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1. 发明授权

KR101133554B1 다중 코팅층을 갖는 복합기능성 이산화티탄 입자의 제조방법 有权
标题翻译：具有多层涂层的多功能二氧化钛颗粒的制造方法
公开(公告)号：KR101133554B1
公开(公告)日：2012-04-05
申请号：KR1020090110328
申请日：2009-11-16
申请人： (주)바이오제닉스
发明人： 김철환 , 박관용 , 하진열 , 서소연 , 한수정
IPC分类号： A61K8/29 , A61K8/30 , A61Q17/04 , A61Q19/02
摘要： PURPOSE: A method for manufacturing titanium dioxide particles of complex function with multi-coating layers is provided to improve texture and transparency. CONSTITUTION: A method for manufacturing titanium dioxide particles of complex function with multi-coating layers comprises: a step of dispersing titanium dioxide in a solvent; a step of mixing with silica precursor to coat silica precursor onto the surface of the titanium dioxide; a step of removing the solvent and separating a first powder having a silica coating layer; a step of mixing organic compounds to coat the organic compounds onto the surface of the first powder; and a step of removing solvent and separating a second powder coated with organic compounds.

2. 发明公开

KR1020110082992A 우레아와 가용화 살리실산을 이용한 각질 제거용 조성물 无效
标题翻译：一种通过使用尿素和溶于乙酸的方法从食物中除去糖浆的组合物
公开(公告)号：KR1020110082992A
公开(公告)日：2011-07-20
申请号：KR1020100002981
申请日：2010-01-13
申请人： (주)바이오제닉스
发明人： 김철환 , 손태훈 , 송기세 , 박관용 , 최원혁 , 이은진 , 서소연
IPC分类号： A61K8/87 , A61K8/84 , A61K8/36 , A61Q19/00
摘要： PURPOSE: A composition for removing horny substances using urea and solubilization salicylic acid is provided to ensure less skin irritation and skin moisturizing. CONSTITUTION: A cosmetic composition for skin moisturizing and horny substance removal contains 1-20 weight% of urea and 0.01-1.25 weight% of solubilization salicylic acid. The solubilization salicylic acid is prepared by: mixing oligomers derived from two kinds of hydrophilic natural polymers; dissolving the oligomers in the water to prepare an oligomer complex; adding salicylic acid to the oligomer complex; and encapsulating into hydrophobic pore structure.
摘要翻译：目的：提供使用尿素和溶解水杨酸去除角质物质的组合物，以确保更少的皮肤刺激和皮肤保湿。构成：用于皮肤保湿和角质去除的化妆品组合物含有1-20重量％的尿素和0.01-1.25重量％的增溶水杨酸。溶解性水杨酸通过以下方法制备：混合衍生自两种亲水性天然聚合物的低聚物; 将低聚物溶解在水中以制备低聚物络合物; 向低聚物复合物中加入水杨酸; 并封装成疏水孔结构。

3. 发明公开

KR1020110053686A 다중 코팅층을 갖는 복합기능성 이산화티탄 입자의 제조방법 有权
标题翻译：具有多层涂层的多功能二氧化钛颗粒的制造方法
公开(公告)号：KR1020110053686A
公开(公告)日：2011-05-24
申请号：KR1020090110328
申请日：2009-11-16
申请人： (주)바이오제닉스
发明人： 김철환 , 박관용 , 하진열 , 서소연 , 한수정
IPC分类号： A61K8/29 , A61K8/30 , A61Q17/04 , A61Q19/02
摘要： PURPOSE: A method for manufacturing titanium dioxide particles of complex function with multi-coating layers is provided to improve texture and transparency. CONSTITUTION: A method for manufacturing titanium dioxide particles of complex function with multi-coating layers comprises: a step of dispersing titanium dioxide in a solvent; a step of mixing with silica precursor to coat silica precursor onto the surface of the titanium dioxide; a step of removing the solvent and separating a first powder having a silica coating layer; a step of mixing organic compounds to coat the organic compounds onto the surface of the first powder; and a step of removing solvent and separating a second powder coated with organic compounds.
摘要翻译：目的：提供具有多层涂层的具有复合功能的二氧化钛颗粒的方法，以改善织构和透明度。构成：用于制备具有多层复合功能的二氧化钛颗粒的方法包括：将二氧化钛分散在溶剂中的步骤; 与二氧化硅前体混合以将二氧化硅前体涂覆到二氧化钛的表面上的步骤; 除去溶剂并分离具有二氧化硅涂层的第一粉末的步骤; 将有机化合物混合以将有机化合物涂覆到第一粉末的表面上的步骤; 以及除去溶剂并分离涂有有机化合物的第二粉末的步骤。

