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1. 发明公开

KR1020010020808A 치환된 피리딘 또는 피페리딘 화합물, 이들의 제조 방법및 이들을 함유하는 약제 조성물 失效
标题翻译：新替代的吡啶或哌啶化合物，其生产和含有该组合物的药物组合物
公开(公告)号：KR1020010020808A
公开(公告)日：2001-03-15
申请号：KR1020000023682
申请日：2000-05-03
申请人： 르 라보레또레 쎄르비에르
发明人： 메스-촌,오토 , 유,추-이 , 레스타게,피에르 , 레브룬,마리에-세실 , 사이그나르드,다니엘-헨리 , 레나르드,피에르
IPC分类号： C07D211/00
CPC分类号： C07D213/30 , C07D211/22 , C07D211/32 , C07D213/36 , C07D213/50
摘要： PURPOSE: A compound is provide which exhibits an analgesic characteristic and a characteristic promoting recognizing process and useful for treatment of pain and treatment of aging of brain and amnesia accompanying neurodegeneration diseases such as Alzheimer's disease, Parkinson's disease and Pick disease. CONSTITUTION: The compound is represented by formula I (A is pyridine or the like; R3 is hydroxy for the like; R4 is phenyl or the like; R1 is H or the like; R5 is a 5-6 membered heterocycle which may contain a nitrogen atom binding to the ring A and may contain another hetero atom selected from sulfur, oxygen and nitrogen; R6 is H or the like), e.g. 1-(4-bromophenyl)-2-(1-methyl-2- piperidinyl)-1-ethanone. The compound of formula I is obtained by reacting, e.g. a compound obtained by alkylating a compound of formula II (X is H or fluorine) with an alkylating agent with a compound of formula III (Ra and Rb form a 5 to 6-membered heterocycle which may contain another hetero atom selected from sulfur, oxygen or nitrogen together with nitrogen binding to these groups; Rc is H or the like).
摘要翻译：目的：提供一种化合物，其具有镇痛特征和特征促进识别方法，并且可用于治疗伴随神经变性疾病如阿尔茨海默病，帕金森病和皮克病的脑和遗忘症的疼痛和治疗老化。构成：该化合物由式I表示（A为吡啶等; R3为羟基等; R4为苯基等; R1为H等; R5为5-6元杂环，可含有氮原子与环A结合并且可以含有选自硫，氧和氮的另外的杂原子; R 6是H等），例如 1-（4-溴苯基）-2-（1-甲基-2-哌啶基）-1-乙酮。式I的化合物是通过使例如通过烷基化剂与式III化合物（R a和R b形成5至6元杂环，其可以含有选自硫，氧的另外的杂原子）将式II化合物（X为H或氟）烷基化得到的化合物或氮与氮结合这些基团; R c是H等）。

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