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1. 发明授权

KR101257376B1 시신경 보호를 위한 열충격 단백질 발현 유도 제재 및 이의 망막 내 주입방법 有权
标题翻译：诱导眼科神经保护的热休克蛋白的材料及其对RETINA的输注技术
公开(公告)号：KR101257376B1
公开(公告)日：2013-04-23
申请号：KR1020100069555
申请日：2010-07-19
申请人： 천선주
发明人： 배성태 , 전민홍 , 박기호 , 정진욱 , 천선주
IPC分类号： A61K33/06 , A61K9/16 , A61P27/02 , A61P25/00
摘要： 본 발명은 시신경 보호를 위한 열충격 단백질 발현 유도 제재 및 이의 망막 내 주입방법에 관한 것으로, 페라이트 계열의 초상자성 나노입자로 이루어진 본 발명의 열충격 단백질 발현 유도 제재는 침전 없이 인체 내에 안전하게 주입가능하고 높은 생체 적합성을 가지며, 두뇌에 무해한 주파수와 자장 범위에서 열충격 단백질을 국부적으로 효과적으로 발현시킬 수 있어 환자의 고통이나 불편 및 부작용을 최소화 할 수 있다. 이와 같이 발현된 열충격 단백질은 시신경 질환 및 퇴행성 신경질환의 치료에 유용하게 사용될 수 있다.

2. 发明授权

KR101300232B1 초고감도 자기공명영상 조영제 및 나노 진단-치료 복합 제재로의 응용을 위한 초상자성 나노입자 코팅 방법 및 그 방법으로 코팅된 초상자성 나노입자 및 초상자성 나노입자제재 有权
标题翻译：用于两种高敏感性MRI对比剂和纳米治疗药物应用的超级纳米颗粒的涂覆方法，以及包覆的超级纳米颗粒和涂覆的超级纳米颗粒剂使用该方法
公开(公告)号：KR101300232B1
公开(公告)日：2013-08-26
申请号：KR1020120115504
申请日：2012-10-17
申请人： 천선주
发明人： 배성태 , 전민홍
IPC分类号： A61K49/08 , A61K49/04 , A61K9/16 , A61K47/30
CPC分类号： A61K49/186 , A61K49/085 , B82Y5/00
摘要： PURPOSE: A method for coating superparamagnetic nanoparticles is provided to implement a very thin dual coating layer of oleic acid and methoxy-polyethylene glycol (PEG)-silane on the surface of the superparamagnetic nanoparticles and to have high single dispersion (low PDI). CONSTITUTION: A method for coating superparamagnetic nanoparticles comprises the steps of: adding oleic acid and ammonia to a solution in which the superparamagnetic nanoparticles are dispersed and stirring to form an oleic acid layer on the superparamagnetic nanoparticles; and shaking the solution and a solution containing methoxy-polyethylene glycol (PEG)-silane, triethylamine, and toluene; and quickly mixing two solutions and forming a methoxy-PEG-silane layer. A superparamagnetic nanoparticle formulation is used in magnetic resonance image (MRI) and has a r_2-relaxivity of 800-2000 mM^-1s^-1.
摘要翻译：目的：提供一种涂覆超顺磁性纳米粒子的方法，以在超顺磁性纳米颗粒的表面上实现非常薄的油酸和甲氧基聚乙二醇（PEG） - 硅烷双层涂层，并具有高单分散性（低PDI）。构成：涂覆超顺磁性纳米颗粒的方法包括以下步骤：将油酸和氨添加到其中超顺磁性纳米颗粒分散并搅拌以在超顺磁性纳米颗粒上形成油酸层的溶液中; 摇动溶液和含有甲氧基 - 聚乙二醇（PEG） - 硅烷，三乙胺和甲苯的溶液; 并快速混合两种溶液并形成甲氧基-PEG-硅烷层。在磁共振图像（MRI）中使用超顺磁性纳米颗粒制剂，并且具有800-2000mM ^ -1s ^ -1的r_2-弛豫度。

