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1. 发明公开

KR1020120126341A 3Ｔ3-Ｌ1 지방세포를 이용한 항비만 개선 효능이 있는 바이오 소재의 스크리닝방법 无效
标题翻译：使用3T3-L1前脂肪细胞的抗肥胖生物材料筛选方法
公开(公告)号：KR1020120126341A
公开(公告)日：2012-11-21
申请号：KR1020110044055
申请日：2011-05-11
申请人： 재단법인 대구테크노파크 , 주식회사 푸드웰
发明人： 성기준 , 정희경 , 정유석 , 홍주헌 , 이기동 , 심상필 , 정지은
IPC分类号： G01N33/15 , G01N33/50 , A61K36/72 , A61P3/04
摘要： PURPOSE: A method for screening a bio-material with an anti-obesity effect is provided to analyze marker-related genes and to evaluate anti-obesity bio-materials. CONSTITUTION: A method for screening a bio-material with an anti-obesity effect comprises: a step of preparing concentrated dry powder of a bio-material extract; and a step of treating 3T3-L1 adipocytes with the extract. The method also comprises a step of measuring the expression level of a gene relating to PPARgamma signaling. The bio-material is a fruit peel or pulp. The extract is a water or organic solvent extract of grape peel or pulp.
摘要翻译：目的：提供一种筛选具有抗肥胖作用的生物材料的方法，用于分析标记相关基因并评估抗肥胖生物材料。构成：用于筛选具有抗肥胖效果的生物材料的方法包括：制备生物材料提取物的浓缩干粉的步骤; 和用提取物处理3T3-L1脂肪细胞的步骤。该方法还包括测量与PPARγ信号传导有关的基因的表达水平的步骤。生物材料是果皮或果肉。提取物是葡萄皮或纸浆的水或有机溶剂提取物。

2. 发明公开

KR1020130063386A 대사증후군의 예방 또는 치료용 조성물 无效
标题翻译：用于预防或治疗代谢综合征的组合物
公开(公告)号：KR1020130063386A
公开(公告)日：2013-06-14
申请号：KR1020110129876
申请日：2011-12-06
申请人： 주식회사 푸드웰 , 재단법인 대구테크노파크
发明人： 성기준 , 조경현 , 홍주헌 , 정희경 , 정유석 , 심상필 , 정지은
IPC分类号： A61K36/87 , A61K36/73 , A61K36/889 , A61P3/04
CPC分类号： A61K36/87 , A23L33/105 , A23V2200/326 , A23V2200/328 , A61K36/73 , A61K36/889 , A61K2236/331 , Y10S514/824 , Y10S514/866 , Y10S514/909
摘要： PURPOSE: A composition containing one or more among a grape extract, an Eriobotrya japonica extract, and an assai extract for preventing and treating metabolic syndrome is provided to reduce blood glucose, and to prevent or treating metabolic syndrome such as obesity, diabetes, insulin resistance, hypertension, arteriosclerosis, and hyperlipidemia. CONSTITUTION: A composition for preventing or treating metabolic syndrome contains one or more extracts selected from the group consisting of a grape extract, an Eriobotrya japonica extract, and an assai extract, as an active ingredient. The composition contains one or more selected from the group consisting of a grape pericarp extract, an Eriobotrya japonica leaf extract, and an assai puree extract, as an active ingredient. The extract is prepared by hot water extraction at 50-90 deg. C for 1-5 hours. The metabolic syndrome is selected from the group consisting of obesity, diabetes, insulin resistance, hypertension, artheriosclerosis, and hyperlipidemia.
摘要翻译：目的：提供含有一种或多种葡萄提取物，j ica提取物和用于预防和治疗代谢综合征的唾液提取物的组合物以降低血糖，并预防或治疗代谢综合征如肥胖，糖尿病，胰岛素抵抗，高血压，动脉硬化和高脂血症。构成：用于预防或治疗代谢综合征的组合物含有一种或多种选自葡萄提取物，蓟马提取物和豌豆提取物的提取物作为活性成分。该组合物含有选自葡萄果皮提取物，j ica叶提取物和ai酱提取物中的一种或多种作为活性成分。提取物通过在50-90度的热水提取制备。 C 1-5小时。代谢综合征选自肥胖症，糖尿病，胰岛素抵抗，高血压，动物硬化和高脂血症。

