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    • 2. 发明公开
    • 머루로부터 분리된 안토시아닌을 함유하는 간암 예방 및치료용 조성물
    • 用于预防和治疗来自MEORU的含有蒽醌的HEPATOMA的组合物
    • KR1020100010646A
    • 2010-02-02
    • KR1020080071624
    • 2008-07-23
    • 경상대학교산학협력단
    • 이원섭신성철이성중최영현
    • A61K36/87A61P35/00A61K31/7028
    • A61K31/7048A61K36/87A61K2236/33A61K2236/51A61K2236/55Y10S514/893
    • PURPOSE: A composition containing anthocyanin isolated from Vitis coignetiae Pulliat for treating liver cancer is provided to induce and strengthen apoptosis of hepatocytes and ensure anti-proliferation and anti-infiltration to liver cancer cells. CONSTITUTION: A composition for preventing and treating liver cancer contains anthocyanin isolated from Vitis coignetiae Pulliat as an active ingredient. A method for isolating the anthocyanin comprises: a step of extracting Vitis coignetiae Pulliat with methanol containing 0.1% of HCl at 5°C for 24 hours; a step of compress-concentrating the Vitis coignetiae Pulliat extract and washing the extract on Ambrite XAD-7 adsorber with water and ethyl acetate; and a step of eluting methanol solution having 1% of HCl to obtain the anthocyanin. The anthocyanin is delphinidin-3,5-diglucoside and cyanidin-3,5-diglucoside.
    • 目的:提供一种含有从葡萄凝乳分离的花青素的组合物,用于治疗肝癌,以诱导和增强肝细胞凋亡,并确保对肝癌细胞的抗增殖和抗浸润。 构成:用于预防和治疗肝癌的组合物含有作为活性成分从葡萄白芷中分离的花青素。 分离花青素的方法包括:在5℃下用含有0.1%HCl的甲醇提取葡萄白葡萄酒24小时的步骤; 将Vitis coignetiae Pulliat提取物压缩浓缩并用水和乙酸乙酯洗涤Ambrite XAD-7吸附器上的提取物的步骤; 和洗脱具有1%HCl的甲醇溶液以获得花青素的步骤。 花青素是花翠素-3,5-二葡萄糖苷和花青素-3,5-二葡萄糖苷。