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1. 发明授权

KR101428712B1 관류식 배양공정을 이용한 미세조류의 배양방법 有权
标题翻译：使用脉冲激发过程的海洋微藻的培养方法
公开(公告)号：KR101428712B1
公开(公告)日：2014-11-04
申请号：KR1020130124354
申请日：2013-10-18
申请人： 한국해양과학기술원 , 서원대학교산학협력단
发明人： 강도형 , 이현용 , 이춘근 , 최운용 , 최철순
IPC分类号： C12N1/12 , C12M3/06
CPC分类号： C12N1/12
摘要： 본 발명은 관류식 배양공정을 이용한 미세조류의 배양방법에 관한 것으로, 더욱 구체적으로 배지에 질소원을 공급하여 배양액을 제조한 후 미세조류를 접종시키는 단계; 상기 배양액과 미세조류의 혼합액에 광을 조사하여 미세조류를 성장시킨 후 여과하는 단계; 및 배지에 탄소원이 공급된 배양액을 제조한 후 상기 여과된 미세조류에 노출시키고 광을 조사하여 미세조류를 성장시키는 단계를 포함하는 관류식 배양공정을 이용한 미세조류의 배양방법에 관한 것이다.
摘要翻译：本发明涉及使用灌注培养方法培养微藻的方法。更具体地说，提供了使用灌注培养方法培养微藻的方法，其包括以下步骤：通过向培养基中提供氮源而在制备培养液之后接种微藻; 通过向培养液和微藻的混合溶液照射光而生长微藻后进行过滤; 并且在制备在培养基中供应有碳源的培养液，然后将其暴露于经过滤的微藻之后，通过照射光来生长微藻。

2. 发明公开

KR1020170001025A 배초향 추출물을 유효성분으로 함유하는 항노화 화장료 조성물 有权
标题翻译：抗衰老化妆品组合物，包括藿香麝香提取物
公开(公告)号：KR1020170001025A
公开(公告)日：2017-01-04
申请号：KR1020150090356
申请日：2015-06-25
申请人： 서원대학교산학협력단 , 주식회사 한국코스모 , 주식회사 세바바이오텍
发明人： 이현용 , 최운용 , 김남영 , 임혜원 , 권희석
IPC分类号： A61K8/97 , A61Q19/08
摘要： 본발명은배초향추출물을유효성분으로함유하는피부주름개선용항노화화장료조성물에관한것으로, 본발명의화장료조성물은뛰어난항산화효과를통하여피부주름을개선하고피부노화를방지하며, 화장품에서문제시되는피부자극적인면에서도매우안전한효과가있다.

3. 发明公开

KR1020150057014A 강황 잎 추출물을 함유하는 여드름 개선용 화장료 조성물 无效
标题翻译：含有CURCUMA LONGA LINNE用于控制抗ACNE或ANTI-COMEDONE的化妆品组合物
公开(公告)号：KR1020150057014A
公开(公告)日：2015-05-28
申请号：KR1020130139789
申请日：2013-11-18
申请人： 주식회사 세바바이오텍 , 서원대학교산학협력단
发明人： 이현용 , 김지선 , 최운용 , 최우석 , 최철순 , 임혜원 , 안민실
IPC分类号： A61K8/97 , A61Q19/00
CPC分类号： A61K8/97 , A61Q19/00
摘要： 본발명은강황잎 추출물을함유하는여드름개선용화장료조성물에관한것이다. 본발명의강황잎 추출물은여드름의원인이되는균에대한항균력이우수하고, 항염활성도우수하여여드름의개선및 예방을위한화장료조성물에사용될수 있고, 또한, 여드름치료를위한의약품의제조에도유용하게사용할수 있는효과가있다.
摘要翻译：本发明涉及一种化妆品组合物，其用于减轻痤疮并且包括姜黄叶（姜黄）提取物。姜黄提取物对引起痤疮的细菌具有优异的抗菌活性，并具有减轻或预防痤疮的抗炎活性。因此，该组合物也可用于开发用于治疗痤疮的药物。

