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1. 发明授权

US08546598B2 Silane compounds having a cyclic carbon chain including an alkyne function for functionalizing solid substrates and immobilizing biological molecules on said substrates 失效
标题翻译：具有环状碳链的硅烷化合物，其包括用于官能化固体底物并将生物分子固定在所述基材上的炔官能团
公开(公告)号：US08546598B2
公开(公告)日：2013-10-01
申请号：US13257326
申请日：2010-03-16
申请人： Aude Bernardin , Guillaume Delapierre , Antoine Hoang , Isabelle Texier-Nogues
发明人： Aude Bernardin , Guillaume Delapierre , Antoine Hoang , Isabelle Texier-Nogues
IPC分类号： C07F7/04 , C40B60/00 , C12M1/34
CPC分类号： C07F7/1804
摘要： The invention relates to a silane compound including a cycloalkyne functionality, to a method for functionalising a solid substrate, and to the solid substrate thus produced. The silane compound of the invention corresponds to the formula X-E-A-Z where X is a silyl group, E is an organic spacer group, A is a single bond or a —CONH—, —NHCO—, —OCH2CONH—, —NHCOCH2O—, —O— or —S— group, and Z is a cycloalkyne or heterocycloalkyne with at least 8 members. The invention is particularly suitable for use in the field of medicine.
摘要翻译：本发明涉及包括环炔官能团的硅烷化合物，固体基质的功能化方法以及如此制备的固体基质。本发明的硅烷化合物对应于式XEAZ，其中X是甲硅烷基，E是有机间隔基团，A是单键或-CONH-，-NHCO-，-OCH 2 CONH-，-NHCOCH 2 O-，-O - 或-S-基团，Z是具有至少8个成员的环炔或杂环炔。本发明特别适用于医药领域。

2. 发明授权

US08541604B2 Process for the functionalization of biological molecules 有权
标题翻译：生物分子功能化的过程
公开(公告)号：US08541604B2
公开(公告)日：2013-09-24
申请号：US12905393
申请日：2010-10-15
申请人： Aude Bernardin , David Bonnaffe , Isabelle Texier-Nogues
发明人： Aude Bernardin , David Bonnaffe , Isabelle Texier-Nogues
IPC分类号： C07D311/82 , C07C229/32
CPC分类号： C07C221/00 , C07B2200/11 , C07C2601/18 , C07D311/82 , C07F7/1804 , C07C225/14
摘要： The present invention is targeted at a novel coupling method of 1,3-dipolar cycloaddition type which is of particular use for the functionalization of biological molecules, such as, for example, proteins, enzymes or nucleic acids, insofar as it can be carried out in an aqueous medium and at ambient temperature.
摘要翻译：本发明针对1,3-偶极环加成型的新型偶联方法，其特别用于生物分子的功能化，例如蛋白质，酶或核酸，只要其可以进行在水性介质中和在环境温度下。

3. 发明授权

US08652360B2 Semiconductor nanocrystals 有权
标题翻译：半导体纳米晶体
公开(公告)号：US08652360B2
公开(公告)日：2014-02-18
申请号：US12555022
申请日：2009-09-08
申请人： Isabelle Texier-Nogues , Aude Bernardin
发明人： Isabelle Texier-Nogues , Aude Bernardin
IPC分类号： H01B1/00 , H01B1/12 , H01R4/42
CPC分类号： G01N33/587 , B82Y15/00 , C07D249/16 , C07D498/08 , G01N33/588
摘要： The present invention aims to provide a method of use for surface-modifying a semiconductor nanocrystal comprising at least the steps consisting in having a semiconductor nanocrystal, the organic coating layer of which is provided, at the outer surface of the nanocrystal, with at least one reactive group G1 that reacts according to a cycloaddition reaction of click chemistry type; and bringing said nanocrystal together with an adjoining material provided at the surface with at least one G2 group complementary to the G1 group with respect to said click chemistry reaction, under conditions favorable to the interaction of said G1 and G2 groups, characterized in that said G1 and G2 groups are respectively an azide and a strained cycloalkynyl radical, or vice versa.
摘要翻译：本发明旨在提供一种用于表面修饰半导体纳米晶体的方法，该方法至少包括在纳米晶体的外表面具有半导体纳米晶体的步骤，其中所述半导体纳米晶体在其纳米晶体的外表面上具有至少一个根据点击化学类型的环加成反应反应的反应性基团G1; 以及在有利于所述G1和G2基团的相互作用的条件下，使所述纳米晶体与在表面处提供有相对于所述点击化学反应互补的至少一个G2基团的邻接材料一起引入，其特征在于所述G1 和G2基团分别是叠氮化物和应变的环炔基基团，反之亦然。

