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1. 发明公开

KR1020150139073A 장류 효모의 자이고사카로마이세스 룩시 에스씨와이 1502를 이용한 발효물을 유효성분으로 하는 알파 글루코시다제 활성 저하용 조성물 有权
标题翻译：用于由YEAST ZYGOSACCHAROMYCES ROUXII SCY 1502产生的植物混合物的抗糖尿病的组合物
公开(公告)号：KR1020150139073A
公开(公告)日：2015-12-11
申请号：KR1020140066780
申请日：2014-06-02
申请人： 전북대학교산학협력단
发明人： 정용섭 , 이남근 , 김용식 , 정종훈
IPC分类号： C12P1/02 , A61P3/08 , A23L33/00 , A61K35/66 , C12N1/20
CPC分类号： C12P1/02
摘要： 본발명은장류효모인자이고사카로마이세스룩시에스씨와이 1502(KCCM11537P)를이용하여발효시킨발효물의α-글루코시다제저해활성에효과에관한것이다. 본발명은 (1) 뽕잎, 원기1호고춧잎, 도라지및 삼채뿌리건조분말의효모발효단계 (2) 효모발효액의데옥시노지리마이신(DNJ) 함량의분석단계 (3) 효모발효액의알파글루코시다제저해활성의평가단계로구성된다. 본발명은효모를이용하여α-글루코시다제저해활성이강화된발효물을개발한사례가없는항당뇨식용식물발효혼합물의제공에관한것이다.
摘要翻译：本发明涉及通过发酵作为酵母存在于酱汁或糊状物中的发酵提取物的酵母提取物对α-葡萄糖苷酶的抑制活性的影响，所述发酵提取物是酵母存在于酱油或糊状物中的发酵佐料酵母SCY 1502（KCCM11537P）。本发明包括以下步骤：（1）酵母发酵干燥动力成分，包括桑叶，Wonki 1胡椒叶，铃叶根和葱属根; （2）分析酵母发酵提取物中脱氧野尻霉素（DNJ）的含量; 和（c）评估酵母发酵提取物的α-葡糖苷酶抑制活性。迄今尚未开发出使用酵母的具有增强的α-葡糖苷酶抑制活性的发酵提取物，因此本发明提供了抗糖尿病发酵食用植物混合物。

2. 发明公开

KR1020120065308A 메트포르민 메탄설폰산염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제 无效
标题翻译：甲基麦芽糖苷，其制备方法，包含其的药物组合物和包含其的组合制剂
公开(公告)号：KR1020120065308A
公开(公告)日：2012-06-20
申请号：KR1020120059607
申请日：2012-06-04
申请人： 한올바이오파마주식회사
发明人： 김성욱 , 전성수 , 민창희 , 구자성 , 강민석 , 김용은
IPC分类号： C07C279/26 , C07C309/02 , A61K31/145 , A61P3/08
CPC分类号： C07C309/04 , C07C279/26
摘要： PURPOSE: A pharmaceutical composition containing metformin methanesulfonate salt is provided to have an excellent AMPKα activity and to increase pharmaceutical and physical advantages including solubility, stability, and non-hygroscopic property. CONSTITUTION: A pharmaceutical composition contains metformin methanesulfonate as an active ingredient. The metformin methanesulfonate has a structure represented by chemical formula 1. A melting point of the metformin methanesulfonate is 194.0-194.5 deg. Celsius. A pharmaceutical composition is effective for preventing or treating diabetes, metabolic syndrome, diabetic complication, menstrual irregularity, hypertension, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome, cancer, muscle pain, rhabdomyolysis, and/or menopausal syndrome.
摘要翻译：目的：提供含有二甲双胍甲磺酸盐的药物组合物以具有优异的AMPKα活性并增加药物和物理优点，包括溶解性，稳定性和非吸湿性。构成：药物组合物含有作为活性成分的甲磺酸二甲双胍。二甲双胍甲磺酸盐具有由化学式1表示的结构。甲磺酸二甲双胍的熔点为194.0-194.5℃。摄氏度。药物组合物可有效预防或治疗糖尿病，代谢综合征，糖尿病并发症，月经不规则，高血压，脂肪肝，冠状动脉疾病，骨质疏松症，多囊卵巢综合症，癌症，肌肉疼痛，横纹肌溶解症和/或绝经综合征。

