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11. 发明公开

KR1020140134249A 멜록시캄을 포함하는 안구 건조증 치료용 약학 조성물 有权
标题翻译：用于治疗包含MELOXICAM的西酞普兰的药物组合物
公开(公告)号：KR1020140134249A
公开(公告)日：2014-11-21
申请号：KR1020140146092
申请日：2014-10-27
申请人： 연세대학교 산학협력단
发明人： 이형근 , 심종우
IPC分类号： A61K31/541 , A61K31/54 , A61P27/02
CPC分类号： A61K31/5415 , A23L29/035 , A23L29/045 , A23L29/055 , A61K9/0019 , A61K9/06 , A61K9/10 , A61K9/14 , A61K9/20 , Y10S514/912
摘要： 본 발명의 화합물을 포함하는 안구 건조증 치료용 약학 조성물에 관한 것이다. 본 발명에 따른 약학 조성물을 이용하면 선택적으로 안구 건조증 증상을 호전시킬 수 있고, 안구 질환 치료 및 예방, 수술 후 상태 등의 다양한 염증 발현 상황에 의한 안구 불편감 해소 및 예방에 효과가 있다. 또한, PGE2, PGD2 및 COX2의 양을 검출하는 키트를 이용하여 임상에서 손쉽게 안구 건조증 또는 안구 통증 증상을 진단할 수 있어 안구건조증 환자 뿐만 아니라 안과 수술 후 환자의 상태를 파악하는 데 널리 활용될 수 있다.
摘要翻译：本发明涉及包含用于治疗干眼症的化合物的药物组合物。当使用本发明的药物组合物时，可以选择性地减轻干眼症，可以治疗和预防眼部疾病，并且可以消除并防止由于诸如术后状态的各种炎性表达条件引起的眼部不适。此外，通过使用用于检测PGE2，PGD2和COX2的量的试剂盒，可以将药物组合物用于临床诊断干眼症或眼睛疼痛症状，从而可广泛用于确定眼刺激患者和眼睛后患者的状况手术。

12. 发明授权

KR101459612B1 베르베논 유도체를 함유하는 퇴행성 뇌질환 치료 또는 예방용 조성물 有权
标题翻译：一种药物组合物，其包含用于治疗或预防退行性脑病的马鞭仙烯衍生物
公开(公告)号：KR101459612B1
公开(公告)日：2014-11-07
申请号：KR1020130064291
申请日：2013-06-04
申请人： 고려대학교 산학협력단
发明人： 김원기 , 최용석
IPC分类号： A61K31/435 , A61K31/495 , A61K31/53 , A61K31/045
CPC分类号： C07C49/86 , A23L29/055 , A23L33/105 , A23V2002/00 , A61K31/045 , A61K31/122 , A61K31/18 , A61K31/401 , A61K31/402 , A61K31/435 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/495 , A61K31/53 , A61K45/06 , C07C49/798 , C07C49/813 , C07C49/835 , C07C2102/42 , C07D207/02 , C07D213/50 , A23V2200/322 , A23V2200/326 , A23V2250/21
摘要： 본 발명은 베르베논 유도체 및 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 퇴행성 뇌질환 치료용 약학 조성물 또는 건강 기능 식품에 관한 것으로서, 상세하게는 본 발명의 베르베논 유도체는 신경세포사 및 산화적 스트레스를 감소시키고 래트에서의 뇌허혈성 손상 및 염증성 세포의 이주에 대하여 저해능이 탁월하므로 퇴행성 뇌질환 치료에 유용한 약학 조성물 또는 건강 기능 식품을 제공한다.
摘要翻译：本发明涉及药物组合物或功能性保健食品，其包含马鞭酮衍生物及其药学上可接受的盐作为治疗或预防神经变性疾病的活性成分。更具体地说，根据本发明的马鞭仙烷衍生物减少神经元细胞死亡和氧化应激，并且在预防大鼠的缺血性脑损伤和炎性细胞迁移方面非常有效，从而提供可用于治疗的药物组合物或功能保健食品神经退行性疾病

