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    • 1. 发明公开
    • 티아졸 유도체의 제조방법 및 이를 제조하기 위한 중간체
    • 制备噻唑衍生物的方法及其制备中间体
    • KR1020030086373A
    • 2003-11-10
    • KR1020020024595
    • 2002-05-04
    • 강헌중함정엽
    • 강헌중함정엽
    • C07D277/36
    • C07C323/20C07D277/26Y02P20/55
    • PURPOSE: A process for preparing thiazole derivatives and intermediates for the preparation thereof are provided, thereby easily preparing the thiazole derivatives in higher yield. CONSTITUTION: A process for preparing 2 - {2 - methyl - 4 - £({4 - methyl - 2 - £4 - (trifluoromethyl) phenyl| - 1,3 - thiazole - 5 - yl}methyl)sulfanyl|phenoxy} acetate of the formula (X) comprises the steps of: reacting a compound of the formula (III) with a compound of the formula (VI) to prepare a compound of the formula (VII); removing a protecting group from the compound of the formula (VII) to prepare a compound of the formula (VIII); reacting the compound of the formula (VIII) with halogenacetic acid alkylester to prepare a compound of the formula (IX); and hydrolysis of the compound of the formula (IX), wherein R1 is C1-C4 alkyl, alkyl or aralkylsilyl phenol protecting group; R2 is hydrogen and methyl; R3 is C1-C4 alkyl containing carboxylic acid protecting group; X1 is halogen atom and hydrogen atom; X2 is halogen atom and a releasing group having improved reactivity in electron affinity reaction; and M is lithium and magnesium ions. Intermediates for the preparation thereof include the thiazole derivative of formula (III) or formula (VII).
    • 目的:提供制备噻唑衍生物的方法及其制备中间体,从而以更高的收率容易地制备噻唑衍生物。 构成:制备2- {2-甲基-4 - ((4-甲基-2-(4-(三氟甲基)苯基] -1,3-噻唑-5-基}甲基)硫烷基|苯氧基}乙酸酯的方法 式(X)的化合物包括以下步骤:使式(III)的化合物与式(VI)的化合物反应以制备式(VII)的化合物; 从式(Ⅶ)化合物中除去保护基以制备式(Ⅷ)化合物; 使式(Ⅷ)化合物与卤代乙酸烷基酯反应制备式(Ⅸ)化合物; 和其中R 1是C 1 -C 4烷基,烷基或芳烷基甲硅烷基苯酚保护基的式(Ⅸ)化合物的水解; R2是氢和甲基; R3是含羧酸保护基的C1-C4烷基; X1是卤原子和氢原子; X2是卤素原子,在电子亲和反应中具有改善的反应性的释放基团; M是锂离子和镁离子。 用于制备其的中间体包括式(III)或式(VII)的噻唑衍生物。
    • 6. 发明公开
    • 5-안드로스텐-3β-올-17-온으로부터4,17(20)-프로스타디엔-3,16-디온의 제조방법 및 이를제조하기 위한 중간체
    • 用于制备具有高效率的短时间反应时间的5-ANDROSTENE-3BETA-OL-17-ONE和中间体化合物的4,17(20) - 丙烯三烯-3,16-二醇的方法
    • KR1020040092078A
    • 2004-11-03
    • KR1020030025919
    • 2003-04-24
    • 강헌중
    • 강헌중함정엽진정욱
    • C07J13/00
    • C07J13/007A61K31/56B01J31/0225
    • PURPOSE: A process for preparing 4,17(20)-prostadien-3,16-dione from 5-androstene-3beta-ol-17-one and intermediate compounds for preparing the same are provided to lower values for low density lipoprotein and cholesterol and to increase a value for high density lipoprotein. CONSTITUTION: The process for preparing 4,17(20)-prostadien-3,16-dione(E-guggulsterone) represented by formula IV comprises the steps of: reacting 5-androstene-3beta-ol-17-one represented by formula I with an ethyltriphenyl phosphonium halide under a presence of a strong base to obtain a compound represented by formula II; introducing a hydroxy group to C-16 position of the obtained compound to obtain a compound represented by formula III; and oxidizing it.
