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1. 发明授权

KR100453980B1 12,13-(피라노실)-인돌로[2,3-ａ]피롤로[3,4-ｃ]카르바졸및 12,13-(피라노실)-푸로[3,4-ｃ]인돌로[2,3-ａ]카르바졸화합물, 이들의 제조 방법 및 이들을 함유하는 약제학적조성물 失效
标题翻译： 12,13-（피라노실） - 인돌로[2,3-a]피롤로[3,4-c]카르바졸및12,13-（피라노실） - 푸로[3,4-c]인돌로[ 2,3-a]카르바졸화합물，이들의제조방법및이들을함유하는약제학적조성물
公开(公告)号：KR100453980B1
公开(公告)日：2004-10-20
申请号：KR1020000068432
申请日：2000-11-17
申请人： 르 라보레또레 쎄르비에르
发明人： 프루도메,미첼르 , 모로,파스칼 , 아니존,패브리스 , 마르미농,크리스텔르 , 아타시,과넴 , 피에르,알랭 , 프페이페르,브루노 , 레나르드,피에르
IPC分类号： C07D209/82
CPC分类号： C07H19/23
摘要： A composition comprises 12,13-(Pyranosyl)-indolo(2,3-a)pyrrolo(3,4-c)carbazole and 12,13-(pyranosyl)-furo(3,4-c)indolo(2,3-a)carbazole derivatives (I), or their isomers, salts with acids or bases, are new A composition comprises 12,13-(Pyranosyl)-indolo(2,3-a)pyrrolo(3,4-c)carbazole and 12,13-(pyranosyl)-furo(3,4-c)indolo(2,3-a)carbazole derivatives of formula (I), or their isomers, salts with acids or bases, are new R1, R2 = U-V; U = 1-6C alkylene, optionally substituted by one or more halo or OH, and which may be unsaturated; V = H, halo, CN, NO2, N3, 1-6C alkyl, aryl, arylalkyl, OH, 1-6C alkoxy, aryloxy, aryl alkoxy, formyl, carboxy, aminocarbonyl, NRaRb, -CO-T1, -CO-NRa-T1, -NRa-CO-T1, -O-CO-T1, -CO-O-T1, -O-T2-NRaRb, -OT2-ORa, -O-T2-COORa, -NRa-T2-NRaRb, -NRa-T2-ORa, -NRa-T2-CO2Raor S(O)n-Ra; Ra, Rb = H, 1-6C alkyl, aryl, or arylalkyl, or both together with the N atom form a 5-7 membered heterocycle which may contain a second heteroatom (O or N) and may be substituted by alkyl, alkoxy, OH, amino, 1-6C alkylamino, or 1-6C dialkylamino; T1 = 1-6C alkyl, aryl, 1-6C arylalkyl, 1-6C alkylene, optionally substituted by -ORa, -NRaRb, -COORa, -CO-Ra, or -CO-NRaRb; T2 = 1-6C alkylene; n = 0 - 2; G = O or NR3; R3 = H, 1-6C alkyl, aryl, arylalkyl, cycloalkyl, cycloalkyl alkyl, -ORa, -NRaRb, -OT2-NRaRb, -NRa-T2-NRaRb, 1-6C hydroxylamino, dihydroxylamino, -CO-Ra, -NH-CO-Ra, 1-6C alkylene, optionally substituted by one or more of halogen, CN, NO2, -ORa, -NRaRb, -COORa, -CORa, hydroxylamino, dihydroxylamino, or -CO-NHRa; X = H, OH, 1-6C alkoxy, SH, or 1-6C alkylthio; Y = H, or X and Y together with the C atom form carbonyl; X1 = H, OH, 1-6C alkoxy, SH, or 1-6C alkylthio; Y1 = H or X1 and Y1 together with the C atom form carbonyl; R4, R5 = H, halogen, OH, alkoxy, aryloxy, aryl alkoxy, alkyl, arylalkyl, aryl, amino (optionally substituted by