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    • 2. 发明公开
    • 생강나무 추출물을 유효성분으로 함유하는 혈행개선 조성물
    • 包含LINDERA OBTUSILOBA提取物作为有效成分的组合物,用于预防和治疗血栓形成
    • KR1020110055872A
    • 2011-05-26
    • KR1020090112484
    • 2009-11-20
    • 한화제약주식회사양지화학 주식회사
    • 옥민호이정옥강소희손정덕김종훈임지웅나용호오유나이승우
    • A61K36/9068A61P7/02A23L1/30
    • A61K36/54A23L33/105A61K2236/333
    • PURPOSE: A composition containing Lindera obtusiloba extract for improving blood circulation or preventing and treating thrombotic diseases is provided to suppress platelet aggregation. CONSTITUTION: A pharmaceutical composition for preventing and treating thrombotic diseases contains Lindera obtusiloba extract as an active ingredient. The extract is prepared from branches, leaves, or mixture thereof using water, low alcohol of C1-C5, or mixture thereof, or 30-95 weight% of ethanol solution. The extract is also prepared by extracting with water, low alcohol of C1-C3, or mixture thereof, concentrating to obtain a crude extract, suspending the crude extract in the water, and re-extracting with hexane, ethyl acetate, and butanol. A health food for preventing thrombotic diseases contains the extract as an active ingredient.
    • 目的:提供一种含有用于改善血液循环或预防和治疗血栓形成疾病的林德氏扁桃体提取物的组合物以抑制血小板聚集。 构成:用于预防和治疗血栓形成疾病的药物组合物含有枸杞子提取物作为活性成分。 使用水,C1-C5的低级醇或其混合物,或30-95%重量的乙醇溶液,从分支,叶或其混合物制备提取物。 提取物还可以通过用水,C1-C3的低级醇或其混合物萃取,浓缩,得到粗提物,将粗提物悬浮在水中,并用己烷,乙酸乙酯和丁醇重新萃取。 用于预防血栓形成疾病的保健食品含有提取物作为活性成分。
    • 7. 发明授权
    • 가죽그물바탕말 추출물을 포함하는 심혈관계 질환의 예방및 치료용 조성물
    • 包括DICTYOTA CORIACEUM的提取物用于预防和治疗心血管障碍的组合物
    • KR100834348B1
    • 2008-06-02
    • KR1020070036627
    • 2007-04-13
    • 양지화학 주식회사
    • 옥민호이정옥최운선손정덕나용호이정근
    • A61K36/03A61P9/02
    • An extract of Dictyota coriaceum is provided to inhibit NAD(P)H strongly and show strong vascular relaxation effect by controlling contraction and relaxation of vascular smooth muscle, thereby being usefully used as a medicine or a health functional good for preventing and treating cardiovascular diseases. A composition for preventing and treating cardiovascular diseases selected from the group consisting of congestine heart failure, ischemia, hypertension, hypotonia, arrhythmia, heart failure, coronary restenosis and dementia comprises an extract of Dictyota coriaceum as an effective ingredient, wherein the extract is extracted by using a solvent selected from the group consisting of water, C1-4 alcohol and a mixture thereof. Further, the C1-4 alcohol is a methanol, ethanol or butanol.
    • 提供Dictyota coriaceum的提取物通过控制血管平滑肌的收缩和松弛强烈地抑制NAD(P)H并显示出强烈的血管松弛作用,从而有效地用作预防和治疗心血管疾病的药物或健康功能。 用于预防和治疗选自以下的心血管疾病的组合物,其选自由充血性心力衰竭,局部缺血,高血压,低血压,心律失常,心力衰竭,冠状动脉再狭窄和痴呆组成的组,其包含作为有效成分的Dictyota coriaceum的提取物, 使用选自水,C 1-4醇及其混合物的溶剂。 此外,C 1-4醇是甲醇,乙醇或丁醇。
    • 10. 发明公开
    • CCR2 길항제로서의 피페라지닐에틸 3-아미노피롤리딘 유도체
    • 作为CCR2拮抗剂的哌嗪基三氨基吡啶衍生物
    • KR1020110005532A
    • 2011-01-18
    • KR1020090063136
    • 2009-07-10
    • 양지화학 주식회사
    • 임지웅김종훈옥민호나용호오유나강소희이정옥손정덕이승우
    • C07D403/06C07D403/04C07D207/273
    • C07D207/14
    • PURPOSE: A compound with CCR(chemokine receptor 2) antagonist is provided to prevent or treat rheumatoid arthritis, arteriosclerosis, multiple sclerosis, asthma and CCR-associated diseases. CONSTITUTION: A compound with CCR antagonistic effect is denoted by chemical formula 1. In chemical formula 1, R1 is independently hydrogen atom, C1-C3 alkyl, phenyl, benzyl, benzoyl, benzene sulfonyl, or cycloalkyl of C3-C7. A pharmaceutical composition for preventing and treating CCR2-mediated inflammatory diseases contains the compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The CCR2-meidated inflammatory diseases are allergic rhinitis, respiratory allergic disease, chronic obstructive lung disease, rheumatic arthritis, uveitis, multiple sclerosis, contact dermatitis, atopic dermatitis, or asthma. An agent for protecting blood vessel or inhibiting immunity contains the compound of chemical formula 1 or pharmaceutically acceptable salt thereof.
    • 目的:提供具有CCR(趋化因子受体2)拮抗剂的化合物以预防或治疗类风湿性关节炎,动脉硬化,多发性硬化,哮喘和CCR相关疾病。 构成:具有CCR拮抗作用的化合物由化学式1表示。在化学式1中,R 1独立地为氢原子,C 1 -C 3烷基,苯基,苄基,苯甲酰基,苯磺酰基或C 3 -C 7的环烷基。 用于预防和治疗CCR2介导的炎性疾病的药物组合物含有化学式1的化合物或其药学上可接受的盐作为活性成分。 CCR2炎症性疾病是过敏性鼻炎,呼吸道过敏性疾病,慢性阻塞性肺病,风湿性关节炎,葡萄膜炎,多发性硬化,接触性皮炎,特应性皮炎或哮喘。 用于保护血管或抑制免疫的药剂含有化学式1的化合物或其药学上可接受的盐。