3. 发明公开

KR1020130064595A 포도과피추출물을 유효성분으로 하는 비만 억제용 조성물 및 그 제조방법 无效
标题翻译：含有皱纹皮肤提取物的抗生素组合物及其制造方法
公开(公告)号：KR1020130064595A
公开(公告)日：2013-06-18
申请号：KR1020110131291
申请日：2011-12-08
申请人： 재단법인 대구테크노파크 , 주식회사 푸드웰
发明人： 성기준 , 정유석 , 정희경 , 조경현 , 홍주헌 , 심상필 , 정지은
IPC分类号： A61K36/87 , A61P3/04 , A61P3/00
摘要： PURPOSE: An anti-obesity composition and a manufacturing method of the same are provided to use refined products of grape skin extracts as new medicines and functional foods. CONSTITUTION: A manufacturing method of a grape skin refined product derived from a grape pulp extracted, frozen, and dried product includes the following steps of: obtaining an ethanol extract of grape skins; analyzing bioactive substances from the extract; and evaluating anti-obesity effect and cytotoxin of the extract. The grape skin refined product is obtained by dissolving grape pulp extracted, frozen, and dried powder of grape skins 100% ethanol, collecting supernatant, and refining using a sephadex-LH 20 column chromatography. An anti-obesity composition includes the grape skin refined product as an effective substance.
摘要翻译：目的：提供一种抗肥胖组合物及其制造方法，使用葡萄皮提取物的精制品作为新药和功能性食品。构成：从葡萄浆提取，冷冻和干燥产品得到的葡萄皮精制品的制造方法包括以下步骤：获得葡萄皮的乙醇提取物; 从提取物中分析生物活性物质; 并评估提取物的抗肥胖作用和细胞毒素。通过将葡萄皮提取，冷冻和干燥的葡萄皮100％乙醇溶解，收集上清液，并使用sephadex-LH 20柱色谱法精制，得到葡萄皮精制品。抗肥胖组合物包括葡萄皮精制品作为有效物质。

4. 发明公开

KR1020130064575A 포도과피 유래의 지방 전구세포의 지방 축적 저해용 화학물질 无效
标题翻译：化学抑制ADIPOCYTE 3T3-L细胞中脂肪的积累
公开(公告)号：KR1020130064575A
公开(公告)日：2013-06-18
申请号：KR1020110131256
申请日：2011-12-08
申请人： 재단법인 대구테크노파크 , 주식회사 푸드웰
发明人： 성기준 , 정유석 , 정희경 , 심상필 , 정지은
IPC分类号： A23L1/30 , A23L19/00
CPC分类号： A23L33/22 , A23L33/12 , A23V2002/00 , A23V2200/3324
摘要： PURPOSE: A chemical substance for fat accumulation of fat preadipocytes originated from grape rind is provided to offer the chemical substance by isolating fat accumulation inhibitor of fat preadipocyte 3T3-L1 adipocyte originated from grape rind. CONSTITUTION: A functional food composition for anti-obesity suppression includes essential fatty acid refined from grape rind as an active ingredient. The essential fatty acid is α -linolenic acid (W-6), α -linolenic acid (W-3), and α -Oleanolic acid.
摘要翻译：目的：通过分离来自葡萄皮的脂肪前脂肪细胞3T3-L1脂肪细胞的脂肪蓄积抑制剂，提供从葡萄皮起源的脂肪前脂肪细胞的脂肪蓄积化学物质。构成：用于抗肥胖抑制的功能性食品组合物包括从葡萄皮精制而成的必需脂肪酸作为活性成分。必需脂肪酸是α-亚麻酸（W-6），α-亚麻酸（W-3）和α-醇酸。

5. 发明公开

KR1020110123105A 진피 추출물을 포함하는 2형 당뇨 예방 및 치료용 조성물 有权
标题翻译：包含CITRUS PEEL提取物的组合物用于预防和治疗2型糖尿病
公开(公告)号：KR1020110123105A
公开(公告)日：2011-11-14
申请号：KR1020100042574
申请日：2010-05-06
申请人： 주식회사 푸드웰
发明人： 성기준 , 정희경 , 정유석 , 박치덕 , 박창호 , 홍주헌 , 최명숙 , 심상필 , 정지은
IPC分类号： A61K36/752 , A61P3/10
CPC分类号： A61K36/752 , A23V2200/328 , A61K2236/33 , A61K2236/51 , Y10S514/866
摘要： PURPOSE: A composition containing Citrus unshiu Markovich extract is provided to enhance insulin secretion and to reduce beta cell. CONSTITUTION: A pharmaceutical composition for preventing and treating type 2 diabetes contains Citrus unshiu Markovich extract as an active ingredient. The extract is a spirit extract. A health food composition for preventing and treating type 2 diabetes contains the extract as an active ingredient. The pharmaceutical composition further contains a carrier, excipient, and diluent. The daily dose of the extract is 0.0001-100 mg/kg. The pharmaceutical composition is used in the form of powder, granules, tablets, capsules, suspension, syrup, external use, and suppository.
摘要翻译：目的：提供含有柑橘不良马氏解毒提取物的组合物，以增强胰岛素分泌和减少β细胞。构成：用于预防和治疗2型糖尿病的药物组合物含有马铃薯柑橘提取物作为活性成分。提取物是精神提取物。用于预防和治疗2型糖尿病的保健食品组合物含有提取物作为活性成分。药物组合物还含有载体，赋形剂和稀释剂。提取物的日剂量为0.0001-100mg / kg。药物组合物以粉末，颗粒剂，片剂，胶囊，悬浮液，糖浆，外用和栓剂的形式使用。