one or two alkyl, alkyl, aryl and arylalkyl groups), azido, -N=NRa, or -O-CO-Rc; Rc = 1-6C alkyl (optionally substituted by one or more halogen, OH, amino, alkylamino and dialkylamino groups), aryl, aralkyl, cycloalkyl or heterocycloalkyl; R6 = -U1-R4; U1 = a bond or methylene; or R4, R5, and R6 taken in pairs together with the C atoms may = 3-6 membered ring containing 1 or 2 O atoms, except for the following specific compounds: 1,11-dichloro-12,13-(1,2-(4-(O-methyl- beta -D-mannopyranosyl))-6,7,12,13-tetrahydro(5H)indolo(2,3-a)pyrrolo(3,4-c )carbazole-5,7-dio ne; 12,13-(1,2-(4-(O-methyl- beta -D-mannopyranosyl))-6,7,12,13-tetrahydro(5H)indolo(2,3-a)pyrrolo(3,4-c )carbazole-5,7-dione; 12,13-(1,2-(4-(O-methyl- beta -D-mannopyranosyl))-6,7,12,13-tetrahydro(5H)indolo(2,3-a)pyrrolo(3,4-c )carbazole-5-one; and 12,13-(1,2-(4-(O-methyl- beta -D-mannopyranosyl))-5,6,12,13-tetrahydro(7H)indolo(2,3-a)pyrrolo(3,4-c )carbazole-7-one.
摘要翻译：组合物包含12,13-（吡喃糖基） - 吲哚并（2,3-a）吡咯并（3,4-c）咔唑和12,13-（吡喃糖基） - 呋喃并（3,4-c）吲哚并 -a）咔唑衍生物（I）或其异构体，与酸或碱形成的盐是新的。组合物包含12,13-（吡喃糖基） - 吲哚并（2,3-a）吡咯并（3,4-c）咔唑和式（I）的12,13-（吡喃糖基） - 呋喃并（3,4-c）吲哚并（2,3-a）咔唑衍生物或其异构体，与酸或碱的盐是新的R 1，R 2 = U = 1-6C亚烷基，任选被一个或多个卤素或OH取代，并且其可以是不饱和的; 卤素，CN，NO2，N3,1-6C烷基，芳基，芳基烷基，OH，1-6C烷氧基，芳氧基，芳基烷氧基，甲酰基，羧基，氨基羰基，NRaRb，-CO-T1，-CO-NRa -NRa-CO-T1，-O-CO-T1，-CO-O-T1，-O-T2-NRaRb，-OT2-ORa，-O-T2-COORa，-NRa-T2-NRaRb， -NRa-T2-ORa，-NRa-T2-CO2Ra或S（O）n-Ra; Ra，Rb = H，1-6C烷基，芳基或芳基烷基或二者与N原子一起形成5-7元杂环，其可以含有第二个杂原子（O或N）并可以被烷基，烷氧基， OH，氨基，1-6C烷基氨基或1-6C二烷基氨基; 任选地被-ORa，-NRaRb，-COORa，-CO-Ra或-CO-NRaRb取代的T1 = 1-6C烷基，芳基，1-6C芳基烷基，1-6C亚烷基; T2 = 1-6C亚烷基; n = 0-2; G = O或NR3; R3 = H，1-6C烷基，芳基，芳基烷基，环烷基，环烷基烷基，-ORa，-NRaRb，-OT2-NRaRb，-NRa-T2-NRaRb，1-6C羟基氨基，二羟基氨基，任选地被一个或多个卤素，CN，NO 2，-OR a，-NR a R b，-COOR a，-COR a，羟基氨基，二羟基氨基或-CO-NHR a取代的-CO-R a， X = H，OH，1-6C烷氧基，SH或1-6C烷硫基; Y = H，或者X和Y与C原子一起形成羰基; X1 = H，OH，1-6C烷氧基，SH或1-6C烷硫基; Y1 = H或X1和Y1与C原子一起形成羰基; （其任选被一个或两个烷基，烷基，芳基和芳基烷基取代），叠氮基，-N = NRa或 - O-CO-RC; Rc = 1-6C烷基（任选被一个或多个卤素，OH，氨基，烷基氨基和二烷基氨基取代），芳基，芳烷基，环烷基或杂环烷基; R6 = -U1-R4; U1 =键或亚甲基; 或与C原子一起成对取代的R 4，R 5和R 6可以=含有1或2个O原子的3-6元环，除了以下具体化合物：1,11-二氯-12,13-（1,2 - （4-（O-甲基-β-D-吡喃甘露糖基））-6,7,12,13-四氢（5H）吲哚并（2,3-a）吡咯并（3,4-c）咔唑-5,7 - 二烯; 12,13-（1,2-（4-（O-甲基-β-D-吡喃甘露糖基））-6,7,12,13-四氢（5H）吲哚并（2,3-a）吡咯并（3,4-c）咔唑-5,7-二酮; 12,13-（1,2-（4-（O-甲基-β-D-吡喃甘露糖基））-6,7,12,13-四氢（ 5H）吲哚并（2,3-a）吡咯并（3,4-c）咔唑-5-酮和12,13-（1,2-（4-（O-甲基-β-D-吡喃甘露糖基）） - 5,6,7,13-四氢（7H）吲哚并（2,3-a）吡咯并（3,4-c）咔唑-7-酮。

