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    • 1. 发明授权
    • 레조르시놀 황화 유도체, 이의 제조방법 및 이의 화장품 용도
    • 间苯二酚硫醚衍生物,其制备方法及其在化妆品中的用途
    • KR101728178B1
    • 2017-04-18
    • KR1020117023205
    • 2010-04-08
    • 삐에르화브르데르모-코스메띠끄
    • 프와그니,스떼팡
    • C07C317/22C07C323/20A01N31/16
    • C07C323/20A01N31/16A01N37/10A01N41/10A01N47/10A61K8/46A61K2800/522A61K2800/524A61Q5/08A61Q19/02A61Q19/08C07C317/22
    • 본발명은일반식 (I)의화합물에관한것이며, 여기에서, X = S, SO 또는 SO및;라디칼 R및 R의하나는수소원자및 다른라디칼: 선택적으로하나이상의할로겐원자(들)로치환되는 C내지 C선형또는분지형알킬; 선택적으로하나이상의할로겐원자(들)로치환되는 C내지 C선형또는분지형알케닐; 선택적으로하나이상의 C내지 C알콕시기(들)로치환되는아르알킬; 또는 COR또는 CONHR, 그러나동시적이지는않고, R은다음라디칼: 선택적으로하나이상의할로겐원자(들)로치환되는 C내지 C선형또는분지형알킬; 선택적으로하나이상의할로겐원자(들)로치환되는 C내지 C선형또는분지형알케닐; 선택적으로하나이상의 C내지 C알콕시기(들)로치환되는아르알킬; 선택적으로하나이상의 C내지 C알콕시기(들), 및/또는 OH기(들)로치환되는아르알케닐; 또는선택적으로하나이상의 C내지 C알콕시기(들)로치환되는아릴라디칼.
    • 本发明涉及通式(I)的化合物,其中X = S,SO或SO,基团R和R为氢原子和任选被一个或多个卤素原子取代的其它基团, C至C直链或支链烷基; 任选地被一个或多个卤素原子取代的C 1 -C 10直链或支链烯基; 任选地被一个或多个C 1 -C 8烷氧基取代的芳烷基; 或COR或CONHR,但不是同时存在的,并且R是任选被一个或多个卤素原子取代的C-C直链或支链烷基; 任选地被一个或多个卤素原子取代的C 1 -C 10直链或支链烯基; 任选地被一个或多个C 1 -C 8烷氧基取代的芳烷基; 芳基,其任选地被一个或多个C 1 -C 8烷氧基和/或OH基团取代; 或者任选地被一个或多个C至C烷氧基取代的芳基。
    • 8. 发明公开
    • 퍼록시솜 증식자 활성화 수용체 리간드 아릴 화합물 및이들 화합물의 용도
    • ARYL化合物作为PPAR配体及其使用
    • KR1020080050348A
    • 2008-06-05
    • KR1020070124052
    • 2007-12-01
    • 재단법인서울대학교산학협력재단
    • 강헌중진정욱이재환
    • C07C323/20C07C323/18C07D413/04C07D261/08
    • C07C391/02A23K20/111A23L33/10C07C323/20C07D213/32C07D261/08
    • An aryl compound as a peroxisome poliferator activated receptor(PPAR) ligand is provided to realize a high selective activation degree to PPAR and to give a pharmaceutical composition, cosmetic composition, anabolic agent, memory enhancing agent, agent for treating dementia or Parkinson's disease, functional food and animal feed composition. An aryl compound as a PPAR ligand is a compound represented by the following formula (I), or hydrate, solvate, stereoisomer or pharmaceutically acceptable salt thereof. In formula (I), A is S or Se; B is H or the formula (a); R1 is an aryl group selected from the formula (b); R2 is H, C1-C8 alkyl or the formula (c); R3 is H, a C1-C8 alkyl or halogen; each of R4 and R5 is H or a C1-C8 alkyl; R6 is H, a C1-C8 alkyl, C2-C7 alkenyl, alkali metal or alkaline earth metal; each of R11 and R12 is H, a C1-C8 alkyl or halogen; R21 is H, a halogen. C1-C7 alkyl, heterocyclic group or C1-C7 alkoxy group; each of m and n is an integer of 1-4; p is an integer of 1-5; q is an integer of 1-4; r is an integer of 1-3; and s is an integer of 1-5, wherein the alkyl and alkoxy of R2, R3, R4, R5, R6, R11, R12 and R21 are optionally substituted with at least one halogen or C1-C5 alkylamine, with the proviso that a compound wherein R2 is H and A is S is excluded.
    • 提供了作为过氧化物酶体增殖物激活受体(PPAR)配体的芳基化合物以实现对PPAR的高选择性活化度,并得到药物组合物,化妆品组合物,合成代谢剂,记忆增强剂,治疗痴呆或帕金森病的药剂,功能性 食物和动物饲料组成。 作为PPAR配体的芳基化合物是由下式(I)表示的化合物或其水合物,溶剂化物,立体异构体或其药学上可接受的盐。 在式(I)中,A是S或Se; B为H或式(a); R1是选自式(b)的芳基; R2是H,C1-C8烷基或式(c); R3是H,C1-C8烷基或卤素; R 4和R 5各自为H或C 1 -C 8烷基; R6是H,C1-C8烷基,C2-C7链烯基,碱金属或碱土金属; R 11和R 12各自为H,C 1 -C 8烷基或卤素; R21是H,卤素。 C1-C7烷基,杂环基或C1-C7烷氧基; m和n各自为1-4的整数; p为1-5的整数; q为1-4的整数; r为1-3的整数; 并且s是1-5的整数,其中R 2,R 3,R 4,R 5,R 6,R 11,R 12和R 21的烷基和烷氧基任选被至少一个卤素或C 1 -C 5烷基胺取代,条件是a 不包括R2为H且A为S的化合物。