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    • 4. 发明公开
    • 인지 기능 장애 예방 또는 치료용 조성물
    • 用于预防或治疗认知障碍的组合物
    • KR1020070070277A
    • 2007-07-04
    • KR1020040109419
    • 2004-12-21
    • 주식회사 유니베라주식회사 유니젠
    • 김영호박영인이종길오선택조태형우성식
    • A61K31/122A61K36/886
    • A composition for preventing or treating cognitive disorders including senile dementia is provided to inhibit Abeta(beta-amyloid) aggregation and apoptosis caused by Abeta, promote proliferation of nerve cells, and reduce side effects. The composition for preventing or treating cognitive disorders comprises the extract of aloe or compounds represented by the formula(1) obtained from the aloe extract, or their pharmaceutically acceptable salts, wherein the aloe is Aloe vera, Aloe Aborescens or Aloe saponaria; the cognitive disorders include lowering of memory or concentration ability, dementia and Alzheimer dementia; the aloe extract is prepared with a polar solvent selected from water, C1-4 alcohol and acetone, or a non-polar solvent selected from n-hexane, dichloromethane, chloroform and ethylacetate; and the composition is a pharmaceutical or health food composition.
    • 提供了用于预防或治疗认知障碍(包括老年性痴呆)的组合物,用于抑制由Aβ引起的Aβ(β-淀粉样蛋白)聚集和凋亡,促进神经细胞的增殖,并减少副作用。 用于预防或治疗认知障碍的组合物包括芦荟提取物或由芦荟提取物获得的式(1)表示的化合物或其药学上可接受的盐,其中芦荟是芦荟芦荟,芦荟芦荟或芦荟; 认知障碍包括降低记忆力或集中能力,痴呆和阿尔茨海默氏痴呆; 芦荟提取物用选自水,C 1-4醇和丙酮的极性溶剂或选自正己烷,二氯甲烷,氯仿和乙酸乙酯的非极性溶剂制备; 并且该组合物是药物或保健食品组合物。
    • 10. 发明授权
    • 위장질환 치료 및 예방용 조성물 및 그의 제조방법
    • 用于治疗和预防胃肠疾病的组合物及其制备方法
    • KR100807645B1
    • 2008-02-28
    • KR1020060101011
    • 2006-10-17
    • 주식회사 유니젠
    • 우성식차지민김동선도선길이영철남정범김태우
    • A61K36/532A61P1/04
    • A61K36/532A61K2236/33Y10S514/886Y10S514/925
    • A composition comprising an extract of Agastache rugosa is provided to inhibit significantly gastrointestinal diseases induced in an animal model, thereby being used as a useful medicine for treating and preventing various gastrointestinal diseases. A pharmaceutical composition for treating gastrointestinal diseases such as chronic or acute gastritis, stomach ulcer and stomach bleeding comprises a C1-2 alcohol extract of Agastache rugosa as an effective ingredient and a pharmaceutically acceptable carrier, where the extract includes tilianin, acacetin or agastachoside. A method for preparing the composition comprises the steps of: (a) extracting the Agastache rugosa with water or C1-2 alcohol at a temperature of 90-100 deg.C for 3-7 hours; (b) filtering the extract; (c) concentrating the filtrate under reduced pressure; and (d) freeze-drying the concentrate.
    • 提供包含藿香提取物的组合物以抑制在动物模型中诱发的显着的胃肠道疾病,从而被用作治疗和预防各种胃肠道疾病的有用药物。 用于治疗胃肠道疾病如慢性或急性胃炎,胃溃疡和胃出血的药物组合物包含作为有效成分的藿香的C1-2醇提取物和药学上可接受的载体,其中所述提取物包括斜霉素,阿卡他宁或沙美他滨。 制备组合物的方法包括以下步骤:(a)在90-100℃的温度下用水或C1-2醇提取藿香粗提物3-7小时; (b)过滤提取物; (c)减压浓缩滤液; 和(d)冷冻干燥浓缩物。