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1. 发明授权

KR101300232B1 초고감도 자기공명영상 조영제 및 나노 진단-치료 복합 제재로의 응용을 위한 초상자성 나노입자 코팅 방법 및 그 방법으로 코팅된 초상자성 나노입자 및 초상자성 나노입자제재 有权
标题翻译：用于两种高敏感性MRI对比剂和纳米治疗药物应用的超级纳米颗粒的涂覆方法，以及包覆的超级纳米颗粒和涂覆的超级纳米颗粒剂使用该方法
公开(公告)号：KR101300232B1
公开(公告)日：2013-08-26
申请号：KR1020120115504
申请日：2012-10-17
申请人： 천선주
发明人： 배성태 , 전민홍
IPC分类号： A61K49/08 , A61K49/04 , A61K9/16 , A61K47/30
CPC分类号： A61K49/186 , A61K49/085 , B82Y5/00
摘要： PURPOSE: A method for coating superparamagnetic nanoparticles is provided to implement a very thin dual coating layer of oleic acid and methoxy-polyethylene glycol (PEG)-silane on the surface of the superparamagnetic nanoparticles and to have high single dispersion (low PDI). CONSTITUTION: A method for coating superparamagnetic nanoparticles comprises the steps of: adding oleic acid and ammonia to a solution in which the superparamagnetic nanoparticles are dispersed and stirring to form an oleic acid layer on the superparamagnetic nanoparticles; and shaking the solution and a solution containing methoxy-polyethylene glycol (PEG)-silane, triethylamine, and toluene; and quickly mixing two solutions and forming a methoxy-PEG-silane layer. A superparamagnetic nanoparticle formulation is used in magnetic resonance image (MRI) and has a r_2-relaxivity of 800-2000 mM^-1s^-1.
摘要翻译：目的：提供一种涂覆超顺磁性纳米粒子的方法，以在超顺磁性纳米颗粒的表面上实现非常薄的油酸和甲氧基聚乙二醇（PEG） - 硅烷双层涂层，并具有高单分散性（低PDI）。构成：涂覆超顺磁性纳米颗粒的方法包括以下步骤：将油酸和氨添加到其中超顺磁性纳米颗粒分散并搅拌以在超顺磁性纳米颗粒上形成油酸层的溶液中; 摇动溶液和含有甲氧基 - 聚乙二醇（PEG） - 硅烷，三乙胺和甲苯的溶液; 并快速混合两种溶液并形成甲氧基-PEG-硅烷层。在磁共振图像（MRI）中使用超顺磁性纳米颗粒制剂，并且具有800-2000mM ^ -1s ^ -1的r_2-弛豫度。

2. 发明公开

KR1020120077931A 엠알유도 고강도집속초음파 치료 및 진단용 인지질 나노입자 및 이의 제조방법 有权
标题翻译：一种用于MR引导高强度聚焦超声波治疗的磷脂纳米颗粒及其制备方法
公开(公告)号：KR1020120077931A
公开(公告)日：2012-07-10
申请号：KR1020100140070
申请日：2010-12-31
申请人： 삼성전자주식회사
发明人： 최규실 , 최세영 , 임효근 , 임현철 , 김영선
IPC分类号： A61K9/127 , A61K47/48 , A61K47/44 , A61K49/18
CPC分类号： A61K9/127 , A61K41/0028 , A61K47/44 , A61K49/085 , A61K49/1809 , A61K47/50 , A61K49/18
摘要： PURPOSE: A phospholipid nanoparticle for MR-guided high-intensity focused ultrasound treatment and diagnosis is provided to enable hihg-intensity focused ultrasound treatment and monitoring by MR. CONSTITUTION: A phospholipid nanoparticle contains decafluoropentane(C5F12) gas in an internal region of hydrogen. The nanoparticles are is labeled with PEG350 and forms an internal hydrophobic layer by uniformly binding fatty acid chain of phospholipid and hydrophoilic bond of the surfactant. A T1 constrast contains gadolium or ferric oxide.
摘要翻译：目的：提供用于MR引导的高强度聚焦超声治疗和诊断的磷脂纳米颗粒，以实现MR的高强度聚焦超声治疗和监测。构成：磷脂纳米粒子在氢的内部区域含有十氟戊烷（C 5 F 12）气体。纳米颗粒用PEG350标记，通过均匀结合磷脂的脂肪酸链和表面活性剂的疏水键形成内部疏水层。 T1对称物含有钆或氧化铁。