13. 发明授权

KR101268021B1 알코올로 인한 홍조 증상 억제용 의약, 식품 또는 음료 조성물 失效
标题翻译：一种药物和食品组合物，用于使用由酒精摄取引起的冲洗条件
公开(公告)号：KR101268021B1
公开(公告)日：2013-05-27
申请号：KR1020120131275
申请日：2012-11-20
申请人： 이 크리스 정연 , 신순용
发明人： 이크리스정연 , 신순용
IPC分类号： A61K31/415 , A61K31/41 , A61P43/00
CPC分类号： A61K31/4164 , A23L29/045 , A23L29/055 , A23V2200/334 , Y10S514/886
摘要： PURPOSE: A composition for a medicine, food, or a beverage is provided to prevent telangiectasia on the face, neck, hands, and/or shoulders of a consumer by comprising a H2 histamine receptor antagonist. CONSTITUTION: A composition for a medicine for suppressing telangiectasia due to alcohol consumption comprises cimetidine and a carrier which is pharmaceutically acceptable. The composition is injected 2-60 minutes before alcohol consumption. The composition for food or a beverage for suppressing telangiectasia due to alcohol consumption comprises cimtidine, an excipient, and an additive. The composition is injected 2-60 minutes before drinking alcohol. [Reference numerals] (AA) Front; (BB) Back
摘要翻译：目的：提供用于药物，食物或饮料的组合物，以通过包含H2组胺受体拮抗剂来防止消费者的面部，颈部，手部和/或肩部发生毛细血管扩张。构成：用于抑制由于饮酒引起的毛细血管扩张的药物组合物包括西咪替丁和药学上可接受的载体。在饮食前2-60分钟注射组合物。用于抑制由于饮酒引起的毛细血管扩张的食品或饮料组合物包括西咪替丁，赋形剂和添加剂。在饮用酒精前2-60分钟注射组合物。（附图标记）（AA）前面; （BB）返回

14. 发明公开

KR1020130045605A 부토코나졸을 포함한 퇴행성 신경질환 예방 또는 치료용 조성물 无效
标题翻译：用于预防或治疗神经损伤疾病的组合物
公开(公告)号：KR1020130045605A
公开(公告)日：2013-05-06
申请号：KR1020110109910
申请日：2011-10-26
申请人： 울산대학교 산학협력단 , 재단법인 아산사회복지재단
发明人： 윤승용 , 김동호 , 김인기
IPC分类号： A61K31/4164 , A61K31/41 , A61P25/28 , A61P25/00
CPC分类号： A61K31/4164 , A23L29/045 , A23L29/055 , A23V2200/322
摘要： PURPOSE: A composition containing butoconazole is provided to prevent or treat neurodegenerative diseases, especially Alzheimer's disease. CONSTITUTION: A composition for preventing or treating neurodegenerative diseases contains butoconazole, a derivative thereof, or a pharmaceutically acceptable salt thereof. The neurodegerative diseases are selected from stroke, memory loss, memory injury, dementia, Parkinson's disease, Pick disease, Creutzfeld-Kacob disease, Huntingtun's disease, and amyotrophic lateral sclerosis. A pharmaceutical composition for preventing or treating neurodegenerative diseases contains butoconazole, a derivative thereof, or a pharmaceutically acceptable salt thereof. A health food composition for preventing or treating neurodegenerative diseases contains butoconazole, a derivative thereof, or a pharmaceutically acceptable salt thereof.
摘要翻译：目的：提供含有布康唑的组合物以预防或治疗神经变性疾病，特别是阿尔茨海默病。构成：用于预防或治疗神经变性疾病的组合物含有布康唑，其衍生物或其药学上可接受的盐。神经变性疾病选自中风，记忆丧失，记忆损伤，痴呆，帕金森氏病，皮克病，克瑙斯 - 卡科病，亨特屯氏病和肌萎缩性侧索硬化。用于预防或治疗神经变性疾病的药物组合物含有布康唑，其衍生物或其药学上可接受的盐。用于预防或治疗神经变性疾病的保健食品组合物含有布康唑，其衍生物或其药学上可接受的盐。

15. 发明公开

KR1020130038585A 네크록스-5를 유효성분으로 함유하는 기관지 천식의 예방 또는 치료용 조성물 有权
标题翻译：包含NECROX-5的药物组合物用于预防或治疗青春期哮喘
公开(公告)号：KR1020130038585A
公开(公告)日：2013-04-18
申请号：KR1020110103024
申请日：2011-10-10
申请人： 주식회사 엘지생명과학
发明人： 이용철
IPC分类号： A61K31/54 , A61K31/404 , A61K31/095 , A61P11/06
CPC分类号： A61K31/541 , A23L29/035 , A23L29/045 , A23L29/055 , A23V2200/314 , A61K31/185 , A61K2300/00 , Y10S514/826
摘要： PURPOSE: A composition containing necrox-5 as an active ingredient for preventing or treating bronchial asthma is provided to reduce total number of inflammatory cells, lymphocytes, neutrophils, and eosinophils in bronchoalveolar lavage fluid of an asthma-induced mouse. CONSTITUTION: A composition for preventing or treating bronchial asthma contains necrox-5 as an active ingredient. Necrox-5 reduces the number of total inflammatory cells, lymphocytes, neutrophils, eosinophils and relieves hypersensitivity of airway and airway inflammation.
摘要翻译：目的：提供含有坏死因子-5作为预防或治疗支气管哮喘的有效成分的组合物，以减少哮喘诱发小鼠支气管肺泡灌洗液中炎性细胞，淋巴细胞，嗜中性粒细胞和嗜酸性粒细胞的总数。构成：用于预防或治疗支气管哮喘的组合物含有坏死因子-5作为活性成分。 Necrox-5减少了总炎症细胞，淋巴细胞，嗜中性粒细胞，嗜酸性粒细胞的数量，减轻了气道和气道炎症的过敏反应。

