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1. 发明公开

KR1020100089443A 칼슘 이온 검출용 센서 有权
标题翻译：用于检测钙离子的传感器
公开(公告)号：KR1020100089443A
公开(公告)日：2010-08-12
申请号：KR1020090008685
申请日：2009-02-04
申请人： 광주과학기술원 , 국민대학교산학협력단
发明人： 전상용 , 김성현 , 박정원 , 김동규 , 김대진
IPC分类号： G01N33/20 , G01N33/544 , G01N33/553
摘要： PURPOSE: A sensor for detecting calcium ion, containing calcium binding protein-functionalized nanoparticles is provided to quickly and simply detect calcium ion. CONSTITUTION: A sensor for detecting calcium ion contains calcium binding proteing-functionalized nanoparticles. The calcium binding protein causes aggregation of nanoparitcles. The calcium binding protein is calsequestrin. The nanoparticle is a gold nanoparticle(GNP). The diameter of the nanoparticle is 1-100nm. The sensor for detecting calcium ion is used for detecting calcium ion in blood, serum, or plasma sample. The sensor is a color-based detection sensor. A kit for diagnosing calcium-relating disease contains the sensor. A method for detecting calcium ion in a sample comprises: a step of contacting the sample to the sensor, and a step of analyzing calcium ion concentration.
摘要翻译：目的：提供一种用于检测含钙结合蛋白官能化纳米粒子的钙离子传感器，用于快速简单地检测钙离子。构成：用于检测钙离子的传感器含有钙结合蛋白官能化纳米粒子。钙结合蛋白导致纳米颗粒的聚集。钙结合蛋白是钙结合蛋白。纳米颗粒是金纳米颗粒（GNP）。纳米颗粒的直径为1-100nm。用于检测钙离子的传感器用于检测血液，血清或血浆样品中的钙离子。传感器是基于颜色的检测传感器。用于诊断与钙有关的疾病的试剂盒包含传感器。用于检测样品中钙离子的方法包括：使样品与传感器接触的步骤和分析钙离子浓度的步骤。

2. 发明授权

KR101151800B1 칼슘 이온 검출용 센서 有权
标题翻译：用于检测钙离子的传感器
公开(公告)号：KR101151800B1
公开(公告)日：2012-06-01
申请号：KR1020090008685
申请日：2009-02-04
申请人： 광주과학기술원 , 국민대학교산학협력단
发明人： 전상용 , 김성현 , 박정원 , 김동규 , 김대진
IPC分类号： G01N33/20 , G01N33/544 , G01N33/553
摘要： 본발명은칼슘결합단백질-작용기성(calcium binding protein-functionalized) 나노입자를포함하는칼슘이온검출용센서, 칼슘-관련질환진단용키트그리고칼슘이온검출방법에관한것이다. 본발명은칼슘이온검출용칼슘결합단백질(예컨대, 칼세퀘스트린)-작용기성나노입자를제공한다. 본발명은생체내 칼슘이온의변화를검출할수 있는센서를이용하여칼슘-관련질환을진단할수 있는키트를제공한다. 본발명의센서는칼슘이온의검출을보다특이적으로할 수있고색상변화를육안으로확인하여칼슘이온을보다빠르고간단하게검출할수 있다.