6. 发明公开

KR1020130033072A 포도과피 유래 안토시아닌 색소 안정화 방법 및 그 분말의 제조방법 无效
标题翻译：来自花岗岩和其粉末的蒽醌染料的稳定化方法
公开(公告)号：KR1020130033072A
公开(公告)日：2013-04-03
申请号：KR1020110096909
申请日：2011-09-26
申请人： 주식회사 푸드웰
发明人： 성기준 , 심상필 , 정지은 , 홍주헌 , 정희경 , 정유석 , 이대훈 , 박혜미 , 양수진
IPC分类号： C09B61/00 , A23L33/00 , A23L5/40
CPC分类号： C09B61/00 , C09B23/00 , C09B67/0002 , C09B67/0003
摘要： PURPOSE: A stabilizing method of a grape-derived anthocyanin colorant is provided to manufacture a powder product with a spherical particle shape, capable of maintaining the anthocyanin colorant stability thereof. CONSTITUTION: A stabilizing method of a grape-derived anthocyanin colorant comprises a step of manufacturing anthocyanin colorant extraction liquid from grape-dried powder; a step of adding a diluting agent to the coloration extraction liquid and homogenizing the mixture; and a step of drying the liquid mixture and grinding the mixture. The anthocyanin colorant extraction liquid is extracted by 50%(v/v) ethanol which contains 1%(v/v) citric acid and 0.5%(v/v) HCl. The diluting agent is one of maltodextrine and sodium alginate.
摘要翻译：目的：提供一种葡萄源花青素着色剂的稳定化方法，用于制造具有保持花青素着色剂稳定性的球形颗粒形状的粉末产品。构成：葡萄源花青素着色剂的稳定化方法包括从葡萄干粉中制备花青素着色剂提取液的步骤; 向着色萃取液中添加稀释剂并均化混合物的步骤; 以及干燥该混合物并研磨该混合物的步骤。通过含有1％（v / v）柠檬酸和0.5％（v / v）HCl的50％（v / v）乙醇提取花青素着色剂提取液。稀释剂是麦芽糊精和藻酸钠之一。

7. 发明授权

KR101187310B1 진피 추출물을 포함하는 2형 당뇨 예방 및 치료용 조성물 有权
标题翻译：用于预防和治疗2型糖尿病的柑橘皮提取物的组合物
公开(公告)号：KR101187310B1
公开(公告)日：2012-10-05
申请号：KR1020100042574
申请日：2010-05-06
申请人： 주식회사 푸드웰
发明人： 성기준 , 정희경 , 정유석 , 박치덕 , 박창호 , 홍주헌 , 최명숙 , 심상필 , 정지은
IPC分类号： A61K36/752 , A61P3/10
摘要： 본 발명은 진피 추출물을 포함하는 2형 당료 예방 및 치료용 조성물에 관한 것으로, 본 발명에 따른 진피 추출물은 산화적 스트레스로부터 췌장 세포의 회복을 통해 인슐린 분비를 증대시키는 항산화적 방어로 2형 당뇨의 β-세포 질량의 감소와 인슐린 저항성을 개선시킬 수 있는 효과가 있다.

8. 发明公开

KR1020110031722A 포도과피 추출물의 제조 방법 无效
标题翻译：一种制备草皮提取物的方法
公开(公告)号：KR1020110031722A
公开(公告)日：2011-03-29
申请号：KR1020090089087
申请日：2009-09-21
申请人： 주식회사 푸드웰
发明人： 성기준 , 홍주헌 , 정희경 , 정유석 , 박치덕 , 박창호 , 최명숙 , 심상필 , 정지은
IPC分类号： A61K36/87 , A61P3/08 , A23L33/20 , A23L1/30
摘要： PURPOSE: A method for preparing grape peel extract and a composition containing the same with an anti-obesity activity is provided to suppress secretion and accumulation of adipocytes. CONSTITUTION: A grape peel extract is prepared by extracting grape peel with 30-80% of spirit for 1-3 hours. A pharmaceutical composition for preventing or treating obesity contains the grape peel extract as an active ingredient. The pharmaceutical composition further contains carrier, excipient, and diluent. The pharmaceutical composition is administered solely or together with other materials. A health food composition for treating obesity contains the grape peel extract as an active ingredient.
摘要翻译：目的：提供一种制备葡萄皮提取物的方法和含有其的含有抗肥胖活性的组合物，以抑制脂肪细胞的分泌和积聚。构成：用30-80％精油提取葡萄皮1-3小时制备葡萄皮提取物。用于预防或治疗肥胖症的药物组合物含有葡萄皮提取物作为活性成分。药物组合物还含有载体，赋形剂和稀释剂。药物组合物单独或与其它材料一起施用。用于治疗肥胖症的保健食品组合物含有葡萄皮提取物作为活性成分。

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