16. 发明公开

KR1020050002109A 메톡시아크릴레이트계 화합물을 포함하는, 골다공증 예방 또는 치료용 조성물 有权
标题翻译：包含甲氧基丙烯酸酯的化合物的组合物，其抑制卵巢发生和骨吸收而不具有细胞毒性以预防或治疗OSTEOPOROSIS
公开(公告)号：KR1020050002109A
公开(公告)日：2005-01-07
申请号：KR1020030043425
申请日：2003-06-30
申请人： 주식회사 오스코텍 , 한국화학연구원
发明人： 김정근 , 김세원 , 오귀옥 , 고선일 , 김종여 , 이병의 , 김호순 , 김범태 , 이연수 , 민용기 , 박노균
IPC分类号： A61K31/15
CPC分类号： A61K31/15 , A23L29/055 , A61K9/20 , A61K9/48
摘要： PURPOSE: Provided is a composition comprising a methoxyacrylate-based compound. The composition inhibits osteoclast generation and bone absorption strongly without cytotoxicity to prevent or treat osteoporosis easily and effectively. CONSTITUTION: The pharmaceutical composition for prevention and treatment of osteoporosis is characterized by containing as an active ingredient, a methoxyacrylate-based compound represented by the formula(1) and pharmaceutically acceptable carriers. In the formula, X is CH or N; Y is O or S; Z is O or NHR1 and R2 are independently H; C1-4 alkyl; C1-4 alkyl having at least one of halogen substituents; phenyl having at least one substituent selected from halogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, phenoxy and methylenedioxy; or naphthyl.
摘要翻译：目的：提供包含甲氧基丙烯酸酯类化合物的组合物。该组合物强烈地抑制破骨细胞产生和骨吸收而不具有细胞毒性以便容易且有效地预防或治疗骨质疏松症。构成：用于预防和治疗骨质疏松症的药物组合物的特征在于含有式（1）表示的基于甲氧基丙烯酸酯的化合物和药学上可接受的载体作为活性成分。在该式中，X是CH或N; Y为O或S; Z是O或NHR1，R2独立地是H; C 1-4烷基; 具有至少一个卤素取代基的C 1-4烷基; 具有至少一个选自卤素，C 1-4烷基，C 1-4卤代烷基，C 1-4烷氧基，苯氧基和亚甲二氧基的取代基的苯基; 或萘基。

17. 发明公开

KR1020140060792A 알코올로 인한 홍조 증상 억제용 의약, 식품 또는 음료 조성물 审中-实审
标题翻译：一种药物和食品组合物，用于使用由酒精摄取引起的冲洗条件
公开(公告)号：KR1020140060792A
公开(公告)日：2014-05-21
申请号：KR1020120127557
申请日：2012-11-12
申请人： 이 크리스 정연 , 신순용
发明人： 이크리스정연 , 신순용
IPC分类号： A61K31/415 , A61K31/41 , A61P43/00
CPC分类号： A61K31/4164 , A23L29/035 , A23L29/045 , A23L29/055 , A23V2200/334 , A61K9/0095 , A61K31/341 , A61K31/426 , Y10S514/886
摘要： The present invention relates to a pharmaceutical, a food, or a beverage composition for suppressing flushing symptoms caused by alcohol uptake. The composition is a pharmaceutical composition comprising histamine H2 receptor antagonists for suppressing the flushing symptoms caused by alcohol uptake. The pharmaceutical composition or the food composition according to the present invention is effective for suppressing the flushing symptoms on face, neck, hand, and/or shoulder caused by alcohol uptake.
摘要翻译：本发明涉及用于抑制由酒精摄入引起的潮红症状的药物，食品或饮料组合物。该组合物是包含组胺H2受体拮抗剂用于抑制由酒精摄入引起的潮红症状的药物组合物。根据本发明的药物组合物或食品组合物对于抑制由酒精摄取引起的面部，颈部，手和/或肩部的潮红症状是有效的。