3. 发明公开

KR1020140015036A 펩타이드의 타겟 친화도 개선방법 有权
标题翻译：改善肽的目标亲和力的方法
公开(公告)号：KR1020140015036A
公开(公告)日：2014-02-06
申请号：KR1020120082696
申请日：2012-07-27
申请人： 광주과학기술원
发明人： 전상용 , 김성현 , 김대진
IPC分类号： C07K1/10 , C07K1/00 , C40B40/10
CPC分类号： G01N33/6845 , C07K1/047 , C07K14/001
摘要： The present invention relates to a method for improving the target affinity of peptide combining to a protein target. The present invention is capable of remarkably improving the target affinity of the peptide, and is simple and effective. Through the present invention, the target affinity of the peptide can be improved to 1,000 times, for example. A KPI-bipodal peptide binder technique of the present invention can remarkably improve the applicability of the peptide. [Reference numerals] (AA) Known peptide; (BB,FF) Protein; (CC) Random peptide; (DD) Library; (EE) Screening
摘要翻译：本发明涉及一种提高肽与蛋白质靶组合的靶亲和力的方法。本发明能够显着提高肽的靶亲和力，而且简单有效。通过本发明，例如可将肽的靶亲和性提高至1000倍。本发明的KPI-双足肽粘合剂技术可显着改善肽的适用性。 [AA]已知肽; （BB，FF）蛋白质; （CC）随机肽; （DD）图书馆; （EE）筛选

4. 发明授权

KR101443839B1 펩타이드의 타겟 친화도 개선방법 有权
标题翻译：提高肽目标亲和力的方法
公开(公告)号：KR101443839B1
公开(公告)日：2014-09-26
申请号：KR1020120082696
申请日：2012-07-27
申请人： 광주과학기술원
发明人： 전상용 , 김성현 , 김대진
IPC分类号： C07K1/10 , C07K1/00 , C40B40/10
CPC分类号： G01N33/6845 , C07K1/047 , C07K14/001
摘要： 본 발명은 단백질 타겟에 결합하는 펩타이드의 타겟 친화도를 증가시키는 방법에 관한 것이다. 본 발명은 공지 펩타이드의 타겟 친화도를 획기적으로 향상시킬 수 있는 방법으로서, 매우 효율적이면서도 간단하다. 본 발명에 의하여, 공지 펩타이드의 타겟 친화도를 예컨대 1000배 증가킬 수 있다. 본 발명의 KPI-바이포달 펩타이드 바인더 기술은 공지의 펩타이드의 응용성을 크게 향상시킬 수 있다.

5. 发明公开

KR1020130103301A 전사인자에 특이적으로 결합하는 ＴＦ-ＢＰＢ无效
标题翻译： TF-BPB特异性绑定转录伤口
公开(公告)号：KR1020130103301A
公开(公告)日：2013-09-23
申请号：KR1020127023552
申请日：2011-04-20
申请人： 광주과학기술원
发明人： 전상용 , 김성현 , 박세호 , 김대진 , 이상헌
IPC分类号： C07K1/107 , C40B40/10 , C12N15/63 , G01N33/68
CPC分类号： C07K14/47
摘要： PURPOSE: A transcription factor-bipodal peptide binder (TF-BPB) is provided to be used as a medicine and an escort molecule and for in vivo molecular imaging and targeting for drug delivery. CONSTITUTION: A method for preparing a TF-BPB which specifically binds to TF comprises the steps of: providing a TF-BPB library containing TF-target binding region I and TF-target binding region II; making the library and TF as a target come in contact; and selecting TF-conjugated TF-BPB. TF-target binding region I and TF-target binding region II have: a structure stabilizing region comprising a parallel with interstrand non-covalent bond, an antiparallel, or amino acid strands of the parallel and the antiparallel; and n or m amino acids which are conjugated to both ends of the structure stabilizing region and are randomly selective. [Reference numerals] (AA,CC,EE) Random; (BB) Liner; (DD) Looped; (FF) Bipodal peptide Binder; (GG) Structure stabilization part; (HH) GPCR-target binding part i; (II) GPCR-target binding part ii
摘要翻译：目的：提供转录因子 - 双足肽结合物（TF-BPB）作为药物和护送分子，用于药物递送的体内分子成像和靶向。构成：制备与TF特异性结合的TF-BPB的方法包括以下步骤：提供含有TF-靶结合区I和TF-靶结合区II的TF-BPB文库; 使图书馆和TF作为目标接触; 并选择TF-共轭TF-BPB。 TF-靶结合区I和TF-靶结合区II具有：包含与链间非共价键平行的结构稳定区，平行的和反向平行的反向平行或氨基酸链; 和n或m个氨基酸，其与结构稳定区的两端共轭并且是随机选择性的。（标号）（AA，CC，EE）随机; （BB）衬垫; （DD）循环; （FF）双峰肽粘合剂; （GG）结构稳定部分; （HH）GPCR靶标结合部分i; （II）GPCR靶标结合部分ii