2. 发明公开

KR1020030010513A 벤조[ｂ]피라노[3,2-ｈ]아크리딘-7-온 화합물, 이의 제조방법 및 이를 함유하는 약제 조성물 失效
标题翻译： BENZO B | PYRANO（3,2-H）ACRIDIN-7-ONE的新衍生物，其制备方法和含有该衍生物的药物化合物
公开(公告)号：KR1020030010513A
公开(公告)日：2003-02-05
申请号：KR1020020043537
申请日：2002-07-24
申请人： 르 라보레또레 쎄르비에르
发明人： 코흐,미쉘 , 틸레퀸,프랑소와즈 , 미쉘,실비에 , 세구인,엘리자베스 , 엘옴리,아브델하킴 , 히크만,존 , 피에르,알라인 , 페이페르,브루노 , 레나르드,피에르
IPC分类号： C07D491/048
CPC分类号： C07D491/04
摘要： PURPOSE: Provided are new benzo(b)pyrano(3,2-h)acridin-7-one compounds, their isomers and N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer. CONSTITUTION: A new benzo(b)pyrano(3,2-h)acridin-7-one compound is selected from those of formula(I), wherein: X and Y represent group selected from hydrogen, halogen, mercapto, cyano, nitro, alkyl, trihaloalkyl, trihaloalkylcarbonylamino, -ORa, -NRaRb, -NRa-C(O)-T1, -O-C(O)-T1, -O-T2-NRaRb, -O-T2ORa, -NRa-T2NRaRb, -NRa-T2-ORa and -NRa-T2-CO2Ra wherein Ra, Rb, T1, T2 are as defined in the specification, or X and Y together form a methylenedioxy or ethylenedioxy, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, -ORa, -NRaRb, -NRa-C(O)-T1, -O-C(O)-T1, -O-T2-NRaRb, -O-T2-ORa, -NRa-T2-NRaRb, -NRa-T2-ORa and -NRa-T2-CO2Ra wherein Ra, Rb, T1 and T2 are as defined hereinbefore, R3 and R4 represent hydrogen or alkyl, W represents a group of formula -CH(R5)-CH(R6)-, -CH=C(R7)-, -C(R7)=CH- or -C(O)-CH(R8)- wherein R5, R6, R7 and R8 are as defined in the specification.
摘要翻译：目的：提供新的苯并（b）吡喃并（3,2-h）吖啶-7-酮化合物，其异构体和N-氧化物及其与药学上可接受的酸或碱的加成盐，以及含有它们的药物可用于治疗癌症。构成：新的苯并（b）吡喃并（3,2-h）吖啶-7-酮化合物选自式（I）的化合物，其中：X和Y表示选自氢，卤素，巯基，氰基，硝基，烷基，三卤代烷基，三卤代烷基羰基氨基，-ORa，-NRaRb，-NRa-C（O）-T1，-OC（O）-T1，-O-T2-NRaRb，-O-T2ORa，-NRa-T2NRaRb， -T2-ORa和-NRa-T2-CO2Ra，其中Ra，Rb，T1，T2如说明书中所定义，或X和Y一起形成亚甲二氧基或亚乙二氧基，R 1表示氢或烷基，R 2表示选自氢，-ORa，-NR a R b，-NR a -C（O）-T1，-OC（O）-T1，-O-T 2 -NR a R b，-O-T 2 -OR a，-NR a -T 2 -NR a R b，-NR a -T 2 -ORa和-NR a -T 2 -CO 2 R a其中R a，R b，T 1和T 2如上所定义，R 3和R 4表示氢或烷基，W表示式-CH（R 5）-CH（R 6） - ， - CH = C（R 7） - ， - C（R 7）= CH-或-C（O）-CH（R 8） - ，其中R 5，R 6，R 7和R 8如说明书中所定义。

