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1. 发明授权

KR100444599B1 피부자극 및 염증완화 효과를 갖는 라스베리 잎 또는 열매추출물을 함유한 피부 외용제 조성물 有权
标题翻译： 피부자극및염증완화효과갖갖갖갖라스베리잎또는열매추출물을함유한피부외용제조성물물
公开(公告)号：KR100444599B1
公开(公告)日：2004-08-16
申请号：KR1020010049518
申请日：2001-08-17
申请人： 주식회사 아모레퍼시픽그룹
发明人： 김수현 , 노민수 , 이병곤
IPC分类号： A61K36/73 , A61P17/00
摘要： PURPOSE: Provided is a composition containing an extract of leaves or fruits of raspberry inhibiting IL-6, IL-8 and PGE2 being involved in skin irritation and inflammation production. Therefore, the composition can be used as a cosmetic composition having an effect for preventing skin irritation caused by UV light or cosmetic. CONSTITUTION: The skin composition for external application contains 0.00001 to 30% by weight of an extract of leaves or fruits of raspberry such as Rubus coreanum, Rubus idaeus and Rubus parvifolius. The composition inhibits IL-6, IL-8 and PGE2 by substance P and bradykinin, and consequently prevents skin irritation and inflammation.
摘要翻译：用途：提供了一种含有抑制IL-6，IL-8和PGE2参与皮肤刺激和炎症产生的覆盆子叶或果实提取物的组合物。因此，该组合物可以用作具有防止由紫外线或化妆品引起的皮肤刺激的效果的化妆品组合物。构成：用于外用的皮肤组合物含有按重量计0.00001％至30％的覆盆子的树叶或果实的提取物，例如悬钩子属植物（Rubus coreanum），悬钩子属植物（Rubus idaeus）和悬钩子属植物（Rubus parvifolius）。该组合物通过物质P和缓激肽抑制IL-6，IL-8和PGE 2，并因此防止皮肤刺激和炎症。

2. 发明授权

KR100431503B1 자외선에 의한 피부세포 손상을 억제하는 프럭토스1,6-디포스페이트 및 그의 염을 함유한 화장료 조성물 有权
标题翻译： 자외선에의한피부세포손을억제하는프럭토스1,6-디포스페이트및그의염을함유한화장료조성물
公开(公告)号：KR100431503B1
公开(公告)日：2004-05-14
申请号：KR1020010040631
申请日：2001-07-07
申请人： 주식회사 아모레퍼시픽그룹
发明人： 노민수 , 김수현 , 안수미 , 이병곤 , 이수환
IPC分类号： A61K8/55 , A61Q17/00
摘要： PURPOSE: A cosmetic composition containing D-fructose 1,6-diphosphate and a salt thereof is provided which causes no skin irritation and inhibits skin damage caused by irritation such as UV ray. Therefore it can be used as a cosmetic material playing a role of endogenous antioxidant substances for improving self-reducing power of skin cells. CONSTITUTION: The cosmetic composition contains 0.0001 to 20 parts by weight of D-fructose 1,6-diphosphate and a salt thereof, based on the total weight of the composition and reduces the concentration of an inflammatory intermediate factor of prostaglandins by inhibition of activity of cyclooxygenase-2.
摘要翻译：目的：提供含有D-果糖1,6-二磷酸及其盐的化妆品组合物，其不引起皮肤刺激并且抑制由紫外线等刺激引起的皮肤损伤。因此它可以作为一种化妆品材料发挥内源性抗氧化物质的作用，提高皮肤细胞的自我还原能力。构成：基于组合物的总重量，化妆品组合物含有0.0001至20重量份的D-果糖-1,6-二磷酸及其盐，并且通过抑制前列腺素的活性来降低前列腺素的炎性中间因子的浓度环氧合酶-2。

