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    • 9. 发明公开
    • 항균 활성 및 항암 활성이 강화된 리소좀의 제조방법
    • 制备具有抗细菌活性和抗癌活性的物质的方法
    • KR1020130124110A
    • 2013-11-13
    • KR1020120047763
    • 2012-05-04
    • 전북대학교산학협력단
    • 윤지희민지호김양훈
    • A61K48/00A61K38/46A61K38/43A61P35/00
    • Y02A50/473Y02A50/475A61K48/00C12N15/66Y10S424/801Y10S514/885
    • The present invention relates to a method for preparing lysosome with antibacterial and anticancer activities; an antibacterial composition containing the lysosome prepared by the method; as an active ingredient; and an anticancer composition containing the lysosome prepared by the method as an active ingredient. More particularly, the method for preparing the lysosome with antibacterial and anticancer activities comprises the steps of: introducing N-terminal peptide hydrolase gene and a regulatory gene into a eukaryote and preparing a mutant; culturing the mutant in which N-terminal peptide hydrolase and the regulatory gene are introduced; and obtaining lysosome from the cultured mutant. The lysosome is identified to have remarkably improved anticancer and anti-bacterial activities.
    • 本发明涉及具有抗菌活性和抗癌活性的溶酶体制备方法。 含有通过该方法制备的溶酶体的抗菌组合物; 作为活性成分; 以及含有通过该方法制备的溶酶体作为活性成分的抗癌组合物。 更具体地说,具有抗细菌和抗癌活性的制备溶酶体的方法包括以下步骤:将N-末端肽水解酶基因和调节基因导入真核生物并制备突变体; 培养其中引入N末端肽水解酶和调节基因的突变体; 并从培养的突变体获得溶酶体。 鉴定溶酶体具有明显改善的抗癌和抗细菌活性。
    • 10. 发明公开
    • 라이소소멀 엔자임-TIO2 나노입자 복합체, 이의 제조방법 및 이를 포함하는 항균제품
    • 溶酶体酶 - 二氧化钛纳米颗粒复合物,其制备方法和包含其中的抗微生物产品
    • KR1020120010037A
    • 2012-02-02
    • KR1020100071558
    • 2010-07-23
    • 전북대학교산학협력단
    • 민지호윤지희김양훈방승혁
    • B82B3/00C12N9/14C01G23/047
    • PURPOSE: A lysosomal enzyme-titanium dioxide nano-particle composite, a method for manufacturing the same, and antimicrobial products including the same are provided to improve the immobilization of lysosomal enzygme(LSSE) with respect to titanium dioxide nano-particles by shaking the LSSE and the titanium dioxide nano-particles without a harmful additive. CONSTITUTION: A lysosomal enzyme-titanium dioxide nano-particle composite includes LSSE and titanium dioxide nano-particles. The LSSE is extracted from egg whites or the lisosome of yeast. The average diameter of the titanium dioxide nano-particles is between 200 and 500nm. The titanium dioxide is anatase type or rutile type. A method for manufacturing the LSSE-titanium dioxide nano-particle composite shakes the LSSE and the titanium dioxide nano-particles to fix the LSSE on the surface of the titanium dioxide nano-particles. The weight ratio of the LSSE and the titanium dioxide nano-particles is 1:4 to 1:25.
    • 目的:提供溶酶体酶 - 二氧化钛纳米颗粒复合材料,其制备方法和包含其的抗微生物产品,以通过摇动LSSE来改善溶酶体酶(LSSE)相对于二氧化钛纳米颗粒的固定化 和二氧化钛纳米颗粒没有有害的添加剂。 构成:溶酶体酶 - 二氧化钛纳米颗粒复合材料包括LSSE和二氧化钛纳米颗粒。 LSSE是从蛋清或酵母的lisosome提取的。 二氧化钛纳米颗粒的平均直径为200-500nm。 二氧化钛是锐钛矿型或金红石型。 制造LSSE-二氧化钛纳米颗粒复合材料的方法是将LSSE和二氧化钛纳米颗粒固定在二氧化钛纳米颗粒表面上。 LSSE和二氧化钛纳米颗粒的重量比为1:4至1:25。