3. 发明授权

KR101280808B1 초고온 자기유도발열능 및 높은 비손실력을 갖는 페라이트계 초상자성 나노입자, 이의 제조방법 및 이를 포함하는 고온 열소작법 제재 有权
标题翻译：具有超高磁感应发热能力和高特定功率的基于铁氧体的超级纳米颗粒，其制备方法和包含其的热解剂
公开(公告)号：KR101280808B1
公开(公告)日：2013-07-02
申请号：KR1020120078220
申请日：2012-07-18
申请人： 천선주
发明人： 천선주 , 배성태 , 전민홍
IPC分类号： B82B3/00 , H01F1/10 , A61K9/14 , A61P25/00
CPC分类号： H01F1/11 , A61K9/141 , A61K9/51 , A61K41/0057 , B82Y5/00 , B82Y40/00
摘要： PURPOSE: A manufacturing method of super-paramagnetic nanoparticles in a ferrite system is provided to synthesize super-paramagnetic nanoparticles with high self induction caloricity and specific loss power (SLP) in a low magnetic field and a frequency range by performing a previous process and a bumping process in a nucleus generating step. CONSTITUTION: A manufacturing method of super-paramagnetic nanoparticles in a ferrite system comprises (1) a nucleus generation step and (2) a particle growth step. The (1) nucleus generation step includes the following steps; (a) a raw solution at a room temperature is heated to 190-195 degreeC and is kept at the same temperature; and (b) the raw solution at 190-195 degree C is heated to be at 200-204 degreeC and the raw solution contains one or more substance selected from Fe (III) acetylacetonate, Mg, Mn, Ni, Zn and Co. The (2) particle growth step includes the following steps; the raw solution obtained from the nucleus generation step is heated until it meets a boiling point of a solvent and is kept at the same temperature. [Reference numerals] (AA) Nucleation step; (BB) Growth step; (CC) 7 minute (bumping process); (DD) 20 minute; (EE) 60 minute; (FF) 54 minute 30 second; (GG) Temperature; (HH) Time (minute)
摘要翻译：目的：提供一种铁氧体系中超顺磁纳米颗粒的制造方法，通过执行以前的工艺和低温磁场，在低磁场和频率范围内合成具有高自感量热和特定损耗功率（SLP）的超顺磁性纳米粒子细胞核产生步骤中的碰撞过程。构成：铁氧体系中的超顺磁性纳米颗粒的制造方法包括：（1）核产生步骤和（2）颗粒生长步骤。（1）核产生步骤包括以下步骤：（a）将室温下的原溶液加热至190-195℃，并保持在相同的温度; 和（b）将190-195℃的原料溶液加热至200-204℃，原料溶液含有一种或多种选自乙酰丙酮铁（III），Mg，Mn，Ni，Zn和Co的物质。（2）颗粒生长步骤包括以下步骤：将从核生成工序得到的原料溶液加热至满足溶剂的沸点并保持在相同的温度。（AA）成核步骤; （BB）生长步骤; （CC）7分钟（碰撞过程）; （DD）20分钟; （EE）60分钟; （FF）54分30秒; （GG）温度; （HH）时间（分钟）

4. 发明授权

KR101121022B1 이중 금속 박막형 발전기 및 이를 이용한 집적 발전기 有权
标题翻译：具有双层金属薄膜的双层金属发电机的电力发电机和使用相同的集成电力发电机
公开(公告)号：KR101121022B1
公开(公告)日：2012-06-12
申请号：KR1020100077334
申请日：2010-08-11
申请人： 천선주
发明人： 천선주 , 배성태 , 이상훈
IPC分类号： H01L31/0445 , H01L35/26
CPC分类号： H01L35/30 , H02S40/44 , Y02B10/20 , Y02B10/70 , Y02E10/60
摘要： PURPOSE: A double metal thin-film type generator and an integrated generator using the same are provided to simplify manufacturing processes by omitting a separate patterning process, thereby significantly reducing manufacturing costs. CONSTITUTION: A first metal thin film(304) is formed on a substrate(302). A second metal thin film(306) is formed on a part of the upper parts of the substrate and the first metal thin film. The first metal thin film is a nonmagnetic metal thin film. The second metal thin film is a magnetic metal thin film. The first and second metal thin films have different Seebeck coefficients.
摘要翻译：目的：提供双金属薄膜型发生器和使用其的集成发电机，以通过省略单独的图案化工艺来简化制造工艺，从而显着降低制造成本。构成：在基板（302）上形成第一金属薄膜（304）。在基板的上部的一部分和第一金属薄膜上形成第二金属薄膜（306）。第一金属薄膜是非磁性金属薄膜。第二金属薄膜是磁性金属薄膜。第一和第二金属薄膜具有不同的塞贝克系数。

5. 发明公开

KR1020120009597A 시신경 보호를 위한 열충격 단백질 발현 유도 제재 및 이의 망막 내 주입방법 有权
标题翻译：诱导眼科神经保护的热休克蛋白的材料及其对RETINA的输注技术
公开(公告)号：KR1020120009597A
公开(公告)日：2012-02-02
申请号：KR1020100069555
申请日：2010-07-19
申请人： 천선주
发明人： 배성태 , 전민홍 , 박기호 , 정진욱 , 천선주
IPC分类号： A61K33/06 , A61K9/16 , A61P27/02 , A61P25/00
摘要： PURPOSE: A material for inducing heat shock protein for protecting optic nerve is provided to minimize patient's pain or side effect. CONSTITUTION: A material for inducing heat shock protein expression contains ferrite-based superparamagnetic nanoparticles. The average particles size is 5-13 nm and has 18°C or more of heat generation temperature in a solid state. The superparamagnetic nanoparticles are Co-ferrite, processed Mg-dopped-ferrite, NiZn-ferrite, processed MnZn-ferrite, or mixture thereof. The superparamagnetic nanoparticles are coated with a biocompatible material.
摘要翻译：目的：提供一种用于诱导用于保护视神经的热休克蛋白的材料，以尽量减少患者的疼痛或副作用。构成：用于诱导热休克蛋白表达的材料含有铁氧体型超顺磁性纳米粒子。平均粒径为5〜13nm，固体发热温度为18℃以上。超顺磁性纳米粒子是铁素体，加工的Mg掺杂铁素体，NiZn铁氧体，加工MnZn铁氧体或其混合物。用超生物相容性材料涂覆超顺磁性纳米粒子。

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