告)日：2016-01-26
申请号：US13529955
申请日：2012-06-21
申请人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
发明人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
IPC分类号： A61F2/24 , A61F2/848 , A61F2/91 , A61F2/92
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/2436 , A61F2/848 , A61F2/91 , A61F2/92 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2250/006 , Y10S623/90
摘要： Expandable, percutaneously deployable, prosthetic heart valves and systems for minimally invasive replacement of damaged or diseased native aortic valves comprise an expandable, tubular stent body and a unidirectional valve assembly. Embodiments of the stent body comprise an annulus anchoring section, a sinus section, and an outflow section, with the outflow section flared outwardly from the sinus section in an expanded configuration. Embodiments of the stent body are self-expanding, comprising, for example nitinol. The valve assembly disposed within the sinus section of the stent body and sutured thereto. Embodiments of the valve assembly comprise three leaflets, each leaflet comprising a curved outer edge sutured to the sinus section of the stent body, and a coapting free edge. Embodiments of the valve leaflets comprise pericardium, for example, porcine pericardium. Embodiments of the prosthetic heart valve have a contracted configuration dimensioned for percutaneous delivery thereof.
摘要翻译：可扩展的，经皮可展开的假体心脏瓣膜和用于微创更换受损或患病的天然主动脉瓣的系统包括可扩张的管状支架体和单向阀组件。支架主体的实施例包括环形锚固部分，窦部分和流出部分，其中流出部分以扩张构型从窦部向外扩张。支架体的实施例是自膨胀的，包括例如镍钛诺。该阀组件设置在支架主体的窦区内并缝合到其上。瓣膜组件的实施例包括三个小叶，每个小叶包括缝合到支架主体的窦部分的弯曲外边缘以及自由边缘。瓣膜小叶的实施例包括心包膜，例如猪心包膜。假体心脏瓣膜的实施例具有尺寸用于经皮递送的收缩构造。

2. 发明授权

US08206438B2 Prosthetic heart valve having flared outflow section 有权
标题翻译：假性心脏瓣膜有扩张流出部分
公开(公告)号：US08206438B2
公开(公告)日：2012-06-26
申请号：US13029033
申请日：2011-02-16
申请人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
发明人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/2436 , A61F2/848 , A61F2/91 , A61F2/92 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2250/006 , Y10S623/90
摘要： Expandable, percutaneously deployable, prosthetic heart valves and systems for minimally invasive replacement of damaged or diseased native aortic valves comprise an expandable, tubular stent body and a unidirectional valve assembly. Embodiments of the stent body comprise an annulus anchoring section, a sinus section, and an outflow section, with the outflow section flared outward from the sinus section in an expanded configuration. Embodiments of the stent body are self-expanding, comprising, for example nitinol. The valve assembly disposed within the sinus section of the stent body and sutured thereto. Embodiments of the valve assembly comprise three leaflets, each leaflet comprising a curved outer edge sutured to the sinus section of the stent body, and a coapting free edge. Embodiments of the valve leaflets comprise pericardium. Embodiments of the prosthetic heart valve have a contracted configuration dimensioned for percutaneous delivery thereof.
摘要翻译：可扩展的，经皮可展开的假体心脏瓣膜和用于微创更换受损或患病的天然主动脉瓣的系统包括可扩张的管状支架体和单向阀组件。支架主体的实施例包括环形锚定部分，窦部分和流出部分，其中流出部分以扩张构型从窦部向外扩张。支架体的实施例是自膨胀的，包括例如镍钛诺。该阀组件设置在支架主体的窦区内并缝合到其上。瓣膜组件的实施例包括三个小叶，每个小叶包括缝合到支架主体的窦部分的弯曲外边缘以及自由边缘。瓣膜小叶的实施例包括心包。假体心脏瓣膜的实施例具有尺寸用于经皮递送的收缩构造。