4. 发明授权

US08592619B2 Bifunctional molecules comprising a cycloalkyne or heterocycloalkyne group and a redox group 有权
标题翻译：包含环炔或杂环炔基和氧化还原基团的双功能分子
公开(公告)号：US08592619B2
公开(公告)日：2013-11-26
申请号：US13257365
申请日：2010-03-16
申请人： Guillaume Delapierre , Regis Barattin , Aude Bernardin , Isabelle Texier-Nogues
发明人： Guillaume Delapierre , Regis Barattin , Aude Bernardin , Isabelle Texier-Nogues
IPC分类号： C07F17/02 , H01L45/00 , H01L21/312
CPC分类号： C07F17/02
摘要： The invention relates to compounds comprising a cycloalkyne or heterocycloalkyne group and a redox group. Said compounds are of general formula (I) wherein Z is a cycloalkyne or heterocycloalkyne with at least 8 links, optionally substituted by a halogen atom or a linear or branched C1 to C5 alkyl, A is an organic structure having oxidation-reduction properties, and B is an organic link between the cycloalkyne or heterocycloalkyne cycle and the organic structure A. The invention is especially applicable to the field of molecular electronics.
摘要翻译：本发明涉及包含环炔或杂环炔基和氧化还原基团的化合物。所述化合物具有通式（I），其中Z是具有至少8个连接的环烯烃或杂环炔基，任选被卤素原子或直链或支链C 1至C 5烷基取代，A是具有氧化还原性质的有机结构，和 B是环炔或杂环炔环与有机结构A之间的有机连接。本发明特别适用于分子电子领域。

5. 发明申请

US20120095247A1 METHOD FOR SURFACE FUNCTIONALIZATION BY DISUBSTITUTED ALKYNES 失效
标题翻译：通过分离的烷基表面官能化的方法
公开(公告)号：US20120095247A1
公开(公告)日：2012-04-19
申请号：US13257398
申请日：2010-03-16
申请人： Guillaume Delapierre , Regis Barattin , Aude Bernardin , Isabelle Texier-Nogues
发明人： Guillaume Delapierre , Regis Barattin , Aude Bernardin , Isabelle Texier-Nogues
IPC分类号： C07F17/02
CPC分类号： C07F17/02 , C07B2200/11
摘要： The invention relates to the use of disubstituted alkynes for the functionalisation of the surface of a substrate consisting of a semi-conductor material, with molecules of interest. According to the invention, a compound of formula A-(E1)n1-F1 is used, wherein A is a linear or cyclic disubstituted alkyne, E1 is an alkyl chain and n2 is 0 or 1, and F1 is a reactive group that can react with the reactive group F2 of a compound of formula F2-(E2)n2-X wherein E2 is an alkyl chain and X is a group having properties of interest. The invention is especially applicable to the field of molecular biology or biotechnology.
摘要翻译：本发明涉及二取代炔用于由半导体材料与感兴趣的分子组成的基底的表面官能化的用途。根据本发明，使用式A-（E1）n1-F1的化合物，其中A是直链或环状二取代的炔，E1是烷基链，n2是0或1，F1是可以是与式F2-（E2）n2-X的化合物的反应性基团F2反应，其中E2是烷基链，X是具有感兴趣性质的基团。本发明特别适用于分子生物学或生物技术领域。