3. 发明公开

KR1020030088945A 화장료용 안료의 표면개질 방법, 이 방법에 의한 표면개질안료, 및 상기 표면개질 안료를 함유하는 화장료 失效
标题翻译：化妆品表面改性化妆品颜料的方法和含有改性颜料的化妆品组合物的方法
公开(公告)号：KR1020030088945A
公开(公告)日：2003-11-21
申请号：KR1020020026763
申请日：2002-05-15
申请人： 주식회사 아모레퍼시픽그룹
发明人： 육심욱 , 이성호 , 김수현
IPC分类号： A61K8/84 , A61Q1/02
摘要： PURPOSE: Provided are a method for modifying the surface of cosmetic pigment, modified cosmetic pigment by the same method and a cosmetic composition containing the modified pigment. Therefore, the modified cosmetic pigment has excellent water-proofing, oil-proofing and wearability. CONSTITUTION: A method for modifying the surface of cosmetic pigment is characterized by treating the surface of cosmetic pigment with a fluoric polymer of diphosphate represented by the formula 1, wherein p/q is 0.5-3.0 and n is 1-2.
摘要翻译：目的：提供通过相同方法改性化妆颜料，改性化妆颜料的表面和含有改性颜料的化妆品组合物的方法。因此，改性化妆品颜料具有优异的防水性，防油性和耐磨性。构成：改性化妆品颜料表面的方法的特征在于用式1表示的二磷酸氟聚合物处理化妆颜料的表面，其中p / q为0.5-3.0，n为1-2。

4. 发明公开

KR1020030052689A 백자인 추출물 함유 발모촉진용 화장료 조성물 有权
标题翻译：包含THUJAE SEMEN萃取物的促进头发生长的化妆品组合物
公开(公告)号：KR1020030052689A
公开(公告)日：2003-06-27
申请号：KR1020010082716
申请日：2001-12-21
申请人： 주식회사 아모레퍼시픽그룹
发明人： 박원석 , 이창훈 , 손의동 , 남개원 , 김수현 , 이병곤
IPC分类号： A61K8/97 , A61Q7/00
CPC分类号： A61K8/97 , A61Q7/00
摘要： PURPOSE: A cosmetic composition containing a Thujae Semen extract which includes a large amount of active material capable of effectively inhibiting alopecia-inducing 5alpha-reductase by converting testosterone to dihydrotestosterone is provided. Therefore, the composition can be effectively used as a cosmetic for promoting hair growth and treating alopecia. CONSTITUTION: A cosmetic composition contains 0.0001 to 5% by weight of a Thujae Semen extract as an active ingredient, based on the dried weight of the composition. Thujae Semen is extracted in a organic solvent selected from C1-4 anhydrous or hydrous lower alcohol, hexane, ethylacetate or ethylether in an extractor with a cooling condenser at 50 to 10deg.C for 1 to 10hr and then distilled under reduced pressure in a distillation apparatus with a cooling condenser. For an example, 1.0% by weight of a Thujae Semen extract is mixed with 55.0% by weight of ethanol, 5.0% by weight of castor oil, 3.0% by weight of glycerine, 0.1% by weight of piroctone olamine, a suitable amount of a fragrance, pigment and the balance of water to produce a hair tonic preparation.
摘要翻译：目的：提供含有Thujae精液提取物的化妆品组合物，其包含大量能够通过将睾酮转化为二氢睾酮而有效抑制秃发诱导的5α-还原酶的活性物质。因此，该组合物可以有效地用作促进头发生长和治疗脱发的化妆品。构成：化妆品组合物含有0.0001至5重量％的Thujae Semen提取物作为活性成分，基于组合物的干重。将Thujae Semen在50至10℃的冷却冷凝器中在萃取器中在选自C1-4无水或含水低级醇，己烷，乙酸乙酯或乙醚的有机溶剂中萃取1至10小时，然后在减压下蒸馏蒸馏装有冷凝器。例如，将1.0重量％的Thujae Semen提取物与55.0重量％的乙醇，5.0重量％的蓖麻油，3.0重量％的甘油，0.1重量％的吡罗酮醇混合，适量的香料，颜料和水的平衡，以产生头发补品。