18. 发明公开

KR1020140050943A 티아졸론 유도체를 유효성분으로 포함하는 혈소판 응집 억제용 조성물 无效
标题翻译：包含噻唑烷衍生物的组合物用于抑制片剂聚集
公开(公告)号：KR1020140050943A
公开(公告)日：2014-04-30
申请号：KR1020120117379
申请日：2012-10-22
申请人： 동국대학교 산학협력단
发明人： 이무열 , 류영추 , 장경화
IPC分类号： A61K31/426 , A61K31/34 , A61P7/02
CPC分类号： A61K31/427 , A23L29/035 , A23L29/045 , A23L29/055
摘要： The present invention relates to a composition comprising a thiazolone derivative as an active ingredient for inhibiting platelet aggregation. The thiazolone derivative according to the present invention can be used as a composition for inhibiting platelet aggregation and as a composition for preventing or treating thrombotic diseases since the thiazolone derivative has an excellent effect for inhibiting platelet aggregation induced by thrombin.
摘要翻译：本发明涉及包含噻唑酮衍生物作为抑制血小板聚集的活性成分的组合物。根据本发明的噻唑酮衍生物可以用作抑制血小板聚集的组合物和用作预防或治疗血栓形成疾病的组合物，因为噻唑酮衍生物对于抑制凝血酶诱导的血小板聚集具有优异的效果。

19. 发明公开

KR1020140018698A 네크록스-5를 유효성분으로 포함하는 급성 폐 손상 및 급성 호흡 곤란 증후군의 예방 또는 치료용 조성물 无效
标题翻译：包含NECROX-5用于预防或治疗急性肺损伤和急性呼吸系统综合征的组合物
公开(公告)号：KR1020140018698A
公开(公告)日：2014-02-13
申请号：KR1020120085238
申请日：2012-08-03
申请人： 주식회사 엘지생명과학
发明人： 이용철 , 김소리
IPC分类号： A61K31/404 , A61K31/54 , A61P11/00
CPC分类号： A61K31/541 , A23L29/035 , A23L29/045 , A23L29/055 , A23V2200/314
摘要： The present invention relates to a composition comprising necrox-5 as an active ingredient for preventing or treating acute lung injury and acute respiratory distress syndrome. The necrox-5 according to the present invention can be used for preventing or treating the acute lung injury and acute respiratory distress syndrome by reducing: a total number of inflammatory cells and a number of lymphocytes, neutrophils, and eosinocytes; lung injury and a degree of infection; and vascular permeability and protein exudative in bronchoalveolar lavage fluid of mice with LPS-induced acute lung injury.
摘要翻译：本发明涉及包含坏死因子-5作为预防或治疗急性肺损伤和急性呼吸窘迫综合征的活性成分的组合物。根据本发明的坏死因子5可以用于通过减少：炎性细胞和许多淋巴细胞，嗜中性粒细胞和嗜酸细胞的总数来预防或治疗急性肺损伤和急性呼吸窘迫综合征; 肺损伤和感染程度; 和LPS诱导的急性肺损伤小鼠支气管肺泡灌洗液中的血管通透性和蛋白质渗出。

20. 发明公开

KR1020130140402A 염증성 질환의 예방 또는 치료용 약학 조성물 및 건강기능식품 有权
标题翻译：用于制备或治疗炎症疾病的药物组合物和健康功能食品
公开(公告)号：KR1020130140402A
公开(公告)日：2013-12-24
申请号：KR1020120063767
申请日：2012-06-14
申请人： 부산대학교 산학협력단
发明人： 민도식 , 유현정 , 최강열 , 강동우 , 송주현
IPC分类号： A61K31/54 , A61K31/404 , A61K31/35 , A61P29/00
CPC分类号： A61K31/541 , A23L29/035 , A23L29/045 , A23L29/055 , Y10S514/825
摘要： The present invention relates to a pharmaceutical composition and a health supplement for preventing or treating inflammatory diseases and, more specifically, to the pharmaceutical composition and a health supplement for preventing or treating inflammatory diseases having improved effects which includes a compound represented by chemical formula 1. The compound represented by the chemical formula 1 suppresses production of inflammatory cytokines in synovitis, alleviates occurrence and development of arthritis, and suppresses inflammatory cytokines in blood such as TNF-alpha, IL-1 beta, IL-6, IFN-gamma, MCP-1, IL-17, and the likes. [Reference numerals]
摘要翻译：本发明涉及用于预防或治疗炎性疾病的药物组合物和健康补充剂，更具体地，涉及用于预防或治疗具有改善作用的炎性疾病的健康补充剂，其包括化学式1所示的化合物。由化学式1表示的化合物抑制滑膜炎中的炎性细胞因子的产生，减轻关节炎的发生和发展，并抑制血液中的炎性细胞因子如TNF-α，IL-1β，IL-6，IFN-γ，MCP- 1，IL-17等。 [附图标记]

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