6. 发明申请

US20120095203A1 NOVEL SILANE COMPOUNDS HAVING A CYCLIC CARBON CHAIN INCLUDING AN ALKYNE FUNCTION FOR FUNCTIONALISING SOLID SUBSTRATES AND IMMOBILISING BIOLOGICAL MOLECULES ON SAID SUBSTRATES 失效
标题翻译：具有循环碳链的新型硅烷化合物，其包括用于功能性固体基底的碱性官能团和固体底物上的生物分子生物学分子
公开(公告)号：US20120095203A1
公开(公告)日：2012-04-19
申请号：US13257326
申请日：2010-03-16
申请人： Aude Bernardin , Guillaume Delapierre , Antoine Hoang , Isabelle Texier-Nogues
发明人： Aude Bernardin , Guillaume Delapierre , Antoine Hoang , Isabelle Texier-Nogues
IPC分类号： C07H3/02 , C07F7/08
CPC分类号： C07F7/1804
摘要： The invention relates to a silane compound including a cycloalkyne functionality, to a method for functionalising a solid substrate, and to the solid substrate thus produced. The silane compound of the invention corresponds to the formula X-E-A-Z where X is a silyl group, E is an organic spacer group, A is a single bond or a —CONH—, —NHCO—, —OCH2CONH—, —NHCOCH2O—, —0— or —S— group, and Z is a cycloalkyne or heterocycloalkyne with at least 8 members. The invention is particularly suitable for use in the field of medicine.
摘要翻译：本发明涉及包括环炔官能团的硅烷化合物，固体基质的功能化方法以及如此制备的固体基质。本发明的硅烷化合物对应于式XEAZ，其中X为甲硅烷基，E为有机间隔基，A为单键或-CONH-，-NHCO-，-OCH2CONH-，-NHCOCH2O-，-O - 或-S-基团，Z是具有至少8个成员的环炔或杂环炔。本发明特别适用于医药领域。

7. 发明申请

US20110118484A1 PROCESS FOR THE FUNCTIONALIZATION OF BIOLOGICAL MOLECULES 有权
标题翻译：生物分子功能化过程
公开(公告)号：US20110118484A1
公开(公告)日：2011-05-19
申请号：US12905393
申请日：2010-10-15
申请人： Aude Bernardin , David Bonnaffe , Isabelle Texier-Nogues
发明人： Aude Bernardin , David Bonnaffe , Isabelle Texier-Nogues
IPC分类号： C07F7/18 , C07C51/373
CPC分类号： C07C221/00 , C07B2200/11 , C07C2601/18 , C07D311/82 , C07F7/1804 , C07C225/14
摘要： The present invention is targeted at a novel coupling method of 1,3-dipolar cycloaddition type which is of particular use for the functionalization of biological molecules, such as, for example, proteins, enzymes or nucleic acids, insofar as it can be carried out in an aqueous medium and at ambient temperature.
摘要翻译：本发明针对1,3-偶极环加成型的新型偶联方法，其特别用于生物分子的功能化，例如蛋白质，酶或核酸，只要其可以进行在水性介质中并在环境温度下进行。

8. 发明申请

US20100200813A1 SEMICONDUCTOR NANOCRYSTALS 有权
公开(公告)号：US20100200813A1
公开(公告)日：2010-08-12
申请号：US12555022
申请日：2009-09-08
申请人： Isabelle Texier-Nogues , Aude Bernardin
发明人： Isabelle Texier-Nogues , Aude Bernardin
IPC分类号： H01B1/12 , H01L21/302
CPC分类号： G01N33/587 , B82Y15/00 , C07D249/16 , C07D498/08 , G01N33/588
摘要： The present invention aims to provide a method of use for surface-modifying a semiconductor nanocrystal comprising at least the steps consisting in having a semiconductor nanocrystal, the organic coating layer of which is provided, at the outer surface of the nanocrystal, with at least one reactive group G1 that reacts according to a cycloaddition reaction of click chemistry type; and bringing said nanocrystal together with an adjoining material provided at the surface with at least one G2 group complementary to the G1 group with respect to said click chemistry reaction, under conditions favourable to the interaction of said G1 and G2 groups, characterized in that said G1 and G2 groups are respectively an azide and a strained cycloalkynyl radical, or vice versa.
摘要翻译：本发明的目的在于提供一种用于表面修饰半导体纳米晶体的方法，该方法至少包括在纳米晶体的外表面上具有半导体纳米晶体的步骤，该半导体纳米晶体在其纳米晶体的外表面上具有至少一个根据点击化学类型的环加成反应反应的反应性基团G1; 以及在有利于所述G1和G2基团的相互作用的条件下，使所述纳米晶体与在表面处提供有相对于所述点击化学反应互补的至少一个G2基团的邻接材料一起引入，其特征在于所述G1 和G2基团分别是叠氮化物和应变的环炔基基团，反之亦然。