3. 发明公开

KR1020010020808A 치환된 피리딘 또는 피페리딘 화합물, 이들의 제조 방법및 이들을 함유하는 약제 조성물 失效
标题翻译：新替代的吡啶或哌啶化合物，其生产和含有该组合物的药物组合物
公开(公告)号：KR1020010020808A
公开(公告)日：2001-03-15
申请号：KR1020000023682
申请日：2000-05-03
申请人： 르 라보레또레 쎄르비에르
发明人： 메스-촌,오토 , 유,추-이 , 레스타게,피에르 , 레브룬,마리에-세실 , 사이그나르드,다니엘-헨리 , 레나르드,피에르
IPC分类号： C07D211/00
CPC分类号： C07D213/30 , C07D211/22 , C07D211/32 , C07D213/36 , C07D213/50
摘要： PURPOSE: A compound is provide which exhibits an analgesic characteristic and a characteristic promoting recognizing process and useful for treatment of pain and treatment of aging of brain and amnesia accompanying neurodegeneration diseases such as Alzheimer's disease, Parkinson's disease and Pick disease. CONSTITUTION: The compound is represented by formula I (A is pyridine or the like; R3 is hydroxy for the like; R4 is phenyl or the like; R1 is H or the like; R5 is a 5-6 membered heterocycle which may contain a nitrogen atom binding to the ring A and may contain another hetero atom selected from sulfur, oxygen and nitrogen; R6 is H or the like), e.g. 1-(4-bromophenyl)-2-(1-methyl-2- piperidinyl)-1-ethanone. The compound of formula I is obtained by reacting, e.g. a compound obtained by alkylating a compound of formula II (X is H or fluorine) with an alkylating agent with a compound of formula III (Ra and Rb form a 5 to 6-membered heterocycle which may contain another hetero atom selected from sulfur, oxygen or nitrogen together with nitrogen binding to these groups; Rc is H or the like).
摘要翻译：目的：提供一种化合物，其具有镇痛特征和特征促进识别方法，并且可用于治疗伴随神经变性疾病如阿尔茨海默病，帕金森病和皮克病的脑和遗忘症的疼痛和治疗老化。构成：该化合物由式I表示（A为吡啶等; R3为羟基等; R4为苯基等; R1为H等; R5为5-6元杂环，可含有氮原子与环A结合并且可以含有选自硫，氧和氮的另外的杂原子; R 6是H等），例如 1-（4-溴苯基）-2-（1-甲基-2-哌啶基）-1-乙酮。式I的化合物是通过使例如通过烷基化剂与式III化合物（R a和R b形成5至6元杂环，其可以含有选自硫，氧的另外的杂原子）将式II化合物（X为H或氟）烷基化得到的化合物或氮与氮结合这些基团; R c是H等）。