3. 发明公开

KR1020120072404A 생체적합성이 우수한 코어/쉘 나노복합체, 이의 제조방법 및 이를 이용한 ＭＲＩ 조영제, 암 치료용 ＮＣＴ 시약 有权
标题翻译：具有生物相容性的核/壳纳米微粒，其制备方法和使用该方法的MRI对照介质，使用NCT的NCT用于治疗癌症
公开(公告)号：KR1020120072404A
公开(公告)日：2012-07-04
申请号：KR1020100134130
申请日：2010-12-24
申请人： 경북대학교 산학협력단
发明人： 정인우 , 조희경
IPC分类号： A61K9/127 , A61K9/28 , A61K49/06 , A61P35/00
CPC分类号： A61K9/0092 , A61K41/009 , A61K49/085 , A61K49/101 , A61K49/183 , A61K49/1854 , B82Y5/00 , G01N2800/102
摘要： PURPOSE: A core/shell nanocomposite with excellent biocompatibility and a method for preparing the same are provided to enhance long-term blood circulation. CONSTITUTION: A core/shell nanocomposite contains a core formed of gadolinium oxide(Gd_2O_3) nanoparticles, a silica shell(SiO_2) covering the core outer circumference, and a poly(2-methacryloyloxyethyl phosphorylcholine) coating layer on the surface of the silica shell. The average particle of the nanoparticle is 20-100 nm. The average of the silica shell is 10-50 nm. A method for preparing the nanocomposite comprises: a step of mixing a mixture solution of gadolinium oxide nanoparticle and dialkylene glycol, APTES(3-aminopropyltriethoxysilane) of chemical formula 1, and TEOS(tetraethoxy silicate); a step of adding TEA(triethanolamine) and performing polyol reaction and sol-gel reaction to prepare a Gd_2O_3/SiO_2-X complex-containing solution; a step of mixing the Gd_2O_3/SiO_2-X complex-containing solution and C1-C3 alcohol; and a step of adding ligand and 2-methacryloyloxyethyl phosphocholine monomers.
摘要翻译：目的：提供具有优异生物相容性的核/壳纳米复合材料及其制备方法，以增强长期血液循环。构成：核/壳纳米复合材料包含由氧化钆（Gd_2O_3）纳米颗粒，覆盖芯外周的二氧化硅壳（SiO_2）和二氧化硅壳表面上的聚（2-甲基丙烯酰氧乙基磷酰胆碱）涂层形成的核心。纳米颗粒的平均颗粒为20-100nm。二氧化硅壳的平均值为10-50nm。制备纳米复合材料的方法包括：将化学式1的APTES（3-氨基丙基三乙氧基硅烷）和TEOS（四乙氧基硅酸酯）的混合溶液钆氧化物纳米颗粒和二亚烷基二醇的混合物的步骤。加入TEA（三乙醇胺）并进行多元醇反应和溶胶 - 凝胶反应以制备含有Gd_2O_3 / SiO_2-X络合物的溶液的步骤; 混合含有Gd_2O_3 / SiO_2-X络合物的溶液和C1-C3醇的步骤; 以及添加配体和2-甲基丙烯酰氧基乙基磷酸胆碱单体的步骤。