5. 发明公开

KR1020030005524A 프럭토스-1,6-디포스페이트 유도체 및 이의 제조방법 有权
标题翻译： D-呋喃-1,6-二磷酸酯衍生物的制备方法
公开(公告)号：KR1020030005524A
公开(公告)日：2003-01-23
申请号：KR1020010040856
申请日：2001-07-09
申请人： 주식회사 아모레퍼시픽그룹
发明人： 장이섭 , 유재원 , 김덕희 , 노민수 , 김수현 , 이은영 , 남춘자
IPC分类号： C07F9/38
CPC分类号： C07F9/65515
摘要： PURPOSE: Provided is a method for producing a D-fructose-1,6-diphosphate derivative which is formed by ester bond of fatty acid to D-fructose-1,6-diphosphate to increase its penetration into the skin, and which is hydrolyzed by an enzyme in a body to show bioactivity of a D-fructose-1,6-diphosphate. CONSTITUTION: The D-fructose-1,6-diphosphate derivative is represented by the formula(I), wherein at least one of R1, R2 and R3 is -OCOR'; R' is hydrogen, C2-C24 linear or branched chain saturated alkyl or unsaturated alkyl, or hydroxy substituted C2-C24 linear or branched chain saturated alkyl or unsaturated alkyl; and M is hydrogen, alkali metal or alkali earth metal. The method for producing the D-fructose-1,6-diphosphate derivative comprises the steps of: (A) reaction of fatty acid with thionyl chloride in an organic solvent in the equivalent ratio of 1:1 to 1:1.3 at 0 to 10 deg. C for 1 to 2 hours to prepare acyl chloride of fatty acid; and (B) reaction of the acyl chloride of fatty acid of the step (A) with fructose-1,6-diphosphate in a mixed solvent of water and an organic solvent in the equivalent ratio of 1:1 to 3.3:1.
摘要翻译：目的：提供通过脂肪酸与D-果糖-1,6-二磷酸酯的酯键形成的D-果糖-1,6-二磷酸衍生物的方法，以增加其对皮肤的渗透性，并且其被水解通过体内的酶显示D-果糖-1,6-二磷酸的生物活性。构成：D-果糖-1,6-二磷酸衍生物由式（I）表示，其中R 1，R 2和R 3中的至少一个为-OCOR'; R'是氢，C 2 -C 24直链或支链饱和烷基或不饱和烷基，或羟基取代的C 2 -C 24直链或支链饱和烷基或不饱和烷基; M是氢，碱金属或碱土金属。 D-果糖-1,6-二磷酸酯衍生物的制造方法包括以下步骤：（A）在有机溶剂中，在0〜10当量比为1：1〜1：1.3时，脂肪酸与亚硫酰氯的反应度。 C 1〜2小时制备脂肪酸酰基氯; 和（B）步骤（A）的脂肪酸酰基氯与果糖-1,6-二磷酸酯在水和有机溶剂的混合溶剂中的反应，其当量比为1：1至3.3：1。

6. 发明授权

KR100441726B1 상표초 추출물 함유 발모촉진용 화장료 조성물 有权
标题翻译： 상표초추출물함유발모촉진용화장료조성물
公开(公告)号：KR100441726B1
公开(公告)日：2004-07-27
申请号：KR1020010082717
申请日：2001-12-21
申请人： 주식회사 아모레퍼시픽그룹
发明人： 박원석 , 이창훈 , 손의동 , 남개원 , 김수현 , 이병곤
IPC分类号： A61K8/97 , A61Q7/00
摘要： PURPOSE: Provided is a cosmetic composition containing a Mantidis Ootheca extract possessing inhibitory activity on 5 alpha-reductase which promotes the formation and activity of dihydrotestosterone as active testosterone which induces alopecia. The extract has excellent promotion effect on hair growth. Therefore, the composition containing the extract can be effectively used as a cosmetic for promoting hair growth and treating alopecia. CONSTITUTION: Mantidis Ootheca is extracted 2 to 5 times in a organic solvent selected from C1-4 anhydrous or hydrous lower alcohol, hexane, ethylacetate or ethylether in an extractor with a cooling condenser at 50 to 10deg.C for 1 to 10hr and then distilled under reduced pressure in a distillation apparatus with a cooling condenser. The cosmetic composition contains 0.0001 to 5% by weight of a Mantidis Ootheca extract as an active ingredient, based on the dried weight of the composition. For an example, 1.0% by weight of a Mantidis Ootheca extract is blended with 2.0% by weight of cetostearyl alcohol, 2.0% by weight of stearyl triethyl ammonium chloride, 0.5% by weight of hydroxyethylcellulose, 0.1% by weight of piroctone olamine, a suitable amount of a fragrance, pigment and the balance of water to produce a hair lotion preparation.
摘要翻译：目的：提供一种含有对5α-还原酶具有抑制活性的Man O蒿提取物的化妆品组合物，其促进作为诱导脱发的活性睾酮的二氢睾酮的形成和活性。该提取物对头发生长有极好的促进作用。因此，含有提取物的组合物可以有效地用作促进毛发生长和治疗脱发的化妆品。构成：将Man蛇花药在选自C1-4无水或含水低级醇，己烷，乙酸乙酯或乙醚的有机溶剂中，在提取器中用冷却冷凝器在50至10℃进行1至10小时提取2-5次，然后蒸馏在具有冷凝器的蒸馏装置中在减压下进行。基于组合物的干重，该化妆品组合物含有0.0001至5重量％的Man O子提取物作为活性成分。例如，将1.0重量％的Man O卵extract提取物与2.0重量％的鲸蜡硬脂醇，2.0重量％的硬脂基三乙基氯化铵，0.5重量％的羟乙基纤维素，0.1重量％的吡罗克酮乙醇胺，适量的香料，颜料和余量的水以制备洗发剂制剂。

