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    • 6. 发明公开
    • 인지 기능 장애 예방 또는 치료용 조성물
    • 用于预防或治疗认知障碍的组合物
    • KR1020070070277A
    • 2007-07-04
    • KR1020040109419
    • 2004-12-21
    • 주식회사 유니베라주식회사 유니젠
    • 김영호박영인이종길오선택조태형우성식
    • A61K31/122A61K36/886
    • A composition for preventing or treating cognitive disorders including senile dementia is provided to inhibit Abeta(beta-amyloid) aggregation and apoptosis caused by Abeta, promote proliferation of nerve cells, and reduce side effects. The composition for preventing or treating cognitive disorders comprises the extract of aloe or compounds represented by the formula(1) obtained from the aloe extract, or their pharmaceutically acceptable salts, wherein the aloe is Aloe vera, Aloe Aborescens or Aloe saponaria; the cognitive disorders include lowering of memory or concentration ability, dementia and Alzheimer dementia; the aloe extract is prepared with a polar solvent selected from water, C1-4 alcohol and acetone, or a non-polar solvent selected from n-hexane, dichloromethane, chloroform and ethylacetate; and the composition is a pharmaceutical or health food composition.
    • 提供了用于预防或治疗认知障碍(包括老年性痴呆)的组合物,用于抑制由Aβ引起的Aβ(β-淀粉样蛋白)聚集和凋亡,促进神经细胞的增殖,并减少副作用。 用于预防或治疗认知障碍的组合物包括芦荟提取物或由芦荟提取物获得的式(1)表示的化合物或其药学上可接受的盐,其中芦荟是芦荟芦荟,芦荟芦荟或芦荟; 认知障碍包括降低记忆力或集中能力,痴呆和阿尔茨海默氏痴呆; 芦荟提取物用选自水,C 1-4醇和丙酮的极性溶剂或选自正己烷,二氯甲烷,氯仿和乙酸乙酯的非极性溶剂制备; 并且该组合物是药物或保健食品组合物。