3. 发明公开

KR1020110031722A 포도과피 추출물의 제조 방법 无效
标题翻译：一种制备草皮提取物的方法
公开(公告)号：KR1020110031722A
公开(公告)日：2011-03-29
申请号：KR1020090089087
申请日：2009-09-21
申请人： 주식회사 푸드웰
发明人： 성기준 , 홍주헌 , 정희경 , 정유석 , 박치덕 , 박창호 , 최명숙 , 심상필 , 정지은
IPC分类号： A61K36/87 , A61P3/08 , A23L33/20 , A23L1/30
摘要： PURPOSE: A method for preparing grape peel extract and a composition containing the same with an anti-obesity activity is provided to suppress secretion and accumulation of adipocytes. CONSTITUTION: A grape peel extract is prepared by extracting grape peel with 30-80% of spirit for 1-3 hours. A pharmaceutical composition for preventing or treating obesity contains the grape peel extract as an active ingredient. The pharmaceutical composition further contains carrier, excipient, and diluent. The pharmaceutical composition is administered solely or together with other materials. A health food composition for treating obesity contains the grape peel extract as an active ingredient.
摘要翻译：目的：提供一种制备葡萄皮提取物的方法和含有其的含有抗肥胖活性的组合物，以抑制脂肪细胞的分泌和积聚。构成：用30-80％精油提取葡萄皮1-3小时制备葡萄皮提取物。用于预防或治疗肥胖症的药物组合物含有葡萄皮提取物作为活性成分。药物组合物还含有载体，赋形剂和稀释剂。药物组合物单独或与其它材料一起施用。用于治疗肥胖症的保健食品组合物含有葡萄皮提取物作为活性成分。

4. 发明公开

KR1020100102140A 피라졸 유도체의 모노세박산염 有权
标题翻译：吡唑衍生物的单体
公开(公告)号：KR1020100102140A
公开(公告)日：2010-09-20
申请号：KR1020107014837
申请日：2008-12-24
申请人： 깃세이 야쿠힌 고교 가부시키가이샤
发明人： 타케우치,히데키 , 츠루,에이지
IPC分类号： C07H17/02 , A61K31/7056 , A61P3/10 , A61P3/08
CPC分类号： C07H17/02
摘要： 본 발명은 3-(3-{4-[3-(β-D-글루코피라노실옥시)-5-이소프로필-1H-피라졸-4-일메틸]-3-메틸페녹시}프로필아미노)-2,2-디메틸프로피온아미드의 보존안정성이 개량된 신규형태를 제공한다.
비스[3-(3-{4-[3-(β-D-글루코피라노실옥시)-5-이소프로필-1H-피라졸-4-일메틸]-3-메틸페녹시}프로필아미노)-2,2-디메틸프로피온아미드]·모노세박산염은 극히 우수한 보존안정성을 가지므로, 의약품 원체로서 유용하다. 게다가, 극히 양호한 결정성을 보이며, 간편한 방법에 의해 정제가 가능하기 때문에, 공업적 생산에 적합하다.

5. 发明公开

KR1020090012349A 아세틸 조효소 Ａ 디아실글리세롤 아실트랜스퍼라제의 억제제로서의 치환된 5-페닐아미노-1,3,4-옥사디아졸-2-일카르보닐아미노-4-페녹시-시클로헥산 카르복실산 无效
标题翻译：取代的5-苯基亚氨基-1,3,4-氧杂双酚-2-亚甲基氨基-4-羟基 - 环己烷羧酸作为乙酰苯胺的一种抑制剂二乙酰胆碱酯酶
公开(公告)号：KR1020090012349A
公开(公告)日：2009-02-03
申请号：KR1020087029467
申请日：2007-05-29
申请人： 아스트라제네카 아베
发明人： 버틀린로저쟌 , 플로우라이트알레인
IPC分类号： C07D271/10 , A61K31/4245 , A61P3/08 , A61P37/02
CPC分类号： C07D271/10 , C07D271/113
摘要： Compounds of formula (I), or salts thereof, which inhibit acetyl CoA(acetyl coenzyme A):diacylglycerol acyltransferase (DGAT1) activity are provided, wherein R1, R2 and R3 are each independently selected from hydrogen, fluoro, chloro, cyano, trifluoromethyl, trifluoromethoxy and difluoromethoxy; together with processes for their preparation, pharmaceutical compositions containing them and their use as medicaments.
摘要翻译：提供了抑制乙酰CoA（乙酰辅酶A）：二酰基甘油酰基转移酶（DGAT1）活性的式（I）化合物或其盐，其中R 1，R 2和R 3各自独立地选自氢，氟，氯，氰基，三氟甲基，三氟甲氧基和二氟甲氧基; 以及其制备方法，含有它们的药物组合物及其作为药物的用途。