4. 发明授权

KR100951719B1 세포투과성 펩타이드와 형광표지 자성나노입자의 복합체 및그 용도 有权
标题翻译：细胞迁移肽和磁性纳米粒子的复合物及其应用
公开(公告)号：KR100951719B1
公开(公告)日：2010-04-07
申请号：KR1020070099511
申请日：2007-10-02
申请人： 재단법인서울대학교산학협력재단
发明人： 박윤정 , 정종평 , 빅터양 , 서진숙
IPC分类号： B82B1/00 , B82Y5/00
CPC分类号： A61K49/1866 , A61K49/0041 , A61K49/0043 , A61K49/0093 , A61K49/085 , A61K49/14 , B82Y5/00
摘要： 본 발명은 세포투과성 펩타이드와 형광표지 자성 나노입자의 복합체 및 그 용도에 관한 것으로, 보다 구체적으로, 세포내 투과성 펩타이드와 형광표지 자성나노입자를 화학적으로 결합시킴으로써, 내포작용(endocytosis) 없이, 형광표지 자성나노입자를 세포 내로 안정하게 직접 도입시킬 수 있는 세포투과성 펩타이드-형광표지 자성나노입자 복합체 및 이를 함유하는 세포 영상용 조성물에 관한 것이다.
본 발명에 따르면, 기존의 바이러스성 펩타이드 수송체에서 탈피하여 높은 안정성을 보이고, 최적의 표적 지향화를 통한 영상진단용법의 효과를 극대화하며, 부작용을 최소화하여 혁신적인 치료기술을 제시할 수 있다.
수송도메인, 투과기능성, 펩타이드, 자성나노입자, 세포영상, 조영제

5. 发明公开

KR1020090096816A 암진단용 ＭＲ 조영제와 그 제조방법 有权
标题翻译：对比介质及其制备方法
公开(公告)号：KR1020090096816A
公开(公告)日：2009-09-15
申请号：KR1020080021866
申请日：2008-03-10
申请人： 경북대학교 산학협력단
发明人： 장용민 , 김태정 , 박지애
IPC分类号： A61K51/08 , A61K51/02 , A61K51/00
CPC分类号： A61K49/14 , A61K49/085
摘要： An MR (magnetic resonance) contrast medium for diagnosing cancer, which contains a peptide and Gd precursor is provided to improve selective specificity to a cancer cell and reduce cytotoxicity. An MR (magnetic resonance) contrast medium for diagnosing cancer comprises a peptide containing a ligand and RGD (Arg-Gly-Asp) sequence and Gd precursor. A method for manufacturing MR contrast medium comprises: a step of esterifying the peptide containing the ligand and RGD sequence; and a step of binding Gd (gadolinium) precursor on the esterified compound. The ligand is DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), DPTA (Diethylenetriamine pentaacetic acid) or DO3A (1,4,7,10-tetraazacyclododecan).
摘要翻译：提供用于诊断癌症的MR（磁共振）造影剂，其包含肽和Gd前体，以改善对癌细胞的选择性特异性并降低细胞毒性。用于诊断癌症的MR（磁共振）造影剂包含含有配体和RGD（Arg-Gly-Asp）序列和Gd前体的肽。制造MR造影剂的方法包括：使含有配体和RGD序列的肽酯化的步骤; 以及在所述酯化化合物上结合Gd（钆）前体的步骤。配体是DOTA（1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸），DPTA（二亚乙基三胺五乙酸）或DO 3 A（1,4,7,10-四氮杂环十二烷）。

6. 发明公开

KR1020090039751A 단백질성 물질의 입자를 제조하기 위한 방법 有权
标题翻译：制备蛋白质材料颗粒的方法
公开(公告)号：KR1020090039751A
公开(公告)日：2009-04-22
申请号：KR1020097002579
申请日：2007-07-13
申请人： 업퍼톤 리미티드 , 알부메딕스 에이/에스
发明人： 존슨,리차드,알렌 , 우드로우,존,로드니
IPC分类号： C07K1/02 , C07K1/10 , C07K14/76 , A61K38/38
CPC分类号： C07K1/02 , A61K9/1658 , A61K9/5169 , A61K47/64 , A61K47/643 , A61K47/6435 , A61K47/644 , A61K47/6929 , A61K49/0485 , A61K49/085 , A61K49/143 , A61K49/1881 , A61K51/081 , A61K51/1255 , B82Y5/00 , C07K1/08 , C07K1/10
摘要： Protein particles are prepared by causing or allowing protein molecules dispersed in a liquid medium at a concentration of 8mg.mL-1 or greater to react in the presence of a zero-length crosslinker, so as to produce protein particles comprising protein molecules that are covalently bonded together. The protein particles may be produced with sizes in the sub-micron range with closely defined sizes and size distributions. The particles have applications in many fields, but are useful inter alia for the delivery of therapeutic agents and other agents, eg imaging contrast agents, to the body.
摘要翻译：通过使分散在8mg.mL-1或更高浓度的液体培养基中的蛋白质分子在零长度交联剂的存在下反应来制备蛋白质颗粒，以产生包含共价的蛋白质分子的蛋白质颗粒结合在一起蛋白质颗粒可以以亚微米范围内的尺寸制造，具有紧密限定的尺寸和尺寸分布。这些颗粒在许多领域中具有应用，但是尤其可用于将治疗剂和其它试剂（例如成像造影剂）递送至身体。