4. 发明授权

KR101521491B1 커피 발효물 및 이의 추출물을 포함하는 고기능성 화장료 조성물 有权
标题翻译：高功能化妆品组合物，其包含咖啡发酵产物及其提取物
公开(公告)号：KR101521491B1
公开(公告)日：2015-05-21
申请号：KR1020120084110
申请日：2012-07-31
申请人： 강원대학교산학협력단 , 서원대학교산학협력단 , 주식회사 세바바이오텍
发明人： 이현용 , 최운용 , 서용창 , 송치호 , 이춘근 , 임혜원
IPC分类号： A61K8/97 , A61Q19/02 , A61Q19/08 , A61Q19/00
摘要： 본발명은커피(원두또는부산물) 발효물및 이의추출물을함유하는화장료조성물에관한것으로서, 보다구체적으로는가공되지않은커피원두자체또는대부분이소비되지않고폐기되는커피부산물을유산균주를이용하여발효한후 얻어진발효액과이의발효액을제외한나머지건체커피발효잔여물을에탄올추출하여얻어진커피발효잔여추출물을유효성분으로포함하는고기능성화장료조성물에관한것이다. 본발명의커피(원두또는부산물) 발효물및 이의추출물은천연물유래의소재로서피부에안정하면서도피부세포증식효과, 항산화효과, 보습효과, 주름개선효과, 피부미백효과및 항염효과를동시에나타낼수 있으므로, 이를유효성분으로포함하는본 발명의조성물은고기능성화장료조성물로서유용하게사용될수 있다. 또한본 발명의상기커피(원두또는부산물) 발효물및 이의추출물은단가가저렴한원두자체또는폐기되어버려지는커피부산물을활용하여간단한공정을통해제조될있으므로, 시간, 노력및 비용을절감할수 있는경제적인효과를가질뿐만아니라폐기물의재활용을통한친환경적인효과도기대할수 있다.

5. 发明公开

KR1020140148166A 아로니아 추출물을 유효성분으로 포함하는 기능성 화장료 조성물 및 그 제조방법 有权
标题翻译：包含阿仑尼亚麻黄碱提取物的化妆品组合物及其生产方法
公开(公告)号：KR1020140148166A
公开(公告)日：2014-12-31
申请号：KR1020130071734
申请日：2013-06-21
申请人： 서원대학교산학협력단 , 양봉임
发明人： 이현용 , 김지선 , 최운용 , 최우석 , 최철순
IPC分类号： A61K8/97 , A61Q19/00
CPC分类号： A61K8/97 , A61Q19/00
摘要： The present invention relates to a cosmetic composition containing an extract of Aronia melanocarpa and having an antioxidative, whitening, or anti-wrinkle effect, and to a method for preparing the same. The present invention relates to an extract of Aronia melanocarpa prepared by subjecting Aronia melanocarpa to a low-temperature extreme cold process, followed by fermentation with lactic acid bacteria; to a functional cosmetic composition containing the extract as an active ingredient; and to a method for preparing the same. The extract of Aronia melanocarpa according to the present invention has gone through the low-temperature extreme cold process, such as a super high pressure or ultrasonic waves, thereby minimizing the destruction of useful active materials of Aronia melanocarpa itself. Furthermore, the extract of Aronia melanocarpa can be appropriately used as a cosmetic material by metabolizing the useful materials, which are eluted by the treatment with lactic acid bacteria, to induce the generation of various active materials. Furthermore, the cosmetic composition prepared by the method of the present invention has excellent antioxidant, whitening, moisturizing, and anti-wrinkle effects compared with when the general extraction method is performed and Aronia melanocarpa is subjected to an extreme cold process alone.
摘要翻译：本发明涉及一种含有黑腹果皮提取物并具有抗氧化，增白或抗皱作用的化妆品组合物及其制备方法。本发明涉及黑腹果皮提取物，其通过使黑腹果蝇进行低温极冷处理，随后用乳酸菌发酵; 涉及含有提取物作为活性成分的功能性化妆品组合物; 以及其制备方法。根据本发明的黑腹果蝇的提取物已经经历了诸如超高压或超声波的低温极冷过程，从而最小化了黑腹果蝇本身的有用活性物质的破坏。此外，黑腹果皮提取物可以通过代谢通过用乳酸菌处理洗脱的有用物质诱导各种活性物质的产生而适当地用作化妆品。此外，通过本发明的方法制备的化妆品组合物与进行一般提取方法相比，与单宁进行极冷法相比，具有优异的抗氧化，增白，保湿和抗皱作用。