3. 发明授权

US07276084B2 Rolled minimally invasive heart valves 有权
标题翻译：滚动微创心脏瓣膜
公开(公告)号：US07276084B2
公开(公告)日：2007-10-02
申请号：US10653843
申请日：2003-09-02
申请人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
发明人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/2436 , A61F2/848 , A61F2/91 , A61F2/92 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2250/006 , Y10S623/90
摘要： Expandable heart valves for minimally invasive valve replacement surgeries are disclosed. The valves are rolled into a first, contracted configuration for minimally invasive delivery and then unrolled or unfurled at the implantation site. One- and two-piece stents may be used in conjunction with a plurality of flexible leaflet-forming membranes. The one-piece stents may include an annulus anchoring section, a sinus section with the membranes attached over sinus apertures, and a rigid outflow section. The two-piece stent may include a primary stent to provide a tubular base at the annulus, and a secondary stent having the membranes that couples within the primary stent. Lockout tabs to secure the stents in their expanded shapes are provided. Also, alignment structure may be provided to ensure concentric unfurling. Anchoring barbs at the stent edges or in the stent body secure the valve within the annulus. Methods of implantation are also provided.
摘要翻译：公开了用于微创瓣膜置换手术的可扩张心脏瓣膜。这些阀门被卷入第一个收缩构造，用于微创输送，然后在植入部位展开或展开。单件和两件式支架可与多个柔性成叶膜结合使用。一体式支架可以包括环形锚固部分，具有附着在窦口上的膜的窦部分和刚性流出部分。两件式支架可以包括在环形空间处提供管状基部的主支架，以及具有在主支架内连接的膜的辅助支架。提供锁定标签以将支架固定在其扩展形状中。此外，可以提供对准结构以确保同心展开。在支架边缘或支架主体中锚定倒钩固定瓣膜内的瓣膜。还提供了植入方法。

4. 发明授权

US07947072B2 Two-part expandable heart valve 有权
标题翻译：两部分可扩张心脏瓣膜
公开(公告)号：US07947072B2
公开(公告)日：2011-05-24
申请号：US11749722
申请日：2007-05-16
申请人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
发明人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/2436 , A61F2/848 , A61F2/91 , A61F2/92 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2250/006 , Y10S623/90
摘要： Expandable heart valves for minimally invasive valve replacement surgeries are disclosed. The valves are rolled into a first, contracted configuration for minimally invasive delivery and then unrolled or unfurled at the implantation site. One- and two-piece stents may be used in conjunction with a plurality of flexible leaflet-forming membranes. The one-piece stents may include an annulus anchoring section, a sinus section with the membranes attached over sinus apertures, and a rigid outflow section. The two-piece stent may include a primary stent to provide a tubular base at the annulus, and a secondary stent having the membranes that couples within the primary stent. Lockout tabs to secure the stents in their expanded shapes are provided. Also, alignment structure may be provided to ensure concentric unfurling. Anchoring barbs at the stent edges or in the stent body secure the valve within the annulus. Methods of implantation are also provided.
摘要翻译：公开了用于微创瓣膜置换手术的可扩张心脏瓣膜。这些阀门被卷入第一个收缩构造，用于微创输送，然后在植入部位展开或展开。单件和两件式支架可与多个柔性成叶膜结合使用。一体式支架可以包括环形锚固部分，具有附着在窦口上的膜的窦部分和刚性流出部分。两件式支架可以包括在环形空间处提供管状基部的主支架，以及具有在主支架内连接的膜的辅助支架。提供锁定标签以将支架固定在其扩展形状中。此外，可以提供对准结构以确保同心展开。在支架边缘或支架主体中锚定倒钩固定瓣膜内的瓣膜。还提供了植入方法。