6. 发明授权

KR100848491B1 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법 有权
标题翻译：具有βA的2-噻唑烷衍生物; - 氨基，药物可接受的盐及其制备方法
公开(公告)号：KR100848491B1
公开(公告)日：2008-07-28
申请号：KR1020070004577
申请日：2007-01-16
申请人： 영진약품 주식회사 , 한국화학연구원
发明人： 김성수 , 천혜경 , 이상달 , 안진희 , 김기영 , 강남숙 , 강승규 , 정원훈 , 김성규 , 김선영 , 권재홍 , 손상권 , 신민기 , 하니나
IPC分类号： C07D277/06 , C07D417/06 , A61P3/08 , A61P3/04
CPC分类号： C07D277/06 , C07D417/12 , Y02P20/55
摘要： 2-Thiazolidine derivatives having beta-amino group are provided to inhibit activity of DPP-IV(dipeptidyl peptidase-IV) associated with activity regulation of various hormones, so that the compounds are useful for treating diseases mediated by DPP-IV including type 2 diabetes mellitus. The 2-thiazolidine derivatives having beta-amino group represented by the formula(1) are prepared by reacting an amino acid represented by the formula(2) with 2-thiazolidine compounds represented by the formula(3) to prepare compounds represented by the formula(4), and deprotecting the compounds represented by the formula(4), wherein BOC is a protecting group; A is -NR^e(CH2)nR2 or -OR^b; R^a is hydrogen, C1-6 alkyl, C1-6 alkoxy, -OCF3, halogen, -CN or -CF3; R^b is hydrogen, C1-6 alkyl, C3-6 cycloalkyl, isopropyl, t-butyl, -CH2CH2OH, -CH2CH2NH2, -CH2CH2N(CH2CH2)2O, -CH2CH2N(CH2CH3)2 or -CH2CH2NHCOCH3; R^c is hydrogen, C1-6 alkyl, C3-6 cycloalkyl, benzyl, isopropyl or t-butyl; R^d and R^e are each independently hydrogen, C1-6 alkyl or C3-6 cycloalkyl; Y is carbon, oxygen, sulfur or nitrogen; Z is hydrogen, C1-6 alkyl, C3-6 cycloalkyl or -CO2R^b; and n is an integer of 0, 1 or 2.
摘要翻译：提供具有β-氨基的2-噻唑烷衍生物以抑制与各种激素的活性调节相关的DPP-IV（二肽基肽酶-IV）的活性，使得该化合物可用于治疗包括2型糖尿病的DPP-IV介导的疾病糖尿病。由式（1）表示的具有β-氨基的2-噻唑烷衍生物通过使由式（2）表示的氨基酸与由式（3）表示的2-噻唑烷化合物反应来制备由式（4）表示的化合物，并使由式（4）表示的化合物脱保护，其中BOC为保护基; A是-NR e（CH 2）n R 2或-OR b; R a a是氢，C 1-6烷基，C 1-6烷氧基，-OCF 3，卤素，-CN或-CF 3; 异丙基，叔丁基，-CH 2 CH 2 OH，-CH 2 CH 2 NH 2，-CH 2 CH 2 N（CH 2 CH 2）2 O，-CH 2 CH 2 N（CH 2 CH 3）2或-CH 2 CH 2 NHCOCH 3; R c是氢，C 1-6烷基，C 3-6环烷基，苄基，异丙基或叔丁基; R d和R e e各自独立地为氢，C 1-6烷基或C 3-6环烷基; Y是碳，氧，硫或氮; Z是氢，C 1-6烷基，C 3-6环烷基或-CO 2 R b; 且n为0,1或2的整数。

7. 发明公开

KR1020080019050A 당흡수 조절제 및 당뇨병 또는 당뇨병 합병증의 치료방법 有权
标题翻译：葡萄糖摄取调节剂和治疗糖尿病或糖尿病并发症的方法
公开(公告)号：KR1020080019050A
公开(公告)日：2008-02-29
申请号：KR1020087000284
申请日：2006-07-07
申请人： 학교법인 포항공과대학교 , 주식회사 포스코
发明人： 예경무 , 김재윤 , 김종현 , 이병대 , 이승재 , 이태훈 , 서판길 , 류성호
IPC分类号： A61K31/7032 , A61P3/08
CPC分类号： A61K31/7032 , A61K38/2228 , A61K38/28 , A61K2300/00
摘要： A glucose uptake modulator is provided to promote glucose uptake of adipocytes and reduce blood glucose without side effects by using a new ligand isolated from the serum, so that it is useful for treatment of diabetes or diabetic complications. A glucose uptake modulator comprises a serum derived compound selected from lysophosphatidylcholine(LPC), lysophosphatidylserine(LPS), lysophosphatidic acid(LPA) and urocortin(UCN), wherein the glucose uptake modulation for lysophosphatidylserine is inhibited by PKC(protein kinase C) delta inhibitor rotlerine and dominant negative expression of PKC delta and independent from PI3(Phosphoinositide 3)-kinase dependent signal transfer pathway; the lysophosphatidylcholine is myristoyl LPC or palmitoyl LPC; and the urocortin acts as insulin-sensitizer together with insulin. The diabetes or diabetic complications are treated by administering the glucose uptake modulator to a mammal.
摘要翻译：提供葡萄糖摄取调节剂以通过使用从血清分离的新配体来促进脂肪细胞的葡萄糖摄取并降低血糖而没有副作用，因此它可用于治疗糖尿病或糖尿病并发症。葡萄糖摄取调节剂包含选自溶血磷脂酰胆碱（LPC），溶血磷脂酰丝氨酸（LPS），溶血磷脂酸（LPA）和尿皮质素（UCN））的血清衍生化合物，其中溶血磷脂酰丝氨酸的葡萄糖摄取调节被PKC（蛋白激酶C）罗格列酮和PKCδ的显性负性表达，独立于PI3（磷酸肌醇3） - 激酶依赖性信号转导途径; 溶血磷脂酰胆碱是肉豆蔻酰的LPC或棕榈酰LPC; 尿激酶与胰岛素一起作为胰岛素敏化剂。通过向哺乳动物施用葡萄糖摄取调节剂来治疗糖尿病或糖尿病并发症。