9. 发明授权

US08653291B2 Method for surface functionalization by disubstituted alkynes 失效
标题翻译：二取代炔进行表面官能化的方法
公开(公告)号：US08653291B2
公开(公告)日：2014-02-18
申请号：US13257398
申请日：2010-03-16
申请人： Guillaume Delapierre , Regis Barattin , Aude Bernardin , Isabelle Texier-Nogues
发明人： Guillaume Delapierre , Regis Barattin , Aude Bernardin , Isabelle Texier-Nogues
IPC分类号： C07F17/00 , C07F7/00
CPC分类号： C07F17/02 , C07B2200/11
摘要： The invention relates to the use of disubstituted alkynes for the functionalisation of the surface of a substrate consisting of a semi-conductor material, with molecules of interest. According to the invention, a compound of formula A-(E1)n1-F1 is used, wherein A is a linear or cyclic disubstituted alkyne, E1 is an alkyl chain and n2 is 0 or 1, and F1 is a reactive group that can react with the reactive group F2 of a compound of formula F2-(E2)n2-X wherein E2 is an alkyl chain and X is a group having properties of interest. The invention is especially applicable to the field of molecular biology or biotechnology.
摘要翻译：本发明涉及二取代炔用于由半导体材料与感兴趣的分子组成的基底的表面官能化的用途。根据本发明，使用式A-（E1）n1-F1的化合物，其中A是直链或环状二取代的炔，E1是烷基链，n2是0或1，F1是可以是与式F2-（E2）n2-X的化合物的反应性基团F2反应，其中E2是烷基链，X是具有感兴趣性质的基团。本发明特别适用于分子生物学或生物技术领域。

10. 发明申请

US20120037871A1 NOVEL BIFUNCTIONAL MOLECULES COMPRISING A CYCLOALKYNE OR HETEROCYCLOALKYNE GROUP AND A REDOX GROUP 有权
标题翻译：包含环烷基或杂环基团的新型双功能分子和一个还原基团
公开(公告)号：US20120037871A1
公开(公告)日：2012-02-16
申请号：US13257365
申请日：2010-03-16
申请人： Guillaume Delapierre , Regis Barattin , Aude Bernardin , Isabelle Texier-Nogues
发明人： Guillaume Delapierre , Regis Barattin , Aude Bernardin , Isabelle Texier-Nogues
IPC分类号： H01L45/00 , H01L21/312 , C07F17/02
CPC分类号： C07F17/02
摘要： The invention relates to compounds comprising a cycloalkyne or heterocycloalkyne group and a redox group. Said compounds are of general formula (I) wherein Z is a cycloalkyne or heterocycloalkyne with at least 8 links, optionally substituted by a halogen atom or a linear or branched C1 to C5 alkyl, A is an organic structure having oxidation-reduction properties, and B is an organic link between the cycloalkyne or heterocycloalkyne cycle and the organic structure A. The invention is especially applicable to the field of molecular electronics.
摘要翻译：本发明涉及包含环炔或杂环炔基和氧化还原基团的化合物。所述化合物具有通式（I），其中Z是具有至少8个连接的环烯烃或杂环炔基，任选被卤素原子或直链或支链C 1至C 5烷基取代，A是具有氧化还原性质的有机结构，和 B是环炔或杂环炔环与有机结构A之间的有机连接。本发明特别适用于分子电子领域。

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