4. 发明授权

KR100588222B1 히드록시알킬 인돌로카르바졸 유도체, 제조방법 및 이들을함유하는 약제 조성물 失效
标题翻译：新型羟基间苯二酚衍生物，制备方法和含有其的药物组合物
公开(公告)号：KR100588222B1
公开(公告)日：2006-06-12
申请号：KR1020047005995
申请日：2002-10-21
申请人： 르 라보레또레 쎄르비에르
发明人： 프르드옴므,미첼레 , 마르미논,크리스텔레 , 모레유,파스칼 , 히크만,존 , 피에르,알렝 , 피페이퍼,브루노 , 레나르드,피에르 , 비조트-에스피알드,쟝-가이
IPC分类号： C07H19/23
CPC分类号： C07H19/23
摘要： Compound of formula (I): wherein: R1 and R2 each represents a group selected from hydrogen, alkyl, arylalkyl, hydroxy, hydroxyalkyl, dihydroxyalkyl, alkoxy, alkoxyalkyl, amino and aminoalkyl (optionally substituted), Ra and Rb each represents an alkylene chain, X1, X2 and X3 each represents a group selected from hydroxy, alkoxy, aryloxy, arylalkoxy, alkyl, amino (optionally substituted), halogen, alkylcarbonyloxy and azido, X4 represents a methylidene group or a group of formula -Rc-X1 as defined in the description, their isomers and also their addition salts with a pharmaceutically acceptable acid or base.

5. 发明授权

KR100453981B1 아미노피롤린 화합물, 이의 제조 방법 및 이를 함유하는약제 조성물 失效
标题翻译： 아미노피롤린화합물，이의제조방법및이를함유하는약제조성물
公开(公告)号：KR100453981B1
公开(公告)日：2004-10-20
申请号：KR1020000068434
申请日：2000-11-17
申请人： 르 라보레또레 쎄르비에르
发明人： 부께,빠스깔 , 에하르,쟝-다니엘 , 브뤼방,베로니끄 , 펠드망,죠지안느 , 샨,스테판 , 스깔베르,엘리자베스 , 프페이페르,브루노 , 레나르드,피에르
IPC分类号： C07D207/09
CPC分类号： C07D207/14 , C07D209/40
摘要： 2-Cyclopropylhydrocarbylamino-pyrrolidine derivatives (I) are new. 2-Cyclopropylhydrocarbylamino-pyrrolidine derivatives of formula (I) and their isomers and salts are new: n = 1 or 2; X = 1-6C alkylene, 2-6C alkenylene (containing 1-3 double bonds), 2-6C alkynylene (containing 1-3 triple bonds) or optionally Q-substituted arylene or heteroarylene; R10, R12 = H or 1-6C alkyl; R11 = H; or R10+R11 or R11+R12 = a bond; R2-R4 = H, 1-6C alkyl, 1-6C hydroxyalkyl, 1-6C alkoxy, 2-7C alkoxycarbonyl or optionally Q-substituted aryl, aryl(1-6C)alkyl or aryloxy(1-6C)alkyl, or two of R2-R4 form a 5-7C cycloalkane ring; Q = halogen, 1-6C alkyl, 1-6C alkoxy, OH, CN, NO2, NH2 and/or mono- or di(1-6C alkyl)amino; aryl = phenyl or naphthyl; arylene = phenylene or naphthylene; and heteroaryl and heteroarylene = 4- to 11-membered mono- or bicyclic saturated or partially unsaturated groups containing 1-5 heteroatoms selected from N, O and S. An Independent claim is also included for a process for preparing compounds (I).
摘要翻译： 2-环丙基烃基氨基 - 吡咯烷衍生物（I）是新的。式（I）的2-环丙基烃基氨基 - 吡咯烷衍生物及其异构体和盐是新的：n = 1或2; X = 1-6C亚烷基，2-6C亚烯基（包含1-3个双键），2-6C亚炔基（包含1-3个三键）或任选地Q-取代的亚芳基或杂亚芳基; R10，R12 = H或1-6C烷基; R11 = H; 或R10 + R11或R11 + R12 =键; R2-R4 = H，1-6C烷基，1-6C羟烷基，1-6C烷氧基，2-7C烷氧羰基或任选被Q取代的芳基，芳基（1-6C）烷基或芳氧基（1-6C）烷基或两的R2-R4形成5-7C环烷烃环; Q =卤素，1-6C烷基，1-6C烷氧基，OH，CN，NO 2，NH 2和/或单 - 或二（1-6C烷基）氨基; 芳基=苯基或萘基; 亚芳基=亚苯基或亚萘基; 和杂芳基和杂亚芳基=含有1-5个选自N，O和S的杂原子的4-至11-元单 - 或双环饱和或部分不饱和基团。还包括独立权利要求用于制备化合物（I）的方法。