6. 发明公开

KR1020140140932A 방제 활성이 증진된 비타민 B1 유도체 나노 입자 수용액 및 그 제조방법 有权
标题翻译：维生素B1衍生物具有改善的病虫害控制能力的纳米颗粒溶液及其制造方法
公开(公告)号：KR1020140140932A
公开(公告)日：2014-12-10
申请号：KR1020130061978
申请日：2013-05-30
申请人： 서원대학교산학협력단 , 강원대학교산학협력단 , 주식회사 두산에코비즈넷
发明人： 이현용 , 서용창 , 최운용 , 김지선 , 최우석 , 최철순 , 임태빈 , 조정섭
IPC分类号： A01N43/78 , A01P3/00
摘要： 본 발명은 비타민 B1 유도체인 티아민 라우릴 황산염(Thiamine Di-lauryl Sulfate, TDS)을 분말 상태에서 나노 입자 형태로 수용액화 하여 방제 활성이 증진되도록 한 비타민 B1 유도체 나노 입자 수용액 및 그 제조방법에 관한 것이다. 본 발명은 종래 비타민 B1 유도체를 수용액 상태로 사용할 경우 안정성이 낮은 문제를 개선할 수 있는 비타민 B1 유도체 나노입자 수용액 제조방법을 제공하여, 비타민 B1 유도체가 항진균제 및 농약제제로 활용됨에 있어서 그 사용량을 최소화하여도 방제 효과를 증진시킬 수 있어 우수한 생물 농약으로 활용이 가능할 것이다.
摘要翻译：本发明涉及一种维生素B1衍生物纳米粒子溶液及其制造方法，该维生素B1衍生物纳米粒子溶液通过将维生素B1衍生物的二十二烷基硫酸二烷基酯（TDS）粉末制成纳米粒子进行溶解而提高害虫防治能力。本发明提供一种维生素B1衍生物纳米粒子溶液的制造方法，其可以解决常规维生素B1衍生物在溶液状态下的稳定性低的问题。从而即使最小化作为抗真菌药物和农药的维生素B1衍生物的使用量也能提高害虫防治能力。因此，维生素B1衍生物可用作优良的生物农药。

7. 发明公开

KR1020140117096A 두피 보호용 산화형 염모제 조성물 有权
标题翻译：用于保护标准品的氧化染发组合物
公开(公告)号：KR1020140117096A
公开(公告)日：2014-10-07
申请号：KR1020130032052
申请日：2013-03-26
申请人： 주식회사 서울화장품 , 주식회사 세바바이오텍 , 서원대학교산학협력단 , 강원대학교산학협력단
发明人： 이현용 , 임혜원 , 김학수 , 이정구 , 장민 , 김지선 , 최운용 , 최우석 , 최철순
IPC分类号： A61K8/34 , A61K8/19 , A61K8/97 , A61Q5/00
CPC分类号： A61K8/36 , A61K8/342 , A61K8/37 , A61K8/97 , A61K2800/72 , A61K2800/82 , A61Q5/10 , A61Q17/04
摘要： The present invention relates to an oxidized hair dye composition comprising an oxidized hair dye, a sunscreen, and at least one selected among natural substances, a calendula extract, a Ulmus macrocarpa extract, a Scutellaria baicalensis extract. More specifically, since the hair dye composition of the present invention contains a sunscreen in addition to the existing oxidized hair dye, the composition effectively prevents an oxidized dye polymer formed on the cortex of the hair from degrading by ultraviolet rays, hence delaying the decolorization of the dyed hair; thereby expecting the effects of maintaining the color of the dyed hair for a long time. Additionally, the hair dye composition is mixed with the natural substances including calendula, Ulmus macrocarpa, and Scutellaria baicalensis, thereby preventing allergic contact dermatitis caused by irritative substances contained in the hair dye. Therefore, the oxidized hair dye manufactured by a method of the present invention can be used by a person having hypersensitive skin without side effects.
摘要翻译：本发明涉及包含氧化染发剂，防晒剂和选自天然物质，金盏花提取物，榆树提取物，黄芩提取物中的至少一种的氧化染发组合物。更具体地说，由于除了现有的氧化染发剂以外，本发明的染发剂组合物还含有防晒剂，因此有效地防止了形成在毛发皮质上的氧化染料聚合物因紫外线而降解，因此延迟了脱色染发从而期望长时间保持染发的颜色的效果。另外，将染发剂组合物与包括金盏花，榆木，黄芩的天然物质混合，从而防止由染发剂中含有的刺激物质引起的过敏性接触性皮炎。因此，通过本发明的方法制造的氧化染发剂可以由具有过敏皮肤的人使用而没有副作用。