5. 发明授权

US07374571B2 Rolled minimally-invasive heart valves and methods of manufacture 有权
标题翻译：滚动的微创心脏瓣膜和制造方法
公开(公告)号：US07374571B2
公开(公告)日：2008-05-20
申请号：US10286009
申请日：2002-11-01
申请人： Matthew L. Pease , Brandon G. Walsh , Jibin Yang
发明人： Matthew L. Pease , Brandon G. Walsh , Jibin Yang
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/848 , A61F2/92 , A61F2220/0016 , A61F2220/0075
摘要： Expandable heart valves for minimally invasive valve replacement surgeries are disclosed. The valves are rolled into a first, contracted configuration for minimally invasive delivery using a catheter, and then unrolled or unfurled at the implantation site. One- and two-piece stents may be used in conjunction with a plurality of flexible leaflet-forming membranes. The stents may include an annulus section, a sinus section with the membranes attached over sinus apertures, and an outflow section. Lockout tabs and making slots secure the stents in their expanded shapes. Alignment structure ensures concentric unfurling of the stent. Anchoring elements at the stent edges or in the stent body secure the valve within the annulus. A method of manufacture includes shape setting the sheet-like stent to ensure an outward bias during deployment. The stent may also include dear tracks for engagement with a gear mechanism for deployment. The stent is desirably made of a superelastic material such as Nitinol and may have areas removed or thinned to reduce the bending stresses when rolled into its small spiral for catheter delivery.
摘要翻译：公开了用于微创瓣膜置换手术的可扩张心脏瓣膜。使用导管将瓣膜卷成第一收缩构造用于微创递送，然后在植入部位展开或展开。单件和两件式支架可与多个柔性成叶膜结合使用。支架可以包括环形部分，具有附接在窦孔上的膜的窦部分和流出部分。锁定标签和插槽将支架固定在其扩展形状中。对准结构确保支架的同心展开。在支架边缘处或支架主体中的锚定元件将瓣膜固定在环形空间内。一种制造方法包括使片状支架的形状设定，以确保在展开期间向外偏置。支架还可以包括用于与用于展开的齿轮机构接合的亲爱的轨道。支架理想地由诸如镍钛诺的超弹性材料制成，并且可以具有去除或变薄的区域，以便在卷入其用于导管递送的小螺旋时减小弯曲应力。

6. 发明授权

US06733525B2 Rolled minimally-invasive heart valves and methods of use 有权
标题翻译：滚动的微创心脏瓣膜和使用方法
公开(公告)号：US06733525B2
公开(公告)日：2004-05-11
申请号：US09815521
申请日：2001-03-23
申请人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
发明人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
IPC分类号： A61F224
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/2436 , A61F2/848 , A61F2/91 , A61F2/92 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2250/006 , Y10S623/90
摘要： Expandable heart valves for minimally invasive valve replacement surgeries are disclosed. The valves are rolled into a first, contracted configuration for minimally invasive delivery and then unrolled or unfurled at the implantation site. One- and two-piece stents may be used in conjunction with a plurality of flexible leaflet-forming membranes. The one-piece stents may include an annulus anchoring section, a sinus section with the membranes attached over sinus apertures, and a rigid outflow section. The two-piece stent may include a primary stent to provide a tubular base at the annulus, and a secondary stent having the membranes that couples within the primary stent. Lockout tabs to secure the stents in their expanded shapes are provided. Also, alignment structure may be provided to ensure concentric unfurling. Anchoring barbs at the stent edges or in the stent body secure the valve within the annulus. Methods of implantation are also provided.
摘要翻译：公开了用于微创瓣膜置换手术的可扩张心脏瓣膜。这些阀门被卷入第一个收缩构造，用于微创输送，然后在植入部位展开或展开。单件和两件式支架可与多个柔性成叶膜结合使用。一体式支架可以包括环形锚固部分，具有附着在窦口上的膜的窦部分和刚性流出部分。两件式支架可以包括在环形空间处提供管状基部的主支架，以及具有在主支架内连接的膜的辅助支架。提供锁定标签以将支架固定在其扩展形状中。此外，可以提供对准结构以确保同心展开。在支架边缘或支架主体中锚定倒钩固定瓣膜内的瓣膜。还提供了植入方法。

