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    • 29. 发明公开
    • 인간 파필로마바이러스에 대한 백신용 벡터 및 그에 의해형질전환된 미생물
    • 用于抗HPV(人造血管病毒)疫苗和转化的微生物的载体
    • KR1020040034511A
    • 2004-04-28
    • KR1020030072407
    • 2003-10-17
    • 주식회사 바이오리더스한국생명공학연구원
    • 성문희부하령이종수정창민홍승표김철중박순희표현미
    • C12N15/86
    • C07K14/005A61K39/0011A61K2039/523C12N7/00C12N2710/20022C12N2730/10122C12N2830/008
    • PURPOSE: A vector for anti-HPV(human Papillomavirus) vaccine and a transformed microorganism therewith are provided, thereby expressing capsid L1 protein of human Papillomavirus on the surface of the microorganism, so that the transformed microorganism can be useful for prevention and treatment of hPV. CONSTITUTION: A vector for anti-HPV(human Papillomavirus) vaccine contains one or two gene selected from pgsB, pgsC and pgsA encoding polygammaglutamic acid synthase complex and an antigen protein gene of human Papillomavirus, wherein the antigen protein gene is one or two surface antigen protein gene selected from HPV capsid L1 and L2 or one or two antigen protein gene selected from HPV E6 and E7. The transformed microorganism with the vector for anti-HPV(human Papillomavirus) vaccine is provided, wherein the microorganism is selected from Escherichia coli, Salmonella typhi, Salmonella typhimurium, Vibrio cholera, Mycobacterium bovis, Shigella, Bacillus, Lactobacillus, Lactococcus, Staphylococcus, Listeria monocytogenes and Streptococcus.
    • 目的:提供用于抗HPV(人乳头瘤病毒)疫苗和转化的微生物的载体,从而在微生物表面上表达人乳头瘤病毒的衣壳L1蛋白,从而转化的微生物可用于预防和治疗hPV 。 构成:用于抗HPV(人乳头瘤病毒)疫苗的载体含有选自编码聚氨基葡萄酸合酶的pgsB,pgsC和pgsA的一个或两个基因和人乳头瘤病毒的抗原蛋白基因,其中抗原蛋白基因是一个或两个表面抗原 选自HPV衣壳L1和L2的蛋白质基因或选自HPV E6和E7的一个或两个抗原蛋白基因。 提供了具有抗HPV(人乳头瘤病毒)疫苗载体的转化微生物,其中微生物选自大肠杆菌,伤寒沙门氏菌,鼠伤寒沙门氏菌,霍乱弧菌,牛分枝杆菌,志贺氏菌,芽孢杆菌,乳杆菌属,乳球菌属,葡萄球菌属,李斯特菌 单核细胞增多和链球菌。