8. 发明公开

KR1020140098503A 감압 재순환 고속 증숙 공정장치를 이용한 인삼의 저분자 진세노사이드 함량 증진 방법 有权
标题翻译：通过分解回收高速蒸馏过程装置提高金山低分子金属皂苷含量的制备
公开(公告)号：KR1020140098503A
公开(公告)日：2014-08-08
申请号：KR1020130011257
申请日：2013-01-31
申请人： 주식회사 세바바이오텍 , 서원대학교산학협력단 , 강원대학교산학협력단
发明人： 이현용 , 최운용 , 서용창 , 김지선 , 이춘근 , 최우석 , 임혜원
IPC分类号： A23L19/00 , A47J27/00
摘要： The present invention relates to a decompression-recirculation high-speed steaming device and a method for producing ginseng having an increased low-molecular ginsenosides content and, more specifically, to a method for producing the ginseng in which the content of the low-molecular ginsenosides such as Rh2, Rg2, Rg3, and CK is increased by inputting ginseng into the device of the present invention and steaming the inputted ginseng under a decompression condition. When steaming ginseng by using the decompression-recirculation high-speed steaming device of the present invention, an effect of rapidly producing red ginseng by effectively increasing the low-molecular ginsenosides (Rh2, Rg2, Rg3, and CK) contained in ginseng can be obtained and an effect of having a little content of benzopyrene that is a carcinogen by not going through a repetitive steaming step for a long time as in the past. Furthermore, when steaming ginseng by using the device of the present invention, a value of the ginseng can be increased by applying the method to cheap ginseng as a huge morphologic change of ginseng is not generated. Therefore, the decompression-recirculation high-speed steaming device and method for producing ginseng having the increased low-molecular ginsenosides content of the present invention can be usefully applied in not only medicine and medical supplies but also functional food and cosmetics.
摘要翻译：本发明涉及一种减压 - 再循环高速蒸汽装置和一种生产具有增加的低分子人参皂甙含量的人参的方法，更具体地说，涉及一种生产人参的方法，其中低分子量人参皂苷的含量通过将人参输入本发明的装置并在减压条件下蒸煮输入的人参，从而增加了Rh2，Rg2，Rg3和CK。当通过使用本发明的减压 - 再循环高速蒸汽装置蒸人参时，可以获得通过有效增加人参中所含的低分子量人参皂甙（Rh2，Rg2，Rg3和CK）迅速生产红参的效果并且通过与过去不经历长时间的重复蒸汽步骤，具有作为致癌物的苯并芘含量少的效果。此外，当通过使用本发明的装置蒸制人参时，通过将该方法应用于廉价人参可以提高人参的价值，因为不会产生人参的巨大形态变化。因此，本发明的具有增加的低分子量人参皂甙含量的人参的减压 - 再循环高速蒸汽装置和制造方法不仅可用于医药和医疗用品，还可用于功能性食品和化妆品。

