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1. 发明授权

KR101133554B1 다중 코팅층을 갖는 복합기능성 이산화티탄 입자의 제조방법 有权
标题翻译：具有多层涂层的多功能二氧化钛颗粒的制造方法
公开(公告)号：KR101133554B1
公开(公告)日：2012-04-05
申请号：KR1020090110328
申请日：2009-11-16
申请人： (주)바이오제닉스
发明人： 김철환 , 박관용 , 하진열 , 서소연 , 한수정
IPC分类号： A61K8/29 , A61K8/30 , A61Q17/04 , A61Q19/02
摘要： PURPOSE: A method for manufacturing titanium dioxide particles of complex function with multi-coating layers is provided to improve texture and transparency. CONSTITUTION: A method for manufacturing titanium dioxide particles of complex function with multi-coating layers comprises: a step of dispersing titanium dioxide in a solvent; a step of mixing with silica precursor to coat silica precursor onto the surface of the titanium dioxide; a step of removing the solvent and separating a first powder having a silica coating layer; a step of mixing organic compounds to coat the organic compounds onto the surface of the first powder; and a step of removing solvent and separating a second powder coated with organic compounds.

2. 发明授权

KR101128450B1 안정화제로서 β-싸이클로덱스트린 유도체를 포함하는 조성물 有权
标题翻译：包含β-环糊精衍生物作为稳定剂的组合物
公开(公告)号：KR101128450B1
公开(公告)日：2012-03-28
申请号：KR1020080125733
申请日：2008-12-11
申请人： (주)바이오제닉스
发明人： 김철환 , 조군호 , 신찬재 , 박관용 , 하진열 , 고승학 , 이주희
IPC分类号： A61K31/724 , A61K31/121
摘要： 본 발명은 유효성분으로서 아스코르브산, 레틴올, 또는 에피갈로카테킨 갈레이트(Epigallocatechin gallate)를 포함하고, 안정화제로서 β-싸이클로덱스트린 유도체를 포함하는 안정화된 조성물을 제공한다. 상기 β-싸이클로덱스트린 유도체는 β-싸이클로덱스트린 또는 그의 유도체(예를 들어, 6-Op-토실-β-싸이클로덱스트린)와 화학식 1의 화합물; 화학식 2의 화합물; 또는 항산화제(예를 들어, 디티오쓰레이톨, 레티놀, 실리빈, 티오글리세롤, 시스테인, α-리포산, 글루타치온 등)와의 반응 생성물이다.

식 중, R
1 및 R
2 는 서로 독립적으로 C
1 ～C
15 알킬이다.
β-싸이클로덱스트린, 항산화제

3. 发明公开

KR1020110053686A 다중 코팅층을 갖는 복합기능성 이산화티탄 입자의 제조방법 有权
标题翻译：具有多层涂层的多功能二氧化钛颗粒的制造方法
公开(公告)号：KR1020110053686A
公开(公告)日：2011-05-24
申请号：KR1020090110328
申请日：2009-11-16
申请人： (주)바이오제닉스
发明人： 김철환 , 박관용 , 하진열 , 서소연 , 한수정
IPC分类号： A61K8/29 , A61K8/30 , A61Q17/04 , A61Q19/02
摘要： PURPOSE: A method for manufacturing titanium dioxide particles of complex function with multi-coating layers is provided to improve texture and transparency. CONSTITUTION: A method for manufacturing titanium dioxide particles of complex function with multi-coating layers comprises: a step of dispersing titanium dioxide in a solvent; a step of mixing with silica precursor to coat silica precursor onto the surface of the titanium dioxide; a step of removing the solvent and separating a first powder having a silica coating layer; a step of mixing organic compounds to coat the organic compounds onto the surface of the first powder; and a step of removing solvent and separating a second powder coated with organic compounds.
摘要翻译：目的：提供具有多层涂层的具有复合功能的二氧化钛颗粒的方法，以改善织构和透明度。构成：用于制备具有多层复合功能的二氧化钛颗粒的方法包括：将二氧化钛分散在溶剂中的步骤; 与二氧化硅前体混合以将二氧化硅前体涂覆到二氧化钛的表面上的步骤; 除去溶剂并分离具有二氧化硅涂层的第一粉末的步骤; 将有机化合物混合以将有机化合物涂覆到第一粉末的表面上的步骤; 以及除去溶剂并分离涂有有机化合物的第二粉末的步骤。