7. 发明公开

KR1020090034240A 세포투과성 펩타이드와 형광표지 자성나노입자의 복합체 및그 용도 有权
标题翻译：细胞转移肽和磁性纳米颗粒的复合物及其用途
公开(公告)号：KR1020090034240A
公开(公告)日：2009-04-07
申请号：KR1020070099511
申请日：2007-10-02
申请人： 재단법인서울대학교산학협력재단
发明人： 박윤정 , 정종평 , 빅터양 , 서진숙
IPC分类号： B82B1/00 , B82Y5/00
CPC分类号： A61K49/1866 , A61K49/0041 , A61K49/0043 , A61K49/0093 , A61K49/085 , A61K49/14 , B82Y5/00
摘要： A composite of cell-penetrating peptides and magnetic nano particles is provided to secure high stability in comparison with existing viral peptide transporters and maximize effects of video diagnosis by aiming optimal targets. A method for preparing a composite of cell-penetrating peptides and magnetic nano particles comprises the following steps of: preparing a magnetic nano particle containing amino groups by reforming a surface of the magnetic nano particle with amino groups; mixing fluorescent materials to the magnetic nano particle containing amino groups to prepare fluorescent marker magnetic nano particle; and coupling a cell-penetrating peptide with the prepared fluorescent marker magnetic nano particle to produce a composite of cell-penetrating peptides and magnetic nano particles.
摘要翻译：提供细胞穿透肽和磁性纳米颗粒的复合物，以确保与现有的病毒肽转运蛋白相比具有高度的稳定性，并通过瞄准最佳靶标来最大化视频诊断的效果。一种制备细胞穿透肽和磁性纳米颗粒复合物的方法包括以下步骤：通过用氨基重整磁性纳米颗粒的表面来制备含有氨基的磁性纳米颗粒; 将荧光材料与含有氨基的磁性纳米颗粒混合，制备荧光标记磁性纳米颗粒; 并将细胞穿透肽与制备的荧光标记物磁纳米颗粒偶联，以产生细胞穿透肽和磁性纳米颗粒的复合物。

8. 发明公开

KR1020080095183A 근적외선 형광체가 결합된 담즙산-글라이콜키토산 복합체나노입자를 포함하는 류마티스 관절염 진단용 조영제 有权
标题翻译：包含与胆汁酸甘油酯复合物形成的纳米颗粒的对比介质结合用于诊断湿疹斑块的近红外荧光素
公开(公告)号：KR1020080095183A
公开(公告)日：2008-10-28
申请号：KR1020080036215
申请日：2008-04-18
申请人： 한국과학기술연구원
发明人： 권익찬 , 김광명 , 최귀원 , 윤인찬 , 김종호 , 박경순 , 이슬기
IPC分类号： A61K8/63
CPC分类号： A61K49/0093 , A61K47/6843 , A61K47/6929 , A61K49/0032 , A61K49/0067 , A61K49/085 , A61K49/1818 , G01N2800/102
摘要： A contrast medium is provided to diagnose autoimmune diseases in early stage by chemically boding a polymer, which is able to be selectively accumulated in a diseased tissue due to high transmissivity of a neovascular membrane of the autoimmune diseased tissue, to a near-infrared fluorochrome. A contrast medium for diagnosing rheumatoid arthritis comprises nanoparticles of a near infrared fluorochrome bonded bile acid-glycol chitosan complex, wherein the near infrared fluorochrome is selected from the group consisting of cyanin, allophycocyanin, fluorescein, tetramethylrhodamine, BODIPY and Alexa. A drug delivery system for treating the rheumatoid arthritis is characterized in that a hydrophobic drug such as methotrexate, cyclosporin A, D-penicillamine gold salt, hydroxychloroquinin and leflunomide is encapsulated into the nanoparticles of the near infrared fluorochrome bonded bile acid-glycol chitosan complex.
摘要翻译：提供了一种造影剂，用于通过化学结合聚合物来早期诊断自身免疫性疾病，该聚合物由于自身免疫性病变组织的新血管膜的高透射率而能够选择性地积累在病变组织中至近红外荧光染料。用于诊断类风湿性关节炎的造影剂包括近红外荧光染料结合胆汁酸 - 乙二醇壳聚糖复合物的纳米颗粒，其中近红外荧光染料选自花青素，别藻蓝蛋白，荧光素，四甲基罗丹明，BODIPY和Alexa。用于治疗类风湿性关节炎的药物递送系统的特征在于将疏水性药物如甲氨蝶呤，环孢菌素A，D-青霉胺金盐，羟氯喹啉和来氟米特封装在近红外荧光染料结合胆汁酸 - 乙二醇壳聚糖复合物的纳米颗粒中。

