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    • 8. 发明公开
    • 림프관 생성 유도제
    • 组合生产淋巴血液血管
    • KR1020120139311A
    • 2012-12-27
    • KR1020110059046
    • 2011-06-17
    • 전북대학교산학협력단전북대학교병원
    • 김원박성광강경표이애신
    • A61K38/19A61K38/18A61P35/00
    • A61K38/193C07K14/535Y10S530/837
    • PURPOSE: A lymphatic vascularization composition containing granulocyte-colony stimulating-factors is provided to induce capillarization, cell proliferation, and lymphatic sprout of human lymphatic vascular endothelial cells. CONSTITUTION: A lymphatic vascularization composition contains granulocyte-colony stimulating-factors as an active ingredient. The granulocyte-colony stimulating-factors include granulocyte macrophage colony stimulating factors(GM-CSF) and macrophage colony stimulating factors(MCSF). A composition for preventing or treating lymphedema contains the granulocyte-colony stimulating-factors as an active ingredient. A composition for preventing or treating lymphatic vessel loss or lymphopenia contains the granulocyte-colony stimulating-factors. An agent for enhancing ERK1/2 phosphorylation and Akt phosphorylation contains the granulocyte-colony stimulating-factors as an active ingredient.
    • 目的:提供含有粒细胞集落刺激因子的淋巴管血管化组合物,以诱导人淋巴管血管内皮细胞的毛细血管化,细胞增殖和淋巴发芽。 构成:淋巴管血管化组合物含有粒细胞集落刺激因子作为活性成分。 粒细胞集落刺激因子包括粒细胞巨噬细胞集落刺激因子(GM-CSF)和巨噬细胞集落刺激因子(MCSF)。 用于预防或治疗淋巴水肿的组合物含有作为活性成分的粒细胞集落刺激因子。 用于预防或治疗淋巴管损失或淋巴细胞减少的组合物含有粒细胞集落刺激因子。 增强ERK1 / 2磷酸化和Akt磷酸化的药物含有粒细胞集落刺激因子作为活性成分。
    • 9. 发明授权
    • 연골 저중합체 매트릭스 단백질 안지오포이틴-1을 포함하는당뇨병성 신장병 치료용 약제조성물
    • 包含COMP-ANG1用于糖尿病性脑病的药物组合物
    • KR100847751B1
    • 2008-07-22
    • KR1020070042754
    • 2007-05-02
    • 전북대학교산학협력단
    • 박성광김원이식
    • A61K38/17A61P13/12A61P3/10
    • A61K38/17Y10S514/866
    • A pharmaceutical composition comprising COMP-Ang1(cartilage oligomeric matrix protein-angiopoietin-1) is provided to inhibit inflammation and regulate sugar and lipid metabolism, so that the composition is useful for treatment of diabetic nephropathy. A pharmaceutical composition for treatment of diabetic nephropathy comprises COMP-Ang1 and is administered orally or parenterally, wherein the COMP-Ang1 is prepared by replacing a coiled coil domain in a native angiopoietin-1 gene by cartilage oligomeric matrix protein, inserting the recombinant angiopoietin-1 gene into CHO(Chinese hamster ovary cell) cell line, and culturing the recombinant CHO cell line; the oral composition is formulated as tablet, pill, powder, granule, syrup, solution, suspension, emulsion or capsule, and the parenteral composition is formulated as injection, transrectal enteric preparations or transdermal preparations.
    • 提供了包含COMP-Ang1(软骨低聚基质蛋白 - 血管生成素-1)的药物组合物以抑制炎症并调节糖和脂质代谢,使得该组合物可用于治疗糖尿病性肾病。 用于治疗糖尿病肾病的药物组合物包括COMP-Ang1并口服或非肠道给药,其中COMP-Ang1通过用软骨寡聚基质蛋白替代天然血管生成素-1基因中的卷曲螺旋结构域,将重组血管生成素 - 1基因转入CHO(中国仓鼠卵巢细胞)细胞系,培养重组CHO细胞系; 口服组合物配制成片剂,丸剂,粉剂,颗粒剂,糖浆剂,溶液剂,悬浮液,乳剂或胶囊剂,肠胃外组合物配制成注射剂,经直肠制剂或透皮制剂。