4. 发明公开

KR1020100067257A 안정화제로서 β-싸이클로덱스트린 유도체를 포함하는 조성물 有权
标题翻译：包含β-环糊精衍生物作为稳定剂的组合物
公开(公告)号：KR1020100067257A
公开(公告)日：2010-06-21
申请号：KR1020080125733
申请日：2008-12-11
申请人： (주)바이오제닉스
发明人： 김철환 , 조군호 , 신찬재 , 박관용 , 하진열 , 고승학 , 이주희
IPC分类号： A61K31/724 , A61K31/121
CPC分类号： A61K31/375 , A61K8/342 , A61K8/4973 , A61K8/498 , A61K8/738 , A61K31/07 , A61K31/353 , A61K47/40 , Y10S514/97
摘要： PURPOSE: A composition containing beta-cyclodextrin derivative and antioxidant is provide to minimize denaturation by storage for a long time and to improve efficiency of the antioxidant. CONSTITUTION: A stabilized composition contains ascorbic acid, letinol, or epigallocatechin gallate. The composition contains: a reaction product of a compound of chemical formula 1 and beta-cyclodextrin; a reaction product of a compound of chemical formula 2(CH_3SO_3R_2) with beta-cyclodextrin; a reaction product of 6-O-p-tosyl-beta-cyclodextrin with an antioxidant of dithiotheroitol, retinol, silybin, thioglycerol, or cysteine; and a reaction product of alpha-lipoic acid or glutathione and beta-cyclodextrin. The composition is a pharmaceutical composition or cosmetic composition.
摘要翻译：目的：提供含有β-环糊精衍生物和抗氧化剂的组合物，通过长时间储存使变性最小化，提高抗氧化剂的效率。构成：稳定的组合物含有抗坏血酸，letinol或表没食子儿茶素没食子酸酯。该组合物含有：化学式1的化合物与β-环糊精的反应产物; 化学式2化合物（CH 3 SO 3 R 2）与β-环糊精的反应产物; 6-O-对甲苯磺酰基-β-环糊精与二硫代葡萄糖醇，视黄醇，水飞蓟宾，硫甘油或半胱氨酸的抗氧化剂的反应产物; 和α-硫辛酸或谷胱甘肽与β-环糊精的反应产物。该组合物是药物组合物或化妆品组合物。

5. 发明公开

KR1020100127580A 안정화된 비타민 Ｃ 유도체를 포함하는 화장용 조성물 및 그 제조 방법 无效
标题翻译：具有维生素C的稳定化衍生物的化妆品组合物及其制备方法
公开(公告)号：KR1020100127580A
公开(公告)日：2010-12-06
申请号：KR1020090046078
申请日：2009-05-26
申请人： (주)바이오제닉스
发明人： 김철환 , 조군호 , 하진열 , 고승학 , 이주희
IPC分类号： A61K8/49 , A61K8/73 , A61K8/19 , A61Q19/02
CPC分类号： A61K8/676 , A61K8/738 , A61K2800/624 , A61Q19/02
摘要： PURPOSE: A cosmetic composition containing stabilized vitamin C derivative is provided to form coating layer and to improve stability of ascorbic acid derivative containing alpha-lipoyl group. CONSTITUTION: A cosmetic composition contains alpha-lipoyl group-containing ascorbic acid derivative of chemical formula 1 as a guest and inclusion complex having cyclodextrin as a host. The cosmetic composition further contains a coating layer which covers the inclusion complex. The coating layer contains water soluble polymer coating layer or insoluble polymer coating layer. The soluble polymer coating layer contains polyvinyl alcohol, polyacrylic acid or polyethylene glycol. The insoluble polymer coating layer contains silane polymers, poly carprolactone, or polycarprolactam.
摘要翻译：目的：提供含有稳定的维生素C衍生物的化妆品组合物以形成包衣层并改善含有α-脂酰基的抗坏血酸衍生物的稳定性。构成：化妆品组合物含有作为客体的化学式1的含有α-脂酰基的抗坏血酸衍生物和以环糊精为主体的包合络合物。化妆品组合物还包含覆盖包合物的涂层。涂层含有水溶性聚合物涂层或不溶性聚合物涂层。可溶性聚合物涂层含有聚乙烯醇，聚丙烯酸或聚乙二醇。不溶性聚合物涂层含有硅烷聚合物，聚己内酯或聚己内酰胺。

6. 发明授权

KR100976850B1 세라미드 히아루론산 복합체 및 이의 제조방법 有权
标题翻译： CERAMIDE HYALURONIC复合材料及其制造方法
公开(公告)号：KR100976850B1
公开(公告)日：2010-08-20
申请号：KR1020090100893
申请日：2009-10-22
申请人： (주)바이오제닉스
发明人： 김철환 , 하진열 , 고승학 , 서소연 , 이주희
IPC分类号： C08B37/08 , C07H15/00
CPC分类号： C08B37/0072 , A61K8/68 , A61K8/735 , A61Q19/00 , C07H15/00
摘要： PURPOSE: A water-soluble ceramide-hyaluronic acid composite and a producing method thereof are provided to secure the high water phase solubility and stability by including hyaluronic acid to fat-soluble ceramide. CONSTITUTION: A producing method of a water-soluble ceramide-hyaluronic acid composite marked with chemical formula I comprises the following steps: forming a hyaluronic acid solution activated on a carboxylic acid portion by adding an activation reagent to water-soluble hyaluronic acid; mixing a basic reagent with the activated hyaluronic acid solution; mixing ceramide with the solution; and forming the ceramide-hyaluronic acid composite in which a primary alcohol portion is reacted.
摘要翻译：目的：提供水溶性神经酰胺 - 透明质酸复合物及其制备方法，通过将透明质酸包括在脂溶性神经酰胺中来确保高水相溶解度和稳定性。构成：用化学式I标记的水溶性神经酰胺 - 透明质酸复合物的制备方法包括以下步骤：通过向水溶性透明质酸中加入活化剂形成在羧酸部分上活化的透明质酸溶液; 将碱性试剂与活化的透明质酸溶液混合; 将神经酰胺与溶液混合; 并形成其中伯醇部分反应的神经酰胺 - 透明质酸复合物。

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