6. 发明授权

KR100495365B1 축합된 아졸 화합물 및 이들의 혈당강하 제제로서의 용도 失效
标题翻译：简单的AZOLE化合物及其作为高分子化合物
公开(公告)号：KR100495365B1
公开(公告)日：2005-06-14
申请号：KR1020027009942
申请日：2001-02-01
申请人： 르 라보레또레 쎄르비에르
发明人： 레시에우르,다니엘 , 블랑-델마,엘로디에 , 유스,세드 , 데프렉스,패트릭 , 쥘로우메,제랄드 , 닥켓,캐더린 , 레벤스,니겔 , 부틴,쟝,앨버트 , 베네쟝,캐롤린 , 레나르드,피에르
IPC分类号： C07D277/68
摘要： 본 발명은 하기의 화합물(I)의 화합물로서:

X는 산소 또는 황 원자, 또는 CH
2 또는 기 이고,
R
1 및 R
2 는 수소 원자 또는 명세서에서 정의된 기이고,
A는 명세서에서 기술된 알킬렌 사슬이고,
B는 명세서에서 정의된 바와 같고,
R
3 및 R
4 는 수소 원자 또는 명세서에서 기술된 기이고,
D는 선택적으로 치환된 벤젠, 선택적으로 치환된 피라진, 선택적으로 치환된 피리미딘 또는 선택적으로 치환된 피리다진 핵인 화합물에 관한 것이다.

7. 发明公开

KR1020010051775A 12,13-(피라노실)-인돌로[2,3-ａ]피롤로[3,4-ｃ]카르바졸및 12,13-(피라노실)-푸로[3,4-ｃ]인돌로[2,3-ａ]카르바졸화합물, 이들의 제조 방법 및 이들을 함유하는 약제학적조성물 失效
标题翻译：（2,3-A）吡咯烷（3,4-C）卡波铵和12,13-（吡喃糖基） - 呋喃（3,4-C）吲哚（2,3-二甲基苯基） A）卡巴唑，其工艺及其含有的药物组合物
公开(公告)号：KR1020010051775A
公开(公告)日：2001-06-25
申请号：KR1020000068432
申请日：2000-11-17
申请人： 르 라보레또레 쎄르비에르
发明人： 프루도메,미첼르 , 모로,파스칼 , 아니존,패브리스 , 마르미농,크리스텔르 , 아타시,과넴 , 피에르,알랭 , 프페이페르,브루노 , 레나르드,피에르
IPC分类号： C07D209/82
CPC分类号： C07H19/23
摘要： PURPOSE: Provided are derivatives of 12,13-(pyranosyl)-indolo(2,3-a)pyrrolo(3,4-c)carbazole and 12,13-(pyranosyl)-furo(3,4-c)indolo(2,3-a)carbazole, which are used for the treatment of cancer, their process, and pharmaceutical compositions containing them. CONSTITUTION: The derivatives are represented by the formula(I), wherein R1 and R2 are the same or different from each other, represent formula: U-V (wherein, U is optionally substituted or unsaturated single bond chain or alkylene chain, and V is described as in the description); G is oxygen atom or NR3 group, wherein R3 is described as in the description; X is hydrogen atom, hydroxy, alkoxy, mercapto or alkylthio group, and Y represents hydrogen atom or X+Y is carbonyl group; X1 is hydrogen atom, hydroxy, alkoxy, mercapto or alkylthio group, and Y1 is hydrogen atom or X1+Y1 is carbonyl group; and R4, R5, and R6 are described in the description.
摘要翻译：目的：提供12,13-（吡喃糖基） - 吲哚（2,3-a）吡咯并（3,4-c）咔唑和12,13-（吡喃糖基） - 呋喃（3,4-c）吲哚（ 2,3-a）咔唑，其用于治疗癌症，其方法和含有它们的药物组合物。构成：衍生物由式（I）表示，其中R 1和R 2彼此相同或不同，表示式：UV（其中，U是任选取代或不饱和单键链或亚烷基链，并且描述V 如描述）; G是氧原子或NR 3基团，其中R3如描述中所述; X是氢原子，羟基，烷氧基，巯基或烷硫基，Y代表氢原子或X + Y是羰基; X1是氢原子，羟基，烷氧基，巯基或烷硫基，Y1是氢原子或X1 + Y1是羰基; 和R4，R5和R6在说明书中描述。

