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    • 4. 发明公开
    • 머루로부터 분리된 안토시아닌을 함유하는 간암 예방 및치료용 조성물
    • 用于预防和治疗来自MEORU的含有蒽醌的HEPATOMA的组合物
    • KR1020100010646A
    • 2010-02-02
    • KR1020080071624
    • 2008-07-23
    • 경상대학교산학협력단
    • 이원섭신성철이성중최영현
    • A61K36/87A61P35/00A61K31/7028
    • A61K31/7048A61K36/87A61K2236/33A61K2236/51A61K2236/55Y10S514/893
    • PURPOSE: A composition containing anthocyanin isolated from Vitis coignetiae Pulliat for treating liver cancer is provided to induce and strengthen apoptosis of hepatocytes and ensure anti-proliferation and anti-infiltration to liver cancer cells. CONSTITUTION: A composition for preventing and treating liver cancer contains anthocyanin isolated from Vitis coignetiae Pulliat as an active ingredient. A method for isolating the anthocyanin comprises: a step of extracting Vitis coignetiae Pulliat with methanol containing 0.1% of HCl at 5°C for 24 hours; a step of compress-concentrating the Vitis coignetiae Pulliat extract and washing the extract on Ambrite XAD-7 adsorber with water and ethyl acetate; and a step of eluting methanol solution having 1% of HCl to obtain the anthocyanin. The anthocyanin is delphinidin-3,5-diglucoside and cyanidin-3,5-diglucoside.
    • 目的:提供一种含有从葡萄凝乳分离的花青素的组合物,用于治疗肝癌,以诱导和增强肝细胞凋亡,并确保对肝癌细胞的抗增殖和抗浸润。 构成:用于预防和治疗肝癌的组合物含有作为活性成分从葡萄白芷中分离的花青素。 分离花青素的方法包括:在5℃下用含有0.1%HCl的甲醇提取葡萄白葡萄酒24小时的步骤; 将Vitis coignetiae Pulliat提取物压缩浓缩并用水和乙酸乙酯洗涤Ambrite XAD-7吸附器上的提取物的步骤; 和洗脱具有1%HCl的甲醇溶液以获得花青素的步骤。 花青素是花翠素-3,5-二葡萄糖苷和花青素-3,5-二葡萄糖苷。
    • 8. 发明公开
    • 비만 예방 또는 치료제의 스크리닝 방법
    • 筛选用于治疗或预防肥胖症的药剂的方法
    • KR1020130009207A
    • 2013-01-23
    • KR1020110070125
    • 2011-07-14
    • 경상대학교산학협력단
    • 김명옥신성철김소은이혜령전은우정종일박문석
    • G01N33/68G01N33/15
    • G01N33/6872A61K31/7048C12Q1/6883C12Q2600/136G01N33/74G01N33/9426G01N2333/5755G01N2333/726G01N2800/042G01N2800/044
    • PURPOSE: A capsule formulation containing an independent levocetirizine layer for preventing or treating allergic rhinitis and asthma is provided to ensure excellent product stability and to maximize treatment effect. CONSTITUTION: A capsule formulation for preventing or treating allergic rhinitis comprises: an independent layer containing montelukast or a pharmaceutically acceptable salt thereof; and an independent layer containing levocetirizine or a pharmaceutically acceptable salt thereof. The independent layers are formed in granules or a tablet. The independent layers are prepared without water or an organic solvent or the independent layers substantially do not contain water or the organic solvent. The table has a coating layer. A coating base for the coating layer is methyl cellulose, ethyl cellulose, polyvinyl alcohol, polyvinyl pyrrolidone, hydroxyl ethyl cellulose, hydroxylpropyl methyl cellulose, or a mixture thereof. The capsule is a soft capsule.
    • 目的:提供含有用于预防或治疗过敏性鼻炎和哮喘的独立的左西替利嗪层的胶囊制剂,以确保优异的产品稳定性和最大化治疗效果。 构成:用于预防或治疗过敏性鼻炎的胶囊制剂包括:含有孟鲁司特或其药学上可接受的盐的独立层; 和含有左西替利嗪或其药学上可接受的盐的独立层。 独立层以颗粒或片剂形成。 独立的层在没有水或有机溶剂的情况下制备,或独立层基本上不含水或有机溶剂。 桌子有一个涂层。 用于涂层的涂布基底是甲基纤维素,乙基纤维素,聚乙烯醇,聚乙烯吡咯烷酮,羟乙基纤维素,羟丙基甲基纤维素或它们的混合物。 胶囊是软胶囊。
    • 10. 发明公开
    • 검정콩 추출물을 포함하는 퇴행성 뇌신경 질환 치료 또는 예방용 조성물
    • 用于治疗或预防神经障碍的组合物,其包含黑豆提取物
    • KR1020120131149A
    • 2012-12-04
    • KR1020120132592
    • 2012-11-21
    • 경상대학교산학협력단
    • 김명옥신성철정종일
    • A61K31/7048A61K31/70A61K36/48A61P25/28
    • PURPOSE: A composition containing black bean extract for preventing or treating neurodegenerative diseases is provided to protect and regenerate nerves. CONSTITUTION: A composition or for preventing or treating neurodegenerative diseases contains 15-25 wt% of delphinidin-3-glucoside, 65-80 wt% of cyanidine-3-glucoside, and 5-10 wt% of petunidin-3-glucoside. The composition additionally contains pharmaceutically acceptable carriers. A functional food composition for enhancing brain or cognitive function contains 15-25 wt% of delphinidin-3-glucoside, 65-80 wt% of cyanidine-3-glucoside, and 5-10 wt% of petunidin-3-glucoside. A method for manufacturing the composition comprises: a step of extracting black soybeans with water, organic solvent, or a mixture thereof to prepare black soybean extract; a step of fractioning the extract using water or a non-polar organic solvent; and a step of isolating and purifying delphinidin-3-glucoside, cyanidine-3-glucoside, and cyanidine-3-glucoside from the fraction.
    • 目的:提供含有预防或治疗神经变性疾病的黑豆提取物的组合物,以保护和再生神经。 构成:一种组合物或用于预防或治疗神经变性疾病的组合物含有15-25%(重量)的花翠素-3-葡萄糖苷,65-80%(重量)的氰胺-3-葡萄糖苷和5-10%重量的花旗豆-3-糖苷。 该组合物另外含有药学上可接受的载体。 用于增强脑或认知功能的功能性食品组合物含有15-25重量%的花翠素-3-葡萄糖苷,65-80重量%的氰胺-3-葡萄糖苷和5-10重量%的花萘醌-3-葡萄糖苷。 制备该组合物的方法包括:用水,有机溶剂或其混合物萃取黑色大豆以制备黑豆提取物的步骤; 使用水或非极性有机溶剂对提取物进行分级的步骤; 从该级分分离和纯化花翠素-3-葡萄糖苷,氰胺-3-葡萄糖苷和氰胺-3-葡萄糖苷的步骤。