    • 目的:从5-雄甾烯-3β-ol-17-一制备4,17(20) - 前列腺素-3,16-二酮及其制备方法,用于低密度脂蛋白和胆固醇的较低值 并增加高密度脂蛋白的价值。 构成:由式IV表示的制备4,17(20) - 前草酮-3,16-二酮(E-guccersterone)的方法包括以下步骤:将由式I表示的5-雄甾烯-3β-醇-17- 与乙基三苯基鏻卤化物在强碱存在下反应得到式II表示的化合物; 将所得化合物的羟基引入C-16位,得到式III表示的化合物; 并氧化它。
    • 9. 发明公开
    • 해양성 와편모조류 린구로디늄 폴리에드룸으로부터 디에이치에이 및 이피에이의 제조방법
    • 通过具有高纯度和高YIELD的简单加工步骤从海洋DINOFLAGELLATE,LINGULODINIUM POLYEDRUM制备DHA和EPA的方法
    • KR1020040105422A
    • 2004-12-16
    • KR1020030036793
    • 2003-06-09
    • 강헌중정해진
    • 강헌중정해진김재성원동환남상집
    • C11B1/10
    • C11B1/10C11B1/04
    • PURPOSE: Provided is a method for preparing DHA(docosahexaenoic acid) and EPA(eicosapentaenoic acid) useful for food additives, which uses Lingulodinium polyedrum as a starting material to produce DHA and EPA with high purity and high yield. CONSTITUTION: The method for preparing DHA and EPA uses a dry product containing DHA and EPA obtained by freeze drying Lingulodinium polyedrum, which is dinoflagellate. The method comprises the steps of: extracting the dry product with a mixed solvent; evaporating the organic solvent layer under reduced pressure and purifying the resultant product by chromatography, or evaporating the solvent under reduced pressure and extracting the resultant residue with lower alcohol/C6-8 alkane solvent, so that fractions of lower alcohol layer can be obtained; evaporating the fractions to remove the solvent; extracting the resultant residue with ethyl acetate/water to obtain the ethyl acetate layer; mixing the ethyl acetate layer with the C6-8 alkane layer; evaporating the resultant mixture under reduced pressure and purifying the residue by chromatography.
    • 目的:提供一种可用于食品添加剂的DHA(二十二碳六烯酸)和EPA(二十碳五烯酸)的制备方法,该方法以高纯度和高产率生产DHA和EPA为起始原料。 构成:用于制备DHA和EPA的方法使用含有DHA和EPA的干燥产品,其通过冷冻干燥葡萄柚多糖得到。 该方法包括以下步骤:用混合溶剂萃取干燥产物; 在减压下蒸发有机溶剂层,通过色谱法纯化所得产物,或在减压下蒸发溶剂,并用低级醇/ C6-8烷烃溶剂萃取所得残余物,从而可得到低级醇层级分; 蒸发馏分以除去溶剂; 用乙酸乙酯/水萃取所得残留物,得到乙酸乙酯层; 将乙酸乙酯层与C6-8烷烃层混合; 在减压下蒸发所得混合物并通过色谱法纯化残余物。
    • 10. 发明公开
    • 프로제스테론으로부터 구굴스테론의 제조방법 및 이를제조하기 위한 중간체
    • 用于制备前列腺素的方法,用于制备低密度脂蛋白和胆固醇的下限值的PROGESTERONE和中间体化合物
    • KR1020040092518A
    • 2004-11-04
    • KR1020030025989
    • 2003-04-24
    • 강헌중
    • 강헌중함정엽진정욱
    • C07J13/00
    • C07J13/007A61K31/56C07B31/00C07B33/00
    • PURPOSE: A process for preparing 4,17(20)-prostadien-3,16-dione from progesterone and intermediate compounds for preparing the same are provided to lower values for low density lipoprotein and cholesterol and to increase a value for high density lipoprotein. CONSTITUTION: The process for preparing 4,17(20)-prostadien-3,16-dione represented by formula VII from progesterone comprises the steps of: reducing the progesterone represented by formula I; oxidizing with a manganese dioxide; reacting with a methane sulfonyl chloride or p-toluene sulfonyl chloride; olefinating by treating the obtained compound with a strong base; selective oxidizing with a selenium compound and a peroxide; and oxidizing it.
    • 目的:从孕酮和中间体化合物制备4,17(20) - 前列腺素-3,16-二酮的制备方法可用于降低低密度脂蛋白和胆固醇的含量,并增加高密度脂蛋白的价值。 构成:由孕酮制备由式VII代表的4,17(20) - 前列腺素-3,16-二酮的方法包括以下步骤:减少由式I表示的孕酮; 用二氧化锰氧化; 与甲磺酰氯或对甲苯磺酰氯反应; 用强碱处理得到的化合物进行烯化; 用硒化合物和过氧化物选择性氧化; 并氧化它。