9. 发明公开

KR1020070086803A ＭＲＩ 유도 광역학 암 치료 无效
标题翻译： MRI指导癌症的光化疗法
公开(公告)号：KR1020070086803A
公开(公告)日：2007-08-27
申请号：KR1020077014910
申请日：2005-12-02
申请人： 유니버시티 오브 유타 리써치 파운데이션
发明人： 루쩡-롱 , 비아디아아나가 , 커티엔이
IPC分类号： A61K49/06 , A61K39/385 , A61P35/00
CPC分类号： A61K49/085 , A61K41/0071 , A61K47/645 , A61K49/146
摘要： Disclosed is a method of therapy used in combination with a diagnostic tool for enhanced photodynamic therapy using MRI, called (magnetic resonance imaging)-guided photodynamic therapy. The methods of the present invention includes administration of MRI contrast agent labeled polymer photosensitizer conjugates, detection and localization of tumor or cancer tissues with contrast-enhanced MRI and specific illumination and treatment of localized target tissues, such as tumors or cancer cells, using laser energy. The delivered laser energy activates the photosentizer accumulated in the target tissue, resulting in treatment. Also disclosed are novel conjugate compounds, such as PLGA-Mce6-DOTA-Gd complexes, having multi-functionality in that the complex may include an MRI contrasting agent linked to a photosensitizing agent.
摘要翻译：公开了一种治疗方法，与用于使用称为（磁共振成像） - 光导光疗法的MRI的增强光动力疗法的诊断工具结合使用。本发明的方法包括施用MRI造影剂标记的聚合物光敏剂缀合物，使用对比度增强的MRI和特定照明的肿瘤或癌组织的检测和定位以及使用激光能量的局部靶组织如肿瘤或癌细胞的治疗。递送的激光能量激活积聚在靶组织中的光敏剂，从而进行治疗。还公开了具有多功能性的新型缀合物化合物，例如PLGA-Mce6-DOTA-Gd复合物，因为该复合物可包括与光敏剂连接的MRI造影剂。

10. 发明公开

KR1020050105474A 삼량체 거대고리 치환된 벤젠 유도체 无效
标题翻译： TRIMERIC MACROCYCLICALLY取代苯甲醛衍生物
公开(公告)号：KR1020050105474A
公开(公告)日：2005-11-04
申请号：KR1020057015199
申请日：2003-12-12
申请人： 바이엘 파마 악티엔게젤샤프트
发明人： 플라트젝,요한네스 , 바인만,한스-요아킴 , 쉬르머,하이코 , 마르틴,호세,루이스 , 하르토,후안,알. , 리프케,비요른
IPC分类号： C07D257/02 , C07F5/00
CPC分类号： A61K49/10 , A61K49/0002 , A61K49/0433 , A61K49/0438 , A61K49/085 , A61K51/0497 , C07D257/02
摘要： The invention relates to the metal complexes of general formula (I), wherein Hal represents bromine or iodine, and A1 and A2 have different meanings. The inventive metal complexes are suitable for use as contrast media.
摘要翻译：本发明涉及通式（I）的金属络合物，其中Hal表示溴或碘，A1和A2具有不同的含义。本发明的金属络合物适合用作造影剂。

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