8. 发明公开

KR1020010020806A 1-아자-2-알킬-6-아릴-시클로알칸 화합물, 이들의 제조방법 및 이들을 함유하는 약제 조성물 失效
标题翻译：新的1-AZA-2-ALKYL-6-ARYL-CYCLOALKANE化合物，其生产和含有它们的药物组合物
公开(公告)号：KR1020010020806A
公开(公告)日：2001-03-15
申请号：KR1020000023668
申请日：2000-05-03
申请人： 르 라보레또레 쎄르비에르
发明人： 라울트,실뱅 , 리놀트,올리비에 , 귈롱,쟝 , 달레매니,패트릭 , 레나르드,피에르 , 페이페르,브루노 , 레스타게,피에르 , 레브룬,마리에-세실
IPC分类号： C07D223/00
CPC分类号： C07D401/04 , C07D211/38 , C07D211/46 , C07D211/54 , C07D211/72 , C07D211/74 , C07D211/86 , C07D223/08 , C07D409/04
摘要： PURPOSE: A new 1-aza-2-alkyl-6-aryl-cycloalkane compound is provided, which is capable of counteracting dysgnosia accompanied by senile changes, improving a recognition process and having analgesic characteristics without hypothermic activity. CONSTITUTION: The new 1-aza-2-alkyl-6-aryl-cycloalkane compound is a compound expressed by formula I (R is H, an aryl, a 1-6C alkyl or the like; R is a 1-6C alkyl; X is 0, C1 or the like; a dotted line is a single bond or a double bond; Ar is an aryl or a heteroaryl; n is 0 or 1; specific compounds such as 6-methyl-2-phenyl-2,3-dihydro-4-pyridinone, etc., are omitted), e.g. (±)-2-(3- chlorophenyl)-6-methyl-2,3-dihydro-4(1H)-pyridinone. The compound of formula I is obtained by reacting a compound of formula II with thionyl chloride to prepare an acid chloride, which is reacted with a compound of formula III in the presence of samarium triiodide and protected with an acid HA (HA is a proton donor) to prepare a compound of formula IV which is reacted in a basic medium.
摘要翻译：目的：提供新的1-氮杂-2-烷基-6-芳基 - 环烷烃化合物，其能够抵抗伴随老年变化的失调，改善识别过程并具有没有降低体温活性的止痛特征。构成：新的1-氮杂-2-烷基-6-芳基 - 环烷烃化合物是由式I表示的化合物（R是H，芳基，1-6C烷基等; R是1-6C烷基; X为0，C1等;虚线为单键或双键; Ar为芳基或杂芳基; n为0或1;具体化合物如6-甲基-2-苯基-2,3 - 二氢-4-吡啶酮等），例如（±）-2-（3-氯苯基）-6-甲基-2,3-二氢-4（1H） - 吡啶酮。式I化合物是通过使式II化合物与亚硫酰氯反应制备酰基氯，其在三碘化钐存在下与式III化合物反应并用酸HA（HA是质子供体））以制备在碱性介质中反应的式IV化合物。