9. 发明公开

KR1020140027614A 커피 발효물 및 이의 추출물을 유효성분으로 포함하는 기능성 커피 음료 조성물 및 이의 제조방법 有权
标题翻译：功能性咖啡饮料组合物，包括咖啡发酵产品及其提取物及其生产方法
公开(公告)号：KR1020140027614A
公开(公告)日：2014-03-07
申请号：KR1020120085913
申请日：2012-08-06
申请人： 강원대학교산학협력단 , 서원대학교산학협력단 , 주식회사 세바바이오텍
发明人： 이현용 , 최운용 , 서용창 , 송치호 , 이춘근 , 임혜원
IPC分类号： A23F5/28 , A23F5/40
摘要： The present invention relates to a manufacturing method of a functional coffee drink composition including fermented coffee products (coffee beans or by-products) and an extract thereof, and, more specifically, to a manufacturing method of a functional coffee drink composition including fermented liquid and fermented coffee residual extract, and a functional coffee drink composition manufactured thereby, wherein the fermented liquid is obtained by fermenting unprocessed coffee beans or coffee by-products, which are mostly discarded without being consumed, by using lactobacillus, and the fermented coffee residual extract is obtained by extracting the dried fermented coffee residue besides the fermented liquid, with ethanol. As the manufacturing method of the present invention is able to enhance elution of chlorogenic acid in the coffee through a simple process, the composition of the present invention manufactured through the method contains a large quantity of chlorogenic acid having a lipoperoxide production suppressing effect, cholesterol biosynthesis inhibition effect, an anti-oxidation activity, an anti-inflammatory effect and an anti-cancer effect, enabling the composition to be used as a functional coffee drink composition. Further, the manufacturing method of the present invention utilizes coffee beans, of which the unit price is cheap, or discarded coffee by-products to create novel health materials having functionalities, to provide an eco-friendly effect through the recycling of waste. [Reference numerals] (AA) Free radical elimination rate (%); (BB) Concentration (쨉m); (CC) Hydrothermal extract of coffee beans (Comparative example); (DD) Hydrothermal extract of coffee by-product (Comparative example)
摘要翻译：本发明涉及一种包含发酵咖啡产品（咖啡豆或副产物）及其提取物的功能性咖啡饮料组合物的制造方法，更具体地，涉及包含发酵液体的功能性咖啡饮料组合物的制造方法，发酵咖啡残余提取物和由此制造的功能性咖啡饮料组合物，其中，所述发酵液体通过使用乳杆菌发酵未处理大部分被废弃而未被消耗的未加工咖啡豆或咖啡副产物而获得，所述发酵咖啡残余提取物为通过用乙醇萃取除了发酵液之外的干燥的发酵咖啡残渣获得。由于本发明的制造方法能够通过简单的方法提高咖啡中的绿原酸的洗脱，所以通过该方法制造的本发明的组合物含有大量具有脂肪过氧化物产生抑制作用的绿原酸，胆固醇生物合成抑制效果，抗氧化活性，抗炎作用和抗癌作用，使得该组合物可用作功能性咖啡饮料组合物。此外，本发明的制造方法利用单价廉价的咖啡豆或者丢弃的咖啡副产品来制造具有功能的新型健康材料，通过废物的再循环来提供环保效果。（标号）（AA）自由基消除率（％）; （BB）浓度（쨉m）; （CC）咖啡豆水热提取物（比较例）; （DD）咖啡副产物水热提取物（比较例）

10. 发明公开

KR1020140013800A 동시 중온 추출 및 발효 공정을 이용한 천연물의 생리활성 물질 함량을 증진시키는 방법 有权
标题翻译：一种利用自然提取自然物质促进生物活性的方法
公开(公告)号：KR1020140013800A
公开(公告)日：2014-02-05
申请号：KR1020120082332
申请日：2012-07-27
申请人： 강원대학교산학협력단 , 서원대학교산학협력단 , 주식회사 세바바이오텍
发明人： 이현용 , 최운용 , 서용창 , 송치호 , 이춘근 , 임혜원
IPC分类号： A23L19/00 , A23L1/30 , A61K36/258 , A61K8/97
CPC分类号： A61K36/258 , A23L33/105 , A61K8/97 , A61K36/344 , A61K36/539 , A61K2236/39 , A61K2800/85 , A61Q19/00
摘要： The present invention relates to a method for enhancing the content of bioactive substances of a natural substance using simultaneous middle temperature extraction and a fermentation process and more specifically, in the present invention, since natural substances are fermented at 45-70°C using Bacillus coagulans, which is an edible thermophilic bacterium, and extracted at the same time, the content of effective bioactive substances is enhanced compared to the content thereof obtained by traditional fermentation, and an economic effect can be increased as the entire time required for the process is shortened. Thus, the effective bioactive substances can be effectively extracted from natural substances which have undergone simultaneous middle temperature extraction and fermentation and can be used for manufacturing health functional foods, pharmaceutical products, and cosmetics.
摘要翻译：本发明涉及使用同时中温提取和发酵方法提高天然物质生物活性物质含量的方法，更具体地说，在本发明中，由于天然物质在45-70℃下使用凝结芽孢杆菌，这是一种可食用的嗜热细菌，同时提取，与传统发酵得到的含量相比，有效生物活性物质的含量增加，并且缩短了整个过程所需的整个时间，可以提高经济效果。因此，有效的生物活性物质可以从经过同时中温提取和发酵的天然物质中有效提取，并可用于制造健康功能性食品，药品和化妆品。

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