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    • 2. 发明公开
    • 천마 추출물 및 유효성분인 4-HBA를 함유하는 신경 염증 예방 및 치료용 조성물 및 천마 추출물 추출 방법
    • GASTRODIA ELATA提取物和4-羟基苄基醇(4-HBA) - 用于预防和治疗神经元炎症的组合物和提取胃肠道提取物的方法
    • KR1020130134795A
    • 2013-12-10
    • KR1020120058568
    • 2012-05-31
    • 건국대학교 산학협력단
    • 최동국김병욱임형우이강용김인수윤광섭
    • A61K36/8988A61P29/00A61P25/00
    • A61K36/8988A61K2236/33A61K2236/39A61K2236/51
    • The present invention relates to a composition for preventing and treating neuroinflammation containing Gastrodia elata extracts and a method for manufacturing the Gastrodia elata extracts and, more specifically, a composition for preventing and treating neuroinflammation which contains 4-HBA(Hydroxybenzyl alcohol), which is an active ingredient in the Gastrodia elata extracts and which has an effect in inhibiting neuroinflammation by suppressing pro inflammatory mediators in neuroglial cells, and a method for manufacturing the Gastrodia elata extracts. The present invention compsises: (A) a step for producing Gastrodia elata-ethanol compound by putting Gastrodia elata into ethanol; (B) a step for pulverizing the Gastrodia elata-ethanol compound produced by the (A) step; amd (C) a step for obtaining Gastrodia elata-ethanol extracts by enriching and drying the Gastrodia elata-ethanol compound pulverized by the (B) step.
    • 本发明涉及用于预防和治疗含有天麻提取物的神经炎症的组合物和制备天麻提取物的方法,更具体地,涉及含有4-HBA(羟基苄醇)的神经炎症的组合物,其含有4-HBA 天麻提取物中的活性成分,并且通过抑制神经胶质细胞中的促炎症介质来抑制神经炎症的作用,以及天麻提取物的制造方法。 本发明构成:(A)通过将天麻加入乙醇中生产天麻乙醇化合物的步骤; (B)粉碎由(A)步骤生产的天麻 - 乙醇化合物的步骤; (C)通过对(B)步骤粉碎的天麻 - 乙醇化合物的富集和干燥获得天麻乙醇提取物的步骤。
    • 7. 发明公开
    • 세포사 억제 및 항산화 활성을 갖는 감국 추출물을함유하는 뇌질환의 예방 및 치료용 약학조성물
    • 包含抗炎和抗氧化活性的枸杞子提取物的药物组合物,用于预防和治疗神经损伤性疾病
    • KR1020090112133A
    • 2009-10-28
    • KR1020080037840
    • 2008-04-23
    • 건국대학교 산학협력단
    • 최동국김인수황금희최현장이강용
    • A61K36/28A61P25/28
    • PURPOSE: A pharmaceutical composition containing Chrysanthemum indicum extract is provided to protect nerves and use as a medical product for prevent and treating brain diseases such as Parkison disease and Alzheimer. CONSTITUTION: A method for producing a pharmaceutical composition for preventing and treating brain disease containing Chrysanthemum indicum extract with apoptosis and antioxidation activity comprises: a step of pulverizing dried Chrysanthemum indicum; a step of mixing 8-18 times volume of water, polar solvent of C1-C4 alcohol or their mixture solvent pulverized Chrysanthemum indicum in mixture ratio of 1:0.1-1:10; a step of extracting for 2 to 4 hours through hot-water extraction, cold water extraction, flux extraction or ultrasonic wave extraction; and a step of concentrating supernatant.
    • 目的:提供含有菊花提取物的药物组合物,以保护神经,并用作预防和治疗脑疾病如帕金森病和阿尔茨海默病的医疗产品。 构成:用于预防和治疗含有菊花提取物的脑病的药物组合物的凋亡和抗氧化活性的方法包括:将干燥的菊花粉碎的步骤; 混合8-18倍体积的水,C1-C4醇的极性溶剂或它们的混合溶剂粉碎菊花的混合比例为1:0.1-1:10的步骤; 通过热水提取,冷水萃取,助熔剂提取或超声波提取提取2〜4小时的步骤; 和浓缩上清液的步骤。