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    • 1. 发明公开
    • 림프관 생성 유도제
    • 组合生产淋巴血液血管
    • KR1020120139311A
    • 2012-12-27
    • KR1020110059046
    • 2011-06-17
    • 전북대학교산학협력단전북대학교병원
    • 김원박성광강경표이애신
    • A61K38/19A61K38/18A61P35/00
    • A61K38/193C07K14/535Y10S530/837
    • PURPOSE: A lymphatic vascularization composition containing granulocyte-colony stimulating-factors is provided to induce capillarization, cell proliferation, and lymphatic sprout of human lymphatic vascular endothelial cells. CONSTITUTION: A lymphatic vascularization composition contains granulocyte-colony stimulating-factors as an active ingredient. The granulocyte-colony stimulating-factors include granulocyte macrophage colony stimulating factors(GM-CSF) and macrophage colony stimulating factors(MCSF). A composition for preventing or treating lymphedema contains the granulocyte-colony stimulating-factors as an active ingredient. A composition for preventing or treating lymphatic vessel loss or lymphopenia contains the granulocyte-colony stimulating-factors. An agent for enhancing ERK1/2 phosphorylation and Akt phosphorylation contains the granulocyte-colony stimulating-factors as an active ingredient.
    • 目的:提供含有粒细胞集落刺激因子的淋巴管血管化组合物,以诱导人淋巴管血管内皮细胞的毛细血管化,细胞增殖和淋巴发芽。 构成:淋巴管血管化组合物含有粒细胞集落刺激因子作为活性成分。 粒细胞集落刺激因子包括粒细胞巨噬细胞集落刺激因子(GM-CSF)和巨噬细胞集落刺激因子(MCSF)。 用于预防或治疗淋巴水肿的组合物含有作为活性成分的粒细胞集落刺激因子。 用于预防或治疗淋巴管损失或淋巴细胞减少的组合物含有粒细胞集落刺激因子。 增强ERK1 / 2磷酸化和Akt磷酸化的药物含有粒细胞集落刺激因子作为活性成分。