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    • 8. 发明公开
    • 도메인 예측 장치, 방법 및 이를 컴퓨터에서 실행하기 위한 프로그램을 기록하는 컴퓨터 판독 가능한 기록매체
    • 用于实现其的域预测装置,方法和计算机可读记录记录程序
    • KR1020130102395A
    • 2013-09-17
    • KR1020120023595
    • 2012-03-07
    • 한국과학기술원
    • 이관수김진욱김진기김율
    • G06F19/10G06F19/24G06F19/28
    • G06F19/24G06F19/16G06F19/28
    • PURPOSE: A domain prediction device, a method, and a computer-readable recording medium for recording a program for performing thereof in a computer are provided to predict a domain, based on physico-chemical properties of an amino acid sequence and a secondary structure of a protein, which is difficult to predict with a method for comparing only similarities between sequences. CONSTITUTION: A domain prediction device, a method, and a computer-readable recording medium for recording a program for performing thereof in a computer comprise the following steps: a database (100) stores sequential information of a domain, physico-chemical property information of an amino acid sequence, and secondary structure information; a sequence feature detecting part (200) extracts a sequence feature about the sequential information by using the sequential information, the physico-chemical property information, and the secondary structure information; a machine learning part (300) machine-learns a sequence feature; a sequence analysis part (400) extracts a candidate sequence from inputted protein sequential information; and the sequence analysis part predicts a domain corresponding to the candidate sequence by using a sequence feature of the domain which is machine-learned from the machine learning part. [Reference numerals] (100) Database; (110) Domain DB; (120) Physicochemical feature DB; (130) Secondary structure DB; (200) Sequence feature detecting part; (210) Physicochemical feature generating unit; (220) Secondary structure generating unit; (230) Sequence feature combination unit; (300) Machine learning part; (310) Separating unit; (320) Training unit; (330) Importance determining unit; (400) Sequence analysis part; (410) Input unit; (420) Candidate sequence extracting unit; (430) Domain prediction unit; (440) Output unit
    • 目的:提供一种用于在计算机中记录用于执行程序的域预测装置,方法和计算机可读记录介质,用于基于氨基酸序列和二级结构的物理化学性质来预测域 一种蛋白质,难以用仅用于比较序列之间相似性的方法来预测。 构成:用于记录在计算机中执行的程序的域预测装置,方法和计算机可读记录介质包括以下步骤:数据库(100)存储域的顺序信息,物理化学属性信息 氨基酸序列和二级结构信息; 序列特征检测部分(200)通过使用顺序信息,物理化学性质信息和二级结构信息来提取关于顺序信息的序列特征; 机器学习部分(300)机器 - 学习序列特征; 序列分析部分(400)从输入的蛋白质序列信息中提取候选序列; 并且序列分析部分通过使用从机器学习部分机器学习的域的序列特征来预测与候选序列相对应的域。 (附图标记)(100)数据库; (110)域DB; (120)物理化学特征DB; (130)二次结构DB; (200)序列特征检测部分; (210)物理化学特征生成单元; (220)二次结构生成单元; (230)序列特征组合单位; (300)机器学习部分; (310)分离单元; (320)培训单位; (330)重要性确定单元; (400)序列分析部分; (410)输入单元; (420)候选序列提取单元; (430)域预测单元; (440)输出单元