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2. 发明公开

KR1020070082440A 신경세포사멸 또는 신경기능장애를 치료하기 위한 약학제제 및 병용용법 无效
标题翻译：治疗神经性死亡或神经性功能障碍的药物制备和组合治疗
公开(公告)号：KR1020070082440A
公开(公告)日：2007-08-21
申请号：KR1020060015301
申请日：2006-02-16
申请人： 주식회사 지엔티파마 , 주식회사 아라온테크
发明人： 곽병주 , 이영애 , 신진희 , 조성익 , 노재성 , 조제영 , 김기원 , 임향란 , 이재근 , 변한열
IPC分类号： A61K33/14 , A61K31/60 , A61P25/28
CPC分类号： A61K31/606 , A61K31/192 , A61K33/00 , A61K2300/00
摘要： A pharmaceutical preparation and combination therapy for treating neuronal cell death or neurological dysfunction is provided to inhibit both apoptosis and necrosis of neuronal cells by using synergism of an apoptosis inhibitor and lithium. The pharmaceutical preparation and combination therapy for treating neuronal cell death or neurological dysfunction comprises: an apoptosis inhibitor selected from benzylaminosalicylic acid derivatives represented by the formula(1), wherein X is CO, SO2 or (CH2)n in which n is an integer from 1 to 5, R1 is hydrogen, alkyl or alkanoyl, R2 is hydrogen or alkyl, R3 is hydrogen or acetyl, and R4 is phenyl optionally substituted by nitro, halogen, haloalkyl and C1-C5 alkoxy; and tetrafluorobenzyl derivatives represented by the formula(2), wherein R1, R2 and R3 are each independently hydrogen or halogen, R4 is hydroxy, alkyl, alkoxy, halogen, halogen-substituted alkoxy, alkanoyloxy or nitro, and R5 is carboxylic acid, ester having C1-C4 alkyl group, carboxyamide, sulfonic acid, halogen or nitro, and lithium or its pharmaceutically acceptable salts.
摘要翻译：提供用于治疗神经元细胞死亡或神经功能障碍的药物制剂和组合疗法，以通过使用凋亡抑制剂和锂的协同作用来抑制神经元细胞的凋亡和坏死。用于治疗神经元细胞死亡或神经功能障碍的药物制剂和组合疗法包括：选自由式（1）表示的苄基氨基水杨酸衍生物的凋亡抑制剂，其中X为CO，SO 2或（CH 2）n，其中n为 1至5，R 1为氢，烷基或烷酰基，R 2为氢或烷基，R 3为氢或乙酰基，R 4为任选被硝基，卤素，卤代烷基和C 1 -C 5烷氧基取代的苯基; 和式（2）表示的四氟苄基衍生物，其中R 1，R 2和R 3各自独立地为氢或卤素，R 4为羟基，烷基，烷氧基，卤素，卤素取代的烷氧基，烷酰氧基或硝基，R 5为羧酸酯具有C 1 -C 4烷基，羧酰胺，磺酸，卤素或硝基，以及锂或其药学上可接受的盐。

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