8. 发明公开

KR1020010084828A 석이로부터 유효성분의 추출·정제방법 및 그 추출물을함유한 생약 조성물 失效
标题翻译：从栀子提取和净化有效成分的方法及其提取物的草药组合物
公开(公告)号：KR1020010084828A
公开(公告)日：2001-09-06
申请号：KR1020000010156
申请日：2000-02-29
申请人： 김남재 , 최혁재 , 김동현
发明人： 김남재 , 김동현 , 최혁재
IPC分类号： A61K36/09 , A61P3/10 , A61P3/08 , A61P3/04
摘要： PURPOSE: A method of effectively extracting and purifying a component effective for inhibiting alpha-glucosidase from Gyrophora esculenta under specified conditions is provided. Whereby, the extract is useful for the treatment of a disease caused by metabolic defect of carbohydrate. CONSTITUTION: The extraction and purification method comprises the steps: hot water extracting of Gyrophora esculenta with water 8 to 12 times by weight at 90 to 120deg.C; pouring 30 to 70% by volume of methanol or acetone into the hot water extract, removing a precipitate and fractionating ethanol, methanol or acetone; processing vacuum-concentration of the ethanol, methanol or acetone fractionate at 60 to 95deg.C in 3 to 20 mmHg; pouring 25 to 50% by volume of butanol into the concentrate, removing a butanol layer and fractionating a water layer; and processing vacuum-concentration of the water layer, azeotropic concentration of the concentrate with distilled water 2 to 7 times by volume of the total weight of concentrate and freeze drying.
摘要翻译：目的：提供一种有效提取和纯化在特定条件下有效抑制Gyrophora esculenta中α-葡萄糖苷酶的成分的方法。因此，该提取物可用于治疗由碳水化合物的代谢缺陷引起的疾病。构成：提取纯化方法包括以下步骤：用水8〜12重量份在90〜120℃下热水提取栀子花; 将30〜70体积％的甲醇或丙酮倒入热水提取液中，除去沉淀物并分馏乙醇，甲醇或丙酮; 在3〜20mmHg的温度下，在60〜95℃下处理乙醇，甲醇或丙酮分馏液的真空浓度; 将25至50体积％的丁醇倒入浓缩物中，除去丁醇层并分馏水层; 并处理水层的真空浓缩，浓缩物与蒸馏水的共沸浓缩浓缩物的浓度为总重量的2〜7倍，并冷冻干燥。

9. 发明公开

KR880000395A 피리딘에탄올아민 유도체 失效
公开(公告)号：KR880000395A
公开(公告)日：1988-03-25
申请号：KR870006499
申请日：1987-06-26
IPC分类号： C07D213/36 , A61K20060101 , A61K31/13 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61P3/04 , A61P3/08 , A61P3/10 , C07D20060101 , C07D213/38 , C07D213/61
摘要： 내용없음

10. 发明公开

KR870008876A 치환된 티아졸 및 옥사졸 및 그의 제조방법 失效
公开(公告)号：KR870008876A
公开(公告)日：1987-10-21
申请号：KR870002258
申请日：1987-03-13
IPC分类号： A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/02 , C07D263/32 , C07D263/34 , C07D263/48 , C07D265/30 , C07D265/32 , C07D277/20 , C07D277/22 , C07D277/24 , C07D277/28 , C07D277/32 , C07D277/38 , C07D277/40 , C07D277/42 , C07D277/44 , C07D277/46 , C07D413/04 , C07D417/04 , C07D417/14
摘要： 내용없음

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