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    • 10. 发明公开
    • 치자 추출물의 헥센 분획물을 유효성분으로 함유하는 혈소판 응집 저해용 약학적 조성물 및 건강 기능 식품
    • 包含花生类JASMINOIDES提取物的HEXANE分段的药物组合物作为用于抗肿瘤聚集的有效成分和包含其的健康功能食品
    • KR1020140109099A
    • 2014-09-15
    • KR1020130023359
    • 2013-03-05
    • 안동대학교 산학협력단주식회사 케미메디황성연
    • 손호용황성연
    • A61K36/744A23L1/30A61P7/02A61P7/00
    • A61K36/744A23V2200/326A23V2250/21Y10S514/822
    • The present invention relates to a pharmaceutical composition and a functional health food, which contain a hexene fraction of a Gardenia jasminoides extract as an active ingredient for preventing or treating thrombosis-related diseases and, more specifically, to a pharmaceutical composition containing a hexene fraction from an ethanol extract of Gardenia jasminoides as an active ingredient for preventing or treating thrombosis-related diseases, and to a functional health food containing the hexene fraction. As verified through embodiments of the present specification, the pharmaceutical composition and the functional health food which contain a hexene fraction of a Gardenia jasminoides extract as an active ingredient for preventing or treating thrombosis-related diseases exhibit a strong ability to inhibit platelet aggregation, thereby efficiently suppressing thrombosis. Particularly, the hexene fraction of the Gardenia jasminoides extract, which is an active ingredient of the pharmaceutical composition and the functional health food, does not show acute oral toxicity, has excellent thermal stability, and does not exhibit the loss of platelet aggregation inhibitory activity even under an acidic condition of pH 2 and in the plasma, thereby being processed into various types, such as an extract, a powder, a pill, and a tablet, and thus being prepared in a form that can be taken at normal times. Therefore, the present invention is very useful in the pharmaceutical industry and food industry.
    • 本发明涉及含有栀子栀子提取物的己烯级分作为预防或治疗血栓形成相关疾病的活性成分的药物组合物和功能保健食品,更具体地说,涉及含有己内酯级分的药物组合物, 栀子栀子的乙醇提取物作为预防或治疗血栓形成相关疾病的活性成分,以及含有己烯级分的功能保健食品。 如通过本说明书的实施例所证实的,含有栀子栀子提取物的己烯级分的药物组合物和功能保健食品作为预防或治疗血栓形成相关疾病的活性成分表现出强烈的抑制血小板聚集的能力,从而有效地 抑制血栓形成。 特别地,作为药物组合物和功能保健食品的活性成分的栀子提取物的己烯分数,不显示急性口服毒性,具有优异的热稳定性,并且不显示血小板聚集抑制活性的丧失,甚至 在pH2的酸性条件下和在等离子体中,由此被加工成各种类型,例如提取物,粉末,丸剂和片剂,因此以可以在正常时间摄取的形式制备。 因此,本发明在制药工业和食品工业中非常有用。