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    • 1. 发明公开
    • 티아졸리딘-4-온 유도체, 그 제조방법 및 약제학적 조성물
    • 噻唑烷-4-酮衍生物,其制备方法和含有该衍生物的药物组合物
    • KR1020030089221A
    • 2003-11-21
    • KR1020020027332
    • 2002-05-17
    • 씨제이제일제당 (주)
    • 조일환임지웅박상욱노지영유형철김종훈채명윤박현정정성학연규정진해탁
    • C07D277/14A61P29/00
    • C07D277/14
    • PURPOSE: Thiazolidin-4-one derivatives, a preparation process thereof and a pharmaceutical composition containing the same are provided. The compounds have antifebrile, analgesic and antiphlogistic activities. CONSTITUTION: Thiazolidin-4-one derivatives represented by the formula 1 or nontoxic salts thereof are provided, wherein R1 and R2 are independently hydrogen, C1-C3 alkyl, halogen, halogen substituted methyl, halogen substituted C1-C3 alkoxy, cyano or nitro. A process for preparing the thiazolidin-4-one derivatives of the formula 1 comprises reacting 4-methanesulfonylbenzaldehyde of the formula 2 with aniline derivatives of the formula 3 in the presence of mercaptoacetic acid. A pharmaceutical composition having antifebrile, analgesic and antiphlogistic effects contains the thiazolidin-4-one derivatives of the formula 1 or nontoxic salts thereof and pharmaceutically acceptable carriers.
    • 目的:提供噻唑烷-4-酮衍生物,其制备方法和含有它们的药物组合物。 该化合物具有抗发热,止痛和消炎活性。 构成:提供由式1表示的噻唑烷-4-酮衍生物或其无毒盐,其中R 1和R 2独立地为氢,C 1 -C 3烷基,卤素,卤素取代的甲基,卤素取代的C 1 -C 3烷氧基,氰基或硝基。 制备式1的噻唑烷-4-酮衍生物的方法包括在巯基乙酸的存在下使式2的4-甲磺酰基苯甲醛与式3的苯胺衍生物反应。 具有抗发炎,止痛和消炎作用的药物组合物含有式1的噻唑烷-4-酮衍生物或其无毒盐和药学上可接受的载体。