7. 发明授权

US09452046B2 Methods and apparatuses for deploying minimally-invasive heart valves 有权
标题翻译：用于部署微创心脏瓣膜的方法和装置
公开(公告)号：US09452046B2
公开(公告)日：2016-09-27
申请号：US13350730
申请日：2012-01-13
申请人： Jibin Yang , Matthew L. Pease , Scott H. Heneveld , Brandon G. Walsh
发明人： Jibin Yang , Matthew L. Pease , Scott H. Heneveld , Brandon G. Walsh
IPC分类号： A61F2/24
CPC分类号： A61F2/243 , A61F2/2409 , A61F2/2412 , A61F2/2427
摘要： A method for replacing a diseased aortic valve includes selecting a prosthetic heart valve based on a measurement of a patient's aortic annulus, the prosthetic heart valve stored in a storage container while in an expanded configuration. The preservative solution is drained from the storage container and the prosthetic heart valve is removed. The prosthetic heart valve is compressed to a contracted configuration and advanced through a patient's vasculature along a distal end portion of a catheter system. The prosthetic heart valve is positioned within the diseased aortic valve and re-expanded to an initial expanded configuration. A deployment mechanism is actuated via an operating handle to further expand the prosthetic heart valve into secure engagement with surrounding tissue until lockout features on the prosthetic heart valve secure the prosthetic heart valve in a final expanded configuration.
摘要翻译：用于替换患病主动脉瓣的方法包括基于患者的主动脉环的测量来选择假体心脏瓣膜，所述假体心脏瓣膜在扩张构型中存储在储存容器中。从储存容器中排出防腐剂溶液，除去假体心脏瓣膜。假体心脏瓣膜被压缩成收缩构造并且沿着导管系统的远端部分穿过病人的脉管系统。假体心脏瓣膜位于患病主动脉瓣内，并重新扩张至初始扩张构型。通过操作手柄驱动展开机构，以进一步将假体心脏瓣膜扩展成与周围组织的牢固接合，直到假肢心脏瓣膜上的锁定特征将假体心脏瓣膜固定在最终扩张的构型中。

8. 发明申请

US20130023983A1 METHOD FOR TREATING AN AORTIC VALVE 有权
标题翻译：用于处理动力阀的方法
公开(公告)号：US20130023983A1
公开(公告)日：2013-01-24
申请号：US13529955
申请日：2012-06-21
申请人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
发明人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/2436 , A61F2/848 , A61F2/91 , A61F2/92 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2250/006 , Y10S623/90
摘要： Expandable, percutaneously deployable, prosthetic heart valves and systems for minimally invasive replacement of damaged or diseased native aortic valves comprise an expandable, tubular stent body and a unidirectional valve assembly. Embodiments of the stent body comprise an annulus anchoring section, a sinus section, and an outflow section, with the outflow section flared outwardly from the sinus section in an expanded configuration. Embodiments of the stent body are self-expanding, comprising, for example nitinol. The valve assembly disposed within the sinus section of the stent body and sutured thereto. Embodiments of the valve assembly comprise three leaflets, each leaflet comprising a curved outer edge sutured to the sinus section of the stent body, and a coapting free edge. Embodiments of the valve leaflets comprise pericardium, for example, porcine pericardium. Embodiments of the prosthetic heart valve have a contracted configuration dimensioned for percutaneous delivery thereof.
摘要翻译：可扩展的，经皮可展开的假体心脏瓣膜和用于微创更换受损或患病的天然主动脉瓣的系统包括可扩张的管状支架体和单向阀组件。支架主体的实施例包括环形锚固部分，窦部分和流出部分，其中流出部分以扩张构型从窦部向外扩张。支架体的实施例是自膨胀的，包括例如镍钛诺。该阀组件设置在支架主体的窦区内并缝合到其上。瓣膜组件的实施例包括三个小叶，每个小叶包括缝合到支架主体的窦部分的弯曲外边缘以及自由边缘。瓣膜小叶的实施例包括心包膜，例如猪心包膜。假体心脏瓣膜的实施例具有用于经皮递送的尺寸的收缩构造。

