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    • 6. 发明公开
    • 치환된 아제티딘 유도체 및 이를 포함하는 약학적 조성물
    • 取代的AZETIDINE衍生物及其制备方法
    • KR1020130015727A
    • 2013-02-14
    • KR1020110077893
    • 2011-08-04
    • 현대약품 주식회사
    • 양진김진웅이한규김재현손창모이규환최형호김대훈하태영이재걸
    • C07D205/04C07D403/04A61K31/397A61P3/00
    • PURPOSE: A pharmaceutical composition containing a novel compound or a pharmaceutically acceptable salt thereof is provided to activate GPR119 and to treat diabetes and related diseases, cardiovascular disorders, metabolic syndrome, and obesity. CONSTITUTION: A substituted azetidine derivative is denoted by chemical formula 1. In chemical formula 1, X is O or NH; R_1 is -CN, -CF_3, -NO_2, -NR'R'', -NHC(O)R', -NHS(O)_2R', -NHC(O)NR'R'', -COR', -COOR', -CONR'R'', -SR', -S(O)2R', or a substituted or non-substituted C5-10 heteroaryl group; and R_2 is -CN, -CF_3, -NO_2, -COR', -COOR', -CONR'R'', -SR', -S(O)_2R', or a substituted or non-substituted C5-10 heteroaryl group. A pharmaceutical composition for treating metabolic disorders contains a compound of chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient. The metabolic disorders include obesity, type I diabetes, type II diabetes, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, dyslipidemia, or X syndrome.
    • 目的:提供含有新化合物或其药学上可接受的盐的药物组合物以激活GPR119并治疗糖尿病和相关疾病,心血管疾病,代谢综合征和肥胖症。 构成:取代的氮杂环丁烷衍生物由化学式1表示。在化学式1中,X为O或NH; R 1是-CN,-CF 3,-NO 2,-NR'R“,-NHC(O)R',-NHS(O)_2R',-NHC(O)NR'R”,-COR' COOR',-CONR'R“,-SR',-S(O)2R'或取代或未取代的C5-10杂芳基; 并且R 2是-CN,-CF 3,-NO 2,-COR',-COOR',-CONR'R“,-SR',-S(O)2 R'或取代或未取代的C5-10杂芳基 组。 用于治疗代谢紊乱的药物组合物含有化学式1的化合物或其药学上可接受的盐作为活性成分。 代谢障碍包括肥胖症,I型糖尿病,II型糖尿病,胰岛素抵抗,高脂血症,高甘油三酯血症,高胆固醇血症,血脂异常或X综合征。