6. 发明公开

KR1020130103299A ＲＴＫ에 특이적으로 결합하는 ＲＴＫ―ＢＰＢ无效
标题翻译： RTK-BPB特异性绑定到RTK
公开(公告)号：KR1020130103299A
公开(公告)日：2013-09-23
申请号：KR1020127023550
申请日：2011-04-20
申请人： 광주과학기술원
发明人： 전상용 , 김성현 , 박세호 , 김대진 , 이상헌
IPC分类号： C07K1/107 , C40B30/04 , C40B40/10 , C12N15/63
CPC分类号： C07K14/47 , G01N2333/715
摘要： PURPOSE: A receptor tyrosine kinase-bipodal peptide binder (RTK-BPB) is provided to be used as a medicine and an escort molecule and for in vivo molecular imaging and targeting for drug delivery. CONSTITUTION: A method for preparing an RTK-BPB which specifically binds to RTK comprises the steps of: providing an RTK-BPB library containing RTK-target binding region I and RTK-target binding region II; making RTK as a target and the library come in contact; and selecting RTK-conjugated RTK-BPB. RTK-target binding region I and RTK-target binding region II contain: a structure stabilizing region containing a parallel with interstrand non-covalent bond, an antiparallel, or amino acid strands of the parallel and the antiparallel; and n or m amino acids which are conjugated to both ends of the structure stabilizing region and are randomly selective. [Reference numerals] (AA,CC,EE) Random; (BB) Liner; (DD) Looped; (FF) Bipodal peptide Binder; (GG) Structure stabilization part; (HH) GPCR-target binding part i; (II) GPCR-target binding part ii
摘要翻译：目的：提供受体酪氨酸激酶双足肽结合物（RTK-BPB），用作药物和护送分子，用于药物递送的体内分子成像和靶向。构成：制备与RTK特异性结合的RTK-BPB的方法包括以下步骤：提供包含RTK-靶结合区I和RTK-靶结合区II的RTK-BPB文库; 使RTK成为目标，图书馆接触; 并选择RTK结合的RTK-BPB。 RTK-靶结合区域I和RTK-靶结合区域II包含：平行于平行和反向平行的包含平行于链间非共价键的结构稳定区域，反向平行或氨基酸链; 和n或m个氨基酸，其与结构稳定区的两端共轭并且是随机选择性的。（标号）（AA，CC，EE）随机; （BB）衬垫; （DD）循环; （FF）双峰肽粘合剂; （GG）结构稳定部分; （HH）GPCR靶标结合部分i; （II）GPCR靶标结合部分ii

7. 发明公开

KR1020120125455A 세포내 타겟 결합용 바이포달 펩타이드 바인더 无效
标题翻译：腹腔内定向双功能胶原蛋白BINDER BINDER
公开(公告)号：KR1020120125455A
公开(公告)日：2012-11-15
申请号：KR1020127015777
申请日：2010-12-03
申请人： 광주과학기술원
发明人： 전상용 , 김성현 , 김대진
IPC分类号： C07K19/00 , C07K7/08
CPC分类号： C07K19/00 , A61K38/00
摘要： PURPOSE: A bipodal peptide binder and a method for preparing the same are provided to be used for in vivo molecule and used as an escort molecule. CONSTITUTION: A method for preparing an intracellular bipodal peptide binder which specifically binds to the intracellular target molecule comprises: a step of providing a library of the bipodal peptide binder containing a structure stabilizing region and a target binding region I and II; a step of contacting the library and the target; a step of selecting the bipodal peptide binder conjugated to the target; and a step of binding cell penetrating peptide(CPP) to the selected bipodal peptide binder.
摘要翻译：目的：提供双峰肽粘合剂及其制备方法用于体内分子并用作护送分子。构成：制备特异性结合细胞内靶分子的细胞内双足肽结合剂的方法包括：提供含有结构稳定区和靶结合区I和II的双齿肽结合物的文库的步骤; 联系图书馆和目标的步骤; 选择与靶标缀合的双齿肽粘合剂的步骤; 以及将细胞穿透肽（CPP）与选定的双齿肽结合物结合的步骤。

