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2. 发明公开

KR1020100118736A 나프토퀴논 유도체 및 그 제조방법 失效
标题翻译：萘醌衍生物及其制备方法
公开(公告)号：KR1020100118736A
公开(公告)日：2010-11-08
申请号：KR1020090037570
申请日：2009-04-29
申请人： 한경대학교 산학협력단
发明人： 최중국 , 정용석 , 이학교
IPC分类号： C07C225/30 , A61K31/12 , A61P35/00
摘要： PURPOSE: A naphthoquinone derivative, and a manufacturing method thereof are provided to control the activity of DNA topoisomerase II of cancer cells, and to secure the excellent induction effect of the meronecrosis. CONSTITUTION: A manufacturing method of a naphthoquinone derivative comprises the following steps: producing N-substituted iminomethyl-1,4,5,8-tetramethoxy naphthalene compound, by reacting an oxime compound formed by reacting 2-formyl-1,4,5,8-tetramethoxynaphthalene with hydroxylamine, with iodopropane; oxidizing the outcome with CrO3 or cerium ammonium nitrate, to form 6-alkyliminomethyl-5,8-dimethoxy-1,4-naphthalenedione; and reacting the outcome with AlCl3 or dichloromethane, to form 6-propoxyiminomethyl-5,8-dihydroxy-1,4-naphthalenedione.
摘要翻译：目的：提供一种萘醌衍生物及其制备方法，以控制癌细胞DNA拓扑异构酶II的活性，并确保良好的食管坏死的诱导作用。构成：萘醌衍生物的制造方法包括以下步骤：使2-取代的亚氨基甲基-1,4,5,8-四甲氧基萘化合物通过使2-甲酰基-1,4,5， 8-四甲氧基萘与羟胺，与碘丙烷; 用CrO 3或硝酸铈铵氧化结果，形成6-烷基亚氨基甲基-5,8-二甲氧基-1,4-萘二酮; 并将结果与AlCl 3或二氯甲烷反应，形成6-丙氧基亚氨基甲基-5,8-二羟基-1,4-萘二酮。

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