9. 发明授权

KR100498868B1 벤조[ｂ]피라노[3,2-ｈ]아크리딘-7-온 화합물, 이의 제조방법 및 이를 함유하는 약제 조성물 失效
标题翻译：新苯并[b]吡喃[3,2-h]阿魏酸-7-酮化合物，其制备方法和含有它们的药物组合物
公开(公告)号：KR100498868B1
公开(公告)日：2005-07-04
申请号：KR1020020043537
申请日：2002-07-24
申请人： 르 라보레또레 쎄르비에르
发明人： 코흐,미쉘 , 틸레퀸,프랑소와즈 , 미쉘,실비에 , 세구인,엘리자베스 , 엘옴리,아브델하킴 , 히크만,존 , 피에르,알라인 , 페이페르,브루노 , 레나르드,피에르
IPC分类号： C07D491/048
CPC分类号： C07D491/04
摘要： 본 발명은 하기 화학식 (Ⅰ)의 화합물, 이것의 이성질체 및 N-산화물, 및 약제학적으로 허용되는 산 또는 염기와의 부가염과 약제에 관한 것이다;

상기 식에서,
X 및
Y 는 수소, 할로겐, 멜캅토, 시아노, 니트로, 알킬, 트리할로알킬, 트리할로알킬카르보닐아미노, -ORa, -NRaRb, -NRa-C(O)-T
1 , -OC(O)-T
1 , -OT
2 -NRaRb, -OT
2 -ORa, -NRa-T
2 -NRaRb, -NRa-T
2 -ORa 및 -NRa-T
2 -CO
2 Ra(여기서, Ra, Rb, T
1 , T
2 는 본문에 설명된 바와 같음)로부터 선택된 기이거나, X 및 Y는 함께 메틸렌디옥시기 또는 에틸렌디옥시기를 형성하며;
R
1 은 수소 원자 또는 알킬기이며;
R
2 는 수소, -ORa, -NRaRb, -NRa-C(O)-T
1 , -OC(O)-T
1 , -OT
2 -NRaRb, -OT
2 -ORa, -NRa-T
2 -NRaRb, -NRa-T
2 -ORa 및 -NRa-T
2 -CO
2 Ra(여기서, Ra, Rb, T
1 및 T
2 는 본문에 설명된 바와 같음)로부터 선택된 기이며;
R
3 및
R
4 는 수소 원자 또는 알킬기이며;
W 는 -CH(R
5 )-CH(R
6 )-, -CH=C(R
7 )-, -C(R
7 )=CH- 또는 -C(O)-CH(R
8 )-(여기서, R
5 , R
6 , R
7 및 R
8 은 명세서에서 정의된 바와 같음)의 기이다.

10. 发明公开

KR1020040054735A 히드록시알킬 인돌로카르바졸 유도체, 제조방법 및 이들을함유하는 약제 조성물 失效
标题翻译：羟烷基吲哚并咔唑衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：KR1020040054735A
公开(公告)日：2004-06-25
申请号：KR1020047005995
申请日：2002-10-21
申请人： 르 라보레또레 쎄르비에르
发明人： 프르드옴므,미첼레 , 마르미논,크리스텔레 , 모레유,파스칼 , 히크만,존 , 피에르,알렝 , 피페이퍼,브루노 , 레나르드,피에르 , 비조트-에스피알드,쟝-가이
IPC分类号： C07H19/23
CPC分类号： C07H19/23
摘要： 본 발명은 하기 화학식 (I)의 화합물, 이들의 이성질체 및 이들의 약제학적으로 허용되는 산 또는 염기 부가 염에 관한 것이다:

상기 식에서,
R
1 및 R
2 각각은 수소, 알킬, 아릴알킬, 히드록시, 히드록시알킬, 디히드록시알킬, 알콕시, 알콕시알킬, 아미노, 아미노알킬(치환되거나 치환되지 않고)을 나타내고,
Ra 및 Rb 각각은 알킬렌 사슬을 나타내고,
X
1 , X
2 및 X
3 각각은 수소, 알콕시, 아릴옥시, 아릴알콕시, 아미노(치환되거나 치환되지 않음), 할로겐, 알킬카르보닐옥시, 아지도로부터 선택된 기를 나타내고,
X
4 는 상세한 설명에서 정의된 바와 같이, 메틸리덴기 또는 화학식 -Rc-X
1 의 기를 나타낸다. 본 발명은 약제로서 사용된다.

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