8. 发明公开

KR1020130103302A ＣＹＴＯＫＩＮＥ에 특이적으로 결합하는 ＣＹＴＯＫＩＮＥ―ＢＰＢ无效
标题翻译：细胞因子-BPB特异性结合细胞因子
公开(公告)号：KR1020130103302A
公开(公告)日：2013-09-23
申请号：KR1020127023553
申请日：2011-04-20
申请人： 광주과학기술원
发明人： 전상용 , 김성현 , 박세호 , 김대진 , 이상헌
IPC分类号： C07K1/107 , C40B30/04 , C40B40/10 , C12N15/63
CPC分类号： C07K14/47 , G01N2333/705
摘要： PURPOSE: A cytokine-bipodal peptide binder (cytokine-BPB) is provided to be used as a medicine and an escort molecule and for in vivo molecular imaging and targeting for drug delivery. CONSTITUTION: A method for preparing a cytokine-BPB which specifically binds to a cytokine target comprises the steps of: providing a cytokine-BPB library containing cytokine-target binding region I and cytokine-target binding region II; making the library and a cytokine as a target come in contact; and selecting cytokine-BPB which is conjugated with the cytokine. Cytokine-target binding region I and cytokine-target binding region II comprise: a structure stabilizing region containing a parallel with interstrand non-covalent bond, an antiparallel, or amino acid strands of the parallel and the antiparallel; and n or m amino acids which are conjugated to both ends of the structure stabilizing region and are randomly selective. [Reference numerals] (AA,BB,CC) Random; (DD) Linear; (EE) Ring shape; (FF) Bipodal-peptide binder; (GG) Structure stabilizing region; (HH) GPCR-target binding region I; (II) GPCR-target binding region II
摘要翻译：目的：提供细胞因子 - 双足肽粘合剂（细胞因子-BPB），用作药物和护送分子，用于药物递送的体内分子成像和靶向。构成：用于制备特异性结合细胞因子靶标的细胞因子-BPB的方法包括以下步骤：提供含有细胞因子 - 靶结合区I和细胞因子 - 靶结合区II的细胞因子-BPB文库; 使图书馆和细胞因子作为目标接触; 并选择与细胞因子缀合的细胞因子-BPB。细胞因子 - 靶标结合区域I和细胞因子 - 靶标结合区域II包含：平行于平行和反向平行的平行于链间非共价键的结构稳定区域，反向平行或氨基酸链; 和n或m个氨基酸，其与结构稳定区的两端共轭并且是随机选择性的。（标号）（AA，BB，CC）随机; （DD）线性; （EE）环形; （FF）双峰肽结合剂; （GG）结构稳定区; （HH）GPCR靶结合区I; （II）GPCR靶结合区II