9. 发明申请

US20110137409A1 PROSTHETIC HEART VALVE HAVING FLARED OUTFLOW SECTION 有权
标题翻译：具有弹性流出部分的前置心脏瓣膜
公开(公告)号：US20110137409A1
公开(公告)日：2011-06-09
申请号：US13029033
申请日：2011-02-16
申请人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
发明人： Jibin Yang , Matthew L. Pease , Brandon G. Walsh
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/2436 , A61F2/848 , A61F2/91 , A61F2/92 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2250/006 , Y10S623/90
摘要： Expandable, percutaneously deployable, prosthetic heart valves and systems for minimally invasive replacement of damaged or diseased native aortic valves comprise an expandable, tubular stent body and a unidirectional valve assembly. Embodiments of the stent body comprise an annulus anchoring section, a sinus section, and an outflow section, with the outflow section flared outward from the sinus section in an expanded configuration. Embodiments of the stent body are self-expanding, comprising, for example nitinol. The valve assembly disposed within the sinus section of the stent body and sutured thereto. Embodiments of the valve assembly comprise three leaflets, each leaflet comprising a curved outer edge sutured to the sinus section of the stent body, and a coapting free edge. Embodiments of the valve leaflets comprise pericardium, for example, porcine pericardium. Embodiments of the prosthetic heart valve have a contracted configuration dimensioned for percutaneous delivery thereof.
摘要翻译：可扩展的，经皮可展开的假体心脏瓣膜和用于微创更换受损或患病的天然主动脉瓣的系统包括可扩张的管状支架体和单向阀组件。支架主体的实施例包括环形锚定部分，窦部分和流出部分，其中流出部分以扩张构型从窦部向外扩张。支架体的实施例是自膨胀的，包括例如镍钛诺。该阀组件设置在支架主体的窦区内并缝合到其上。瓣膜组件的实施例包括三个小叶，每个小叶包括缝合到支架主体的窦部分的弯曲外边缘以及自由边缘。瓣膜小叶的实施例包括心包膜，例如猪心包膜。假体心脏瓣膜的实施例具有尺寸用于经皮递送的收缩构造。

10. 发明申请

US20090254177A1 Method and Apparatuses for Deploying Minimally-Invasive Heart Valves 有权
标题翻译：用于部署微创心脏瓣膜的方法和装置
公开(公告)号：US20090254177A1
公开(公告)日：2009-10-08
申请号：US12488480
申请日：2009-06-19
申请人： Jibin Yang , Matthew Lane Pease , Scott Hyler Heneveld, SR. , Brandon G. Walsh
发明人： Jibin Yang , Matthew Lane Pease , Scott Hyler Heneveld, SR. , Brandon G. Walsh
IPC分类号： A61F2/24
CPC分类号： A61F2/243 , A61F2/2409 , A61F2/2412 , A61F2/2427
摘要： A system for delivering and deploying a self-expandable heart valve to a site of implantation such as the aortic annulus includes a deployment mechanism that engages the valve and regulates the rate of expansion of both the proximal and distal ends thereof. The heart valve may be a rolled-type valve and the deployment mechanism may include a plurality of distal fingers and a plurality of proximal fingers that engage the outer layer of the head valve. Controlled radial movement of the fingers regulates the unwinding of the rolled heart valve. The fingers may be removed prior to inflation of a balloon to fully expand the valve, or the fingers may be repositioned to the inside of the valve for this purpose. The deployment mechanism may include an umbrella structure that forces the rolled valve outward into its fully expanded configuration. Alternatively, a gear shaft that engages one or more gear tracks on the valve may be utilized to regulate expansion of the valve. A stabilization balloon may be used to axially and radially locate the deployment mechanism relative to the site of implantation. Methods of operation of the delivery and deployment mechanism include regulating the rate of self-expansion of the valve and forcing the valve outward into its fully expanded configuration utilizing the same or different means.
摘要翻译：用于将自扩张心脏瓣膜递送和部署到诸如主动脉瓣环的植入部位的系统包括与阀门接合并调节其近端和远端的膨胀速率的展开机构。心脏瓣膜可以是卷状阀，并且展开机构可以包括多个远侧指状物和与头部阀门的外层接合的多个近端指状物。手指的受控径向运动调节卷绕的心脏瓣膜的展开。在气囊膨胀之前可以将手指移除以完全膨胀阀，或者为了这个目的，手指可以重新定位到阀的内部。展开机构可以包括伞形结构，其将卷起的阀向外推入其完全展开的构型。或者，与阀上的一个或多个齿轮啮合的齿轮轴可用于调节阀的膨胀。可以使用稳定气囊来相对于植入位置轴向地和径向地定位展开机构。输送和展开机构的操作方法包括利用相同或不同的装置来调节阀的自膨胀速率并迫使阀向外进入其完全膨胀的构型。

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