7. 发明公开

KR1020040006148A 라쓰란계 다이터르펜류를 함유하는 5-알파 리덕테이즈억제제 및 이를 함유한 피부 외용제 조성물 有权
标题翻译：含ALPHA-还原酶抑制剂含有LATHYRANE DITERPENE和含有其的DERMATOIOGICS组合物
公开(公告)号：KR1020040006148A
公开(公告)日：2004-01-24
申请号：KR1020020039690
申请日：2002-07-09
申请人： 주식회사 아모레퍼시픽그룹
发明人： 이창훈 , 박원석 , 손의동 , 남개원 , 김수현 , 김승훈 , 주경미 , 이병곤
IPC分类号： A61K31/4402
摘要： PURPOSE: Provided is a dermatoiogics composition which contains a 5 alpha-reductase inhibitor to treat the diseases related to the 5 alpha-reductase, such as male alopecia, prostatic carcinoma, and prostatic hypertrophy. CONSTITUTION: A 5 alpha-reductase inhibitor contains one or more compounds selected from the group consisting of lathyrane diterpene L1(5,15-diacetoxy-3-phenylacetoxy-14-oxolathyra-6(17),(12E)-diene-6(17)-epoxide), L3(5,15-diacetoxy-3-benzoyloxy-14-oxolathyra-6(17),(12E)-diene-6(17)-epoxide), L8(5,15-diacetoxy-3-nicotinoyloxy-14-oxolathyra-6(17),(12E)-diene-6(17)-epoxide) and L9(5,15-diacetoxy-3-benzoyloxy-7-nicotinoyloxy-14-oxolathyra-6(17),(12E)-diene-6(17)-epoxide), expressed by formulas 1 to 4. The lathyrane diterpene L1, L3, L8 and L9 compounds are extracted from Euphorbiae Lathyroides Semen.
摘要翻译：目的：提供一种含有5α-还原酶抑制剂以治疗与5α-还原酶相关疾病的皮肤药物组合物，例如雄性脱发，前列腺癌和前列腺肥大。构成：5α-还原酶抑制剂含有一种或多种选自下列化合物的化合物：盐酸二萜L1（5,15-二乙酰氧基-3-苯乙酰氧基-14-氧杂七酰-6（17），（12E） - 二烯-6（ 17） - 环氧化物），L3（5,15-二乙酰氧基-3-苯甲酰氧基-14-氧代硫酰-6（17），（12E） - 二烯-6（17） - 环氧化物），L8（5,15-二乙酰氧基-3 （17E） - 二烯-6（17） - 环氧化物）和L9（5,15-二乙酰氧基-3-苯甲酰氧基-7-烟酰氧基-14-氧代硫酰-6（17），（12E） - 二烯-6（17） - 环氧化物），由式1〜4表示。从大戟科Lathyroides Semen中提取盐藻ene L1，L3，L8和L9化合物。

8. 发明公开

KR1020030064107A 백화사설초 추출물을 함유하는 피부 외용제 조성물 有权
标题翻译：含有OLDENLANDIAE HERBA提取物外用于皮肤的制剂
公开(公告)号：KR1020030064107A
公开(公告)日：2003-07-31
申请号：KR1020020004551
申请日：2002-01-25
申请人： 주식회사 아모레퍼시픽그룹
发明人： 김한성 , 김덕희 , 장이섭 , 구봉석 , 김수현 , 김한곤
IPC分类号： A61K8/97 , A61Q19/08 , A61Q19/02
CPC分类号： A61K8/97 , A61Q17/005 , A61Q19/00 , A61Q19/08
摘要： PURPOSE: An external preparation composition containing as an effective ingredient an Oldenlandiae Herba extract which has excellent antioxidant effect and is obtained by successively extracting in accordance with a change in polarity is provided. Therefore, the composition has excellent skin improving and/or activating effects. CONSTITUTION: An external preparation composition contains 0.0001 to 10% by weight of an Oldenlandiae Herba extract, based on the total weight of the composition. The Oldenlandiae Herba extract is obtained by pulverizing Oldenlandiae Herba and extracting the pulverized material in a solvent and concentrating in a distillation apparatus attached to a cooling condenser under reduced pressure. The solvent is selected from the group consisting of C1-4 anhydrous or hydrous lower alcohol(methanol, ethanol), acetone, ethyl acetate, diethylether, benzene, chloroform or hexane.
摘要翻译：目的：提供含有作为有效成分的具有优异的抗氧化作用并通过根据极性变化连续提取而得到的奥兰登ba草提取物的外用制剂组合物。因此，该组合物具有优异的皮肤改善和/或激活效果。构成：根据组合物的总重量，外用制剂组合物含有0.0001至10重量％的Oldenlandiae Herba提取物。通过粉碎奥兰斯兰氏草原并在溶剂中萃取粉碎物质并浓缩在减压冷凝器附近的蒸馏装置中，得到古兰德兰草药提取物。溶剂选自C1-4无水或含水低级醇（甲醇，乙醇），丙酮，乙酸乙酯，乙醚，苯，氯仿或己烷组成的组。