4. 发明公开

KR1020100133673A 복합 기능성 화장용 조성물 및 그 제조 방법 无效
标题翻译：多功能化妆品组合物及其制备方法
公开(公告)号：KR1020100133673A
公开(公告)日：2010-12-22
申请号：KR1020090052353
申请日：2009-06-12
申请人： (주)바이오제닉스
发明人： 김철환 , 조군호 , 박관용 , 서소연 , 한영희 , 한수정
IPC分类号： A61K8/46 , A61K8/49 , A61K8/06 , A61Q19/02
摘要： PURPOSE: A complex functional cosmetic composition with relieved denaturation or oxidation of whitening compound by UV blocking agent is provided to ensure whitening and antioxidation. CONSTITUTION: A complex functional cosmetic composition comprises: a whitening compound particles having a whitening compound core and a coating layer on the whitening compound core; a UV blocking agent; and a formulation containing whitening compound particles and UV blocking agent. The whitening compound core is epigallocatechin gallate(EGCG) or ascorbic acid. The coating layer contains a first coating layer with thiol group compound, a second coating layer with a water-insoluble polymer, and a third coating layer with hydrophobic inorganic particles.
摘要翻译：目的：提供通过紫外线阻断剂减轻美白化合物变性或氧化的复合功能化妆品，以确保美白和抗氧化。构成：复合功能化妆品组合物包含：美白化合物核心上的美白化合物颗粒和美白化合物核心上的涂层; 紫外线阻断剂; 和含有美白化合物颗粒和UV阻断剂的制剂。美白复合核心是表没食子儿茶素没食子酸酯（EGCG）或抗坏血酸。涂层含有具有硫醇基化合物的第一涂层，具有水不溶性聚合物的第二涂层和具有疏水性无机颗粒的第三涂层。

5. 发明公开

KR1020100067257A 안정화제로서 β-싸이클로덱스트린 유도체를 포함하는 조성물 有权
标题翻译：包含β-环糊精衍生物作为稳定剂的组合物
公开(公告)号：KR1020100067257A
公开(公告)日：2010-06-21
申请号：KR1020080125733
申请日：2008-12-11
申请人： (주)바이오제닉스
发明人： 김철환 , 조군호 , 신찬재 , 박관용 , 하진열 , 고승학 , 이주희
IPC分类号： A61K31/724 , A61K31/121
CPC分类号： A61K31/375 , A61K8/342 , A61K8/4973 , A61K8/498 , A61K8/738 , A61K31/07 , A61K31/353 , A61K47/40 , Y10S514/97
摘要： PURPOSE: A composition containing beta-cyclodextrin derivative and antioxidant is provide to minimize denaturation by storage for a long time and to improve efficiency of the antioxidant. CONSTITUTION: A stabilized composition contains ascorbic acid, letinol, or epigallocatechin gallate. The composition contains: a reaction product of a compound of chemical formula 1 and beta-cyclodextrin; a reaction product of a compound of chemical formula 2(CH_3SO_3R_2) with beta-cyclodextrin; a reaction product of 6-O-p-tosyl-beta-cyclodextrin with an antioxidant of dithiotheroitol, retinol, silybin, thioglycerol, or cysteine; and a reaction product of alpha-lipoic acid or glutathione and beta-cyclodextrin. The composition is a pharmaceutical composition or cosmetic composition.
摘要翻译：目的：提供含有β-环糊精衍生物和抗氧化剂的组合物，通过长时间储存使变性最小化，提高抗氧化剂的效率。构成：稳定的组合物含有抗坏血酸，letinol或表没食子儿茶素没食子酸酯。该组合物含有：化学式1的化合物与β-环糊精的反应产物; 化学式2化合物（CH 3 SO 3 R 2）与β-环糊精的反应产物; 6-O-对甲苯磺酰基-β-环糊精与二硫代葡萄糖醇，视黄醇，水飞蓟宾，硫甘油或半胱氨酸的抗氧化剂的反应产物; 和α-硫辛酸或谷胱甘肽与β-环糊精的反应产物。该组合物是药物组合物或化妆品组合物。