9. 发明公开

KR1020130103300A ＧＰＣＲ에 특이적으로 결합하는 ＧＰＣＲ-ＢＰＢ无效
标题翻译： GPRR-BPB特异性绑定到GPCR
公开(公告)号：KR1020130103300A
公开(公告)日：2013-09-23
申请号：KR1020127023551
申请日：2011-04-20
申请人： 광주과학기술원
发明人： 전상용 , 김성현 , 박세호 , 김대진 , 이상헌
IPC分类号： C07K1/107 , C40B30/04 , C40B40/10 , C12N15/63
CPC分类号： C07K14/705 , A61K47/64 , A61K49/0002 , A61K49/0056 , G01N2333/726
摘要： PURPOSE: A G protein-coupled receptor-bipodal peptide binder (GPCR-BPB) is provided to be used as a medicine and an escort molecule and for in vivo molecular imaging and targeting for drug delivery. CONSTITUTION: A method for preparing a GPCR-BPB which specifically binds to a GPCR target comprises the steps of: providing a GPCR-BPB library containing GPCR-target binding region I and GPCR-target binding region II; making the library and GPCR as a target come in contact; and selecting GPCR-conjugated GPCR-BPB. GPCR-target binding region I and GPCR-target binding region II contain: a structure stabilizing region containing a parallel with interstrand non-covalent bond, an antiparallel, or amino acid strands of the parallel and the antiparallel; and n or m amino acids which are conjugated to both ends of the structure stabilizing region and are randomly selective.
摘要翻译：目的：提供G蛋白偶联受体 - 双足肽结合物（GPCR-BPB），用作药物和护送分子，并用于体内分子成像和靶向药物递送。构成：制备与GPCR靶特异性结合的GPCR-BPB的方法包括以下步骤：提供包含GPCR-靶结合区I和GPCR-靶结合区II的GPCR-BPB文库; 使图书馆和GPCR作为目标接触; 并选择GPCR-缀合的GPCR-BPB。 GPCR-靶结合区域I和GPCR-靶结合区域II包含：平行于和平行的平行的反向平行或氨基酸链的结构稳定区域，其包含平行于链间非共价键的结构稳定区域; 和n或m个氨基酸，其与结构稳定区的两端共轭并且是随机选择性的。

10. 发明公开

KR1020110116930A 이온채널에 특이적으로 결합하는 이온채널―ＢＰＢ无效
标题翻译：离子通道BPB能够特别绑定到离子通道
公开(公告)号：KR1020110116930A
公开(公告)日：2011-10-26
申请号：KR1020100036618
申请日：2010-04-20
申请人： 광주과학기술원
发明人： 전상용 , 김성현 , 박세호 , 김대진 , 이상헌
IPC分类号： C07K1/107 , C40B40/10 , C12N15/63 , G01N33/68
CPC分类号： C07K14/00 , A61K47/62 , C07K7/06 , G01N33/58
摘要： 본 발명은 (a) 가닥간(interstrand) 비공유결합이 형성된 패러럴(parallel), 안티패러럴(antiparallel) 또는 패러럴(parallel)과 안티패러럴(antiparallel) 아미노산 가닥들을 포함하는 구조 안정화 부위(structure stabilizing region); 및 (b) 상기 구조 안정화 부위의 양 말단에 결합되어 있고 무작위적으로 선택된 각각 n 및 m개의 아미노산을 포함하는 Ion channel-타겟 결합 부위 I(Ion channel-target binding region I) 및 Ion channel-타겟 결합 부위 Ⅱ(Ion channel-target binding region Ⅱ)를 포함하는 Ion channel에 특이적으로 결합하는 Ion channel-바이포달 펩타이드 바인더에 관한 것으로서, 본 발명의 Ion channel-바이포달 펩타이드 바인더는 Ion channel에 대하여 매우 낮은 수준(예컨대, nM 수준)의 K
D 값(해리상수)을 나타내어, Ion channel 타겟에 매우 높은 친화도를 나타낸다. 본 발명의 Ion channel-바이포달 펩타이드 바인더는 의약으로서의 용도를 가질 뿐만 아니라,
인 비보 분자 이미징, 및 약물전달용 타겟팅을 하는 데 이용될 수 있으며, 에스코트 분자로도 매우 유용하게 이용될 수 있다.

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