9. 发明授权

KR100376089B1 자외선 차단용 베이스 조성물 및 이를 포함하는 화장품 失效
标题翻译： 자외선차단용베이스조성물및이를포함하화장품
公开(公告)号：KR100376089B1
公开(公告)日：2003-03-15
申请号：KR1020010013145
申请日：2001-03-14
申请人： 주식회사 아모레퍼시픽그룹
发明人： 김수현 , 송동혁 , 김한성 , 홍종언 , 박창훈 , 한상훈 , 이해광
IPC分类号： A61K8/19 , A61Q19/00
摘要： PURPOSE: Provided are a base composition for blocking ultraviolet rays and a cosmetics containing the same. The composition has no gelation, gives pleasant feeling in use and blocks ultraviolet rays excellently. CONSTITUTION: In the composition containing titan dioxide microparticles, a dispersing medium and a dispersing agent, the titan dioxide microparticle is coated with alkyltriethoxysilane of the formula(1) and the coated titan dioxide microparticle is dispersed into a nano sized particle. In the formula(1), R1 is C3-C22 alkyl, and R2 is C1-C22 alkyl.
摘要翻译：目的：提供一种用于阻挡紫外线的基础组合物以及包含其的化妆品。该组合物没有凝胶化，给人愉快的使用感，并很好地阻挡紫外线。构成：在含有二氧化钛微粒，分散介质和分散剂的组合物中，用式（1）的烷基三乙氧基硅烷涂布二氧化钛微粒，并将涂布的二氧化钛微粒分散成纳米尺寸的粒子。在式（1）中，R 1是C 3 -C 22烷基，并且R 2是C 1 -C 22烷基。

10. 发明公开

KR1020030018194A 멘톨 유도체 및 그의 제조방법 有权
标题翻译： MENTHOL衍生物及其制备方法的方法
公开(公告)号：KR1020030018194A
公开(公告)日：2003-03-06
申请号：KR1020010051782
申请日：2001-08-27
申请人： 주식회사 아모레퍼시픽그룹
发明人： 유재원 , 김덕희 , 문성준 , 노민수 , 김수현 , 안수선 , 이진선
IPC分类号： C07F9/09
CPC分类号： C07F9/117 , A61K8/55 , A61K2800/75 , A61Q17/00 , A61Q19/00 , A61Q19/08
摘要： PURPOSE: Provided are menthol derivatives which have a phosphate group having excellent affinity to human skin, thus relieves skin irritation, and a process for a method for preparing the same. CONSTITUTION: The menthol derivative is characteristically represented by the formula(I). It is manufactured by reaction of menthol and oxy phosphorus chloride in an equivalent ratio of 1:1-1.3 in the presence of an organic solvent, in an organic solvent to give dichloro(5-methyl-2-(methyl ethyl)cyclohexyl oxy)-phosphino-1-on; reaction of the dichloro(5-methyl-2-(methyl ethyl)cyclohexyl oxy)-phosphino-1-on with 3-aminopropanol in the presence of base, in an organic solvent; hydrolyzing and crystallizing with a polar organic solvent the reaction product.
摘要翻译：目的：提供具有对人体皮肤亲和力优异的磷酸基的薄荷醇衍生物，因此缓解皮肤刺激，以及其制备方法。构成：薄荷醇衍生物由式（I）表征。通过薄荷醇和氧氯化磷在有机溶剂存在下，在有机溶剂存在下，以1:1-1.3的比例反应制备二氯（5-甲基-2-（甲基乙基）环己基氧基）膦基-1-上; 二氯（5-甲基-2-（甲基乙基）环己基氧基） - 膦-1-基与3-氨基丙醇在碱存在下在有机溶剂中的反应; 用极性有机溶剂水解和结晶反应产物。

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