6. 发明授权

KR101128450B1 안정화제로서 β-싸이클로덱스트린 유도체를 포함하는 조성물 有权
标题翻译：包含β-环糊精衍生物作为稳定剂的组合物
公开(公告)号：KR101128450B1
公开(公告)日：2012-03-28
申请号：KR1020080125733
申请日：2008-12-11
申请人： (주)바이오제닉스
发明人： 김철환 , 조군호 , 신찬재 , 박관용 , 하진열 , 고승학 , 이주희
IPC分类号： A61K31/724 , A61K31/121
摘要： 본 발명은 유효성분으로서 아스코르브산, 레틴올, 또는 에피갈로카테킨 갈레이트(Epigallocatechin gallate)를 포함하고, 안정화제로서 β-싸이클로덱스트린 유도체를 포함하는 안정화된 조성물을 제공한다. 상기 β-싸이클로덱스트린 유도체는 β-싸이클로덱스트린 또는 그의 유도체(예를 들어, 6-Op-토실-β-싸이클로덱스트린)와 화학식 1의 화합물; 화학식 2의 화합물; 또는 항산화제(예를 들어, 디티오쓰레이톨, 레티놀, 실리빈, 티오글리세롤, 시스테인, α-리포산, 글루타치온 등)와의 반응 생성물이다.

식 중, R
1 및 R
2 는 서로 독립적으로 C
1 ～C
15 알킬이다.
β-싸이클로덱스트린, 항산화제

7. 外观设计

KR3006004990000S 有权
公开(公告)号：KR3006004990000S
公开(公告)日：2011-05-30
申请号：KR3020090054176
申请日：2009-12-09
申请人： (주)바이오제닉스 , (주)이미인
设计人： 김철환 , 김주원 , 손태훈 , 송기세 , 박관용 , 최원혁 , 이은진

8. 发明公开

KR1020100067260A 우수한 안정성을 갖는 항산화제와 히아루론산과의 복합체 无效
标题翻译：具有改善稳定性的抗氧化剂和羟丙酸的复合物
公开(公告)号：KR1020100067260A
公开(公告)日：2010-06-21
申请号：KR1020080125737
申请日：2008-12-11
申请人： (주)바이오제닉스
发明人： 김철환 , 조군호 , 신찬재 , 박관용 , 고승학 , 이은진 , 한영희
IPC分类号： A61K31/728 , A61P17/18
CPC分类号： A61K47/61 , A61K31/07 , A61K31/122 , A61K31/198 , A61K31/355 , A61K31/381 , A61K2121/00
摘要： PURPOSE: An antioxidant-hyaluronic acid composite is provided to enhance stability of antioxidant and to block antioxidant deterioration. CONSTITUTION: An antioxidant-hyaluronic acid is manufactured by reacting antioxidant and hyaluronic acid under the presence of 3-dimethyl-aminopropyl-N-ethyl carbodimide. The antioxidant is retinol, coenzyme Q10, alpha-tocopherol, ascorbic acid, butylated hydroxyl toluene, genistein, propyl gallate, epigallocatechingallate, or gallocatechin gallate. The reaction is performed under the presence of acid. The acid is hydrochloric acid, acetic acid, sulfonic acid, phosphoric acid. A method for manufacturing the antioxidant-hyaluronic acid composite comprises: a step of reacting hyaluronic acid and adipic acid dihydrazide under the presence of 3-dimethyl-aminopropyl-N-ethyl carbodimide; and a step of reacting alpha-lipoic acid or glutathione under the presence of the product and 3-dimethyl-aminopropyl-N-ethyl carbodimide.
摘要翻译：目的：提供抗氧化剂 - 透明质酸复合材料，以提高抗氧化剂的稳定性和阻止抗氧化剂的降解。构成：通过抗氧化剂和透明质酸在3-二甲基 - 氨基丙基-N-乙基碳二亚胺的存在下反应制备抗氧化剂 - 透明质酸。抗氧化剂是视黄醇，辅酶Q10，α-生育酚，抗坏血酸，丁基化羟基甲苯，染料木素，没食子酸丙酯，表没食子儿茶酸或没食子儿茶素没食子酸酯。反应在酸存在下进行。酸是盐酸，乙酸，磺酸，磷酸。制备抗氧化剂 - 透明质酸复合物的方法包括：在3-二甲基 - 氨基丙基-N-乙基碳二亚胺存在下使透明质酸和己二酸二酰肼反应的步骤; 和在产物和3-二甲基 - 氨基丙基-N-乙基碳二亚胺的存在下使α-硫辛酸或谷胱甘肽反应的步骤。

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